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1. 发明申请

US20160374319A1 TRANSGENIC NON-HUMAN MAMMAL THAT EXPRESSES HUMAN MMP2 有权
标题翻译：表达人MMP2的转基因非人类动物
公开(公告)号：US20160374319A1
公开(公告)日：2016-12-29
申请号：US15103457
申请日：2014-12-10
申请人： MIE UNIVERSITY
发明人： Esteban C. Gabazza , Osamu TAGUCHI , Tetsu KOBAYASHI
IPC分类号： A01K67/027 , C12N15/85 , C12N9/64
CPC分类号： A01K67/0278 , A01K67/027 , A01K2217/052 , A01K2227/105 , A01K2267/035 , A01K2267/0368 , C12N9/6416 , C12N9/6491 , C12N15/09 , C12N15/8509 , C12N2015/8527 , C12N2830/15 , C12Y304/24024
摘要： A transgenic non-human mammal has a genome that includes an early-immediate enhancer of human cytomegalovirus (CMV enhancer), a β-actin promoter and the entire gene region of human matrix metalloproteinase 2 (hMMP2) disposed downstream of the promoter. The hMMP2 is systemically expressed in the transgenic non-human mammal, which thus provides a suitable animal model for studying chronic obstructive pulmonary disease and related diseases and conditions.
摘要翻译：转基因非人哺乳动物具有包含人巨细胞病毒（CMV增强子）的早期直接增强子，β-肌动蛋白启动子和设置在启动子下游的人基质金属蛋白酶2（hMMP2）的整个基因区的基因组。 hMMP2在转基因非人哺乳动物中全身表达，因此提供了适用于研究慢性阻塞性肺疾病和相关疾病和病症的动物模型。

2. 发明申请

US20160053250A1 MATRIX METALLOPROTEINASSES AND USES THEREOF 审中-公开
标题翻译： MATRIX METALLOPROTENESESES及其用途
公开(公告)号：US20160053250A1
公开(公告)日：2016-02-25
申请号：US14782118
申请日：2014-04-04
申请人： Claudia ZYLBERBERG , Gregg B. FIELDS
发明人： Claudia ZYLBERBERG , Gregg B. FIELDS
IPC分类号： C12N9/64 , A61K38/48
CPC分类号： C12N9/6491 , A61K38/4886 , C12N9/6416 , C12Y304/24 , C12Y304/24007 , C12Y304/24017 , C12Y304/24024 , C12Y304/24034 , C12Y304/24035 , C12Y304/24065
摘要： Matrix metalloproteinases (MMPs) compositions, inactive forms of MMPs (e.g. proMMPs), fragments, mutants, variants or combinations thereof. A pharmaceutical composition comprises one or more of the above in a pharmaceutical carrier. A composition comprises at least one of: a matrix metalloproteinase (MMP), an inactive MMP or a proenzyme (proMMP) thereof, wherein the matrix metalloproteinase (MMPs), inactive MMPs or proMMPs thereof, comprise: MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13.MMP-14, MMP-15, MMP-16, MMP-17, MMP-18, MMP-19, MMP-20, MMP-21, MMP-23A, MMP-23B, MMP-24, MMP-25, MMP-26, MMP-27, MMP-28, active fragments, mutants, variants or any combinations thereof. The uses include isolation of cells, in particular stem cells, from tissues, dissociation of tissues, proteins and treatment of a variety of conditions.
摘要翻译：基质金属蛋白酶（MMPs）组合物，MMPs的无活性形式（例如proMMP），片段，突变体，变体或其组合。药物组合物在药物载体中包含上述一种或多种。组合物包含以下中的至少一种：基质金属蛋白酶（MMP），非活性MMP或其酶原（proMMP），其中所述基质金属蛋白酶（MMP），其无活性的MMP或其proMMP包含：MMP-1，MMP-2， MMP-3，MMP-7，MMP-8，MMP-9，MMP-10，MMP-11，MMP-12，MMP-13MMP-14，MMP-15，MMP-16， 18，MMP-19，MMP-20，MMP-21，MMP-23A，MMP-23B，MMP-24，MMP-25，MMP-26，MMP-27，MMP-28，活性片段，突变体，其组合。用途包括从组织中分离细胞，特别是干细胞，分解组织，蛋白质以及各种条件的治疗。

3. 发明申请

US20170204450A1 METHOD AND ENZYME SOLUTION FOR FLOW-CYTOMETRIC DETECTION OF LIGHT CHAIN RESTRICTION 审中-公开
公开(公告)号：US20170204450A1
公开(公告)日：2017-07-20
申请号：US15312780
申请日：2015-05-28
申请人： RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
发明人： Stefan KRIENKE , Michael HUNDEMER
IPC分类号： C12Q1/37 , G01N33/50 , C12N9/52 , G01N15/14 , C12N9/76 , C12N9/64
CPC分类号： C12Q1/37 , C12N9/50 , C12N9/52 , C12N9/6416 , C12N9/6427 , C12Y304/21004 , C12Y304/24021 , C12Y304/24024 , G01N15/1404 , G01N33/5047 , G01N2333/96433 , G01N2333/96486
摘要： The invention relates to an enzyme solution, which is used preferably for pre-treating mammalian cells for flow-cytometric detection of light chain restriction of the cells, the enzyme solution comprising at least two proteases, which are proteolytic and also collagenolytic, in a buffer. Preferably, the enzyme solution comprises trypsin, collagenase 4, dispase and astacin. The invention also relates to uses of the enzyme solution and methods for flow-cytometric detection of light chain restriction of cells.

4. 发明申请

US20130195828A1 Pharmaceutical Compositions and Methods for Digesting Atherosclerotic Plaques 审中-公开
标题翻译：药物组合物和消化动脉粥样硬化斑块的方法
公开(公告)号：US20130195828A1
公开(公告)日：2013-08-01
申请号：US13641375
申请日：2011-04-14
申请人： Melina R. Kibbe , Guillermo A. Ameer , Vinit N. Varu
发明人： Melina R. Kibbe , Guillermo A. Ameer , Vinit N. Varu
IPC分类号： A61K38/48 , A61M37/00 , A61K38/54
CPC分类号： A61K38/4886 , A61B17/2202 , A61K9/0019 , A61K31/724 , A61K38/49 , A61K38/54 , A61K45/06 , A61M25/1011 , A61M37/0092 , C12Y304/21068 , C12Y304/24003 , C12Y304/24024 , C12Y304/24035 , A61K2300/00
摘要： Disclosed are pharmaceutical compositions and methods for digesting atherosclerotic plaques in a patient in need thereof. The compositions include and the methods utilize a mixture of collagenases for digesting plaques and optionally may include or utilize additional agents such as cyclodextrins, chelating agents, and tissue plasminogen activator.
摘要翻译：公开了用于在有需要的患者中消化动脉粥样硬化斑块的药物组合物和方法。组合物包括并且方法利用胶原酶的混合物来消化斑块，并且任选地可以包括或利用另外的试剂例如环糊精，螯合剂和组织纤溶酶原激活剂。

5. 发明授权

US11845801B2 IL-15 prodrugs and methods of use thereof 有权
公开(公告)号：US11845801B2
公开(公告)日：2023-12-19
申请号：US16900677
申请日：2020-06-12
申请人： ASKGENE PHARMA, INC.
发明人： Yuefeng Lu , Chunxiao Yu , Jian-Feng Lu
IPC分类号： C07K16/00 , C07K16/28 , C07K14/81
CPC分类号： C07K16/2866 , C07K14/811 , C07K14/8146 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C12Y304/21109 , C12Y304/24024 , C12Y304/24035
摘要： Provided herein are IL-15 cytokine prodrugs and methods of making and using thereof.

6. 发明授权

US09945865B2 Polymer nanocomposites for early diagnosis of diseases 有权
公开(公告)号：US09945865B2
公开(公告)日：2018-04-17
申请号：US14778287
申请日：2014-01-31
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
发明人： Jennifer Andrew
IPC分类号： G01N33/58 , C12Q1/37 , G01N33/574 , A61K49/00 , A61K47/48
CPC分类号： G01N33/588 , A61K47/64 , A61K47/65 , A61K49/0067 , A61K49/0073 , C12Q1/37 , C12Y304/24007 , C12Y304/24024 , C12Y304/24035 , G01N33/57488 , G01N33/587 , G01N2333/96494
摘要： Disclosed herein is a composition comprising a crosslinked hydrogel; where the hydrogel comprises a polymer having a cleavable bond along a backbone of the polymer, along a substituent that undergoes crosslinking, or along the backbone of the polymer and along the substituent that undergoes crosslinking; where the cleavable bond is operative to be cleaved by an enzyme released in the body of a living being; and a semiconducting quantum dot that emits light in the visible portion of the electromagnetic spectrum.

7. 发明申请

US20160282358A1 POLYMER NANOCOMPOSITES FOR EARLY DIAGNOSIS OF DISEASES 审中-公开
标题翻译：用于早期诊断疾病的聚合物纳米复合体
公开(公告)号：US20160282358A1
公开(公告)日：2016-09-29
申请号：US14778287
申请日：2014-01-31
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
发明人： Jennifer ANDREW
IPC分类号： G01N33/58 , C12Q1/37 , G01N33/574
CPC分类号： G01N33/588 , A61K47/64 , A61K47/65 , A61K49/0067 , A61K49/0073 , C12Q1/37 , C12Y304/24007 , C12Y304/24024 , C12Y304/24035 , G01N33/57488 , G01N33/587 , G01N2333/96494
摘要： Disclosed herein is a composition comprising a crosslinked hydrogel; where the hydrogel comprises a polymer having a cleavable bond along a backbone of the polymer, along a substituent that undergoes crosslinking, or along the backbone of the polymer and along the substituent that undergoes crosslinking; where the cleavable bond is operative to be cleaved by an enzyme released in the body of a living being; and a semiconducting quantum dot that emits light in the visible portion of the electromagnetic spectrum.
摘要翻译：本文公开了包含交联水凝胶的组合物; 其中水凝胶包含沿着聚合物的主链具有可切割键的聚合物，沿着经历交联的取代基，或沿着聚合物的主链并沿着经历交联的取代基; 其中可切割键可用于在活体的体内释放的酶切割; 以及在电磁光谱的可见部分中发光的半导体量子点。

8. 发明申请

US20140322190A1 Pharmaceutical Compositions and Methods for Digesting Atherosclerotic Plaques 有权
标题翻译：药物组合物和消化动脉粥样硬化斑块的方法
公开(公告)号：US20140322190A1
公开(公告)日：2014-10-30
申请号：US14326904
申请日：2014-07-09
申请人： Northwestern University
发明人： Melina R. Kibbe , Guillermo A. Ameer , Vinit N. Varu
IPC分类号： A61K38/48 , A61B17/22 , A61M25/10 , A61K31/724 , A61K45/06
CPC分类号： A61K38/4886 , A61B17/2202 , A61K9/0019 , A61K31/724 , A61K38/49 , A61K38/54 , A61K45/06 , A61M25/1011 , A61M37/0092 , C12Y304/21068 , C12Y304/24003 , C12Y304/24024 , C12Y304/24035 , A61K2300/00
摘要： Disclosed are pharmaceutical compositions and methods for digesting atherosclerotic plaques in a patient in need thereof. The compositions include and the methods utilize a mixture of collagenases for digesting plaques and optionally may include or utilize additional agents such as cyclodextrins, chelating agents, and tissue plasminogen activator.
摘要翻译：公开了用于在有需要的患者中消化动脉粥样硬化斑块的药物组合物和方法。组合物包括并且方法利用胶原酶的混合物来消化斑块，并且任选地可以包括或利用另外的试剂例如环糊精，螯合剂和组织纤溶酶原激活剂。

9. 发明授权

US12098215B2 Fusion protein construct 有权
公开(公告)号：US12098215B2
公开(公告)日：2024-09-24
申请号：US16307621
申请日：2017-06-06
申请人： NORTHWESTERN UNIVERSITY
发明人： Milan Mrksich , Justin A. Modica
IPC分类号： C07K16/46 , A61P19/02 , A61P35/00 , A61P37/00 , C07K16/32 , C12N9/18 , A61K39/00
CPC分类号： C07K16/46 , A61P19/02 , A61P35/00 , A61P37/00 , C07K16/32 , C12N9/18 , C12Y301/01074 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/61 , C12Y201/01037 , C12Y301/21002 , C12Y302/01021 , C12Y304/11018 , C12Y304/24024 , C12Y305/02006
摘要： The disclosure provides constructs comprising a first fusion protein, a second fusion protein, and a linker, wherein the first fusion protein and the second fusion protein each include an affinity reagent and a reactive enzyme, and the linker includes a first and second functional groups specific for irreversibly inhibiting the first and second fusion protein reactive enzymes. The disclosure further provides a method including (a) contacting a first fusion protein including an affinity reagent and a reactive enzyme with a linker including a functional group specific for irreversibly inhibiting the first fusion protein reactive enzyme thereby coupling the first fusion protein and the linker, and (b) contacting a second fusion protein including an affinity reagent and a reactive enzyme with the linker, the linker including a functional group specific for irreversibly inhibiting the second fusion protein reactive enzyme thereby coupling the second fusion protein and the linker.

10. 发明公开

US20240067739A1 NOVEL IL-15 PRODRUGS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20240067739A1
公开(公告)日：2024-02-29
申请号：US18490268
申请日：2023-10-19
申请人： ASKGENE PHARMA, INC.
发明人： Yuefeng LU , Chunxiao YU , Jian-Feng LU
IPC分类号： C07K16/28 , C07K14/81
CPC分类号： C07K16/2866 , C07K14/811 , C07K14/8146 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C12Y304/21109 , C12Y304/24024 , C12Y304/24035
摘要： Provided herein are IL-15 cytokine prodrugs and methods of making and using thereof.

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