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1. 发明申请

US20180311330A1 Novel immunotherapy against several tumors of the blood, such as acute myeloid leukemia (AML) 审中-公开
公开(公告)号：US20180311330A1
公开(公告)日：2018-11-01
申请号：US16032231
申请日：2018-07-11
申请人： Immatics Biotechnologies GmbH
发明人： Hans-Georg Rammensee , Stefan Stevanovic , Juliane Stickel , Daniel Johannes Kowalewski , Claudia Berlin
IPC分类号： A61K39/00 , C07K14/47 , C12Q1/6886 , G01N33/50 , A61K35/17 , C07K14/725 , C07K7/02 , C07K7/08 , C07K7/06 , C12N9/90
CPC分类号： A61K39/0011 , A61K35/17 , A61K2039/5156 , A61K2039/5158 , A61K2039/572 , C07K7/02 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/4748 , C07K14/7051 , C07K2319/70 , C12N5/0638 , C12N9/14 , C12N9/90 , C12Q1/6886 , C12Q2600/136 , C12Y306/04004 , C12Y599/01002 , G01N33/505
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to several novel peptide sequences and their variants derived from HLA class I and HLA class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.

2. 发明申请

US20170073697A1 INCREASE IN MEIOTIC RECOMBINATION IN PLANTS BY INHIBITING AN RECQ4 OR TOP3A PROTEIN OF THE RTR COMPLEX 审中-公开
标题翻译：通过抑制RTR复合物的RECQ4或TOP3A蛋白质在植物中的生物重建中增加
公开(公告)号：US20170073697A1
公开(公告)日：2017-03-16
申请号：US15311151
申请日：2015-03-27
申请人： INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
发明人： Raphaël Mercier , Mathilde Seguela-Arnaud , Wayne Crismani
IPC分类号： C12N15/82 , C12N9/90
CPC分类号： C12N15/8242 , C07K14/415 , C12N9/90 , C12N15/8218 , C12N15/8241 , C12Y599/01002
摘要： The invention relates to a method for increasing the frequency of meiotic recombination in plants, by inhibiting the RECQ4 or TOP3A protein, especially by mutagenesis or extinction of the RECQ4 or TOP3A gene coding for said protein. The invention can be used especially in the field of plant breeding and genetic mapping.
摘要翻译：本发明涉及通过抑制RECQ4或TOP3A蛋白，特别是通过编码所述蛋白质的RECQ4或TOP3A基因的诱变或灭活来增加植物中减数分裂重组频率的方法。本发明可用于植物育种和遗传作图领域。

3. 发明授权

US06255077B1 Human DNA topoisomerase I &agr; 有权
标题翻译：人类DNA拓扑异构酶Iα
公开(公告)号：US06255077B1
公开(公告)日：2001-07-03
申请号：US09325430
申请日：1999-06-04
申请人： Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann
发明人： Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann
IPC分类号： C12N1563
CPC分类号： C12N9/90 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00 , C12Y599/01002
摘要： Disclosed is a human is a hTopI-&agr; polypeptide and DNA (RNA) encoding such hTopI-&agr; polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-&agr; for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
摘要翻译：公开了人是hTopI-α多肽和编码这种hTopI-α多肽的DNA（RNA）。还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。还提供了使用抗体和拮抗剂抑制剂抑制hTopI-α用于治疗目的如抗肿瘤剂的作用以检测自身免疫性疾病或逆转录病毒感染并治疗结肠腺癌的方法。还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

4. 发明授权

US5834279A Methods of identifying compounds that inhibit DNA synthesis in mycobacterium tuberculosis and compositions, reagents and kits for performing the same 失效
标题翻译：识别在结核分枝杆菌中抑制DNA合成的化合物的方法及其组合物，试剂和用于进行结核分枝杆菌的试剂盒的方法
公开(公告)号：US5834279A
公开(公告)日：1998-11-10
申请号：US813940
申请日：1997-03-03
申请人： Harvey Rubin , Fude Yang , David Avarbock , Sean Curran
发明人： Harvey Rubin , Fude Yang , David Avarbock , Sean Curran
IPC分类号： C12N1/21 , C12N9/02 , C12N9/90 , C12N15/31 , C12N9/03
CPC分类号： C12N9/0093 , C12N9/90 , C12Y117/04001 , C12Y599/01002 , A01K2217/05
摘要： Nucleic acid molecules that encode R2 subunit protein and topoisomerase I protein, fragments thereof, recombinant expression vectors and host cells are disclosed. Oligonucleotide molecules with nucleotide sequences complimentary to a nucleotide sequence encode R2 subunit protein and topoisomerase I protein are disclosed.
摘要翻译：公开了编码R2亚基蛋白和拓扑异构酶I蛋白的核酸分子，其片段，重组表达载体和宿主细胞。公开了具有与编码R2亚单位蛋白质和拓扑异构酶I蛋白质的核苷酸序列互补的核苷酸序列的寡核苷酸分子。

5. 发明申请

US20180045727A1 MOLECULAR PROFILING FOR CANCER 审中-公开
公开(公告)号：US20180045727A1
公开(公告)日：2018-02-15
申请号：US15555378
申请日：2016-03-03
申请人： Caris MPI, Inc.
发明人： David SPETZLER , Brian ABBOTT , Philip ELLIS , Sandeep REDDY
IPC分类号： G01N33/574 , G06F19/18 , C12Q1/68
CPC分类号： G01N33/57484 , A61K31/335 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Y201/01045 , C12Y201/01063 , C12Y301/03048 , C12Y599/01002 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/5743 , G01N33/57434 , G01N33/57438 , G01N33/57446 , G01N33/57449 , G01N33/5748 , G01N2333/435 , G01N2333/70521 , G01N2333/70532 , G01N2333/70596 , G01N2333/723 , G01N2333/82 , G01N2333/9029 , G01N2333/91017 , G01N2333/916 , G01N2333/99 , G01N2800/52 , G16B20/00
摘要： Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for the disease, such as treatments that provide likely benefit or likely lack of benefit for the disease. The molecular profiling can include analysis of a sequence of a nucleic acid. The invention provides a method of identifying at least one treatment associated with a cancer in a subject. In still another related aspect, the invention provides use of a reagent in carrying out the methods of the invention, and/or use of a reagent in the manufacture of a reagent or kit for carrying out the methods of the invention. In an aspect, the invention provides a system for identifying at least one treatment associated with a cancer in a subject.

6. 发明申请

US20120190014A1 PHAGE PHI 29 DNA POLYMERASE CHIMERA 有权
标题翻译： PHAGE PHI 29 DNA聚合酶CHIMERA
公开(公告)号：US20120190014A1
公开(公告)日：2012-07-26
申请号：US13381837
申请日：2010-07-01
申请人： Margarita Salas Falgueras , Miguel De Vega Jose , Jose M. Lazaro Bolos , Luis Blanco Davila , Mario Mencia Caballero
发明人： Margarita Salas Falgueras , Miguel De Vega Jose , Jose M. Lazaro Bolos , Luis Blanco Davila , Mario Mencia Caballero
IPC分类号： C12N9/12 , C12P19/34 , C12Q1/68 , C12N9/96
CPC分类号： C12N9/1252 , C07K2319/80 , C12N9/90 , C12Q1/6844 , C12Y207/07007 , C12Y599/01002 , C12Q2521/101 , C12Q2522/101 , C12Q2527/125
摘要： A DNA polymerase chimera comprising an amino-terminal (N-terminal) region encoding a φ29 type DNA polymerase and a carboxyl-terminal (C-terminal) region comprising at least one HhH domain which are bound by means of a connecting amino acid sequence is disclosed along with and the use thereof for replicating, amplifying or sequencing a template DNA. Also disclosed is a method for replicating, amplifying or sequencing a deoxyribonucleic acid with said DNA polymerase chimera and kits for carrying out said methods.
摘要翻译：一种DNA聚合酶嵌合体，其包含编码29型DNA聚合酶的氨基末端（N-末端）区和包含至少一个HhH结构域的羧基末端（C-末端）区，所述HhH结构域通过连接氨基酸公开了序列以及其用于复制，扩增或测序模板DNA的用途。还公开了用所述DNA聚合酶嵌合体复制，扩增或测序脱氧核糖核酸的方法和用于进行所述方法的试剂盒。

7. 发明申请

US20110028536A1 METHODS AND COMPOSITIONS FOR TOPOISOMERASE I MODULATED TUMOR SUPPRESSION 审中-公开
标题翻译：用于TOPOISOMERASE I调节性肿瘤抑制的方法和组合物
公开(公告)号：US20110028536A1
公开(公告)日：2011-02-03
申请号：US12377498
申请日：2007-08-16
申请人： Ruth A. Gjerset , Keya Bandyopadhyay
发明人： Ruth A. Gjerset , Keya Bandyopadhyay
IPC分类号： A61K31/7088 , C12N5/071 , A61K31/4375 , C12Q1/68 , C12N5/09 , A61P35/00
CPC分类号： G01N33/5011 , A61K31/44 , A61K38/1709 , A61K38/45 , A61K45/06 , C12N15/1137 , C12N15/86 , C12N2310/14 , C12N2710/10343 , C12Y599/01002 , G01N33/5035 , G01N2333/99 , G01N2800/52 , A61K2300/00
摘要： Disclosed herein are methods and compositions for enhancing the sensitivity of cells to the effects of topoisomerase I inhibitors. Also disclosed are methods and compositions for inducing apoptosis and/or growth arrest which may be used for tumor suppression.
摘要翻译：本文公开了用于增强细胞对拓扑异构酶I抑制剂的作用的敏感性的方法和组合物。还公开了用于诱导可用于肿瘤抑制的凋亡和/或生长停滞的方法和组合物。

8. 发明申请

US20100317064A1 Covalent joining of DNA strands to RNA strands catalyzed by vaccinia topoisomerase 有权
标题翻译：将DNA链与牛痘拓扑异构酶催化的RNA链共价连接
公开(公告)号：US20100317064A1
公开(公告)日：2010-12-16
申请号：US12658764
申请日：2010-02-12
申请人： Stewart Shuman , JoAnn Sekiguchi , John Comiskey , Joseph Fernandez , James Hoeffler , Robert Marcil
发明人： Stewart Shuman , JoAnn Sekiguchi , John Comiskey , Joseph Fernandez , James Hoeffler , Robert Marcil
IPC分类号： C12P19/34 , C12N15/64 , C07H21/04 , C12N15/63
CPC分类号： C12N15/1096 , C07H21/02 , C07H21/04 , C12N9/90 , C12N15/1006 , C12Y599/01002
摘要： The present invention provides a method of covalently joining a DNA strand to an RNA strand comprising (a) forming a topoisomerase-DNA intermediate by incubating a DNA cleavage substrate comprising a topoisomerase cleavage site with a topoisomerase specific for that site, wherein the topoisomerase-DNA intermediate has one or more 5′ single-strand tails; and (b) adding to the topoisomerase-DNA intermediate an acceptor RNA strand complementary to the 5′ single-strand tail under conditions permitting a ligation of the covalently bound DNA strand of the topoisomerase-DNA intermediate to the RNA acceptor strand and dissociation of the topoisomerase, thereby covalently joining the DNA strand to the RNA strand. The present invention also provides a method of tagging a 5′ end of an RNA molecule. The present invention further provides a DNA-RNA molecule which has been joined in vitro by the use of a topoisomerase. The present invention also provides a method of tagging a 5′ end of an mRNA. The present invention provides a method of isolating and cloning full-length gene sequences using capped mRNA after subtraction of non-capped RNA.
摘要翻译：本发明提供了将DNA链与RNA链共价连接的方法，其包括（a）通过将包含拓扑异构酶切割位点的DNA切割底物与该位点特异性的拓扑异构酶一起孵育而形成拓扑异构酶-DNA中间体，其中拓扑异构酶-DNA 中间体具有一个或多个5'单链尾部; 和（b）在允许拓扑异构酶-DNA中间体与RNA受体链的共价结合的DNA链连接的条件下，向拓扑异构酶-DNA中间体添加与5'单链尾部互补的受体RNA链，并解离从而将DNA链共价连接到RNA链上。本发明还提供了标记RNA分子的5'末端的方法。本发明还提供了通过使用拓扑异构酶体外结合的DNA-RNA分子。本发明还提供了标记mRNA的5'末端的方法。本发明提供了在减去未加帽的RNA之后使用加帽的mRNA分离和克隆全长基因序列的方法。

9. 发明申请

US20090326208A1 Methods and compositions for generating recombinant nucleic acid molecules 有权
标题翻译：用于产生重组核酸分子的方法和组合物
公开(公告)号：US20090326208A1
公开(公告)日：2009-12-31
申请号：US12112649
申请日：2008-04-30
申请人： John Carrino , James Fan , Robert P. Bennett , Jonathan D. Chesnut , Martin A. Gleeson , Knut R. Madden
发明人： John Carrino , James Fan , Robert P. Bennett , Jonathan D. Chesnut , Martin A. Gleeson , Knut R. Madden
IPC分类号： C07H21/04 , C07H1/00
CPC分类号： C12N15/10 , C12N9/90 , C12N15/111 , C12N15/64 , C12N15/66 , C12N2310/14 , C12N2330/30 , C12P19/34 , C12Q1/6855 , C12Y599/01002 , C12Q2521/519
摘要： A method of generating a double stranded (ds) recombinant nucleic acid molecule covalently linked in both strands by contacting two or more ds nucleotide sequences with a topoisomerase under conditions such that both termini of at least one end of a first ds nucleotide sequence are covalently linked by the topoisomerase to both termini of at least one end of a second ds nucleotide sequence is provided. Also provided is a method for generating a ds recombinant nucleic acid molecule covalently linked in one strand, by contacting two or more ds nucleotide sequences with a type IA topoisomerase under conditions such that one strand, but not both strands, of one or both ends of a first ds nucleotide sequence are covalently linked by the topoisomerase. Compositions for performing such methods, and compositions generated from such methods also are provided, as are kits containing components useful for conveniently practicing the methods.
摘要翻译：通过使两个或多个ds核苷酸序列与拓扑异构酶接触的条件使得在第一个ds核苷酸序列的至少一个末端的两个末端共价连接的情况下，产生双链（ds）重组核酸分子共价连接的双链（ds）重组核酸分子的方法提供了拓扑异构酶至第二个ds核苷酸序列的至少一个末端的两个末端。还提供了一种用于产生共价连接在一条链中的ds重组核酸分子的方法，其通过使两个或更多个ds核苷酸序列与IA型拓扑异构酶接触，使得一个或两个末端的一条链但不是两条链第一个ds核苷酸序列由拓扑异构酶共价连接。还提供了用于进行这些方法的组合物，以及由这些方法产生的组合物，以及包含用于方便地实施该方法的组分的试剂盒。

10. 发明申请

US20120322109A1 Covalent Joining of DNA Strands to RNA Strands Catalyzed by Vaccinia Topoisomerase 审中-公开
标题翻译：将DNA链共价连接到由牛痘拓扑异构酶催化的RNA链
公开(公告)号：US20120322109A1
公开(公告)日：2012-12-20
申请号：US13460331
申请日：2012-04-30
申请人： STEWART SHUMAN , JOANN SEKIGUCHI , JOHN COMISKEY , JOSEPH FERNANDEZ , JAMES HOEFFLER , ROBERT MARCIL
发明人： STEWART SHUMAN , JOANN SEKIGUCHI , JOHN COMISKEY , JOSEPH FERNANDEZ , JAMES HOEFFLER , ROBERT MARCIL
IPC分类号： C12P19/34 , C12N15/63 , C07H21/04 , C12N9/96 , C07H21/02
CPC分类号： C12N15/1096 , C07H21/02 , C07H21/04 , C12N9/90 , C12N15/1006 , C12Y599/01002
摘要： The present invention provides a method of covalently joining a DNA strand to an RNA strand, a method of tagging a 5′ end of an RNA molecule, a DNA-RNA molecule which has been joined in vitro by the use of a topoisomerase, a method of tagging a 5′ end of an mRNA, and a method of isolating and cloning full-length gene sequences using capped mRNA after subtraction of non-capped RNA.
摘要翻译：本发明提供了将DNA链与RNA链共价连接的方法，标记RNA分子的5'端的方法，通过使用拓扑异构酶体外结合的DNA-RNA分子，标记mRNA的5'末端，以及在减去未加帽的RNA之后使用加帽的mRNA分离和克隆全长基因序列的方法。

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