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1. 发明申请

US20160244850A1 VIRUS CAUSING RESPIRATORY TRACT ILLNESS IN SUSCEPTIBLE MAMMALS 有权
标题翻译：病毒引起呼吸道感染的可疑性
公开(公告)号：US20160244850A1
公开(公告)日：2016-08-25
申请号：US15147653
申请日：2016-05-05
申请人： ViroNovative BV
发明人： Jan Cornelius De Jong , Ronaldus Adrianus Maria Fouchier , Jan Groen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Bernadetta Gerarda Van Den Hoogen
IPC分类号： C12Q1/70
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18622 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/56983
摘要： The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single-stranded RNA virus (MPV) within the subfamily Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus and components thereof.
摘要翻译：本发明涉及病毒学领域。本发明提供了分离的基本上哺乳动物的负义义单链RNA病毒（MPV），在亚科副粘病毒亚科的肺炎链球菌中，并且可鉴定为与亚属肺炎病毒属及其组分的系统发育。

2. 发明申请

US20140370497A1 METAPNEUMOVIRUS STRAINS AND THEIR USE IN VACCINE FORMULATIONS AND AS VECTORS FOR EXPRESSION OF ANTIGENIC SEQUENCES 有权
标题翻译：金属芽孢杆菌菌株及其在疫苗制剂中的用途以及用于表达抗原序列的载体
公开(公告)号：US20140370497A1
公开(公告)日：2014-12-18
申请号：US14460285
申请日：2014-08-14
申请人： ViroNovative BV
发明人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Jan Cornelius De Jong , Jan Groen
IPC分类号： C12Q1/70
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , A61K2039/552 , A61K2039/58 , A61K2039/70 , A61K2123/00 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2710/22034 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18522 , C12N2760/18534 , C12N2760/18621 , C12N2760/18622 , C12N2760/18634 , C12N2760/18643 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5088 , G01N33/56983 , G01N2333/08 , Y02A90/26
摘要： Provided is an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. Also provided are isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular, provided is a mammalian MPV, subgroups and variants thereof. Also provided are genomic nucleotide sequences of different isolates of mammalian MPV, in particular, human MPV. Disclosed is the use of the sequence information of different isolates of mammalian MPV for diagnostic and therapeutic methods. Provided are nucleotide sequences encoding the genome of an MPV or a portion thereof, including both mammalian and avian MPV. Further described are chimeric or recombinant viruses encoded by the nucleotide sequences and chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. Also provided are vaccine formulations comprising mammalian or avian MPV, including recombinant and chimeric forms thereof. The vaccine preparations encompass multivalent vaccines, including bivalent and trivalent vaccine preparations.
摘要翻译：提供了副粘病毒科家族肺炎链球菌中分离的哺乳动物负链RNA病毒，偏肺病毒（MPV）。还提供了分离的哺乳动物负链RNA病毒，其可鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。特别地，提供哺乳动物MPV，亚组及其变体。还提供了哺乳动物MPV，特别是人MPV的不同分离物的基因组核苷酸序列。公开了哺乳动物MPV的不同分离株的序列信息用于诊断和治疗方法。提供编码MPV或其部分的基因组的核苷酸序列，包括哺乳动物和禽类MPV。进一步描述的是由核苷酸序列和包含一个或多个非天然或异源序列的嵌合和重组哺乳动物MPV编码的嵌合或重组病毒。还提供了包含哺乳动物或禽类MPV的疫苗制剂，包括其重组和嵌合形式。疫苗制剂包括多价疫苗，包括二价和三价疫苗制剂。

3. 发明申请

US20140295409A1 METAPNEUMOVIRUS STRAINS AND THEIR USE IN VACCINE FORMULATIONS AND AS VECTORS FOR EXPRESSION OF ANTIGENIC SEQUENCES 有权
标题翻译：金属芽孢杆菌菌株及其在疫苗制剂中的用途以及用于表达抗原序列的载体
公开(公告)号：US20140295409A1
公开(公告)日：2014-10-02
申请号：US14270237
申请日：2014-05-05
申请人： ViroNovative BV , Medimmune Vaccines, Inc.
发明人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus D M E Osterhaus , Aurelia Haller , Roderick Tang
IPC分类号： C12Q1/70
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18622 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/56983
摘要： The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a mammalian MPV, subgroups and variants thereof. The invention relates to genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The invention relates to the use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods. The present invention relates to nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences. The invention also relates to chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. The invention further relates to vaccine formulations comprising mammalian or avian metapneumovirus, including recombinant and chimeric forms of said viruses. The vaccine preparations of the invention encompass multivalent vaccines, including bivalent and trivalent vaccine preparations.
摘要翻译：本发明提供分离的哺乳动物负链RNA病毒，亚型家族肺炎链球菌中的亚型副粘病毒亚科病毒（MPV）。本发明还提供可分离的哺乳动物负链RNA病毒，其可鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。特别地，本发明提供哺乳动物MPV，亚组及其变体。本发明涉及哺乳动物偏肺炎病毒，特别是人类偏肺病毒的不同分离物的基因组核苷酸序列。本发明涉及用于诊断和治疗方法的哺乳动物偏肺病毒的不同分离株的序列信息的使用。本发明涉及编码偏肺病毒或其部分基因组的核苷酸序列，包括哺乳动物和禽类间质肺病毒。本发明还包括由所述核苷酸序列编码的嵌合或重组病毒。本发明还涉及包含一种或多种非天然或异源序列的嵌合和重组哺乳动物MPV。本发明还涉及包含哺乳动物或禽类偏肺病毒的疫苗制剂，包括所述病毒的重组和嵌合形式。本发明的疫苗制剂包括多价疫苗，包括二价和三价疫苗制剂。

4. 发明授权

US08841433B2 Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences 有权
标题翻译：肺炎病毒菌株及其在疫苗制剂中的用途以及用于表达抗原序列的载体
公开(公告)号：US08841433B2
公开(公告)日：2014-09-23
申请号：US12284347
申请日：2008-09-18
申请人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Jan Cornelius De Jong , Jan Groen
发明人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Jan Cornelius De Jong , Jan Groen
IPC分类号： C12N15/45 , G01N33/50 , C07K14/005 , C12N15/86 , C12N7/00 , A61K39/155 , G01N33/569 , C07K16/10 , A61K39/00
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , A61K2039/552 , A61K2039/58 , A61K2039/70 , A61K2123/00 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2710/22034 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18522 , C12N2760/18534 , C12N2760/18621 , C12N2760/18622 , C12N2760/18634 , C12N2760/18643 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5088 , G01N33/56983 , G01N2333/08 , Y02A90/26
摘要： Provided is an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. Also provided are isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular, provided is a mammalian MPV, subgroups and variants thereof. Also provided are genomic nucleotide sequences of different isolates of mammalian MPV, in particular, human MPV. Disclosed is the use of the sequence information of different isolates of mammalian MPV for diagnostic and therapeutic methods. Provided are nucleotide sequences encoding the genome of a MPV or a portion thereof, including both mammalian and avian MPV. Further described are chimeric or recombinant viruses encoded by the nucleotide sequences, and chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. Also provided are vaccine formulations comprising mammalian or avian MPV, including recombinant and chimeric forms thereof. The vaccine preparations encompass multivalent vaccines, including bivalent and trivalent vaccine preparations.
摘要翻译：提供了副粘病毒科家族肺炎链球菌中分离的哺乳动物负链RNA病毒，偏肺病毒（MPV）。还提供了分离的哺乳动物负链RNA病毒，其可鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。特别地，提供哺乳动物MPV，亚组及其变体。还提供了哺乳动物MPV，特别是人MPV的不同分离物的基因组核苷酸序列。公开了哺乳动物MPV的不同分离株的序列信息用于诊断和治疗方法。提供编码MPV或其部分的基因组的核苷酸序列，包括哺乳动物和禽类MPV。还描述了由核苷酸序列编码的嵌合或重组病毒，以及包含一个或多个非天然或异源序列的嵌合和重组哺乳动物MPV。还提供了包含哺乳动物或禽类MPV的疫苗制剂，包括其重组和嵌合形式。疫苗制剂包括多价疫苗，包括二价和三价疫苗制剂。

5. 发明申请

US20080096263A1 Recombinant Parainfluenza Virus Expression Systems And Vaccines Comprising Heterologous Antigens Derived From Respiratory Syncytial Virus 审中-公开
标题翻译：重组副流感病毒表达系统和疫苗，其包含来自呼吸道合胞病毒的异源抗原
公开(公告)号：US20080096263A1
公开(公告)日：2008-04-24
申请号：US11762814
申请日：2007-06-14
申请人： Aurelia Haller , Kathleen Coelingh
发明人： Aurelia Haller , Kathleen Coelingh
IPC分类号： C12N7/00
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , A61K2039/552 , A61K2039/58 , A61K2039/70 , A61K2123/00 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2710/22034 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18522 , C12N2760/18534 , C12N2760/18621 , C12N2760/18622 , C12N2760/18634 , C12N2760/18643 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5088 , G01N33/56983 , G01N2333/08 , Y02A90/26
摘要： The present invention relates to recombinant bovine parainfluenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. In particular, the heterologous gene products include gene product of another species of PIV or from another negative strand RNA virus, including but not limited to, influenza virus, respiratory syncytial virus, human metapneumovirus and avian pneumovirus. The chimeric viruses and expression products may advantageously be used in vaccine formulations including vaccines against a broad range of pathogens and antigens.
摘要翻译：本发明涉及可用于在合适的宿主细胞系统中表达异源基因产物的重组牛副流感病毒（bPIV）cDNA或RNA，和/或挽救表达，包装和/或呈递异源的负链RNA重组病毒基因产物。特别地，异源基因产物包括另一种PIV或另一种负链RNA病毒的基因产物，包括但不限于流感病毒，呼吸道合胞病毒，人偏肺病毒和禽肺病毒。嵌合病毒和表达产物可有利地用于疫苗制剂中，包括针对各种病原体和抗原的疫苗。

6. 发明授权

US09834824B2 Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences 有权
公开(公告)号：US09834824B2
公开(公告)日：2017-12-05
申请号：US15404854
申请日：2017-01-12
申请人： Erasmus University Medical Center Rotterdam
发明人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Jan Cornelius De Jong , Jan Groen
IPC分类号： C12Q1/70 , A61K39/155 , C07K14/005 , C07K16/10 , C12N7/00 , C12N15/86 , G01N33/50 , G01N33/569 , A61K39/12 , A61K39/00
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , A61K2039/552 , A61K2039/58 , A61K2039/70 , A61K2123/00 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2710/22034 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18522 , C12N2760/18534 , C12N2760/18621 , C12N2760/18622 , C12N2760/18634 , C12N2760/18643 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5088 , G01N33/56983 , G01N2333/08 , Y02A90/26
摘要： Provided is an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. Also provided are isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular, provided is a mammalian MPV, subgroups and variants thereof. Also provided are genomic nucleotide sequences of different isolates of mammalian MPV, in particular, human MPV. Disclosed is the use of the sequence information of different isolates of mammalian MPV for diagnostic and therapeutic methods. Provided are nucleotide sequences encoding the genome of an MPV or a portion thereof, including both mammalian and avian MPV. Further described are chimeric or recombinant viruses encoded by the nucleotide sequences and chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. Also provided are vaccine formulations comprising mammalian or avian MPV, including recombinant and chimeric forms thereof. The vaccine preparations encompass multivalent vaccines, including bivalent and trivalent vaccine preparations.

7. 发明申请

US20170183747A1 VIRUS CAUSING RESPIRATORY TRACT ILLNESS IN SUSCEPTIBLE MAMMALS 有权
公开(公告)号：US20170183747A1
公开(公告)日：2017-06-29
申请号：US15453764
申请日：2017-03-08
申请人： Erasmus University Medical Center Rotterdam
发明人： Jan Cornelius De Jong , Ronaldus Adrianus Maria Fouchier , Jan Groen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Bernadetta Gerarda Van Den Hoogen
IPC分类号： C12Q1/70
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18622 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/56983
摘要： The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single-stranded RNA virus (MPV) within the subfamily Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus and components thereof.

8. 发明授权

US09593386B2 Virus causing respiratory tract illness in susceptible mammals 有权
标题翻译：易感染哺乳动物引起呼吸道疾病的病毒
公开(公告)号：US09593386B2
公开(公告)日：2017-03-14
申请号：US15147653
申请日：2016-05-05
申请人： Erasmus Universiteit Medical Center Rotterdam
发明人： Jan Cornelius De Jong , Ronaldus Adrianus Maria Fouchier , Jan Groen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Bernadetta Gerarda Van Den Hoogen
IPC分类号： C12Q1/70 , C07K14/005 , C12N7/00 , C12N15/86 , A61K39/12 , A61K39/155 , C07K16/10 , G01N33/50 , G01N33/569 , A61K39/00
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18622 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/56983
摘要： The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single-stranded RNA virus (MPV) within the subfamily Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus and components thereof.
摘要翻译：本发明涉及病毒学领域。本发明提供了分离的基本上哺乳动物的负义义单链RNA病毒（MPV），在亚科副粘病毒亚科的肺炎链球菌中，并且可鉴定为与亚属肺炎病毒属及其组分的系统发育。

9. 发明授权

US09376726B2 Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences 有权
公开(公告)号：US09376726B2
公开(公告)日：2016-06-28
申请号：US14270237
申请日：2014-05-05
申请人： Erasmus University Medical Center Rotterdam
发明人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus D M E Osterhaus , Aurelia Haller , Roderick Tang
IPC分类号： C12Q1/70 , A61K39/155 , C07K14/005 , C07K16/10 , C12N7/00 , C12N15/86 , G01N33/50 , G01N33/569 , A61K39/12 , A61K39/00
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18622 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/56983
摘要： The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a mammalian MPV, subgroups and variants thereof. The invention relates to genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The invention relates to the use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods. The present invention relates to nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences. The invention also relates to chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. The invention further relates to vaccine formulations comprising mammalian or avian metapneumovirus, including recombinant and chimeric forms of said viruses. The vaccine preparations of the invention encompass multivalent vaccines, including bivalent and trivalent vaccine preparations.

10. 发明授权

US08722341B2 Metapneumovirus strains and their use in vaccine formulations and sequences 有权
标题翻译：肺炎病毒菌株及其在疫苗制剂中的用途以及用于表达抗原序列的载体
公开(公告)号：US08722341B2
公开(公告)日：2014-05-13
申请号：US12319152
申请日：2008-12-31
申请人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Aurelia Haller , Roderick Tang
发明人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Aurelia Haller , Roderick Tang
IPC分类号： C07K16/00 , C07K16/10 , G01N33/53
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18622 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/56983
摘要： Provided is an isolated mammalian negative strand RNA virus, metapneumovirus (MPV). Described are isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. Also described is mammalian MPV, subgroups and variants thereof, and genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods is provided. Nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus are described. Also provided are chimeric or recombinant viruses encoded by said nucleotide sequences and chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences.
摘要翻译：提供了分离的哺乳动物负链RNA病毒，偏肺病毒（MPV）。描述的是分离的哺乳动物负链RNA病毒，其被鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。还描述了哺乳动物MPV，亚组及其变体，以及哺乳动物偏肺病毒，特别是人类偏肺病毒的不同分离物的基因组核苷酸序列。提供了用于诊断和治疗方法的哺乳动物偏肺炎病毒的不同分离株的序列信息的使用。描述了编码偏肺病毒或其部分基因组的核苷酸序列，包括哺乳动物和禽类间质肺病毒。还提供了由所述核苷酸序列编码的嵌合或重组病毒以及包含一个或多个非天然或异源序列的嵌合和重组哺乳动物MPV。

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