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1. 发明授权

US08652459B2 Splitting GP41 有权
标题翻译：拆分GP41
公开(公告)号：US08652459B2
公开(公告)日：2014-02-18
申请号：US13143873
申请日：2010-02-08
申请人： Sylvain Fleury , Morgane Bomsel
发明人： Sylvain Fleury , Morgane Bomsel
IPC分类号： A61K39/21 , A61K48/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5258 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/55555 , A61K2039/575 , A61K2039/6018 , C07K2319/40 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134 , C12N2760/16142
摘要： The present invention deals with a method for therapeutic or prophylactic treatment of HIV, in particular a prophylactic vaccinal method, comprising at least: administering to a patient a first antigen comprising the broadly neutralizing epitopes of the Membrane Proximal Ectodomain Region (MPER) of gp41, and administering to the same patient a second antigen comprising a modified polypeptide comprising three contiguous segments N, L and C represented by the formula N-L-C and comprising: a N-helix region of gp41(N), a C-helix region of gp41(C), and a connecting loop comprising a synthetic linker (L) between the N and C-helices, the linker replacing amino acids 593-617 of gp41, the numbering scheme being based upon the prototypic isolate HIV-1 HxB2 Clade B strain, said polypeptide comprising the calveolin-1 neutralizing and 98.6 D epitopes, but not 2F5 and 4E10 epitopes, not the fusion peptide, the polypeptide having a minimal immunogenic cross-reactivity with human interleukin 2.
摘要翻译：本发明涉及HIV的治疗或预防性治疗方法，特别是一种预防性疫苗方法，其至少包括：向患者施用包含gp41的膜近端胞外域（MPER）的广泛中和表位的第一抗原，并且向相同的患者施用包含修饰的多肽的第二抗原，其包含由式NLC表示的三个连续区段N，L和C，并且包含：gp41（N）的N-螺旋区域，gp41的C-螺旋区域（C ）和包含在N和C-螺旋之间的合成接头（L）的连接环，所述接头代替gp41的氨基酸593-617，编号方案基于原型分离物HIV-1 HxB2进化枝B菌株，所述所述多肽包含与小白细胞介素2具有最小免疫原性交叉反应性的所述多肽，所述多肽包含所述犊牛素-1中和和98.6D表位，而不是2F5和4E10表位，而不是融合肽。

2. 发明申请

US20140072616A1 Lyophilization of Virosomes 审中-公开
标题翻译：病毒颗粒冻干
公开(公告)号：US20140072616A1
公开(公告)日：2014-03-13
申请号：US13962613
申请日：2013-08-08
申请人： Pevion Biotech Ltd.
发明人： Rinaldo Zurbriggen , Mario Amacker , Silvia Rasi
IPC分类号： A61K47/28 , A61K9/127 , A61K31/704 , A61K39/145
CPC分类号： A61K47/28 , A61K9/1272 , A61K9/19 , A61K31/704 , A61K39/015 , A61K39/12 , A61K39/145 , A61K2039/5258 , A61K2039/55555 , A61K2039/70 , C12N2760/16134 , C12N2760/16142 , C12N2760/16234
摘要： The present invention relates to biologically active compositions and methods for the lyophilization and reconstruction of virosomes comprising special membrane compositions. These compositions are essential to the invention and provide superior freeze-drying stress-resistance for the virosomes of the invention.
摘要翻译：本发明涉及包含特殊膜组合物的病毒颗粒的冻干和重建的生物活性组合物和方法。这些组合物对于本发明是必需的，并且为本发明的病毒体提供优异的抗冻干应激性。

3. 发明申请

US20120164181A1 Non-Specific Immunostimulating Agents 审中-公开
标题翻译：非特异性免疫刺激剂
公开(公告)号：US20120164181A1
公开(公告)日：2012-06-28
申请号：US13403681
申请日：2012-02-23
申请人： Christian Moser , Andreas Kammer , Rinaldo Zurbriggen
发明人： Christian Moser , Andreas Kammer , Rinaldo Zurbriggen
IPC分类号： A61K38/16 , A61K35/76 , A61P31/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P31/12 , A61P31/04 , A61P31/10 , A61P33/00 , A61P35/02 , A61K38/47 , A61P3/10
CPC分类号： A61K39/145 , A61K39/0225 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/585 , C12N2760/12034 , C12N2760/16134 , C12N2760/16142
摘要： The present invention includes a lipid vesicle. The invention further relates to a method of treating and/or preventing a disease or disorder involving administering such a lipid vesicle to an animal in need thereof.
摘要翻译：本发明包括脂质囊泡。本发明还涉及治疗和/或预防涉及向有需要的动物施用这种脂质囊泡的疾病或病症的方法。

4. 发明申请

US20120052082A1 CROSS-PROTECTIVE INFLUENZA VACCINE 审中-公开
标题翻译：交叉保护性流感疫苗
公开(公告)号：US20120052082A1
公开(公告)日：2012-03-01
申请号：US13084367
申请日：2011-04-11
申请人： Richard W. Compans , Sang-Moo Kang , Jadranka Bozja , Bao-Zhong Wang , Jae-Min Song
发明人： Richard W. Compans , Sang-Moo Kang , Jadranka Bozja , Bao-Zhong Wang , Jae-Min Song
IPC分类号： A61K39/145 , A61P31/16 , A61P37/04
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55516 , A61K2039/55544 , A61K2039/58 , C12N2760/16134 , C12N2760/16142
摘要： A cross-protective influenza virus vaccine has been designed based on the incorporation of the genetically engineered, highly conserved M2 influenza viral protein optionally in combination with an adjuvant such as a bacterial flagellin protein incorporated into the membrane of a virosome or virus-like particles. Immunogenicity and the breadth of cross protection efficacy are significantly enhanced using multiple copies of the influenza M2 protein as a membrane bound tetramer and/or in combination with a membrane bound adjuvant. A method for vaccinating a subject for influenza A has also been developed that results in broad and improved cross-protection against multiple subtypes of influenza A virus.
摘要翻译：已经基于将经遗传工程化的高度保守的M2流感病毒蛋白质掺入到病毒颗粒或病毒样颗粒的膜中的佐剂（例如细菌鞭毛蛋白）组合来设计交叉保护型流感病毒疫苗。使用多个拷贝的流感M2蛋白作为膜结合的四聚体和/或与膜结合的佐剂组合，可以显着增强免疫原性和交叉保护功效的广度。还开发了用于接种甲型流感病毒的受试者的方法，其导致广泛和改进的针对多种亚型甲型流感病毒的交叉保护。

5. 发明申请

US20110311614A1 SPLITTING GP41 有权
标题翻译：分割GP41
公开(公告)号：US20110311614A1
公开(公告)日：2011-12-22
申请号：US13143873
申请日：2010-02-08
申请人： Sylvain Fleury , Morgane Bomsel
发明人： Sylvain Fleury , Morgane Bomsel
IPC分类号： A61K9/127 , A61P31/12 , A61K39/385 , A61K39/395
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5258 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/55555 , A61K2039/575 , A61K2039/6018 , C07K2319/40 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134 , C12N2760/16142
摘要： The present invention deals with a method for therapeutic or prophylactic treatment of HIV, in particular a prophylactic vaccinal method, comprising at least: administering to a patient a first antigen comprising the broadly neutralizing epitopes of the Membrane Proximal Ectodomain Region (MPER) of gp41, and administering to the same patient a second antigen comprising a modified polypeptide comprising three contiguous segments N, L and C represented by the formula N-L-C and comprising: a N-helix region of gp41(N), a C-helix region of gp41(C), and a connecting loop comprising a synthetic linker (L) between the N and C-helices, the linker replacing amino acids 593-617 of gp41, the numbering scheme being based upon the prototypic isolate HIV-1 HxB2 Clade B strain, said polypeptide comprising the calveolin-1 neutralizing and 98.6 D epitopes, but not 2F5 and 4E10 epitopes, not the fusion peptide, the polypeptide having a minimal immunogenic cross-reactivity with human interleukin 2.
摘要翻译：本发明涉及HIV的治疗或预防性治疗方法，特别是一种预防性疫苗方法，其至少包括：向患者施用包含gp41的膜近端胞外域（MPER）的广泛中和表位的第一抗原，并且向相同的患者施用包含修饰的多肽的第二抗原，其包含由式NLC表示的三个连续区段N，L和C，并且包含：gp41（N）的N-螺旋区域，gp41的C-螺旋区域（C ）和包含在N和C-螺旋之间的合成接头（L）的连接环，所述接头代替gp41的氨基酸593-617，编号方案基于原型分离物HIV-1 HxB2进化枝B菌株，所述所述多肽包含与小白细胞介素2具有最小免疫原性交叉反应性的所述多肽，所述多肽包含所述犊牛素-1中和和98.6D表位，而不是2F5和4E10表位，而不是融合肽。

6. 发明申请

US20110142912A1 NON-SPECIFIC IMMUNOSTIMULATING AGENTS 审中-公开
标题翻译：非特异性免疫增强剂
公开(公告)号：US20110142912A1
公开(公告)日：2011-06-16
申请号：US12521448
申请日：2007-12-31
申请人： Christian Moser , Andreas Kammer , Rinaldo Zurbriggen
发明人： Christian Moser , Andreas Kammer , Rinaldo Zurbriggen
IPC分类号： A61K9/127 , A61K39/145 , A61K39/205 , A61K39/155 , A61K39/29 , A61K39/12 , A61P31/00 , A61P35/00 , A61P33/00 , A61K39/00
CPC分类号： A61K39/145 , A61K39/0225 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/585 , C12N2760/12034 , C12N2760/16134 , C12N2760/16142
摘要： The present invention relates to the use of a lipid vesicle for the preparation of a medicament. The invention further relates to a method of treating and/or preventing a disease or disorder involving administering such a lipid vesicle to an animal in need thereof.
摘要翻译：本发明涉及脂质囊泡在制备药物中的用途。本发明还涉及治疗和/或预防涉及向有需要的动物施用这种脂质囊泡的疾病或病症的方法。

7. 发明申请

US20080268028A1 Lyophilization of virosomes 审中-公开
标题翻译：冻干病毒体
公开(公告)号：US20080268028A1
公开(公告)日：2008-10-30
申请号：US11823713
申请日：2007-06-28
申请人： Rinaldo Zurbriggen , Mario Amacker , Silvia Rasi
发明人： Rinaldo Zurbriggen , Mario Amacker , Silvia Rasi
IPC分类号： A61K9/127
CPC分类号： A61K47/28 , A61K9/1272 , A61K9/19 , A61K31/704 , A61K39/015 , A61K39/12 , A61K39/145 , A61K2039/5258 , A61K2039/55555 , A61K2039/70 , C12N2760/16134 , C12N2760/16142 , C12N2760/16234
摘要： The present invention relates to biologically active compositions and methods for the lyophilization and reconstruction of virosomes comprising special membrane compositions. These compositions are essential to the invention and provide superior freeze-drying stress-resistance for the virosomes of the invention.
摘要翻译：本发明涉及包含特殊膜组合物的病毒颗粒的冻干和重建的生物活性组合物和方法。这些组合物对于本发明是必需的，并且为本发明的病毒体提供优异的抗冻干应激性。

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