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1. 发明授权

US5416329A Apparatus for counting liquid scintillation samples 失效
标题翻译：用于计数液体闪烁样品的装置
公开(公告)号：US5416329A
公开(公告)日：1995-05-16
申请号：US300084
申请日：1994-09-02
申请人： Vesa Sonne , Kauko Lehtinen , Tapio Yrjonen
发明人： Vesa Sonne , Kauko Lehtinen , Tapio Yrjonen
IPC分类号： G01N35/04 , G01T1/204 , G01T7/02 , G01N35/10
CPC分类号： G01T7/02 , G01T1/2045 , G01N2035/042 , G01N2035/0425
摘要： A device for counting liquid scintillation samples which can count a single sample or several samples simultaneously. A transport system moves samples from a storage section to a counting section. The samples are placed on sample plate holders to assist the transport system in movement of the sample from the storage section to the counting section.
摘要翻译：用于计数液体闪烁样品的装置，其可以同时对单个样品或多个样品进行计数。运输系统将样品从存储部分移动到计数部分。将样品放置在样品板支架上，以帮助运输系统将样品从储存部分移动到计数部分。

2. 发明授权

US4924093A Beta counting means and apparatus 失效
标题翻译： Beta计数手段和装置
公开(公告)号：US4924093A
公开(公告)日：1990-05-08
申请号：US725582
申请日：1985-04-22
申请人： Edgar G. Johnson , James J. Cornelison
发明人： Edgar G. Johnson , James J. Cornelison
IPC分类号： G01Q30/08 , G01T1/204
CPC分类号： G01T1/2045 , G01T1/204
摘要： An improved beta activity counter is disclosed which provides for counting plural, preferably even numbers of, samples simultaneously, while allowing automated handling of sample vial racks which are different widths are multiples of the number of simultaneous testing cells. The number of indexing steps needed per rack are adjusted automatically according to the number of vials that each rack will hold. Quench counting of adjacent samples simultaneously via use of one external source is also provided.
摘要翻译：公开了一种改进的β活性计数器，其提供同时计数多个，优选偶数个样品，同时允许自动处理不同宽度的样品瓶架是同时测试单元数量的倍数。根据每个机架将保持的样品瓶数量，自动调整每个机架所需的索引步骤数。还提供了通过使用一个外部源同时对相邻样品进行淬火计数。

3. 发明授权

US4918310A Liquid scintillation counter for measuring the activity of radioactive samples containing a multiple of radioactive isotopes 失效
标题翻译：液体闪烁计数器，用于测量含有多个放射性同位素的放射性样品的活性
公开(公告)号：US4918310A
公开(公告)日：1990-04-17
申请号：US274488
申请日：1988-11-22
申请人： Kenneth Rundt , Heikki Kouru
发明人： Kenneth Rundt , Heikki Kouru
IPC分类号： G01T1/204
CPC分类号： G01T1/2045 , G01T1/204
摘要： In a liquid scintillation counter the light output from a liquid scintillation sample containing radioactive isotopes of unknown activity is measured by means of a detector. A pulse height analyzer having discriminators that are combined to define pulse height windows, is connected to the detector for measuring and temporarily storing count rates for each of the windows. Moreover, there are means for determining a value for the quench level of the sample. According to the invention the number of pulse height windows is at least N+1, when the number of isotopes is N,N being .gtoreq.2. There are memory means for storing for each of said windows representations of counting intensities determined by measuring calibration samples of each isotope at different levels of quench. Moreover, there are means for extracting from said stored representations a counting intensity for each window and each isotope on the basis of said determined quench level value, and means for determining for each isotope a factor by which the extracted counting intensities are to be multiplied in order to fit the sum of the extracted counting intensities to the count rates measured for the sample in each window, each said factor being directly related to the amount of each isotope in the sample.
摘要翻译：在液体闪烁计数器中，通过检测器测量来自含有未知活性的放射性同位素的液体闪烁样品的光输出。具有组合以限定脉冲高度窗口的鉴别器的脉冲高度分析器连接到检测器，用于测量和临时存储每个窗口的计数率。此外，存在用于确定样品的骤冷水平的值的方法。根据本发明，当同位素数为N时，脉冲高度窗口的数量至少为N + 1，N为> / = 2。存储装置用于存储每个所述窗口表示的计数强度，其通过以不同的骤冷水平测量每个同位素的校准样本而确定。此外，存在用于从所述存储的表示中提取基于所述确定的骤冷电平值的每个窗口和每个同位素的计数强度的装置，以及用于为每个同位素确定所提取的计数强度将被乘以的因子的装置为了将提取的计数强度的总和与在每个窗口中的样品测量的计数率相适合，每个所述因子与样品中每个同位素的量直接相关。

4. 发明授权

US4002909A Data analyzing system having provision for optimizing counting conditions and thus improving statistical counting validity for enabling accurate computation of sample activity levels in liquid scintillation spectrometry 失效
标题翻译：数据分析系统具有优化计数条件，从而提高统计计数的有效性，从而能够准确计算液体闪烁光谱中的样品活性水平
公开(公告)号：US4002909A
公开(公告)日：1977-01-11
申请号：US674083
申请日：1967-09-28
申请人： Lyle E. Packard , Edward F. Polic , Robert E. Cavanaugh, Jr.
发明人： Lyle E. Packard , Edward F. Polic , Robert E. Cavanaugh, Jr.
IPC分类号： G01T1/204 , G01T1/36 , G01T7/08
CPC分类号： G01T1/2045 , G01T1/36
摘要： A data analyzing system for scintillation spectrometers of the type for measuring activity levels of samples containing radioactive isotopes and subjected to varying degrees of quench, including methods and apparatus for optimizing counting conditions and thereby improving statistical counting validity irrespective of the degree of quenching present in any given sample, and wherein a measured parameter indicative of the effective quench condition of each sample is utilized to automatically adjust, by preselected preset amounts, the counting window for any given isotope relative to the observed energy spectrum for that isotope. Various methods and apparatus are described which, although suitable for optimizing counting conditions for both multiple-labeled and single-labeled test samples, are particularly effective in creating significantly improved isotope separations when dealing with multiple-labeled samples -- for example, a double-labeled sample containing tritium (.sup.3 H) and carbon-14 (.sup.14 C).
摘要翻译：用于测量含有放射性同位素并经受不同程度骤冷的样品的活性水平的闪烁光谱仪的数据分析系统，包括用于优化计数条件的方法和装置，从而提高统计计数的有效性，而不管存在于任何并且其中利用指示每个样品的有效骤冷条件的测量参数通过预选的预设量自动调整任何给定同位素相对于该同位素观测能谱的计数窗口。描述了各种方法和装置，其尽管适合于优化多标记和单标记测试样品的计数条件，但是当处理多个标记的样品时产生显着改善的同位素分离特别有效 - 例如双标记含有氚（3H）和碳-14（14C）的样品。

5. 发明授权

US3717753A Liquid scintillation spectrometer with automatic setting of channel limits 失效
标题翻译：具有自动设置通道限制的液体扫描光谱仪
公开(公告)号：US3717753A
公开(公告)日：1973-02-20
申请号：US3717753D
申请日：1969-10-01
申请人： INTERTECHNIQUE SA
发明人： THOMAS E
IPC分类号： G01T1/204 , G01T1/20
CPC分类号： G01T1/2045
摘要： This specification discloses a liquid scintillation spectrometer which analyzes a plurality of liquid scintillation test samples in sequence. The system measures the level of quenching in each sample and then measures the rate that scintillations are produced in selected ranges of intensities. The system sets the limits of the intensity ranges for each sample at values determined from the level of quenching found in such sample. A computer is used to determine the range limits from the level of quenching.
摘要翻译：本说明书公开了一种液相闪烁光谱仪，其顺序分析多个液体闪烁测试样品。该系统测量每个样品中的淬灭水平，然后测量在选定的强度范围内产生闪烁的速率。该系统设定每个样品的强度范围的极限，其值取决于在该样品中发现的猝灭程度。计算机用于从淬火水平确定范围极限。

6. 发明授权

US5134294A Apparatus and a method for measuring the activity of radioactive samples containing a multiple of radioactive isotopes 失效
标题翻译：装置和测量包含多种放射性同位素的放射性样品的活性的方法
公开(公告)号：US5134294A
公开(公告)日：1992-07-28
申请号：US651211
申请日：1991-02-06
申请人： Kenneth Rundt , Heikki Kouru
发明人： Kenneth Rundt , Heikki Kouru
IPC分类号： G01T1/204
CPC分类号： G01T1/2045 , G01T1/204
摘要： Liquid scintillation counter includes a memory having stored spectra of known counting efficiencies and known levels of quench, for the isotopes to be meansured. A device extracts from the spectra, using the determined quench level value for each of the N isotopes, a reference spectrum representing a pure isotope spectrum at the determined quench level. A device determines for each extracted reference spectrum a factor by which the extracted reference spectrum is to be multiplied in order to fit the sum of the multiplied reference spectra to the sample spectrum. Each factor is directly related to the amount of each isotope in the sample. A method for use in a liquid scintillation counter includes, first extracting, from stored spectra of known counting efficiencies and known levels of quench for each of the N isotopes, a reference spectrum representing a pure isotope spectrum at the determined quench level and second, determining, for each extracted reference spectrum, a factor by which the extracted reference spectrum is to be multiplied in order to fit the sum of the multiplied reference spectra to the amount of each isotope in the sample.

7. 发明授权

US5120962A Apparatus and a method for measuring the activity of radioactive samples containing a multiple of radioactive isotopes, without separate determination of the quench level 失效
标题翻译：装置和测量包含多个放射性同位素的放射性样品的活性的方法，没有单独测定QU CH CH CH VEL
公开(公告)号：US5120962A
公开(公告)日：1992-06-09
申请号：US651217
申请日：1991-02-06
申请人： Kenneth Rundt , Heikki Kouru
发明人： Kenneth Rundt , Heikki Kouru
IPC分类号： G01T1/204
CPC分类号： G01T1/2045 , G01T1/204
摘要： Liquid scintillation counter includes a memory having stored spectra of known counting efficiencies and known levels of quench, for isotopes to be measured. A device extracts from the spectra, by using the determined quench level value for each of the N isotopes, a reference spectrum representing a pure isotope spectrum at the predicted quench level. A device determines for each extracted reference spectrum a factor by which the extracted reference spectrum is to be multiplied in order to fit the sum of the multiplied reference spectra to the sample spectrum. Each factor is directly related to the amount of each isotope in the sample. A device computes a goodness-of-fit value and predicts a new value for the quench level based on this goodness-of-fit value. A method in liquid scintillation counter includes predicting a first value of the quench level of the scintillation sample. A reference spectrum is extracted from stored spectra of known counting efficiencies and known levels of quench, for each of the N isotopes. The reference spectrum represents a pure isotope spectrum at the determined quench level. A factor is determined for each extracted reference spectrum by which the extracted reference spectrum is to be multiplied in order to fit the sum of the multiplied reference spectra to the sample spectrum. Each factor is directly related to the amount of each isotope in the sample. A goodness-of-fit value is computed and a new value for the quench level is predicted based on this goodness-of-fit value.
摘要翻译： PCT No.PCT / FI89 / 00147 Sec。 371日期1991年2月6日 102（e）日期1991年2月6日PCT PCT 1989年8月10日PCT公布。第WO90 / 01710号公报日期1990年2月22日。液体闪烁计数器包括具有已知计数效率和已知的淬灭水平的存储光谱的存储器，用于待测量的同位素。通过使用确定的每个N同位素的淬灭水平值，从光谱中提取设备，表示在预测猝灭水平的纯同位素谱的参考光谱。设备为每个提取的参考光谱确定所提取的参考光谱要乘以的因子，以便将相乘的参考光谱的和拟合到采样光谱。每个因素与样品中每个同位素的量直接相关。设备计算拟合优度值，并基于此拟合优度值预测猝灭水平的新值。液体闪烁计数器中的方法包括预测闪烁样品的骤冷水平的第一值。对于N个同位素中的每一个，从已知的计数效率和已知的淬灭水平的存储光谱中提取参考光谱。参考光谱表示在确定的淬灭水平下的纯同位素谱。为了将所提取的参考光谱相乘以便将所乘的参考光谱的和与样本光谱相加，确定每个提取的参考光谱的因子。每个因素与样品中每个同位素的量直接相关。计算拟合优度值，并基于该拟合优度值预测猝灭水平的新值。

8. 发明授权

US4694176A Method and apparatus for indicating quench of a liquid scintillation solution 失效
标题翻译：用于指示液体闪烁溶液淬灭的方法和装置
公开(公告)号：US4694176A
公开(公告)日：1987-09-15
申请号：US818059
申请日：1986-01-10
申请人： Donald L. Horrocks
发明人： Donald L. Horrocks
IPC分类号： G01T1/204
CPC分类号： G01T1/2045
摘要： A method and apparatus for indicating quench associated with a liquid scintillation solution wherein the solution includes a sample, a solvent and a solute. The method includes exposing the solution to flashes of light, detecting a pulse height spectrum for scintillations produced in the solution in response to the light flashes, determining a unique point on such pulse height spectrum, and relating the unique point to a corresponding pulse height value, such pulse height value providing an indication of quench associated with the solution. The wavelength of light preferably excites essentially only the solvent and the light flash intensity and duration is such that the pulse height spectrum produced in response to the light flashes does not overlap a pulse height spectrum for the sample in the solution. An attribute of the shape of the light pulse height spectrum may be examined to provide an indication of the homogeneous or non-homogeneous nature of the quench present in the solution.
摘要翻译：一种用于指示与液体闪烁溶液相关的骤冷的方法和装置，其中溶液包括样品，溶剂和溶质。该方法包括将溶液暴露于闪烁的光，检测响应于光闪烁在溶液中产生的闪烁的脉冲高度谱，确定这样的脉冲高度谱上的唯一点，并将唯一点与对应的脉冲高度值相关联，这样的脉冲高度值提供与解决方案相关联的骤冷指示。光的波长优选仅基本上激发溶剂，并且光闪光强度和持续时间使得响应于闪光而产生的脉冲高度谱与溶液中的样品的脉冲高度谱不重叠。可以检查光脉冲高度谱的形状的属性，以提供溶液中存在的骤冷的均匀或非均匀性质的指示。

9. 发明授权

US4661705A Quench, volume and activity determinations in a liquid scintillation flow system 失效
标题翻译：液体闪烁流系统中的淬火，体积和活度测定
公开(公告)号：US4661705A
公开(公告)日：1987-04-28
申请号：US612181
申请日：1984-05-21
申请人： Donald L. Horrocks
发明人： Donald L. Horrocks
IPC分类号： G01F1/704 , G01T1/204 , G01T1/00
CPC分类号： G01F1/7042 , G01T1/2045
摘要： A method for use with liquid scintillation flow systems including flowing a mixture comprising a sample and a liquid scintillation medium through a flow detector, the liquid scintillation medium including a radionuclide marker having an energy distribution different from the sample. A pulse height distribution spectrum is determined and a unique point on the portion of the pulse height distribution spectrum representing the energy spectrum of the medium is found, a pulse height value related to such unique point providing a value related to the degree of quench present in the mixture. By comparing such pulse height value to a pulse height value obtained in a like manner for a calibration standard, a degree of quench present in the mixture is indicated. Furthermore, the counts detected for the liquid scintillation medium during a measurement period may be related to the specific activity of the liquid scintillation medium to determine the volume of liquid scintillation medium flowing during the measurement period. The volume of sample flowing during such period may also be determined by relating the liquid scintillation medium volume to a ratio of sample to liquid scintillation medium flowing through the flow detector. Sample count rate is corrected for quench and sample specific activity is determined.
摘要翻译：一种与液体闪烁流系统一起使用的方法，包括使包含样品和液体闪烁介质的混合物通过流量检测器流动，所述液体闪烁介质包括具有与样品不同的能量分布的放射性核素标记。确定脉冲高度分布光谱，并且发现表示介质能谱的脉冲高度分布光谱部分上的唯一点，与这样的独特点相关的脉冲高度值提供与淬灭程度相关的值混合物。通过将这样的脉冲高度值与以校准标准相同的方式获得的脉冲高度值进行比较，则表示混合物中存在的骤冷度。此外，在测量期间检测到的液体闪烁介质的计数可能与液体闪烁介质的比活性有关，以确定在测量期间流动的液体闪烁介质的体积。在此期间流动的样品的体积也可以通过将液体闪烁介质体积与流过流量检测器的样品与液体闪烁介质的比率相关联来确定。校正样品计数率，并确定样品比活度。

10. 发明授权

US4628205A Regionless multiple label scintillation counting 失效
标题翻译：无区域多标记闪烁计数
公开(公告)号：US4628205A
公开(公告)日：1986-12-09
申请号：US721264
申请日：1985-04-08
申请人： Gustav C. van Cauter , Leroy J. Everett , Stanley J. DeFilippis
发明人： Gustav C. van Cauter , Leroy J. Everett , Stanley J. DeFilippis
IPC分类号： G01T1/204 , G01T1/20
CPC分类号： G01T1/2045 , G01T1/204
摘要： Apparatus and a regionless method of ascertaining the activity of each radionuclide in a dual-label sample. A set of correlation curves is generated utilizing quench standards for both a low energy radionuclide and a high energy radionuclide. A test sample was then counted and the quench-indicating parameters for the test sample are compared with the quench-indicating parameters of the correlation curves to determine the appropriate contribution of each radionuclide to the overall energy spectra of the test sample. From this comparison the overall count rate for the test sample may be allocated between a low energy radionuclide and a high energy radionuclide. By dividing the count rates by efficiencies determined from another set of correlation curves the actual disintegration per minute (DPM) rate for each radionuclide may be ascertained.
摘要翻译：确定双标记样品中每种放射性核素的活性的装置和无区域方法。利用低能量放射性核素和高能量放射性核素的淬灭标准产生一组相关曲线。然后计数一个测试样品，并将测试样品的淬灭指示参数与相关曲线的淬灭指示参数进行比较，以确定每个放射性核素对测试样品总体能谱的适当贡献。从该比较中，测试样品的总计数率可以在低能量放射性核素和高能量放射性核素之间分配。通过将计数率除以由另一组相关曲线确定的效率，可以确定每个放射性核素的每分钟实际分解速率（DPM）。

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