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1. 发明授权

US06593372B2 Therapeutic uses for nitric oxide inhibitors 失效
标题翻译：一氧化氮抑制剂的治疗用途
公开(公告)号：US06593372B2
公开(公告)日：2003-07-15
申请号：US09999779
申请日：2001-10-25
申请人： Grigori N. Enikolopov , Natalia I. Peunova , Boris A. Kuzin , Hollis Cline , Tatyana Michurina
发明人： Grigori N. Enikolopov , Natalia I. Peunova , Boris A. Kuzin , Hollis Cline , Tatyana Michurina
IPC分类号： A61K31115
CPC分类号： A61K31/223 , A61K31/00 , A61K31/155 , A61K31/17 , A61K31/198 , A61K31/216
摘要： The present invention is based on the discovery that nitric oxide (NO) is an important growth regulator in an intact developing organism. In particular, the present invention relates to a method of increasing in a mammal a population of hematopoietic stem cells which are capable of undergoing normal hematopoiesis, differentiation and maturation in hematopoietic tissue, wherein the hematopoietic tissue is contacted with multiple doses of at least one inhibitor of NO, such as one or more inhibitors of nitric oxide synthase (NOS), thereby producing hematopoietic tissue having an increased population of hematopoietic stem cells which are capable of undergoing normal hematopoiesis, differentiation and maturation. The present invention also relates to a method of increasing a population of cells in S phase in a tissue of a mammal, comprising contacting the tissue with multiple doses of at least one inhibitor (one or more) of NO, such as an inhibitor of NOS. The invention also pertains to a method of regenerating tissue in an adult mammal comprising contacting a selected tissue (e.g., blood, skin, bone and digestive epithelium), or precursor cells of the selected tissue, with multiple doses of at least one inhibitor (one or more) of NO, thereby inhibiting differentiation and inducing proliferation of cells of the tissue.
摘要翻译：本发明基于一氧化氮（NO）是完整的发育生物体中重要的生长调节剂的发现。特别地，本发明涉及增加哺乳动物造血干细胞群体的方法，所述造血干细胞群体能够在造血组织中经历正常造血，分化和成熟，其中造血组织与多剂量的至少一种抑制剂接触的NO，例如一种或多种一氧化氮合酶抑制剂（NOS），从而产生具有增加的能够经历正常造血，分化和成熟的造血干细胞群体的造血组织。本发明还涉及增加哺乳动物组织中S期细胞群的方法，包括使组织与多个剂量的至少一种NO抑制剂（一种或多种）接触，所述抑制剂（一种或多种）例如NOS抑制剂。本发明还涉及一种在成年哺乳动物中再生组织的方法，包括使选定组织（例如血液，皮肤，骨骼和消化上皮）或所选组织的前体细胞与多个剂量的至少一种抑制剂（一种以上），从而抑制组织细胞的分化和诱导增殖。

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