专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20150183834A1 Filoviral Immunosuppressive Peptides 审中-公开
标题翻译：病毒免疫抑制肽
公开(公告)号：US20150183834A1
公开(公告)日：2015-07-02
申请号：US14266355
申请日：2014-04-30
申请人： The Trustees of Columbia University in the City of New York
发明人： W. Ian LIPKIN , Kavitha YADDANAPUDI , Gustavo PALACIOS
IPC分类号： C07K14/005 , G01N33/50 , C12N7/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N7/00 , C12N2760/14122 , C12N2760/14133 , C12N2760/14222 , C12N2760/14233 , G01N33/5047 , G01N33/564 , G01N2333/08 , G01N2500/10
摘要： The invention provides a region of strong secondary structure conservation between the C-terminus domain of the envelope glycoprotein of filoviruses and an immunosuppressive domain found in retroviral envelope glycoproteins. The invention provides filoviral peptides and modified derivatives thereof with strong immunosuppressive bioactivity. The invention further provides methods for treatment of autoimmune disorders by administering the immunosuppressive peptide. The invention also provides methods for the identification of therapeutic agents that modulate the immunosuppressive activity of the peptides. Antibodies against the inventive peptides and the modified derivatives thereof are also provided. Furthermore, the invention provides methods for treatment of filoviral infection by administering compositions comprising the antibodies and/or the therapeutic agents that modulate the immunosuppressive activity of the inventive peptides.
摘要翻译：本发明提供了在病毒包膜糖蛋白的包膜糖蛋白的C末端结构域与在逆转录病毒包膜糖蛋白中发现的免疫抑制结构域之间具有强二级结构保守性的区域。本发明提供具有强免疫抑制生物活性的氟病毒肽及其修饰的衍生物。本发明还提供了通过施用免疫抑制肽来治疗自身免疫疾病的方法。本发明还提供了用于鉴定调节肽的免疫抑制活性的治疗剂的方法。还提供了抗本发明肽及其修饰衍生物的抗体。此外，本发明提供了通过施用包含调节本发明肽的免疫抑制活性的抗体和/或治疗剂的组合物来治疗火山病毒感染的方法。

2. 发明申请

US20030083305A1 Viral interferon antagonists and uses therefor 审中-公开
标题翻译：病毒干扰素拮抗剂及其用途
公开(公告)号：US20030083305A1
公开(公告)日：2003-05-01
申请号：US10269513
申请日：2002-10-10
发明人： Peter Palese , Adolfo Garcia-Sastre
IPC分类号： A61K048/00
CPC分类号： A61K38/162 , C12N2760/14133 , C12N2760/16133 , C12N2760/18533 , Y02A50/401
摘要： The present invention relates to compositions comprising one or more viral interferon antagonists and methods of utilizing said compositions to modulate the cellular interferon immune response. In particular, the present invention relates to pharmaceutical compositions comprising one or more viral interferon antagonists and methods of utilizing said compositions to prevent, treat or ameliorate an immune disorder characterized by aberrant interferon expression and/or activity. The invention also relates to methods of treating, preventing or ameliorating the symptoms of an inflammatory disorder comprising administering to a subject in need thereof one or more viral interferon antagonist. The present invention also relates to compositions comprising fusion proteins comprising one or more viral interferon antagonists and a heterologous polypeptide, and methods of using said compositions to modulate the cellular interferon immune response. The present invention further relates to articles of manufacture comprising one or more viral interferon antagonists or fusion proteins.
摘要翻译：本发明涉及包含一种或多种病毒干扰素拮抗剂的组合物和利用所述组合物调节细胞干扰素免疫应答的方法。特别地，本发明涉及包含一种或多种病毒干扰素拮抗剂的药物组合物和利用所述组合物预防，治疗或改善以异常干扰素表达和/或活性为特征的免疫病症的方法。本发明还涉及治疗，预防或改善炎性病症症状的方法，其包括向有需要的受试者施用一种或多种病毒干扰素拮抗剂。本发明还涉及包含一种或多种病毒干扰素拮抗剂和异源多肽的融合蛋白的组合物，以及使用所述组合物调节细胞干扰素免疫应答的方法。本发明还涉及包含一种或多种病毒干扰素拮抗剂或融合蛋白的制品。

3. 发明申请

US20170247418A1 EBOLAVIRUS PRE-HAIRPIN INTERMEDIATE MIMICS AND METHODS OF USE 审中-公开
公开(公告)号：US20170247418A1
公开(公告)日：2017-08-31
申请号：US15513959
申请日：2015-09-24
申请人： Tracy R. CLINTON , UNIVERSITY OF UTAH RESEARCH FOUNDATION
发明人： Tracy R. CLINTON , Michael Thomas JACOBSEN , Matthew T. WEINSTOCK , Brett D. WELCH , Debra Muir ECKERT , Michael S. KAY
IPC分类号： C07K14/005 , G01N33/68
CPC分类号： C07K14/005 , A61K38/00 , C07K14/08 , C12N2760/14122 , C12N2760/14133 , G01N33/6845 , G01N2333/08 , G01N2500/04
摘要： Ebolavirus is a highly lethal filovirus that causes hemorrhagic fever in humans and non-human primates. With no approved treatments or preventatives, the development of an anti-ebolavirus therapy to protect against natural infections and potential weaponization is an urgent unmet global health need. The design, biophysical characterization, and validation of peptide mimics of the ebolavirus N-trimer (“N-trimer mimics”) are described herein.

4. 发明公开

US20240301006A1 SELF-AMPLIFYING MESSENGER RNA 审中-公开
公开(公告)号：US20240301006A1
公开(公告)日：2024-09-12
申请号：US18269120
申请日：2021-12-21
申请人： GLAXOSMITHKLINE BIOLOGICALS SA
发明人： Giulietta MARUGGI , Jason William WESTERBECK , Dong YU
IPC分类号： C07K14/005 , A61K9/127 , A61K39/00 , C12N15/86
CPC分类号： C07K14/005 , A61K9/127 , C12N15/86 , A61K39/00 , A61K2039/55555 , A61K2039/572 , A61K2039/575 , C12N2710/24122 , C12N2710/24133 , C12N2760/14122 , C12N2760/14133 , C12N2760/16122 , C12N2760/16133 , C12N2770/36143
摘要： Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes an interferon effector.

5. 发明公开

US20240002450A1 ANTIVIRAL STRUCTURALLY-STABILIZED EBOLAVIRUS PEPTIDES AND USES THEREOF 审中-公开
公开(公告)号：US20240002450A1
公开(公告)日：2024-01-04
申请号：US18035427
申请日：2021-11-04
申请人： Dana-Farber Cancer Institute, Inc. , The United States of America, as represented by The Secretary, Department of Health and Human Servi
发明人： Federico Bernal , Amanda L. Whiting , Loren D. Walensky , Gregory H. Bird
IPC分类号： C07K14/08 , A61P31/14 , C12N7/00
CPC分类号： C07K14/08 , A61P31/14 , C12N7/00 , C12N2760/14122 , C12N2760/14133 , A61K38/00
摘要： This disclosure features structurally-stabilized Ebola virus antiviral peptides. Also disclosed are methods of using such structurally-stabilized peptides in the treatment or prevention of an Ebola virus infection or Ebola virus disease.

6. 发明申请

US20070185025A1 Filoviral immunosuppressive peptides and uses thereof 审中-公开
标题翻译：病毒免疫抑制肽及其用途
公开(公告)号：US20070185025A1
公开(公告)日：2007-08-09
申请号：US11518641
申请日：2006-09-11
申请人： Gustavo Palacios , Kavitha Yaddanapudi , W. Lipkin
发明人： Gustavo Palacios , Kavitha Yaddanapudi , W. Lipkin
IPC分类号： A61K38/17 , A61K38/10 , G01N33/574 , C07K14/82 , C07K7/08
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N7/00 , C12N2760/14122 , C12N2760/14133 , C12N2760/14222 , C12N2760/14233 , G01N33/5047 , G01N33/564 , G01N2333/08 , G01N2500/10
摘要： The invention provides a region of strong secondary structure conservation between the C-terminus domain of the envelope glycoprotein of filoviruses and an immunosuppressive domain found in retroviral envelope glycoproteins. The invention provides filoviral peptides and modified derivatives thereof with strong immunosuppressive bioactivity. The invention further provides methods for treatment of autoimmune disorders by administering the immunosuppressive peptide. The invention also provides methods for the identification of therapeutic agents that modulate the immunosuppressive activity of the peptides. Antibodies against the inventive peptides and the modified derivatives thereof are also provided. Furthermore, the invention provides methods for treatment of filoviral infection by administering compositions comprising the antibodies and/or the therapeutic agents that modulate the immunosuppressive activity of the inventive peptides.
摘要翻译：本发明提供了在病毒包膜糖蛋白的包膜糖蛋白的C末端结构域与在逆转录病毒包膜糖蛋白中发现的免疫抑制结构域之间具有强二级结构保守性的区域。本发明提供具有强免疫抑制生物活性的氟病毒肽及其修饰的衍生物。本发明还提供了通过施用免疫抑制肽来治疗自身免疫疾病的方法。本发明还提供了用于鉴定调节肽的免疫抑制活性的治疗剂的方法。还提供了抗本发明肽及其修饰衍生物的抗体。此外，本发明提供了通过施用包含调节本发明肽的免疫抑制活性的抗体和/或治疗剂的组合物来治疗火山病毒感染的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式