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1. 发明申请

US20130281383A1 NOVEL USES OF ELAFIN 审中-公开
标题翻译： ELAFIN的新用途
公开(公告)号：US20130281383A1
公开(公告)日：2013-10-24
申请号：US13582738
申请日：2011-03-02
申请人： Oliver Wiedow , Birge Bargmann , Barbara Kahlke , Lee Shaw , Nils Wichmann
发明人： Oliver Wiedow , Birge Bargmann , Barbara Kahlke , Lee Shaw , Nils Wichmann
IPC分类号： A61K38/57
CPC分类号： C07K14/47 , A61K38/1709 , A61K38/57 , C07K14/8121 , C12N9/6448 , C12Y304/21037
摘要： The invention relates to novel uses of the polypeptide elafin, and/or homologies, derivatives or fragments thereof having inhibitory activity against leukocyte elastase for the prevention and treatment of medical conditions like SIRS.
摘要翻译：本发明涉及对白细胞弹性蛋白酶具有抑制活性的多肽埃拉芬和/或其同源性，衍生物或其片段的新用途，用于预防和治疗诸如SIRS的医学病症。

2. 发明授权

US4968614A Human pancreatic elastase I 失效
公开(公告)号：US4968614A
公开(公告)日：1990-11-06
申请号：US40631
申请日：1987-04-21
申请人： Yo Takiguchi , Tokio Tani , Hidehiko Furukawa , Ohmine, Toshinori , Kawashima, Ichiro
发明人： Yo Takiguchi , Tokio Tani , Hidehiko Furukawa , Ohmine, Toshinori , Kawashima, Ichiro
IPC分类号： C07K1/22 , A61K35/12 , A61K35/74 , A61K36/06 , A61K38/46 , C07K14/00 , C12N1/19 , C12N1/20 , C12N1/21 , C12N5/00 , C12N5/10 , C12N9/66 , C12N15/00 , C12N15/09 , C12N15/57 , C12P21/04 , C12R1/125 , C12R1/19 , C12R1/865 , C12R1/91
CPC分类号： C12N9/6448
摘要： Human pancreatic elastase I can be obtained by genetic engineering.

3. 发明授权

US4458018A Process for purifying elastase 失效
标题翻译：弹性蛋白酶纯化方法
公开(公告)号：US4458018A
公开(公告)日：1984-07-03
申请号：US446079
申请日：1982-12-01
申请人： Tsunehiko Kataoka , Yoshiaki Nagara , Akira Hashimoto , Masayuki Konishi , Koichi Ogawa
发明人： Tsunehiko Kataoka , Yoshiaki Nagara , Akira Hashimoto , Masayuki Konishi , Koichi Ogawa
IPC分类号： C12N9/66
CPC分类号： C12N9/6448 , Y10S435/814
摘要： A process is disclosed for purifying elastase by precipitating elastase from an aqueous, elastase-containing solution, in which the electroconductivity of said aqueous solution is adjusted to 3 millimhos per centimeter or less and the pH of the solution is adjusted to a value of from 2 to 5. The electroconductivity of said aqueous solution is preferably adjusted to 3 millimhos per centimeter or less by means of ultrafiltration.
摘要翻译：公开了一种通过从含水弹性蛋白酶溶液中沉淀弹性蛋白酶来纯化弹性蛋白酶的方法，其中将所述水溶液的导电性调节至3毫摩尔/厘米或更小，并将溶液的pH调节至2的值优选通过超滤将所述水溶液的导电性调节至每毫升3毫摩尔以下。

4. 发明授权

US4071410A Process for preparation of pancreatic elastase 失效
标题翻译：胰弹性蛋白酶的制备方法
公开(公告)号：US4071410A
公开(公告)日：1978-01-31
申请号：US738866
申请日：1976-11-04
申请人： Masayuki Yoshizawa
发明人： Masayuki Yoshizawa
IPC分类号： C12N9/66 , C07G7/026
CPC分类号： C12N9/6448
摘要： Pancreatic elastase is prepared by adding the duodenum of a mammalian animal or an extract thereof to a starting material containing a precursor of elastase to thereby activate the elastase precursor and separating the obtained pancreatic elastase.
摘要翻译：通过将哺乳动物的十二指肠或其提取物添加到含有弹性蛋白酶前体的原料中来制备胰腺弹性蛋白酶，从而活化弹性蛋白酶前体并分离所获得的胰弹性蛋白酶。

5. 发明授权

US08501449B2 Recombinant elastase proteins and methods of manufacturing and use thereof 有权
公开(公告)号：US08501449B2
公开(公告)日：2013-08-06
申请号：US12327809
申请日：2008-12-03
申请人： F. Nicholas Franano , Kimberly S. Bland , Marco D. Wong , Bee C. Ding
发明人： F. Nicholas Franano , Kimberly S. Bland , Marco D. Wong , Bee C. Ding
IPC分类号： C12N9/66 , C12N1/20 , C12N15/00 , C12N1/00 , A23J1/00 , C07H21/04 , C12P21/04 , C12P21/06 , A61K38/43
CPC分类号： C12N9/6448 , A61K9/19 , A61K38/00 , A61K38/486 , C07K1/14 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C12N9/50 , C12N15/815 , C12P21/02 , C12Y304/21036 , C12Y304/21037
摘要： The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention.

6. 发明申请

US20110081705A1 RECOMBINANT ELASTASE PROTEINS AND METHODS OF MANUFACTURING AND USE THEREOF 审中-公开
标题翻译：重组弹性蛋白及其制备方法及其用途
公开(公告)号：US20110081705A1
公开(公告)日：2011-04-07
申请号：US12823098
申请日：2010-06-24
申请人： F. NICHOLAS FRANANO , KIMBERLY S. BLAND , MARCO D. WONG , BEE C. DING
发明人： F. NICHOLAS FRANANO , KIMBERLY S. BLAND , MARCO D. WONG , BEE C. DING
IPC分类号： C12N9/66 , C07K14/00 , C07H21/00 , C12N15/63 , C12N1/15 , C12P21/00
CPC分类号： C12N9/6448 , A61K9/19 , A61K38/00 , A61K38/486 , C07K1/14 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C12N9/50 , C12N15/815 , C12P21/02 , C12Y304/21036 , C12Y304/21037
摘要： The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention.
摘要翻译：本发明涉及生物活性重组弹性蛋白酶蛋白质的制造，纯化，配制和使用方法。描述了用于产生治疗上有用的弹性蛋白酶蛋白质的重组方法，以及包含所述弹性蛋白酶蛋白质的药物组合物。还公开了新的重组弹性蛋白酶蛋白质和蛋白质制剂。描述了使用含有本发明的弹性蛋白酶蛋白质的药物组合物治疗和预防生物管道疾病的方法。

7. 发明申请

US20050025722A1 Removing dental plaque with krill enzymes 有权
标题翻译：用磷虾酶去除牙菌斑
公开(公告)号：US20050025722A1
公开(公告)日：2005-02-03
申请号：US10750184
申请日：2003-12-31
申请人： Richard Franklin
发明人： Richard Franklin
IPC分类号： A61K6/00 , A61K8/66 , A61K8/98 , A61K38/00 , A61K38/48 , A61Q11/00 , C12N9/00 , C12N9/48 , C12N9/64 , C12N9/66 , A61K7/28
CPC分类号： C12N9/6408 , A61K8/66 , A61K8/987 , A61K38/4813 , A61K38/4826 , A61K38/486 , A61K38/4886 , A61Q11/00 , C12N9/00 , C12N9/48 , C12N9/6402 , C12N9/6448 , A61K2300/00
摘要： The invention relates to a multifunctional enzyme that can be derived from crustaceans or fish. The enzyme has at least one of a chymotrypsin, trypsin, elastase, collagenase and exo peptidase activity, and a molecular weight between about 20 kd and about 40 kd as determined by SDS PAGE. Preferably, the multifunctional enzyme has substantial anti cell-cell adhesion activity. Preferably, the multifunctional enzyme has substantial homology with the krill multifunctional enzyme. These enzymes are useful for treating viral infections such as herpes outbreaks, fungal, bacterial or parasitic infections, including the primary and secondary infections of leprosy, colitis, ulcers, hemorrhoids, corneal scarring, dental plaque, acne, cystic fibrosis, blood clots, wounds, immune disorders including autoimmune disease and cancer. Additionally, the invention relates to a method of purifying the multifunctional enzyme, and to a preparation of essentially purified multifunctional enzyme.
摘要翻译：本发明涉及可以衍生自甲壳类或鱼类的多功能酶。该酶具有糜蛋白酶，胰蛋白酶，弹性蛋白酶，胶原酶和外切肽酶活性中的至少一种，并且通过SDS PAGE测定的分子量在约20kd至约40kd之间。优选地，多功能酶具有显着的抗细胞 - 细胞粘附活性。优选地，多功能酶与磷虾多功能酶具有实质的同源性。这些酶可用于治疗病毒感染，如疱疹爆发，真菌，细菌或寄生虫感染，包括麻风病，结肠炎，溃疡，痔疮，角膜瘢痕，牙斑，痤疮，囊性纤维化，血块，伤口的原发性和继发性感染，包括自身免疫疾病和癌症的免疫疾病。此外，本发明涉及一种纯化多功能酶的方法，以及本发明纯化的多功能酶的制备方法。

8. 发明授权

US06204043B1 Human macrophage metalloproteinase 失效
标题翻译：人巨噬细胞金属蛋白酶
公开(公告)号：US06204043B1
公开(公告)日：2001-03-20
申请号：US08396988
申请日：1995-03-01
申请人： Steven D. Shapiro
发明人： Steven D. Shapiro
IPC分类号： C12N964
CPC分类号： C12N9/6448 , C12Y304/24065
摘要： A novel 54 kDa human macrophage metalloelastase (HME) having elastolytic activity and the cDNA which encodes for this enzyme are disclosed.
摘要翻译：公开了具有弹性分解活性的新型54kDa人巨噬细胞金属弹性蛋白酶（HME）和编码该酶的cDNA。

9. 发明授权

US6150152A Human macrophage metalloelastase 失效
标题翻译：人巨噬细胞金属弹性蛋白酶
公开(公告)号：US6150152A
公开(公告)日：2000-11-21
申请号：US68392
申请日：1993-05-28
申请人： Steven D. Shapiro
发明人： Steven D. Shapiro
IPC分类号： C12N9/66 , C12N15/57 , C07H21/04
CPC分类号： C12N9/6448 , C12Y304/24065
摘要： A novel 54 kDa human macrophage metalloelastase (HME) having elastolytic activity and the cDNA which encodes for this enzyme are disclosed.
摘要翻译：公开了具有弹性分解活性的新型54kDa人巨噬细胞金属弹性蛋白酶（HME）和编码该酶的cDNA。

10. 发明授权

US5976529A Methods of enzyme therapy by orally administering crosslinked enzyme crystals 失效
标题翻译：口服交联酶晶体的酶疗法
公开(公告)号：US5976529A
公开(公告)日：1999-11-02
申请号：US477109
申请日：1995-06-07
申请人： Manuel A. Navia , Nancy L. St. Clair
发明人： Manuel A. Navia , Nancy L. St. Clair
IPC分类号： A61K38/43 , A61K38/46 , C07K1/107 , C07K5/072 , C12M1/40 , C12N9/14 , C12N9/20 , C12N9/36 , C12N9/54 , C12N9/66 , C12N9/80 , C12N9/82 , C12N11/00 , C12Q1/00 , C12Q1/37 , G01N33/531 , C07K17/00 , C12P1/00
CPC分类号： C12N9/2462 , C07K1/1077 , C07K5/0613 , C12N11/00 , C12N9/14 , C12N9/20 , C12N9/54 , C12N9/6448 , C12N9/80 , C12N9/82 , C12Q1/00 , C12Q1/003 , C12Q1/37 , G01N33/531 , A61K38/00 , Y10S435/817 , Y10S530/81
摘要： A protein such as an enzyme or antibody is immobilized by crosslinking crystals of the protein with a multifunctional crosslinking agent. The crosslinked protein crystals may be lyophilized for storage. A preferred protein is an enzyme such as thermolysin, elastase, asparaginase, lysozyme, lipase or urease. Crosslinked enzyme crystals preferably retain at least 91% activity after incubation for three hours in the presence of a concentration of Pronase.TM. that causes the soluble uncrosslinked form of the enzyme to lose at least 94% of its initial activity under the same conditions. A preferred enzyme:Pronase.TM. ratio is 1:40. Enzyme crystals that are crosslinked may be microcrystals having a cross-section of 10.sup.-1 mm or less. Crosslinked enzyme or antibody crystals may be used in an assay, diagnostic kit or biosensor for detecting an analyte, in an extracorporeal device for altering a component of a fluid, in producing a product such as using crosslinked thermolysin crystals to produce aspartame and in separating a substance from a mixture. Enzyme therapy such as lipase therapy can be performed by administering orally crosslinked lipase crystals.
摘要翻译：通过用多功能交联剂交联蛋白质的晶体来固定蛋白质如酶或抗体。交联的蛋白质晶体可以冻干以储存。优选的蛋白质是酶，例如嗜热菌蛋白酶，弹性蛋白酶，天冬酰胺酶，溶菌酶，脂肪酶或脲酶。交联的酶晶体优选保持在Termase TM浓度存在下温育3小时后的至少91％的活性，其导致可溶性的未交联形式的酶在相同条件下损失至少94％的初始活性。优选的酶：Pronase TM比为1:40。交联的酶晶体可以是横截面为10-1mm或更小的微晶。交联的酶或抗体晶体可用于用于检测分析物的测定，诊断试剂盒或生物传感器，用于改变流体组分的体外装置中，用于产生例如使用交联的嗜热溶菌素晶体产生天冬酰苯丙氨酸并在分离物质从混合物。酶治疗如脂肪酶治疗可以通过口服交联的脂肪酶晶体进行。

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