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1. 发明授权

US11918633B2 Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating adolescent subjects 有权
公开(公告)号：US11918633B2
公开(公告)日：2024-03-05
申请号：US17747697
申请日：2022-05-18
申请人： BIOMARIN PHARMACEUTICAL INC.
发明人： Debra Lounsbury
IPC分类号： C12N9/88 , A61K38/51 , A61P3/00
CPC分类号： A61K38/51 , A61P3/00 , C12Y403/01024
摘要： Phenylalanine ammonia-lyase (PAL) variants with a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL for therapeutic uses, including the treatment of adolescent subjects having PKU.

2. 发明授权

US11913045B2 Engineered phenylalanine ammonia lyase polypeptides 有权
公开(公告)号：US11913045B2
公开(公告)日：2024-02-27
申请号：US17009925
申请日：2020-09-02
申请人： Codexis, Inc.
发明人： Gjalt W. Huisman , Nicholas J. Agard , Benjamin Mijts , Jonathan Vroom , Xiyun Zhang
IPC分类号： C12N9/88 , A61K38/00
CPC分类号： C12N9/88 , C12Y403/01005 , C12Y403/01024 , A61K38/00
摘要： The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.

3. 发明授权

US10610546B2 Bacteria engineered to reduce hyperphenylalaninemia 有权
公开(公告)号：US10610546B2
公开(公告)日：2020-04-07
申请号：US15154934
申请日：2016-05-13
申请人： Synlogic Operating Company, Inc.
发明人： Dean Falb , Vincent M. Isabella , Jonathan W. Kotula , Paul F. Miller , Yves Millet , Sarah Rowe
IPC分类号： A61K35/741 , C07K14/245 , A61K35/74 , A61K39/02 , C12N9/88 , C12N9/06 , C12N15/70 , C07K14/195 , A61K38/00 , A61K35/00
CPC分类号： A61K35/74 , A61K35/741 , A61K39/02 , C07K14/195 , C07K14/245 , C12N9/0014 , C12N9/0022 , C12N9/88 , C12N15/70 , C12Y104/03002 , C12Y403/01024 , A61K38/00 , A61K2035/11 , Y02A50/473
摘要： Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating diseases associated with hyperphenylalaninemia are disclosed.

4. 发明申请

US20180208897A1 SYNTHETIC MEMBRANE-RECEIVER COMPLEXES 审中-公开
公开(公告)号：US20180208897A1
公开(公告)日：2018-07-26
申请号：US15925212
申请日：2018-03-19
申请人： RUBIUS THERAPEUTICS, INC.
发明人： Avak Kahvejian , Jordi Mata-Fink , John Round , David Arthur Berry , Noubar B. Afeyan
IPC分类号： C12N5/078 , A61K39/385 , A61K9/00 , A61K9/50 , A61K31/7088 , A61K35/18 , C12N9/88 , C07K16/08 , A61K47/69 , A61K39/00 , A61K38/17
CPC分类号： C12N5/0641 , A61K9/0019 , A61K9/5068 , A61K31/7088 , A61K35/18 , A61K38/177 , A61K38/1774 , A61K39/001 , A61K39/385 , A61K47/6901 , C07K16/082 , C07K2317/622 , C12N9/88 , C12N2510/00 , C12Y204/02004 , C12Y304/22 , C12Y403/01024 , Y02A50/473 , A61K2300/00
摘要： Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith.

5. 发明申请

US20180187154A1 SYNTHETIC MEMBRANE-RECEIVER COMPLEXES 审中-公开
公开(公告)号：US20180187154A1
公开(公告)日：2018-07-05
申请号：US15900029
申请日：2018-02-20
申请人： RUBIUS THERAPEUTICS, INC.
发明人： Avak Kahvejian , Jordi Mata-Fink , John Round , David Arthur Berry , Noubar B. Afeyan
IPC分类号： C12N5/078 , A61K9/00 , A61K35/18 , C07K16/08 , A61K39/385 , A61K38/17 , A61K31/7088 , A61K39/00 , A61K47/69 , C12N9/88 , A61K9/50
CPC分类号： C12N5/0641 , A61K9/0019 , A61K9/5068 , A61K31/7088 , A61K35/18 , A61K38/177 , A61K38/1774 , A61K39/001 , A61K39/385 , A61K47/6901 , C07K16/082 , C07K2317/622 , C12N9/88 , C12N2510/00 , C12Y204/02004 , C12Y304/22 , C12Y403/01024 , Y02A50/473 , A61K2300/00
摘要： Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith.

6. 发明授权

US09943555B2 Bacteria engineered to reduce hyperphenylalaninemia 有权
公开(公告)号：US09943555B2
公开(公告)日：2018-04-17
申请号：US15260211
申请日：2016-09-08
申请人： Synlogic, Inc.
发明人： Dean Falb , Vincent M. Isabella , Jonathan W. Kotula , Paul F. Miller , Yves Millet , Sarah Rowe
IPC分类号： A61K35/741 , C07K14/245 , C12R1/19 , A61K35/74 , C12N9/88 , C12N9/06 , C12N15/70 , A61K35/00
CPC分类号： A61K35/74 , A61K35/741 , A61K38/00 , A61K39/02 , A61K2035/11 , C07K14/195 , C07K14/245 , C12N9/0014 , C12N9/0022 , C12N9/88 , C12N15/70 , C12Y104/03002 , C12Y403/01024 , Y02A50/473
摘要： Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating diseases associated with hyperphenylalaninemia are disclosed.

7. 发明申请

US20150306212A1 SYNTHETIC MEMBRANE-RECEIVER COMPLEXES 有权
公开(公告)号：US20150306212A1
公开(公告)日：2015-10-29
申请号：US14738414
申请日：2015-06-12
申请人： RUBIUS THERAPEUTICS, INC.
发明人： Avak Kahvejian , Jordi Mata-Fink , John Round , David Arthur Berry , Noubar B. Afeyan
IPC分类号： A61K39/385 , A61K35/18 , A61K39/44 , A61K39/42 , A61K39/00 , A61K9/00 , A61K47/48
CPC分类号： C12N5/0641 , A61K9/0019 , A61K9/5068 , A61K31/7088 , A61K35/18 , A61K38/177 , A61K38/1774 , A61K39/001 , A61K39/385 , A61K47/6901 , C07K16/082 , C07K2317/622 , C12N9/88 , C12N2510/00 , C12Y204/02004 , C12Y304/22 , C12Y403/01024 , A61K2300/00
摘要： Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith.

8. 发明申请

US20150182588A1 SYNTHETIC MEMBRANE-RECEIVER COMPLEXES 审中-公开
标题翻译：合成膜接收复合物
公开(公告)号：US20150182588A1
公开(公告)日：2015-07-02
申请号：US14581486
申请日：2014-12-23
申请人： VL26, Inc.
发明人： Avak Kahvejian , Jordi Mata-Fink , John Round , David Arthur Berry , Noubar B. Afeyan
IPC分类号： A61K38/17 , A61K39/44 , A61K31/7088 , C12N5/078
CPC分类号： C12N5/0641 , A61K9/0019 , A61K9/5068 , A61K31/7088 , A61K35/18 , A61K38/177 , A61K38/1774 , A61K39/001 , A61K39/385 , A61K47/6901 , C07K16/082 , C07K2317/622 , C12N9/88 , C12N2510/00 , C12Y204/02004 , C12Y304/22 , C12Y403/01024 , Y02A50/473 , A61K2300/00
摘要： Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith.
摘要翻译：包含合成的膜 - 受体复合物的组合物，产生合成的受体复合物的方法，以及用于治疗或预防疾病，病症或病症的方法。

9. 发明授权

US08440182B2 Methods and compositions for treating phenylketonuria 有权
标题翻译：治疗苯丙酮尿症的方法和组合物
公开(公告)号：US08440182B2
公开(公告)日：2013-05-14
申请号：US12592244
申请日：2009-11-20
申请人： Reuben Matalon
发明人： Reuben Matalon
IPC分类号： A61K9/00 , A61K38/43 , A61K38/51 , A61K38/48
CPC分类号： A61K38/44 , A61K9/2833 , A61K9/5021 , A61K38/4813 , A61K38/51 , C12Y114/16001 , C12Y304/13 , C12Y403/01024 , A61K2300/00
摘要： Provided herein are methods for treating a subject suffering from phenylketonuria by administering a phenylalanine hydroxylase (“PAH”) and/or a phenylalanine ammonia lyase (“PAL”) to the subject under conditions effective to deliver the phenylalanine 4-hydroxylase and/or PAL to the subject's small intestine. Also provided are methods for increasing the therapeutic activity of a phenylalanine 4-hydroxylase by thiolating the phenylalanine 4-hydroxylase. In addition, provided are oral dosage forms that include a phenylalanine 4-hydroxylase and/or a PAL and an enteric coating.
摘要翻译：本文提供了通过在有效递送苯丙氨酸4-羟化酶和/或PAL的条件下向受试者施用苯丙氨酸羟化酶（“PAH”）和/或苯丙氨酸氨裂解酶（“PAL”）来治疗患有苯丙酮尿症的受试者的方法对主题的小肠。还提供了通过硫酚化苯丙氨酸4-羟化酶来增加苯丙氨酸4-羟化酶的治疗活性的方法。此外，提供了包括苯丙氨酸4-羟化酶和/或PAL和肠溶衣的口服剂型。

10. 发明申请

US20070174933A1 Altering levels of anti-nutrient factors in plants 审中-公开
标题翻译：改变植物中抗营养因子的水平
公开(公告)号：US20070174933A1
公开(公告)日：2007-07-26
申请号：US11338849
申请日：2006-01-25
申请人： Abdelali Hannoufa , Ulrike Schafer
发明人： Abdelali Hannoufa , Ulrike Schafer
IPC分类号： A01H1/00 , C12N15/82
CPC分类号： C12Y203/01091 , C12N9/0073 , C12N9/1007 , C12N9/1029 , C12N9/88 , C12N15/8243 , C12Y114/13011 , C12Y201/01068 , C12Y403/01024
摘要： A method for reducing the level of one or more than one protein in a plant or a tissue within the plant, and plants with reduced levels of target proteins are provided. The method involves introducing a nucleic acid sequence into the plant, where the nucleic acid sequence comprises a regulatory region operatively associated with a silencing nucleotide sequence. The expression of the silencing nucleotide sequence reduces or eliminates the expression of two or more than two enzymes involved in the synthesis of the one or more than one protein. The reduced level of the one or more than one protein may be determine by comparing the level of the one or more than one protein in the plant, or a tissue of the plant, with a level of the one ore more than one protein in a second plant, or the tissue from the second plant, that does not express the nucleic acid sequence. Plants and seeds obtained from plants with reduced levels of target proteins, and reduced anti-nutrient factors are also provided
摘要翻译：提供了降低植物或植物内的组织中的一种或多于一种蛋白质的水平的方法，以及降低靶蛋白水平的植物。该方法包括将核酸序列引入植物中，其中核酸序列包含与沉默核苷酸序列可操作地相关联的调节区。沉默核苷酸序列的表达降低或消除了参与合成一种或多于一种蛋白质的两种或两种以上的酶的表达。一种或多于一种蛋白质的降低的水平可以通过将植物或植物组织中的一种或多种蛋白质的水平与一种或多种蛋白质的水平在一第二植物或来自第二植物的组织，其不表达核酸序列。还提供了从具有降低的靶蛋白水平的植物获得的植物和种子以及降低的抗营养因子

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