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1. 发明公开

US20240261255A1 COMPOSITION COMPRISING AN ESTER OF ALPHA-TOCOPHEROL FOR REDUCING THE RISK OF PRETERM BIRTH 审中-公开
公开(公告)号：US20240261255A1
公开(公告)日：2024-08-08
申请号：US18562492
申请日：2022-05-16
申请人： HULKA S.R.L.
发明人： Giorgio Panin
IPC分类号： A61K31/355 , A61K9/00 , A61K47/12 , A61K47/44 , A61P15/06
CPC分类号： A61K31/355 , A61K9/006 , A61K47/12 , A61K47/44 , A61P15/06
摘要： A composition for topical application to the oral cavity, for the use in pregnant women to reduce the risk of preterm birth, comprising an ester of vitamin E with a carboxylic acid of formula R—COOH, in which R is an alkyl radical having 1 to 19 carbon atoms, or an alkenyl or alkynyl radical having 2 to 19 carbon atoms, and an oily vehicle; the ester of vitamin E can be selected from vitamin E acetate, n-propionate or linoleate, preferably alpha-tocopheryl acetate.

2. 发明公开

US20230321052A1 ALPHA-AMINO ESTERS OF HYDROXYPROPYLTHIAZOLIDINE CARBOXAMIDE DERIVATIVE AND SALT FORM, CRYSTAL POLYMORPH THEREOF 审中-公开
公开(公告)号：US20230321052A1
公开(公告)日：2023-10-12
申请号：US17984833
申请日：2022-11-10
申请人： ObsEva S.A.
发明人： Patrick Naxos PAGE , Matthias SCHWARZ , Catherine JORAND-LEBRUN , Anna QUATTROPANI , Vincent POMEL , Ernest LOUMAYE , Oliver POHL , Jean-Pierre GOTTELAND
IPC分类号： A61K31/426 , A61K9/00 , A61P15/06 , A61K45/06 , A61K31/40 , A61K31/4422 , A61K38/095
CPC分类号： A61K31/426 , A61K9/0053 , A61P15/06 , A61K45/06 , A61K9/0019 , A61K31/40 , A61K31/4422 , A61K38/095 , A61K9/20
摘要： The invention provides α-amino esters of a hydroxypropylthiazolidine carboxamide derivative, (2S)-3-([1,1′-biphenyl]-4-ylsulfonyl)-N-[(1S)-3-hydroxy-1-phenylpropyl]-1,3-thiazolidine-2-carboxamide, as well as salts and crystal polymorphs thereof, that can be used to inhibit prostaglandin F receptor. The invention further encompasses methods of treating disorders such as preterm labor at the early gestational stage by the administration of these substances to a patient in need of treatment.

3. 发明公开

US20240252513A1 Oral Allopregnanolone Compositions and Methods of Use 审中-公开
公开(公告)号：US20240252513A1
公开(公告)日：2024-08-01
申请号：US18619033
申请日：2024-03-27
申请人： Lipocine Inc.
发明人： Jonathan Ogle , Benjamin J. Bruno , Kongnara Papangkorn , Samuel Akapo , Joel Frank , Nachiappan Chidambaram , Mahesh V. Patel
IPC分类号： A61K31/57 , A61K9/00 , A61K9/14 , A61K31/557 , A61P15/06 , A61P21/00
CPC分类号： A61K31/57 , A61K9/0053 , A61K9/14 , A61K31/557 , A61P15/06 , A61P21/00
摘要： Disclosed is a method and an oral composition for treating CNS disorders. An embodiment of the invention comprises orally administering an allopregnanolone containing composition to a subject having a CNS disorder. Exemplary CNS disorders include sleep disorders, mood disorders, dysthymic disorders, bipolar disorders, anxiety disorders, stress disorders, compulsive disorders, schizophrenia spectrum disorders, convulsive disorders, memory disorders, cognition disorders, movement disorders, personality disorders, autism spectrum disorders, substance abuse disorders, dementia, pain, traumatic brain injury (TBI), vascular disease, withdrawal syndrome, and tinnitus. The composition and methods disclosed herein exhibit effective oral absorption/bioavailability.

4. 发明公开

US20240024294A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OR PREVENTION OF PRETERM LABOR 审中-公开
公开(公告)号：US20240024294A1
公开(公告)日：2024-01-25
申请号：US18037007
申请日：2021-11-16
申请人： XOMA (US) LLC
发明人： Jean-Pierre GOTTELAND
IPC分类号： A61K31/426 , A61K38/095 , A61P15/06
CPC分类号： A61K31/426 , A61K38/095 , A61P15/06
摘要： The disclosure provides compositions and methods for delaying the onset of delivery in a pregnant subject, such as a pregnant human subject, that is undergoing or at risk of undergoing preterm labor at a gestational age of from about 24 weeks to about 34 weeks. Using the compositions and methods described herein, such subjects may be administered atosiban in combination with a prostaglandin F2α (PGF2α) antagonist. Exemplary PGF2α receptor antagonists that may be used for the treatment or prevention of preterm labor as described herein include 1,3-thiazolidine-2-carboxamide compounds, such as (3S)-3-({[(2S)-3-(biphenyl-4-ylsulfonyl)-1,3-thiazolidin-2-yl]carbonyl}-amino)-3-(4-fluorophenyl)propyl L-valinate or a pharmaceutically acceptable salt thereof (e.g., (3S)-3-({[(2S)-3-(biphenyl-4-ylsulfonyl)-1,3-thiazolidin-2-yl]carbonyl}-amino)-3-(4-fluorophenyl)propyl L-valinate hydrochloride). The compositions and methods described herein provide various clinical benefits. Delivery at an early gestational age is a leading cause of perinatal mortality. By delaying labor in pregnant human patients at an early gestational age, the compositions and methods of the disclosure provide unborn infants with additional time to develop vital organs and tissue systems, thereby significantly improving the likelihood of survival following delivery. The compositions and methods described herein may be used to delay the onset of delivery by one or more hours, days, or weeks, for example, so as to enable pregnant subjects to reach a gestational age at which parturition is substantially safer.

5. 发明公开

US20230167410A1 PREVENTION OF RECURRENT MISCARRIAGES THROUGH ADMINISTRATION OF FIBROBLASTS AND FIBROBLAST-EDUCATED PATERNAL CELLS 审中-公开
公开(公告)号：US20230167410A1
公开(公告)日：2023-06-01
申请号：US17754812
申请日：2020-10-14
申请人： FIGENE, LLC
发明人： Pete O'HEERON , Thomas ICHIM
IPC分类号： C12N5/077 , A61P15/06 , C12N5/0783
CPC分类号： C12N5/0656 , A61P15/06 , C12N5/0636 , C12N2501/40 , C12N2501/22 , C12N2501/10 , C12N2501/20
摘要： Embodiments of the disclosure include methods and compositions related to prevention of spontaneous miscarriage in an individual. In certain cases, fibroblasts are provided in an effective amount to an individual in need thereof. Alternatively or in addition, lymphocytes are obtained, cultured with fibroblasts, and provided to an individual. Fibroblasts may modulate an immune response in an individual, thereby reducing the risk of spontaneous miscarriage.

6. 发明公开

US20240358719A1 Formulations for Prolonging Gestation and for Complications of Menstruation or Gestation 审中-公开
公开(公告)号：US20240358719A1
公开(公告)日：2024-10-31
申请号：US18553474
申请日：2021-03-31
申请人： The Board of Trustees of the Leland Stanford Junior University , Trustees of Boston University
发明人： Liang Liang , Michael P. Snyder , Cristina M. Alvira , David N. Cornfield , Lihua Ying , John K. Snyder
IPC分类号： A61K31/58 , A61K31/522 , A61K31/573 , A61K31/704 , A61K45/06 , A61P15/06
CPC分类号： A61K31/58 , A61K31/522 , A61K31/573 , A61K31/704 , A61K45/06 , A61P15/06
摘要： Methods and formulations of treatment for menstrual complications, gestational complications, and to prolong gestation are described. Treatments include administration of a compound related to regulation of gestational progress or uterine contractions.

7. 发明授权

US12016905B2 Pharmaceutical composition for prevention or treatment of preterm birth 有权
公开(公告)号：US12016905B2
公开(公告)日：2024-06-25
申请号：US17108485
申请日：2020-12-01
申请人： KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
发明人： Ki Hoon Ahn , Eun Jin Wang
IPC分类号： A61K38/39 , A61K31/4439 , A61P15/06 , C12Q1/6881 , G01N33/50 , G01N33/68
CPC分类号： A61K38/39 , A61K31/4439 , A61P15/06 , C12Q1/6881 , G01N33/5023 , G01N33/5044 , G01N33/6887 , C12Q2600/106
摘要： Disclosed is a pharmaceutical composition for the prevention or treatment of preterm birth, comprising, as an active ingredient, an agent that inhibits the differentiation of fibroblasts into myofibroblasts in cervix.

8. 发明授权

US11969434B1 Oral allopregnanolone compositions and methods of use 有权
公开(公告)号：US11969434B1
公开(公告)日：2024-04-30
申请号：US17823080
申请日：2022-08-29
申请人： Lipocine Inc.
发明人： Jonathan Ogle , Benjamin J. Bruno , Kongnara Papangkorn , Samuel Akapo , Joel Frank , Nachiappan Chidambaram , Mahesh V. Patel
IPC分类号： A61K31/57 , A61K9/00 , A61K9/14 , A61K31/557 , A61P15/06 , A61P21/00
CPC分类号： A61K31/57 , A61K9/0053 , A61K9/14 , A61K31/557 , A61P15/06 , A61P21/00
摘要： Disclosed is a method and an oral composition for treating CNS disorders. An embodiment of the invention comprises orally administering an allopregnanolone containing composition to a subject having a CNS disorder. Exemplary CNS disorders include sleep disorders, mood disorders, dysthymic disorders, bipolar disorders, anxiety disorders, stress disorders, compulsive disorders, schizophrenia spectrum disorders, convulsive disorders, memory disorders, cognition disorders, movement disorders, personality disorders, autism spectrum disorders, substance abuse disorders, dementia, pain, traumatic brain injury (TBI), vascular disease, withdrawal syndrome, and tinnitus. The composition and methods disclosed herein exhibit effective oral absorption/bioavailability.

9. 发明公开

US20240082261A1 COMPOSITIONS AND USES THEREOF FOR TREATMENT OF IDIOPATHIC PRETERM BIRTH 审中-公开
公开(公告)号：US20240082261A1
公开(公告)日：2024-03-14
申请号：US18502589
申请日：2023-11-06
申请人： UNIVERSITY OF SOUTH FLORIDA
发明人： Charles Lockwood , Ozlem Guzeloglu-Kayisli , Umit Ali Kayisli , Frederick Schatz
IPC分类号： A61K31/557 , A61K31/201 , A61P15/06
CPC分类号： A61K31/557 , A61K31/201 , A61P15/06
摘要： Disclosed are compositions and methods for delaying or preventing idiopathic preterm

10. 发明授权

US11696939B2 Compositions containing exosome carrying NF-κB inhibitors and methods of using thereof 有权
公开(公告)号：US11696939B2
公开(公告)日：2023-07-11
申请号：US17138864
申请日：2020-12-30
申请人： ILIAS Biologics Inc , ILIAS Therapeutics, Inc.
发明人： Chulhee Choi , Kyungsun Choi , Ramkumar Menon
IPC分类号： A61K35/12 , A61K38/17 , A61K47/69 , A61P15/06 , A61K38/095 , A61K9/127 , A61K31/137 , A61K31/4025 , A61K31/405 , A61K31/43 , A61K31/4422 , A61K31/545 , A61K31/57 , A61K31/7048 , A61K33/06 , A61K38/16 , A61K38/45 , A61K38/51
CPC分类号： A61K38/1738 , A61K9/127 , A61K31/137 , A61K31/405 , A61K31/4025 , A61K31/43 , A61K31/4422 , A61K31/545 , A61K31/57 , A61K31/7048 , A61K33/06 , A61K38/095 , A61K38/164 , A61K38/168 , A61K38/1709 , A61K38/1774 , A61K38/45 , A61K38/51 , A61K47/6911 , A61P15/06
摘要： The present invention is related to compositions containing extracellular vesicles (exosomes) and methods of using the same for increasing lifespan of fetus, viability of fetus, or viability of newborn, for treating inflammation in uterus and/or fetus, for delaying preterm birth, or for treating a condition related to inflammation in uterus and/or fetus, wherein the extracellular vesicles comprising a nuclear factor kappa beta (NF-κB) inhibitor and a photo-specific binding protein.

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