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1. 发明授权

US12030058B2 System and method for multi-axis imaging of specimens 有权
公开(公告)号：US12030058B2
公开(公告)日：2024-07-09
申请号：US17738178
申请日：2022-05-06
申请人： Faxitron Bioptics, LLC
发明人： Ciaran Purdy , Donogh O'Driscoll
IPC分类号： B01L9/00 , A61B10/00 , G01N33/483
CPC分类号： B01L9/52 , A61B10/0096 , G01N33/4833 , B01L2300/0609 , B01L2300/0809 , B01L2300/123 , G01N2223/307 , G01N2223/6126
摘要： A specimen holding and positioning apparatus operable to substantially non-movably maintain a specimen (e.g., an excised tissue specimen) in a fixed or stable orientation with respect to the apparatus during imaging operations (e.g., x-ray imaging), transport (e.g., from a surgery room to a pathologist's laboratory), and the like for use in facilitating accurate detection and diagnosis of cancers and/or other abnormalities of the specimen.

2. 发明授权

US09557281B2 Excised specimen imaging using a combined PET and micro CT scanner 有权
标题翻译：使用组合的PET和微CT扫描仪切除标本成像
公开(公告)号：US09557281B2
公开(公告)日：2017-01-31
申请号：US14124654
申请日：2012-06-11
申请人： Ramsey D. Badawi , Kai Yang
发明人： Ramsey D. Badawi , Kai Yang
IPC分类号： G01N23/04 , A61B6/03 , A61B6/00 , G01T1/161 , A61B6/04
CPC分类号： G01N23/046 , A61B6/032 , A61B6/037 , A61B6/0407 , A61B6/4258 , A61B6/508 , A61B6/5235 , G01N2223/1016 , G01N2223/108 , G01N2223/419 , G01N2223/6126 , G01T1/161
摘要： Embodiments of the present invention provide methods and apparatus for imaging a tissue specimen excised during surgery with a combined positron emission tomography (PET) and micro computed tomography (micro CT) scanner. The specimen is scanned with a CT imaging system of the combined PET and micro CT scanner. The specimen is also scanned with a PET imaging system of the combined PET and micro CT scanner. A PET image is constructed based on data acquired by the PET imaging system. A micro CT image is constructed based on data acquired by the micro CT imaging system. The micro CT image includes at least one visualization of a lesion marker.
摘要翻译：本发明的实施例提供了用组合正电子发射断层摄影（PET）和微型计算机断层摄影（micro CT）扫描仪对在手术期间切除的组织样本进行成像的方法和装置。用PET和微型CT扫描仪的CT成像系统对样本进行扫描。样品也用PET和微CT扫描仪的PET成像系统进行扫描。基于PET成像系统获取的数据构建PET图像。基于微CT成像系统获取的数据构建微CT图像。微CT图像包括病变标记物的至少一个可视化。

3. 发明授权

US09435756B2 Method for analysis using X-ray fluorescence 有权
公开(公告)号：US09435756B2
公开(公告)日：2016-09-06
申请号：US14715206
申请日：2015-05-18
申请人： ICAGEN, INC.
发明人： Lori J. Peterson , Cameron A. Mortillaro , Benjamin P. Warner , Nathan H. Zahler , Pratima Bharti , Chang-Tai Hsieh , Emilia A. Solomon
IPC分类号： G01N23/223 , G01N33/483 , G01N33/487 , A61B6/00
CPC分类号： G01N23/223 , A61B6/485 , G01N33/4833 , G01N33/487 , G01N2223/076 , G01N2223/0766 , G01N2223/612 , G01N2223/6126
摘要： The present invention is a method to quantify biomarkers. The method uses an X-ray fluorescence spectrometer to perform an X-ray fluorescence analysis on the sample to obtain spectral features derived from the biomarker; and quantifying the X-ray fluorescence signal of the biomarker.

4. 发明授权

US09418451B2 X-ray CT apparatus, substance identifying method, and image processing apparatus 有权
标题翻译： X射线CT装置，物质识别方法以及图像处理装置
公开(公告)号：US09418451B2
公开(公告)日：2016-08-16
申请号：US13994346
申请日：2012-09-24
申请人： Toshiba Medical Systems Corporation
发明人： Hiroki Taguchi , Masaharu Tsuyuki
IPC分类号： G06T11/00 , G01N23/04 , A61B6/03 , A61B6/00
CPC分类号： G06T11/003 , A61B6/032 , A61B6/482 , G01N23/046 , G01N2223/206 , G01N2223/419 , G01N2223/6126 , G06T11/005 , G06T2211/408
摘要： An X-ray CT apparatus of an embodiment displays an image of the inside of an object based on projection data obtained by scanning the object, and comprises a generator, a converter, an image forming part and an identifier. The generator scans the object with each of X-rays of different energy levels and generates multiple projection data. The converter converts the multiple projection data into multiple new projection data corresponding to multiple reference substances. The image forming part reconstructs each of the multiple new projection data converted by the converter, thereby forming multiple reference substance images corresponding to the multiple reference substances. The identifier identifies a target substance based on a correlation of pixel values in the multiple reference substance images.
摘要翻译：实施例的X射线CT装置基于通过扫描对象获得的投影数据来显示物体内部的图像，并且包括发生器，转换器，图像形成部分和标识符。发电机用不同能级的X射线扫描物体，并产生多个投影数据。该转换器将多个投影数据转换成对应于多个参考物质的多个新的投影数据。图像形成部分重建由转换器转换的多个新的投影数据中的每一个，从而形成对应于多个参考物质的多个参考物质图像。标识符基于多个参考物质图像中的像素值的相关性来识别目标物质。

5. 发明申请

US20140065663A1 METHODS FOR EVALUATING QUANTIFYING FIBROSIS IN LUNG TISSUE 审中-公开
标题翻译：评估肺组织定量纤维化的方法
公开(公告)号：US20140065663A1
公开(公告)日：2014-03-06
申请号：US14020462
申请日：2013-09-06
申请人： Numira Biosciences, Inc.
发明人： Sergio Vasquez , Neha Shah , David Weinstein
IPC分类号： G01N21/17
CPC分类号： G01N21/17 , A61B6/50 , G01N23/046 , G01N2223/419 , G01N2223/6126
摘要： The present disclosure relates in general to methods for staining and imaging lung specimens for the purpose of quantifying fibrotic areas of the lung. Images according to the present invention include images obtained from X-ray microcomputed tomography.
摘要翻译：本公开一般涉及用于定量肺纤维化区域的肺标本的染色和成像的方法。根据本发明的图像包括从X射线微计算机断层摄影获得的图像。

6. 发明申请

US20130287260A1 X-RAY CT APPARATUS, SUBSTANCE IDENTIFYING METHOD, AND IMAGE PROCESSING APPARATUS 有权
标题翻译： X射线CT装置，物质识别方法和图像处理装置
公开(公告)号：US20130287260A1
公开(公告)日：2013-10-31
申请号：US13994346
申请日：2012-09-24
申请人： Hiroki Taguchi , Masaharu Tsuyuki
发明人： Hiroki Taguchi , Masaharu Tsuyuki
IPC分类号： G06T11/00
CPC分类号： G06T11/003 , A61B6/032 , A61B6/482 , G01N23/046 , G01N2223/206 , G01N2223/419 , G01N2223/6126 , G06T11/005 , G06T2211/408
摘要： An X-ray CT apparatus of an embodiment displays an image of the inside of an object based on projection data obtained by scanning the object, and comprises a generator, a converter, an image forming part and an identifier. The generator scans the object with each of X-rays of different energy levels and generates multiple projection data. The converter converts the multiple projection data into multiple new projection data corresponding to multiple reference substances. The image forming part reconstructs each of the multiple new projection data converted by the converter, thereby forming multiple reference substance images corresponding to the multiple reference substances. The identifier identifies a target substance based on a correlation of pixel values in the multiple reference substance images.
摘要翻译：实施例的X射线CT装置基于通过扫描对象获得的投影数据来显示物体内部的图像，并且包括发生器，转换器，图像形成部分和标识符。发电机用不同能级的X射线扫描物体，并产生多个投影数据。该转换器将多个投影数据转换成对应于多个参考物质的多个新的投影数据。图像形成部分重建由转换器转换的多个新的投影数据中的每一个，从而形成对应于多个参考物质的多个参考物质图像。标识符基于多个参考物质图像中的像素值的相关性来识别目标物质。

7. 发明申请

US20130022165A1 X-RAY IMAGING APPARATUS AND METHOD 有权
标题翻译： X射线成像装置和方法
公开(公告)号：US20130022165A1
公开(公告)日：2013-01-24
申请号：US13552976
申请日：2012-07-19
申请人： Kwang-eun Jang , Jong-ha Lee , Kang-eui Lee , Young-hun Sung
发明人： Kwang-eun Jang , Jong-ha Lee , Kang-eui Lee , Young-hun Sung
IPC分类号： A61B6/03 , G01N23/04
CPC分类号： G01N23/04 , A61B6/025 , A61B6/027 , A61B6/482 , A61B6/5205 , G01N2223/419 , G01N2223/6126
摘要： An X-ray imaging apparatus and method is provided. An X-ray imaging apparatus includes an X-ray radiation unit configured to radiate a first X-ray and a second X-ray onto a target along a predetermined path, an X-ray detection unit configured to detect the radiated first X-ray and the second X-ray that have passed through the target, and an image data generation unit configured to generate cross-section data that respectively corresponds to the detected first X-ray and the detected second X-ray and represents a predetermined cross-sectional layer of the target. The first X-ray is radiated at a location on the predetermined path that is different from a location on the predetermined path at which the second X-ray is radiated, the first X-ray including X-ray spectra that are different from X-ray spectra of the second X-ray.
摘要翻译：提供了一种X射线成像装置和方法。一种X射线摄像装置，包括：X射线检测部，被配置为沿着预定路径将第一X射线和第二X射线照射到靶上; X射线检测部，被配置为检测所述第一X射线和已经通过目标的第二X射线，以及图像数据生成单元，被配置为产生分别对应于检测到的第一X射线和检测到的第二X射线的横截面数据，并且表示预定的横截面目标层。第一X射线照射在预定路径上不同于放射第二X射线的预定路径上的位置的第一X射线，包括与X射线不同的X射线光谱的第一X射线，第二X射线的X射线谱。

8. 发明申请

US20070090289A1 Method of observing live unit under electron microscope 审中-公开
标题翻译：电子显微镜观察活体单元的方法
公开(公告)号：US20070090289A1
公开(公告)日：2007-04-26
申请号：US11370916
申请日：2006-03-09
申请人： Chih-Yu Chao , Wen-Jiunn Hsieh
发明人： Chih-Yu Chao , Wen-Jiunn Hsieh
IPC分类号： G01N23/04
CPC分类号： G01N23/04 , G01N2223/6126 , H01J2237/2004
摘要： A method of observing a live unit under an electron microscope includes the steps of (A) preparing a live environment inside the electron microscope, wherein the live environment is provided with at least one live unit and a predetermined environmental condition keeping basic physiology of the live unit functional, at least one pair of view windows is located opposite to each other, and the live unit includes at least two objects that can bear different critical charge densities respectively; and (B) irradiating the live unit with a particle beam of predetermined intensity through the view windows, and then display the live unit on an imaging device of the electron microscope, wherein the product of the predetermined intensity of the particle beam and the predetermined duration equals the predetermined charge density that is smaller than or equal to the critical charge density of the object of the live unit.
摘要翻译：在电子显微镜下观察活体单元的方法包括以下步骤：（A）准备电子显微镜内的活体环境，其中活体环境设置有至少一个活体单元和保持活体基本生理学的预定环境条件单元功能，至少一对视窗彼此相对定位，并且活动单元包括分别可承受不同关键电荷密度的至少两个物体; 和（B）通过视窗用预定强度的粒子束照射活体单元，然后将活体单元显示在电子显微镜的成像装置上，其中粒子束的预定强度与预定持续时间的乘积等于小于或等于活动单元物体的临界电荷密度的预定电荷密度。

9. 发明授权

US11852570B2 Method for preparing a sample for laser induced breakdown spectroscopy 有权
公开(公告)号：US11852570B2
公开(公告)日：2023-12-26
申请号：US18158054
申请日：2023-01-23
申请人： Foss Analytical A/S
发明人： Thomas Nikolajsen , Daniel Aden
IPC分类号： G01N1/28 , G01N1/44 , G01N33/483 , G01N21/71
CPC分类号： G01N1/286 , G01N1/44 , G01N21/718 , G01N33/4833 , G01N2001/2886 , G01N2223/312 , G01N2223/618 , G01N2223/6126
摘要： A method for preparing a sample of organic material for laser induced breakdown spectroscopy (LIBS) may include obtaining granular organic material, forming a portion of the granular organic material into a sample pellet, and searing the organic material. The searing may include searing only an exposed end surface of the sample pellet on which LIBS analysis is to be performed. The method may include pressing the seared sample pellet to consolidate the material comprising the seared end surface.

10. 发明公开

US20230404499A1 SPECIMEN RADIOGRAPHY SYSTEM COMPRISING CABINET AND A SPECIMEN DRAWER POSITIONABLE BY A CONTROLLER IN THE CABINET 审中-公开
公开(公告)号：US20230404499A1
公开(公告)日：2023-12-21
申请号：US18344342
申请日：2023-06-29
申请人： Hologic, Inc.
发明人： Kenneth DeFreitas , Timothy N. Wells , Thomas DeYoung , Henry Landry , Shawn St. Pierre , Shawn Hochstetler , Joseph Vartolone , Neil Roth , Michelle Lustrino
IPC分类号： A61B6/00 , G01N23/04 , G21K7/00 , G01N23/18 , G01N23/083 , G01N23/087 , G01N23/06
CPC分类号： A61B6/4435 , G01N23/04 , A61B6/588 , G21K7/00 , A61B6/587 , A61B6/508 , A61B6/4233 , A61B6/44 , G01N23/18 , A61B6/4208 , A61B6/4411 , G01N23/083 , G01N23/087 , A61B6/4405 , A61B6/40 , A61B6/42 , A61B6/4429 , G01N23/06 , A61B6/4441 , A61B6/4447 , A61B6/4452 , A61B6/469 , A61B6/461 , A61B6/465 , A61B6/46 , A61B6/463 , A61B6/467 , A61B6/542 , G01N2223/301 , G01N2223/309 , G01N2223/3306 , G01N2223/3307 , G01N2223/6126 , A61B6/4423
摘要： A specimen radiography system may include a controller and a cabinet. The cabinet may include an x-ray source, an x-ray detector, and a specimen drawer disposed between the x-ray source and the x-ray detector. The specimen drawer may be automatically positionable along a vertical axis between the x-ray source and the x-ray detector.

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