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1. 发明授权

US5676952A Herpesviruses transformed to express GD in vitro 失效
标题翻译：疱疹病毒转化体外表达GD
公开(公告)号：US5676952A
公开(公告)日：1997-10-14
申请号：US426020
申请日：1995-04-19
申请人： Jean-Christophe Francis Audonnet , Raphael Jean Darteil , Michel Albert Emile Riviere , Vladimir Zelnik , Louis Joseph Norman Ross
发明人： Jean-Christophe Francis Audonnet , Raphael Jean Darteil , Michel Albert Emile Riviere , Vladimir Zelnik , Louis Joseph Norman Ross
IPC分类号： C12N15/09 , A61K39/00 , A61K39/255 , A61P31/22 , C07K14/055 , C12N7/00 , C12N7/01 , C12N7/02 , C12N7/04 , C12N15/86
CPC分类号： C07K14/005 , C12N15/86 , C12N7/00 , A61K39/00 , C12N2710/16322 , C12N2710/16351 , C12N2710/16361 , C12N2710/16722 , Y10S424/816
摘要： Herpesviruses naturally deficient in gD, that is to say not expressing their gD gene in vitro or not possessing this gene, are transformed to express gD in vitro. This transformation by genetic recombination can consist in replacement of the natural promoter by another one or insertion of an expression cassette containing gD and a promoter. The invention also relates to these viruses incorporating a gene coding for an antigen of interest, to the vaccines obtained and to the methods of culture thus improved. The invention relates in particular to avian herpesviruses, especially MDV, and the VZV virus.
摘要翻译：天然缺乏gD的疱疹病毒，也就是说在体外不表达其gD基因或不具有该基因，被转化以在体外表达gD。通过基因重组的这种转化可以由另一个替换天然启动子或插入含有gD和启动子的表达盒。本发明还涉及包含编码感兴趣的抗原的基因的这些病毒，所获得的疫苗和由此改进的培养方法。本发明特别涉及禽疱疹病毒，特别是MDV和VZV病毒。

2. 发明申请

US20150376569A1 PRODUCTION OF AVIAN EMBRYO CELLS 审中-公开
标题翻译： AVIAN EMBRYO细胞的生产
公开(公告)号：US20150376569A1
公开(公告)日：2015-12-31
申请号：US14845992
申请日：2015-09-04
申请人： BIOMUNE COMPANY
发明人： SHARAD DEVIDASRAO SAWARKAR , CHRISTOPHER PATRICK GULLY
IPC分类号： C12N5/073 , A61K39/255 , C12N7/00
CPC分类号： C12N5/0604 , A61K39/255 , C12N7/00 , C12N2511/00 , C12N2710/16334 , C12N2710/16352 , C12N2710/16361 , C12N2720/12052
摘要： The present invention relates to compositions and methods for preparing cells from avian embryos. The invention also relates to cultures of such cells and the uses thereof, particularly for producing viruses such as MDV. The invention also relates to methods for the preparation of vaccines using such cells or viruses.
摘要翻译：本发明涉及从禽类胚胎制备细胞的组合物和方法。本发明还涉及这种细胞的培养物及其用途，特别是用于产生病毒如MDV。本发明还涉及使用这种细胞或病毒制备疫苗的方法。

3. 发明授权

US06913751B2 Recombinant avian herpesvirus useful in vaccine production 失效
标题翻译：用于疫苗生产的重组禽疱疹病毒
公开(公告)号：US06913751B2
公开(公告)日：2005-07-05
申请号：US09881457
申请日：2001-06-14
申请人： Mark D. Cochran , Stephanie M. Cook , Martha A. Wild
发明人： Mark D. Cochran , Stephanie M. Cook , Martha A. Wild
IPC分类号： A61K39/00 , C07K14/03 , C07K14/055 , C07K14/08 , C07K14/125 , C07K14/165 , C12N7/04 , C12N15/869 , A61K39/12
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C12N15/86 , C12N2710/16322 , C12N2710/16343 , C12N2710/16361 , C12N2710/16422 , C12N2760/18122 , C12N2770/20022
摘要： The present invention provides a novel avian herpesvirus (NAHV) vector and recombinant vaccines made therefrom that are useful to immunize avian species against Marek's disease, infectious laryngotracheitis and Newcastle disease. Methods of immunizing an avian species against Marek's disease, infectious laryngotracheitis and Newcastle disease are also provided.
摘要翻译：本发明提供了一种新型鸟类疱疹病毒（NAHV）载体和由其制备的重组疫苗，其可用于免疫禽类针对马立克氏病，感染性喉气管炎和新城疫病。还提供了免疫禽类针对马立克氏病，感染性喉气管炎和新城疫的方法。

4. 发明授权

US07214524B1 Marek's disease virus vaccine 失效
标题翻译：马立克氏病病毒疫苗
公开(公告)号：US07214524B1
公开(公告)日：2007-05-08
申请号：US10430773
申请日：2003-05-06
申请人： Sanjay M. Reddy , Blanca M. Lupiani
发明人： Sanjay M. Reddy , Blanca M. Lupiani
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K39/12 , A61K39/255 , A61K2039/5254 , A61K2039/552 , C12N2710/16334 , C12N2710/16361
摘要： An effective vaccine for Marek's disease may be prepared using a viral agent which is a Marek's disease virus unable to express a functional meq protein. This viral agent is effective to elicit an immune response in a chicken to very virulent strains of Marek's disease virus without causing a significant degree of pathogenicity in the inoculated bird. Suitable formulations of the vaccine for use in chickens include an effective immunization dosage of this novel viral agent with a pharmaceutically acceptable carrier or diluent.
摘要翻译：马立克氏病的有效疫苗可以使用不能表达功能性meq蛋白的马立克氏病病毒的病毒剂来制备。这种病毒剂有效地引起鸡中非常毒性的马立克氏病病毒株的免疫应答，而不会在接种的鸟中引起显着程度的致病性。用于鸡的合适的疫苗制剂包括具有药学上可接受的载体或稀释剂的该新型病毒剂的有效免疫剂量。

5. 发明申请

US20020132337A1 Processes for preparation of marek's disease virus using continuous avian cell lines 审中-公开
标题翻译：使用连续禽类细胞系制备马立克氏病病毒的方法
公开(公告)号：US20020132337A1
公开(公告)日：2002-09-19
申请号：US10134241
申请日：2002-04-29
发明人： Sing Rong , Michael G. Sheppard
IPC分类号： A61K039/12 , C12N007/00 , C12N005/06
CPC分类号： C12N7/00 , A61K39/12 , A61K39/255 , A61K2039/525 , C12N15/86 , C12N2710/16334 , C12N2710/16343 , C12N2710/16351 , C12N2710/16361
摘要： An amplifier distortion reduction system obtains a distortion signal from the amplifier output and feeds the distortion signal back to the input side of the amplifier to cancel with the distortion produced at the amplifier output. For example, a signal to be amplified by an amplifier is received on a main signal path. The amplifier produces an amplified output with a non-distortion spectrum and a distortion spectrum. A sample of the amplified output is produced from the main signal path and placed on a feedback path. On the feedback path, the distortion spectrum is obtained from the sample amplified output. The distortion spectrum is phase and/or amplitude adjusted to produce the distortion signal. The distortion signal is placed onto the main signal path at the input side of the amplifier with the signal to be amplified to destructively combine with the distortion produced from the amplifier in amplifying the signal to be amplified.
摘要翻译：放大器失真减小系统从放大器输出端获得失真信号，并将失真信号反馈到放大器的输入侧，以消除放大器输出端产生的失真。例如，在主信号路径上接收由放大器放大的信号。放大器产生具有非失真频谱和失真频谱的放大输出。放大输出的样本从主信号路径产生并放置在反馈路径上。在反馈路径上，从样本放大输出获得失真谱。失真频谱是相位和/或幅度调整以产生失真信号。失真信号被放置在放大器的输入侧的主信号路径上，其中要放大的信号与在放大信号放大时产生的失真相结合。

6. 发明授权

US07824690B1 Marek's disease virus vaccine 失效
标题翻译：马立克氏病病毒疫苗
公开(公告)号：US07824690B1
公开(公告)日：2010-11-02
申请号：US11800475
申请日：2007-05-04
申请人： Sanjay M. Reddy , Blanca M. Lupiani
发明人： Sanjay M. Reddy , Blanca M. Lupiani
IPC分类号： A61K39/255 , C12N7/00
CPC分类号： C12N7/00 , A61K39/12 , A61K39/255 , A61K2039/5254 , A61K2039/552 , C12N2710/16334 , C12N2710/16361
摘要： An effective vaccine for Marek's disease may be prepared using a viral agent which is a Marek's disease virus unable to express a functional meq protein. This viral agent is effective to elicit an immune response in a chicken to very virulent strains of Marek's disease virus without causing a significant degree of pathogenicity in the inoculated bird. Suitable formulations of the vaccine for use in chickens include an effective immunization dosage of this novel viral agent with a pharmaceutically acceptable carrier or diluent.
摘要翻译：马立克氏病的有效疫苗可以使用不能表达功能性meq蛋白的马立克氏病病毒的病毒剂来制备。这种病毒剂有效地引起鸡中非常毒性的马立克氏病病毒株的免疫应答，而不会在接种的鸟中引起显着程度的致病性。用于鸡的合适的疫苗制剂包括具有药学上可接受的载体或稀释剂的该新型病毒剂的有效免疫剂量。

7. 发明授权

US06410297B1 Processes for preparation of Marek's disease virus using continuous avian cell lines 失效
标题翻译：使用连续禽类细胞系制备马立克氏病病毒的方法
公开(公告)号：US06410297B1
公开(公告)日：2002-06-25
申请号：US09443800
申请日：1999-11-19
申请人： Sing Rong , Michael G. Sheppard
发明人： Sing Rong , Michael G. Sheppard
IPC分类号： C12N700
CPC分类号： C12N7/00 , A61K39/12 , A61K39/255 , A61K2039/525 , C12N15/86 , C12N2710/16334 , C12N2710/16343 , C12N2710/16351 , C12N2710/16361
摘要： The present invention relates to avian cell lines which efficiently support the growth and productive infection of Marek's Disease Virus at high titers. The present invention also relates to avian cell lines which have been engineered to support the growth and productive infection of recombinant Marek's Disease Virus at high titers. The present invention relates a process for the preparation of Marek's Disease Virus in quantities suitable for vaccine purposes.
摘要翻译：本发明涉及以高滴度有效地支持马立克氏病病毒的生长和生产性感染的禽细胞系。本发明还涉及已经被设计用于支持高效价重组马立克氏病病毒的生长和生产性感染的禽细胞系。本发明涉及用于制备适合于疫苗用途的量的马立克氏病病毒的方法。

8. 发明授权

US06183753B2 Recombinant chimeric virus and uses thereof 失效
标题翻译：重组嵌合病毒及其用途
公开(公告)号：US06183753B2
公开(公告)日：2001-02-06
申请号：US08804372
申请日：1997-02-21
申请人： Mark D. Cochran , Martha A. Wild , Barbara J. Winslow
发明人： Mark D. Cochran , Martha A. Wild , Barbara J. Winslow
IPC分类号： A61K3912
CPC分类号： C12N7/00 , A61K39/00 , C12N15/86 , C12N2710/16343 , C12N2710/16361 , C12N2710/16362 , C12N2830/00 , C12N2830/60 , C12N2840/203
摘要： This invention provides a recombinant herpesvirus of turkeys-Marek's disease virus chimera comprising a herpesvirus of turkeys unique long viral genome region and a Marek's disease virus unique short viral genome region.
摘要翻译：本发明提供了包含火鸡独特长病毒基因组区域的疱疹病毒和马立克氏病病毒独特的短病毒基因组区域的火鸡 - 马立克氏病病毒嵌合体的重组疱疹病毒。

9. 发明申请

US20180237743A1 PRODUCTION OF AVIAN EMBRYO CELLS 审中-公开
公开(公告)号：US20180237743A1
公开(公告)日：2018-08-23
申请号：US15920490
申请日：2018-03-14
申请人： BIOMUNE COMPANY
发明人： CHRISTOPHER PATRICK GULLY , SHARAD DEVIDASRAO SAWARKAR
IPC分类号： C12N5/073 , C12N7/00 , A61K39/255
CPC分类号： C12N5/0604 , A61K39/255 , C12N7/00 , C12N2511/00 , C12N2710/16334 , C12N2710/16352 , C12N2710/16361 , C12N2720/12052
摘要： The present invention relates to compositions and methods for preparing cells from avian embryos. The invention also relates to cultures of such cells and the uses thereof, particularly for producing viruses such as MDV. The invention also relates to methods for the preparation of vaccines using such cells or viruses.

10. 发明申请

US20180187164A1 DUCK ENTERITIS VIRUS AND THE USES THEREOF 审中-公开
公开(公告)号：US20180187164A1
公开(公告)日：2018-07-05
申请号：US15740824
申请日：2016-06-29
申请人： CEVA SANTE ANIMALE
发明人： SAEKI YUKARI , SHUJI SAITOH
IPC分类号： C12N7/00 , A61K39/245
CPC分类号： C12N7/00 , A61K39/245 , A61K2039/5252 , A61K2039/54 , C12N7/04 , C12N2710/16334 , C12N2710/16343 , C12N2710/16361 , C12N2710/16362
摘要： The present invention relates to DEV and the uses thereof. The invention is particularly suited to vaccinate poultry against avian pathogens.

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