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1. 发明申请

US20040259832A1 Novel antiherpes drug combinations 失效
标题翻译：新型抗血小板药物组合
公开(公告)号：US20040259832A1
公开(公告)日：2004-12-23
申请号：US10767019
申请日：2004-01-29
发明人： George E. Wright
IPC分类号： A61K031/7076 , A61K031/7072 , A61K031/675
CPC分类号： A61K45/06
摘要： Composition and methods are disclosed that include a synergistic combination of an inhibitor of Herpes simplex virus thymidine kinase, and an antiherpes substance.
摘要翻译：公开了包含单纯疱疹病毒胸苷激酶抑制剂与抗红细胞物质的协同组合的组合物和方法。

2. 发明申请

US20040235761A1 Novel virus proliferaton inhibition/virucidal method and novel pyradine nucleotide/pyradine nucleoside analogue 审中-公开
标题翻译：新型病毒增殖抑制/杀病毒方法和新型吡旦核苷酸/吡旦核苷类似物
公开(公告)号：US20040235761A1
公开(公告)日：2004-11-25
申请号：US10485265
申请日：2004-02-10
发明人： Yousuke Furuta , Hiroyuki Egawa , Kazumi Takahashi , Yasuhiro Takahashi , Sayuri Uehara , Makoto Murakami
IPC分类号： A61K031/7072 , A61K031/497 , A61K031/675
CPC分类号： C07H19/10 , A61K31/706 , C07H19/20 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/463 , Y02A50/465
摘要： 1 wherein each of R1, R2, R3, R4, R5, R6, R7, R8, R9 and A has the same meaning as given in the specification. The present invention relates to a method for exhibiting a virus growth-inhibiting effect and/or a virucidal effect, in which pyrazine nucleotide analog null2null and pyrazine nucleoside analog null3znull are subjected to biotransformation, decomposed and then phosphorylated, so that they become a pyrazine nucleotide analog null1bnull exhibiting the aforementioned effect. This method is useful as a method for treating virus infections. Moreover, the pyrazine carboxamide analog or a salt thereof of the present invention is useful as an agent for preventing or treating virus infections.
摘要翻译：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和A A各自具有与说明书中给出的含义相同。本发明涉及吡嗪核苷酸类似物[2]和吡嗪核苷类似物[3z]进行生物转化，分解，然后磷酸化的病毒生长抑制作用和/或病毒杀伤作用的方法，成为具有上述效果的吡嗪核苷酸类似物[1b]。该方法可用作治疗病毒感染的方法。此外，本发明的吡嗪羧酰胺类似物或其盐可用作预防或治疗病毒感染的药剂。

3. 发明申请

US20040185036A1 Compositions and methods for prolonging survival of platelets 失效
标题翻译：用于延长血小板存活的组合物和方法
公开(公告)号：US20040185036A1
公开(公告)日：2004-09-23
申请号：US10704377
申请日：2003-11-07
发明人： Thomas P. Stossel , John H. Hartwig , Karin M. Hoffmeister , Henrik Clausen
IPC分类号： A61K038/47 , A61K031/7072
CPC分类号： A01N1/0231 , A01N1/0263 , A61K31/7072
摘要： The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to mediate hemostasis.
摘要翻译：本发明提供具有降低的血小板清除率的改良血小板和减少血小板清除率的方法。还提供了用于保存血小板的组合物。本发明还提供了制备含有改性血小板的药物组合物和用于将哺乳动物给药以介导止血的方法。

4. 发明申请

US20040176316A1 Compounds for the normalization of the sleep/wake cycle 审中-公开
标题翻译：用于睡眠/唤醒循环正常化的化合物
公开(公告)号：US20040176316A1
公开(公告)日：2004-09-09
申请号：US10740075
申请日：2003-12-17
发明人： Perry F. Renshaw , Scott Lukas
IPC分类号： A61K031/7072 , A61K031/7076 , A61K031/14
CPC分类号： A61K31/7052 , A61K31/70
摘要： The invention provides methods for normalizing the sleep/wake cycle of a mammal by administering a therapeutically-effective amount of a cytosine-containing or cytidine-containing compound, uridine-containing compound, creatine-containing compound, adenosine-containing, or adenosine-elevating compound. As such the methods described herein may increase wakefulness, reduce tiredness or fatigue during the day, and improve sleep quality. The methods of the invention may also be used in the treatment of sleep disorders, such as insomnia, sleep apnea, periodic limb movements, restless leg syndrome, narcolepsy, and problem sleepiness, or for increasing cognitive function in sleep deprived individuals. Citicoline is an exemplary compound for use in the methods described herein.
摘要翻译：本发明提供了通过施用治疗有效量的含胞嘧啶或含胞苷化合物，含尿苷化合物，含肌酸的化合物，含腺苷或腺苷升高来使哺乳动物的睡眠/觉醒周期正常化的方法复合。因此，本文所述的方法可增加白天的觉醒，减轻疲劳或疲劳，并改善睡眠质量。本发明的方法也可用于治疗睡眠障碍，例如失眠，睡眠呼吸暂停，周期性肢体运动，不宁腿综合征，发作性睡眠和困扰困倦，或用于增加睡眠剥夺个体的认知功能。胞二磷胆碱是用于本文所述方法的示例性化合物。

5. 发明申请

US20040171567A1 Method for detection of neoplastic cells 审中-公开
标题翻译：肿瘤细胞检测方法
公开(公告)号：US20040171567A1
公开(公告)日：2004-09-02
申请号：US10659519
申请日：2003-09-09
申请人： THE JOHNS HOPKINS SCHOOL OF MEDICINE
发明人： David Sidransky , Stephen B. Baylin
IPC分类号： A61K048/00 , A61K031/7072 , A61K031/513 , A61K039/395
CPC分类号： C07K14/82 , A61K38/00 , C12Q1/6886 , C12Q2600/154 , C12Q2600/172
摘要： Methylation of p16 DNA and a resultant decrease in p16 gene expression is associated with transcriptional block and is associated with a variety of neoplasms. A method for detecting a neoplasm in a subject by doming methylation of 5nullCpG islands in p16 DNA, or detecting p16 mRNA or polypeptide levels in a sample is also provided.
摘要翻译： p16 DNA的甲基化和p16基因表达的降低与转录阻滞相关，并与多种肿瘤有关。还提供了通过使p16DNA中的5'CpG岛甲基化反应或检测样品中的p16 mRNA或多肽水平来检测受试者的肿瘤的方法。

6. 发明申请

US20040152661A1 Methods and compositions for treating viral diseases 审中-公开
标题翻译：用于治疗病毒性疾病的方法和组合物
公开(公告)号：US20040152661A1
公开(公告)日：2004-08-05
申请号：US10753840
申请日：2004-01-08
申请人： Syntex (U.S.A.) LLC
发明人： Joseph Armstrong Martin
IPC分类号： A61K031/7072
CPC分类号： A61K45/06 , A61K31/7068 , A61K31/7072 , A61K38/212 , Y02A50/385 , Y02A50/389 , Y02A50/393 , A61K2300/00
摘要： The present invention provides methods of preventing or treating West Nile virus as well as infections caused by other viruses of the Flaviviridae family in animals comprising administering to the animal a tehrapeutically effective amount of a compound of formula I either as alone or in combination with immunomodulators. 1
摘要翻译：本发明提供了预防或治疗西尼罗河病毒以及由动物中的黄病毒科的其他病毒引起的感染的方法，包括给予动物治疗有效量的式I化合物，或单独或与免疫调节剂组合。

7. 发明申请

US20040132739A1 Combination of a gelatinase inhibitor and an anti-tumor agent, and uses thereof 审中-公开
标题翻译：明胶酶抑制剂与抗肿瘤剂的组合及其用途
公开(公告)号：US20040132739A1
公开(公告)日：2004-07-08
申请号：US10476110
申请日：2003-10-24
发明人： Thomas Friess , Hans-Willi Krell , Werner Scheuer , Georg Tiefenthaler
IPC分类号： A61K031/513 , A61K031/7048 , A61K031/704 , A61K031/7072 , A61K038/21 , A61K033/24
CPC分类号： A61K31/70 , A61K31/515 , A61K33/24 , A61K45/06 , A61K31/335 , A61K2300/00
摘要： The invention concerns combinations of a gelatinase inhibitor, e.g. Ro-28-2653 with a cytotoxic/cytostatic agent and its use for the treatment of tumors.
摘要翻译：本发明涉及明胶酶抑制剂的组合，例如 Ro-28-2653具有细胞毒性/细胞生长抑制剂及其用于治疗肿瘤的用途。

8. 发明申请

US20040121979A1 Pharmaceutically active uridine esters 失效
标题翻译：药学活性尿苷酯
公开(公告)号：US20040121979A1
公开(公告)日：2004-06-24
申请号：US10476287
申请日：2003-10-29
发明人： Rudy Susilo
IPC分类号： A61K031/7072 , C07H019/067 , C07H019/073
CPC分类号： C07H19/06 , A61K31/20 , A61K31/385 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： The present invention relates to novel uridine esters of the general formula (I) wherein R represents a carboxylic acid residue, preferably a fatty acid residue and Rnull represents hydrogen or a hydroxy group, their use as pharmaceutically active agents against a variety of diseases, methods for the preparation of said uridine esters and pharmaceutical compositions containing at least one uridine ester as active ingredient. The present invention relates also to a drug combination comprising free fatty acids and/or fatty acid esters and uridine, deoxyuridine, uridine monophosphate and/or deoxyuridine monophosphate, and to the use of such a drug combination. 1
摘要翻译：本发明涉及通式（I）的新型尿苷酯，其中R代表羧酸残基，优选脂肪酸残基，R'代表氢或羟基，它们作为药物活性剂用于各种疾病，用于制备所述尿苷酯的方法和含有至少一种尿苷酯作为活性成分的药物组合物。本发明还涉及包含游离脂肪酸和/或脂肪酸酯和尿苷，脱氧尿苷，单磷酸尿苷和/或脱氧尿苷单磷酸酯的药物组合，以及这种药物组合的用途。

9. 发明申请

US20040072788A1 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase 审中-公开
公开(公告)号：US20040072788A1
公开(公告)日：2004-04-15
申请号：US10431657
申请日：2003-05-07
发明人： Balkrishen Bhat , Anne B. Eldrup , Thazha P. Prakash , Phillip Dan Cook , Robert L. LaFemina , Amy L. Simcoe , Carrie A. Rutkowski , Mario A. Valenciano
IPC分类号： A61K031/7076 , A61K031/7072
CPC分类号： C07H19/16 , A61K9/4858 , A61K31/7056 , A61K31/7064 , A61K31/7076 , A61K38/21 , A61K45/06 , C07D473/00 , C07D487/04 , C07H19/00 , C07H19/06 , C07H19/10 , C07H19/12 , C07H19/14 , C07H19/20 , Y02P20/582 , A61K2300/00
摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

10. 发明申请

US20040047918A1 Napthalamide compositions and uses thereof 审中-公开
标题翻译：萘酰胺组合物及其用途
公开(公告)号：US20040047918A1
公开(公告)日：2004-03-11
申请号：US10631106
申请日：2003-07-31
申请人： ChemGenex Therapeutics, Inc.
发明人： Dennis M. Brown
IPC分类号： A61K048/00 , A61K031/7076 , A61K031/7072 , A61K033/24 , A61K031/473
CPC分类号： A61K31/7048 , A61K31/47 , A61K31/4745 , A61K31/475 , A61K31/505 , A61K31/513 , A61K31/55 , A61K31/70 , A61K31/7076 , A61K33/24 , A61K45/06 , A61K31/365 , A61K31/335 , A61K31/165 , A61K31/12 , A61K2300/00
摘要： A method of treatment of a host with a cellular proliferative disease, comprising contacting the host with a naphthalimide and an antiproliferative agent, each in an amount sufficient to modulate said cellular proliferative disease, is described. In some embodiments, the naphthalimide comprises amonafide (5-amino-2-null2-(dimethylamine)ethylnull-1H-benznullde-nullisoquinoline-1,3-(2H)-dione). Antiproliferative agents of the invention comprise alkylating agents, intercalating agents, metal coordination complexes, pyrimidine nucleosides, purine nucleosides, inhibitors of nucleic acid associated enzymes and proteins, and agents affecting structural proteins and cytoplasmic enzymes. The invention comprises the described methods as well as compositions comprising a naphthalimide and an antiproliferative agent.
摘要翻译：描述了一种治疗具有细胞增殖性疾病的宿主的方法，包括使宿主与萘二甲酰亚胺和抗增殖剂接触，各自的量足以调节所述细胞增殖性疾病。在一些实施方案中，萘二甲酰亚胺包含氨喋啶（5-氨基-2- [2-（二甲基胺）乙基] -1H-苯并[d]异喹啉-1,3-（2H） - 二酮）。本发明的抗增殖剂包括烷化剂，嵌入剂，金属配位络合物，嘧啶核苷，嘌呤核苷，核酸相关酶和蛋白质的抑制剂以及影响结构蛋白和细胞质酶的试剂。本发明包括所述方法以及包含萘二甲酰亚胺和抗增殖剂的组合物。

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