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1. 发明授权

US09056070B2 Autologous biological cancer vaccine 有权
标题翻译：自体生物癌疫苗
公开(公告)号：US09056070B2
公开(公告)日：2015-06-16
申请号：US13695062
申请日：2010-04-27
申请人： Hugo Ramiro Segura Puello
发明人： Hugo Ramiro Segura Puello
IPC分类号： A61K39/00 , A61K39/23
CPC分类号： A61K39/0011 , A61K39/23 , A61K39/39 , A61K2039/5254 , A61K2039/55511 , A61K2039/55588 , C12N2750/14332 , C12N2750/14361
摘要： The present disclosure relates to an autologous biological cancer vaccine and to a method for preparing the same. The vaccine of the present application is a biological vaccine obtained from overexpressed proteins in the serum of cancer patients, proteins to which have been added immunological adjuvants such as an attenuated virus DNA and amino acids in order to cause an immune response, blocking tumor cells. The preparation method includes obtaining the antigen associated with the tumor as well as the vaccine preparation with attenuated virus DNA, combining the components under conditions that have been determined by experimentation, filtration and refrigeration.
摘要翻译：本公开涉及自体生物癌症疫苗及其制备方法。本申请的疫苗是从癌症患者的血清中的过表达蛋白获得的生物疫苗，已经加入免疫佐剂如减毒病毒DNA和氨基酸的蛋白质，以引起免疫应答，阻断肿瘤细胞。制备方法包括获得与肿瘤相关的抗原以及具有减毒病毒DNA的疫苗制剂，在通过实验，过滤和制冷测定的条件下将组分组合。

2. 发明申请

US20150335731A1 Coating Method and Materials 审中-公开
标题翻译：涂层方法和材料
公开(公告)号：US20150335731A1
公开(公告)日：2015-11-26
申请号：US14720783
申请日：2015-05-23
申请人： Gregory Cauchon
发明人： Gregory Cauchon
IPC分类号： A61K39/23 , A61K9/48 , A61K36/87 , A01N65/16 , A61K39/21 , C12N7/00 , A61K39/145 , A01N65/08 , A61K31/352 , A61K36/45
CPC分类号： A61L27/28 , A01N65/08 , A01N65/16 , A61K9/4808 , A61K31/352 , A61K36/45 , A61K36/87 , A61K39/145 , A61K39/21 , A61K39/23 , A61K2039/5254 , A61K2039/552 , A61L27/20 , A61L27/34 , A61L27/54 , A61L2300/216 , A61L2420/02 , C12N7/00 , C12N2740/16034 , C12N2740/16061 , C12N2750/14334 , C12N2750/14361 , C12N2760/16134 , C12N2760/16161
摘要： A system consisting of a component coating a particulate scaffold is able to transfer the coating to an exposed surface in order to yield beneficial effects. The system is useful for many applications, including the treatment of individuals suffering from a disease, cancer, an ailment, an infection, a toxin, or other syndrome, as well as for numerous non-treatment purposes requiring the coating of exposed surfaces.
摘要翻译：由涂覆颗粒支架的组分组成的系统能够将涂层转移到暴露的表面，以产生有益的效果。该系统对许多应用是有用的，包括治疗患有疾病，癌症，疾病，感染，毒素或其他综合征的个体，以及需要涂覆暴露表面的许多非处理目的。

3. 发明授权

US09186398B2 Live attenuated parvovirus 有权
标题翻译：活减毒细小病毒
公开(公告)号：US09186398B2
公开(公告)日：2015-11-17
申请号：US13810349
申请日：2011-07-18
申请人： Norman Spibey
发明人： Norman Spibey
IPC分类号： A61K39/23 , C07K14/005 , C12N7/00 , C12N15/86 , A61K39/12 , A61K39/00
CPC分类号： A61K39/23 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2750/14322 , C12N2750/14334 , C12N2750/14343 , C12N2750/14361
摘要： The invention relates to live attenuated parvoviruses, their uses, vaccines comprising such live attenuated parvoviruses, as well as methods for their production.
摘要翻译：本发明涉及活减毒细小病毒，其用途，包含这种活的减毒细小病毒的疫苗，以及它们的生产方法。

4. 发明申请

US20160339146A1 Coating Method and Materials 审中-公开
公开(公告)号：US20160339146A1
公开(公告)日：2016-11-24
申请号：US14995778
申请日：2016-01-14
申请人： Gregory Cauchon
发明人： Gregory Cauchon
IPC分类号： A61L27/28 , A61L27/20
CPC分类号： A61L27/28 , A01N65/08 , A01N65/16 , A61K9/4808 , A61K31/352 , A61K36/45 , A61K36/87 , A61K39/145 , A61K39/21 , A61K39/23 , A61K2039/5254 , A61K2039/552 , A61L27/20 , A61L27/34 , A61L27/54 , A61L2300/216 , A61L2420/02 , C12N7/00 , C12N2740/16034 , C12N2740/16061 , C12N2750/14334 , C12N2750/14361 , C12N2760/16134 , C12N2760/16161
摘要： A system consisting of a component coating a particulate scaffold is able to transfer the coating to an exposed surface in order to yield beneficial effects. The system is useful for many applications, including the treatment of individuals suffering from a disease, cancer, an ailment, an infection, a toxin, or other syndrome, as well as for numerous non-treatment purposes requiring the coating of exposed surfaces.

5. 发明申请

US20130045235A1 AUTOLOGOUS BIOLOGICAL CANCER VACCINE 有权
公开(公告)号：US20130045235A1
公开(公告)日：2013-02-21
申请号：US13695062
申请日：2010-04-27
申请人： Hugo Ramiro Segura Puello
发明人： Hugo Ramiro Segura Puello
IPC分类号： A61K39/00 , A61P35/00 , A61P37/04
CPC分类号： A61K39/0011 , A61K39/23 , A61K39/39 , A61K2039/5254 , A61K2039/55511 , A61K2039/55588 , C12N2750/14332 , C12N2750/14361
摘要： The present disclosure relates to an autologous biological cancer vaccine and to a method for preparing the same. The vaccine of the present application is a biological vaccine obtained from overexpressed proteins in the serum of cancer patients, proteins to which have been added immunological adjuvants such as an attenuated virus DNA and amino acids in order to cause an immune response, blocking tumor cells. The preparation method includes obtaining the antigen associated with the tumor as well as the vaccine preparation with attenuated virus DNA, combining the components under conditions that have been determined by experimentation, filtration and refrigeration.

6. 发明申请

US20160053233A1 METHOD FOR TERMINAL INACTIVATION OF PATHOGENIC MICROORGANISMS 审中-公开
标题翻译：致病微生物终止灭活的方法
公开(公告)号：US20160053233A1
公开(公告)日：2016-02-25
申请号：US14580200
申请日：2014-12-22
申请人： SICHUAN YUANDASHUYANG PHAMACEUTICAL CO. LTD
发明人： Shuguang Ran , Qiang Wang , Dexi Jiang
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61L2/0023 , C12N2750/14361
摘要： The present invention discloses a method for terminal inactivation of pathogenic microorganisms, comprising the following steps of: a. vacuum freeze-drying a bio-product packaged in a container, feeding in a gas and sealing to obtain the end product and, b. performing inactivation by dry-heating. The method provided by the present invention can effectively inactivate non-lipid enveloped viruses, with excellent inactivation effects and short inactivation time particularly to parvoviruses, and thus overcome the deficiencies of the conventional terminal dry-heating inactivation methods.
摘要翻译：本发明公开了一种终末灭活病原微生物的方法，包括以下步骤：a。真空冷冻干燥包装在容器中的生物产品，送入气体并密封以获得最终产品，和b。通过干热进行灭活。本发明提供的方法可以有效地灭活非脂质包膜病毒，具有优异的灭活效果和短的灭活时间，特别是细小病毒，从而克服了常规末端干热灭活方法的缺点。

7. 发明申请

US20130195913A1 LIVE ATTENUATED PARVOVIRUS 有权
标题翻译：活着的PARVOVIRUS
公开(公告)号：US20130195913A1
公开(公告)日：2013-08-01
申请号：US13810349
申请日：2011-07-18
申请人： Norman Spibey
发明人： Norman Spibey
IPC分类号： A61K39/23
CPC分类号： A61K39/23 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2750/14322 , C12N2750/14334 , C12N2750/14343 , C12N2750/14361
摘要： The invention relates to live attenuated parvoviruses, their uses, vaccines comprising such live attenuated parvoviruses, as well as methods for their production.
摘要翻译：本发明涉及活减毒细小病毒，其用途，包含这种活的减毒细小病毒的疫苗，以及它们的生产方法。

8. 发明申请

US20180187166A1 METHOD FOR LARGE SCALE PRODUCTION AND PURIFICATION OF PARVOVIRUS 审中-公开
公开(公告)号：US20180187166A1
公开(公告)日：2018-07-05
申请号：US15739684
申请日：2016-06-22
申请人： Deutsches Krebsforschungszentrum
发明人： Barbara Leuchs , Mandy Roscher , Marcus Müller , Jean Rommelaere
IPC分类号： C12N7/02 , G01N33/569
CPC分类号： C12N7/02 , C07K16/081 , C12N7/00 , C12N2750/14323 , C12N2750/14351 , C12N2750/14361 , G01N33/56983
摘要： Described is a reproducible, effective and scalable process for parvovirus production including characterization strategies, preferably production of H-1PV.

9. 发明申请

US20160339147A1 Coating Method and Materials 审中-公开
公开(公告)号：US20160339147A1
公开(公告)日：2016-11-24
申请号：US14995800
申请日：2016-01-14
申请人： Gregory Cauchon
发明人： Gregory Cauchon
IPC分类号： A61L27/28 , A61L27/20
CPC分类号： A61L27/28 , A01N65/08 , A01N65/16 , A61K9/4808 , A61K31/352 , A61K36/45 , A61K36/87 , A61K39/145 , A61K39/21 , A61K39/23 , A61K2039/5254 , A61K2039/552 , A61L27/20 , A61L27/34 , A61L27/54 , A61L2300/216 , A61L2420/02 , C12N7/00 , C12N2740/16034 , C12N2740/16061 , C12N2750/14334 , C12N2750/14361 , C12N2760/16134 , C12N2760/16161
摘要： A system consisting of a component coating a particulate scaffold is able to transfer the coating to an exposed surface in order to yield beneficial effects. The system is useful for many applications, including the treatment of individuals suffering from a disease, cancer, an ailment, an infection, a toxin, or other syndrome, as well as for numerous non-treatment purposes requiring the coating of exposed surfaces.

10. 发明申请

US20040258700A1 Vaccine formulation with a preservative 审中-公开
标题翻译：用防腐剂配制疫苗
公开(公告)号：US20040258700A1
公开(公告)日：2004-12-23
申请号：US10601719
申请日：2003-06-23
发明人： Tine Holland Frimann
IPC分类号： A61K039/12 , A61K047/00 , A61K045/00 , A61K039/38 , A61K039/00
CPC分类号： A61K47/46 , A61K9/0019 , A61K39/12 , A61K39/23 , A61K47/10 , A61K2039/5252 , A61K2039/552 , A61K2039/55505 , A61K2039/55577 , C12N2750/14334 , C12N2750/14361
摘要： There is a safety concern about a number of vaccine preservatives in use today, such as formaldehyde, phenol, organic mercury (thiomersal) or betapropiolactone for safety reasons. In a few vaccines, 2-phenoxyethanol has been used as a vaccine perservative, but has not gained widespread use, because the preservative effect is inferior to e.g. thiomersal. Applicant has found that the preservative effect of a mixture of 2-phenoxyethanol and para hydroxybenzoates, (e.g. methyl-, ethyl-, propyl- or butyl-, p-hydroxybenzoate) is more effective than 2-phenoxyethanol alone and that this mixture, called TF-1, exerts a preservative effect which is comparable to that of thiomersal or chloroform in vaccines. Although the preservative effect of TF-1 is satisfactory for securing the microbial stability of the vaccine, none of the constituents in TF-1 are considered as critical in terms of toxicity for the vaccinated animals or humans as chloroform or organic mercury compounds, traditionally used for the same purpose.
摘要翻译：出于安全考虑，今天使用的许多疫苗防腐剂如甲醛，苯酚，有机汞（硫柳汞）或β-丙内酯存在安全问题。在几种疫苗中，2-苯氧基乙醇已经被用作疫苗保乳剂，但是由于防腐剂效果不如例如，所以没有得到广泛的应用。硫柳汞申请人已经发现2-苯氧基乙醇和对羟基苯甲酸酯（例如甲基 - ，乙基 - ，丙基 - 或丁基 - 对羟基苯甲酸酯）的混合物的防腐效果比单独的2-苯氧基乙醇更有效，称为 TF-1具有与疫苗中硫柳汞或氯仿相当的防腐效果。虽然TF-1的防腐效果对于确保疫苗的微生物稳定性而言是令人满意的，但TF-1中的任何成分在接种动物或人类的毒性方面被认为是氯仿或有机汞化合物的传统使用为了相同的目的

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