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1. 发明申请

US20010047032A1 Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases 审中-公开
标题翻译：用于治疗淀粉样变性和α-突触核蛋白原纤维病的多羟基化芳族化合物
公开(公告)号：US20010047032A1
公开(公告)日：2001-11-29
申请号：US09748748
申请日：2000-12-26
发明人： Gerardo M. Castillo , Paula Y. Choi , Alan D. Snow
IPC分类号： A61K031/7042 , A61K031/70 , A61K031/66
CPC分类号： A61K31/7048 , A61K31/05 , A61K31/12 , A61K31/136 , A61K31/192 , A61K31/352 , A61K31/353 , A61K31/37 , A61K31/435 , A61K31/4353 , A61K45/06 , A61K2300/00
摘要： Polyhydroxylated aromatic compounds, and compositions containing them, are useful for the treatment of amyloidosis, especially Alzheimer's disease, and for the treatment of diseases characterized by null-synuclein fibril formation, especially Lewy body disease and Parkinson's disease.
摘要翻译：多羟基化芳族化合物和含有它们的组合物可用于治疗淀粉样变性，特别是阿尔茨海默氏病，以及用于治疗以α-突触核蛋白原纤维形成为特征的疾病，特别是路易体病和帕金森病。

2. 发明申请

US20030017996A1 Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use 有权
公开(公告)号：US20030017996A1
公开(公告)日：2003-01-23
申请号：US10201050
申请日：2002-07-24
申请人： Aventis Pharma Deutschland GmbH
发明人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
IPC分类号： A61K031/7042
CPC分类号： C07K5/06086 , A61K38/00 , C07D337/08 , C08G65/329
摘要： Substituted benzothiepine 1,1-dioxide derivatives of formula I: 1 in which R1, R2, R3, R4, R5 and Z have the meanings indicated, and their physiologically tolerable salts and physiologically functional derivatives and a process for their preparation are described. The compounds are suitable, for example, as hypolipidemics.

3. 发明申请

US20020169134A1 Use of substituted azetidinone compounds for the treatment of sitosterolemia 有权
标题翻译：使用取代的氮杂环丁酮化合物治疗静脉麻醉
公开(公告)号：US20020169134A1
公开(公告)日：2002-11-14
申请号：US10057629
申请日：2002-01-25
申请人： Schering Corporation
发明人： Harry R. Davis
IPC分类号： A61K031/397 , A61K031/7042
CPC分类号： A61K31/7042 , A61K31/397 , A61K2300/00
摘要： The present invention is directed to the use of sterol absorption inhibiting compounds, pharmaceutical compositions thereof, therapeutic combinations and their use in combination with other lipid lowering agents to treat or prevent sitosterolemia and/or to lower the concentration of sterol(s) other than cholesterol in plasma or tissue of a mammal. Methods of treating or preventing vascular disease and coronary events also are provided.
摘要翻译：本发明涉及使用甾醇吸收抑制化合物，其药物组合物，治疗组合及其与其它降脂药联合用于治疗或预防静脉麻醉和/或降低胆固醇以外的固醇浓度的用途在哺乳动物的血浆或组织中。还提供治疗或预防血管疾病和冠状动脉事件的方法。

4. 发明申请

US20020165207A1 Compositions and methods for the treatment of diabetic neuropathy 审中-公开
标题翻译：用于治疗糖尿病性神经病变的组合物和方法
公开(公告)号：US20020165207A1
公开(公告)日：2002-11-07
申请号：US09847121
申请日：2001-05-02
发明人： Richard Rosenbloom
IPC分类号： A61K031/59 , A61K031/7042 , A61K031/353
CPC分类号： A61K45/06 , A61K31/07 , A61K31/355 , A61K31/385 , A61K31/593 , A61K2300/00
摘要： Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.
摘要翻译：公开了用于治疗糖尿病性神经病变的组合物和方法。组合物包含促进神经生长因子合成的化合物，醛糖还原酶抑制剂和抗氧化剂的混合物，任选配制在药学上可接受的载体中。活性剂的这种组合提供了显着的，有效的缓解糖尿病性神经病变的症状，以及在某些情况下至少部分恢复失去的神经功能。此外，本发明的组合物当以有效量用于治疗糖尿病性神经病变时，不表现出用于治疗该疾病的许多现有技术组合物的严重副作用。在第二方面，公开了根据本发明的用于治疗糖尿病性神经病的组合物的给药方法。在该方法中，有效量的本发明组合物在足以提供缓解糖尿病性神经病变症状的有益效果的时间内定期施用，以及受损神经的至少一些恢复组织。

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