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1. 发明申请

US20030141253A1 Apparatus for efficient liquid chromatography/mass spectrometry processing 审中-公开
标题翻译：高效液相色谱/质谱法处理装置
公开(公告)号：US20030141253A1
公开(公告)日：2003-07-31
申请号：US10309937
申请日：2002-12-04
发明人： Thierry Le Bihan
IPC分类号： B01D015/08
CPC分类号： G01N30/466 , G01N30/24 , G01N30/6043 , G01N30/6091 , G01N30/7233 , G01N30/7266 , G01N2030/582 , G01N2030/628 , G01N2030/8417 , G01N2030/8881 , G01N30/32
摘要： A chromatographic apparatus includes at least one sample preparation stage with a plurality of individually mounted separation columns, that can have a common pressurizable header at the column input side for parallel sample preparation. The column output side can be releasably connected to a mass spectrometer input operating, for example, with ESI. The sample preparation stage is moveable in at least one direction for sequential processing of the columns by the mass spectrometer. Sample preparation and analysis can be automatically controlled.
摘要翻译：色谱装置包括至少一个具有多个单独安装的分离柱的样品制备阶段，其可以在柱输入侧具有共同的可加压头部用于平行样品制备。柱输出侧可以可释放地连接到例如用ESI操作的质谱仪输入。样品制备阶段可以在至少一个方向上移动，以便通过质谱仪顺序处理色谱柱。样品制备和分析可以自动控制。

2. 发明授权

US06464882B1 Annular chromatograph 失效
标题翻译：环状色谱仪
公开(公告)号：US06464882B1
公开(公告)日：2002-10-15
申请号：US09646056
申请日：2000-10-20
申请人： Adalbert Prior , Jürgen Wolfgang
发明人： Adalbert Prior , Jürgen Wolfgang
IPC分类号： B01D1508
CPC分类号： G01N30/58 , G01N2030/582 , G01N2030/587
摘要： The invention related to an annular chromatograph including a particle bed which rotates on a rotary plate (3), said plate having eluate drainage lines, with regard to a stationary base and a stationary feeder head (10) with continuous feeder lines. The annular chromatograph has a central column (2) provided on a rotary plate and extending upwards through the feeder head. A tightening device (16,17) for pressing the feeder head (10) on the cylinder sleeve (6) is arranged on said column.
摘要翻译：本发明涉及一种环状色谱仪，其包括在旋转板（3）上旋转的颗粒床，所述板具有洗脱液排出管线，相对于固定基座和具有连续进料管线的静止进料头（10）。环形色谱仪具有设置在旋转板上的中心柱（2），并向上延伸通过进料头。用于将进料头（10）压在气缸套（6）上的紧固装置（16,17）设置在所述柱上。

3. 发明授权

US09221863B2 Transiently bonding drag-tags for separation modalities 有权
标题翻译：用于分离模式的瞬时键合拖曳标签
公开(公告)号：US09221863B2
公开(公告)日：2015-12-29
申请号：US12665994
申请日：2008-06-23
申请人： James W. Schneider , Shane T. Grosser , Jeffrey M. Savard
发明人： James W. Schneider , Shane T. Grosser , Jeffrey M. Savard
IPC分类号： G01N27/26 , C07H21/00 , C07K1/00 , C07H19/04 , G01N30/58
CPC分类号： C07H19/04 , G01N2030/582
摘要： The invention relates transiently attaching drag-tags to molecules during electrophoresis. The invention includes running buffers having drag-tags that transiently attach to lipophilic moieties attached to the molecules. The lipophilic moieties can be covalently or ionically bonded to the molecules. One particular aspect of the invention is a nucleoside analog or a nucleic acid analog comprising a lipophilic moiety. The invention is also directed to methods of separating molecules that comprise a lipophilic moiety. The methods generally comprise transiently attaching a drag-tag to the lipophilic moiety during a separation modality. These methods can be used to separate the molecules by size or weight, to measure a hydrodynamic radius of a drag-tag, or to separate a plurality of drag-tag by their hydrodynamic radius.
摘要翻译：本发明涉及在电泳期间将拖曳标签瞬时附着于分子。本发明包括具有瞬时附着到与分子连接的亲脂部分上的拖曳标签的运行缓冲液。亲脂性部分可以与分子共价或离子键合。本发明的一个特定方面是包含亲脂性部分的核苷类似物或核酸类似物。本发明还涉及分离包含亲油部分的分子的方法。方法通常包括在分离模态期间将拖曳标签瞬时附着到亲脂性部分。这些方法可用于通过尺寸或重量分离分子，以测量拖曳标签的流体动力学半径，或通过其流体动力学半径分离多个拖曳标签。

4. 发明授权

US08552363B2 System and method for optically driven separations using fluid filled core optical fibers 有权
标题翻译：使用流体填充芯光纤的光驱分离系统和方法
公开(公告)号：US08552363B2
公开(公告)日：2013-10-08
申请号：US12143952
申请日：2008-06-23
申请人： David Erickson , Sudeep Mandal
发明人： David Erickson , Sudeep Mandal
IPC分类号： H01S3/00
CPC分类号： G01N30/58 , B01L3/50273 , B01L3/502761 , B01L2300/0838 , B01L2400/0454 , G01N2030/285 , G01N2030/582 , G02B6/02328 , G02B6/02347 , G02B6/02385
摘要： An optical chromatography system employs fluid filled hollow core fibers, such as photonic crystal fibers (PCFs), which confine an incident optical beam from a laser, for example, in the core and cause separation of particles in the fluid along the length of the PCF. The incident optical beam is confined in the fluid filled core of the PCF by a periodic lattice of air capillaries surrounding the core. The lattice either creates a lower refractive index in the cladding than in the fluid filled core or creates a 1D photonic bandgap structure where the guiding is accomplished by surrounding the fluid filled core with a periodically changing array of dielectric constant which prohibits radial dilution of the optical energy over a range of wavelengths through photonic bandgap effects.
摘要翻译：光学色谱系统采用流体填充的中空芯纤维，例如光子晶体纤维（PCF），其将来自激光器的入射光束例如限制在芯中，并且沿着PCF的长度导致流体中的颗粒分离。入射光束通过围绕芯的空气毛细管的周期性晶格限制在PCF的流体填充芯中。晶格在包层中产生比在流体填充芯中低的折射率，或者产生一个1D光子带隙结构，其中引导通过周期性地改变的介电常数阵列来围绕流体填充芯来实现，该阵列禁止光学通过光子带隙效应在一定范围的波长上的能量。

5. 发明授权

US06391196B1 Chromatography apparatus 失效
标题翻译：色谱仪
公开(公告)号：US06391196B1
公开(公告)日：2002-05-21
申请号：US09486321
申请日：2000-03-21
申请人： Adalbert Prior , Jurgen Wolfgang
发明人： Adalbert Prior , Jurgen Wolfgang
IPC分类号： B01D1508
CPC分类号： G01N30/58 , B01D15/1892 , B01D2215/022 , G01N2030/582 , G01N2030/587
摘要： Disclosed is an assembly for continuous annular chromatography provided with a relative movement between one partial bed in the form of a cylinder jacket, at least one feeding position for liquid feeding material and at least one collection position for every emerging fraction of the feeding material out of the partial bed.
摘要翻译：公开了一种用于连续环形色谱的组件，其具有在气缸套形式的一个局部床之间的相对运动，用于液体供给材料的至少一个进料位置和用于每个新鲜部分的进料的至少一个收集位置，部分床。

6. 发明申请

US20170338093A1 Method of Separating Ions 审中-公开
公开(公告)号：US20170338093A1
公开(公告)日：2017-11-23
申请号：US15596451
申请日：2017-05-16
申请人： Micromass UK Limited
发明人： Martin Raymond GREEN , Kevin GILES , David John LANGRIDGE
IPC分类号： H01J49/40 , G01N30/02 , G01N30/58
CPC分类号： H01J49/40 , G01N27/622 , G01N2030/025 , G01N2030/027 , G01N2030/582
摘要： The present disclosure relates generally to a method of separating ions according to their ion mobility, comprising (i) accumulating a first population of ions in a first region of an ion mobility separator, (ii) separating said first population of ions according to their ion mobility in said first region of said ion mobility separator, and (iii) accumulating a second population of ions in said first region of said ion mobility separator whilst said first population of ions are being separated according to their ion mobility in said ion mobility separator.

7. 发明授权

US06758966B2 Capillary columns employing monodispersed particles 有权
标题翻译：使用单分散颗粒的毛细管柱
公开(公告)号：US06758966B2
公开(公告)日：2004-07-06
申请号：US10186488
申请日：2002-07-01
申请人： Peter Myers
发明人： Peter Myers
IPC分类号： B01D1508
CPC分类号： G01N30/482 , B01D15/206 , B01D15/22 , B01J20/281 , B01J2220/54 , B01J2220/84 , G01N30/52 , G01N30/6004 , G01N30/6052 , G01N30/6095 , G01N2030/521 , G01N2030/524 , G01N2030/562 , G01N2030/582
摘要： A capillary column comprising monodispersed particles. The capillary is formed using a suitable substrate, wherein two plates are bonded together. At least one of the plates comprises a channel where particle beads are housed. Particle bead positions are of defined and equivalent diameter are arranged along the longitudinal axis of the housing structure. These positions are used to position packing material used to occupy the column. The particle beads themselves are of equivalent diameter.
摘要翻译：包含单分散颗粒的毛细管柱。使用合适的基底形成毛细管，其中两个板结合在一起。至少一个板包括容纳颗粒珠的通道。颗粒珠位置是限定的，等效的直径沿壳体结构的纵向轴线布置。这些位置用于定位用于占据柱的包装材料。颗粒珠本身具有相当的直径。

8. 发明授权

US06267884B1 Capillary columns employing monodispersed particles 有权
标题翻译：使用单分散颗粒的毛细管柱
公开(公告)号：US06267884B1
公开(公告)日：2001-07-31
申请号：US09477438
申请日：2000-01-04
申请人： Peter Myers
发明人： Peter Myers
IPC分类号： B01D1508
CPC分类号： G01N30/482 , B01D15/206 , B01D15/22 , B01J20/281 , B01J2220/54 , B01J2220/84 , G01N30/52 , G01N30/6004 , G01N30/6052 , G01N30/6095 , G01N2030/521 , G01N2030/524 , G01N2030/562 , G01N2030/582
摘要： A capillary column comprising monodispersed particles. The capillary is formed using a suitable substrate, wherein two plates are bonded together. At least one of the plates comprises a channel where particle beads are housed. Particle bead positions are of defined and equivalent diameter are arranged along the longitudinal axis of the housing structure. These positions are used to position packing material used to occupy the column. The particle beads themselves are of equivalent diameter.
摘要翻译：包含单分散颗粒的毛细管柱。使用合适的基底形成毛细管，其中两个板结合在一起。至少一个板包括容纳颗粒珠的通道。颗粒珠位置是限定的，等效的直径沿壳体结构的纵向轴线布置。这些位置用于定位用于占据柱的包装材料。颗粒珠本身具有相当的直径。

9. 发明申请

US20100213059A1 TRANSIENTLY BONDING DRAG-TAGS FOR SEPARATION MODALITIES 有权
标题翻译：用于分离模式的瞬时接合标签
公开(公告)号：US20100213059A1
公开(公告)日：2010-08-26
申请号：US12665994
申请日：2008-06-23
申请人： James W. Schneider , Shane T. Grosser , Jeffrey M. Savard
发明人： James W. Schneider , Shane T. Grosser , Jeffrey M. Savard
IPC分类号： G01N27/26 , C07H21/00 , C07K1/00
CPC分类号： C07H19/04 , G01N2030/582
摘要： The invention relates transiently attaching drag-tags to molecules during electrophoresis. The invention includes running buffers having drag-tags that transiently attach to lipophilic moieties attached to the molecules. The lipophilic moieties can be covalently or ionically bonded to the molecules. One particular aspect of the invention is a nucleoside analog or a nucleic acid analog comprising a lipophilic moiety. The invention is also directed to methods of separating molecules that comprise a lipophilic moiety. The methods generally comprise transiently attaching a drag-tag to the lipophilic moiety during a separation modality. These methods can be used to separate the molecules by size or weight, to measure a hydrodynamic radius of a drag-tag, or to separate a plurality of drag-tag by their hydrodynamic radius.
摘要翻译：本发明涉及在电泳期间将拖曳标签瞬时附着于分子。本发明包括具有瞬时附着到与分子连接的亲脂部分上的拖曳标签的运行缓冲液。亲脂性部分可以与分子共价或离子键合。本发明的一个特定方面是包含亲脂性部分的核苷类似物或核酸类似物。本发明还涉及分离包含亲油部分的分子的方法。方法通常包括在分离模态期间将拖曳标签瞬时附着到亲脂性部分。这些方法可用于通过尺寸或重量分离分子，以测量拖曳标签的流体动力学半径，或通过其流体动力半径分离多个拖曳标签。

10. 发明申请

US20090032730A1 SYSTEM AND METHOD FOR OPTICALLY DRIVEN SEPARATIONS USING FLUID FILLED CORE OPTICAL FIBERS 有权
标题翻译：使用流体填充核心光纤进行光学驱动分离的系统和方法
公开(公告)号：US20090032730A1
公开(公告)日：2009-02-05
申请号：US12143952
申请日：2008-06-23
申请人： David Erickson , Sudeep Mandal
发明人： David Erickson , Sudeep Mandal
IPC分类号： G01N21/01
CPC分类号： G01N30/58 , B01L3/50273 , B01L3/502761 , B01L2300/0838 , B01L2400/0454 , G01N2030/285 , G01N2030/582 , G02B6/02328 , G02B6/02347 , G02B6/02385
摘要： An optical chromatography system employs fluid filled hollow core fibers, such as photonic crystal fibers (PCFs), which confine an incident optical beam from a laser, for example, in the core and cause separation of particles in the fluid along the length of the PCF. The incident optical beam is confined in the fluid filled core of the PCF by a periodic lattice of air capillaries surrounding the core. The lattice either creates a lower refractive index in the cladding than in the fluid filled core or creates a ID photonic bandgap structure where the guiding is accomplished by surrounding the fluid filled core with a periodically changing array of dielectric constant which prohibits radial dilution of the optical energy over a range of wavelengths through photonic bandgap effects.
摘要翻译：光学色谱系统采用流体填充的中空芯纤维，例如光子晶体纤维（PCF），其将来自激光器的入射光束例如限制在芯中，并且沿着PCF的长度导致流体中的颗粒分离。入射光束通过围绕芯的空气毛细管的周期性晶格限制在PCF的流体填充芯中。晶格或者在流体填充芯中产生较低的折射率，或者产生ID光子带隙结构，其中引导是通过周期性地改变介电常数阵列来实现的，该阵列阻止了光学器件的径向稀释通过光子带隙效应在一定范围的波长上的能量。

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