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1. 发明授权

US09265858B2 Dry haemostatic composition 有权
标题翻译：干性止血组合物
公开(公告)号：US09265858B2
公开(公告)日：2016-02-23
申请号：US14516728
申请日：2014-10-17
申请人： Ferrosan Medical Devices A/S
发明人： Kristian Larsen
IPC分类号： A61K38/48 , A61L24/10 , A61L24/00 , A61L2/04 , A61L2/08 , A61L2/10 , A61L2/20 , B65B1/04 , A61L2/07
CPC分类号： A61L26/0047 , A61K9/1658 , A61K31/047 , A61K31/70 , A61K38/014 , A61L2/04 , A61L2/07 , A61L2/081 , A61L2/082 , A61L2/087 , A61L2/10 , A61L2/202 , A61L2/204 , A61L2/206 , A61L2/208 , A61L24/0015 , A61L24/0036 , A61L24/104 , A61L26/00 , A61L26/0038 , A61L26/0066 , A61L2300/254 , A61L2300/418 , A61L2300/802 , A61L2400/04 , A61L2400/06 , B65B1/04 , B65D81/32
摘要： Disclosed is a dry composition, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste forms spontaneously upon addition of the liquid, hence no mechanical mixing is required for said paste to form. Further disclosed are methods of preparing said dry composition, a paste made from said dry composition and use of said paste for medical and surgical purposes.
摘要翻译：公开了一种干组合物，其在添加水性介质时形成适用于止血程序的基本均匀的糊剂。糊剂在加入液体后自发形成，因此不需要机械混合来形成所述糊料。进一步公开的是制备所述干组合物的方法，由所述干组合物制成的糊剂和所述糊剂用于医疗和外科用途的方法。

2. 发明申请

US20140056761A1 HIGH EFFICIENCY POLYMERIC STERILANT CONTAINER ASSEMBLY 审中-公开
标题翻译：高效聚合物灭菌容器装配
公开(公告)号：US20140056761A1
公开(公告)日：2014-02-27
申请号：US14074058
申请日：2013-11-07
申请人： BRIGHTON DEVELOPMENT, LLC
发明人： Joel Lawson Williams , Lois A. Jones , Paul M. Vernon, JR.
IPC分类号： A61L2/20 , B65B55/02
CPC分类号： A61L2/204 , A61L2/081 , A61L2202/18 , A61L2202/181 , A61L2202/24 , B65B55/02 , B65D33/2508
摘要： The present invention relates to a method for sterilizing an article inside a sealed container by placing a polyoxymethylene melt formable co-polymer fiber that has been irradiated between about 1 and 200 kGy and then heated at from about 20° C. to about 90° C. for a selected period of time.
摘要翻译：本发明涉及通过将已经照射在约1和200kGy之间的聚甲醛可熔融共聚聚合纤维放置在约20℃至约90℃的范围内来对密封容器内部的制品进行灭菌的方法在一段时间内。

3. 发明申请

US20130158486A1 AMPOULE WITH A SEAL IN TWO COMPRESSION STATES 有权
标题翻译：在两个压缩状态下密封的AMPOULE
公开(公告)号：US20130158486A1
公开(公告)日：2013-06-20
申请号：US13783500
申请日：2013-03-04
申请人： ROCHE DIAGNOSTICS INTERNATIONAL AG
发明人： Ruedi Zihlmann , Ronny-Patric Horisberger , Daniel Fehlmann
IPC分类号： A61M5/315
CPC分类号： A61M5/31501 , A61L2/06 , A61L2/07 , A61L2/08 , A61L2/081 , A61L2/20 , A61L2/204 , A61L2/206 , A61M5/1408 , A61M5/19 , A61M5/3129 , A61M5/315 , A61M2005/3123 , A61M2005/31506 , A61M2005/31508
摘要： Ampoules for dispensing flowable substances and metering systems incorporating the same are described herein. An ampoule for a flowable substance includes an ampoule body comprising an interior space for receiving the flowable substance and an inner circumferential surface having a guide region and a sealing region. A piston may be disposed in the interior space of the ampoule body such that the piston is slidably displaceable along a direction of displacement. The piston includes at least one sealing element for forming a seal with the inner circumferential surface in a contact zone on the outer circumference of the sealing element. The sealing element has a first compression state when the contact zone is in the guide region and a second compression state when the contact zone is in the sealing region. A second blocking device prevents movement of the contact zone from the sealing region to the guide region.
摘要翻译：用于分配可流动物质的安瓿和包含其的计量系统在此描述。用于可流动物质的安瓿包括安瓿本体，其包括用于接收可流动物质的内部空间和具有引导区域和密封区域的内周面。活塞可以设置在安瓿主体的内部空间中，使得活塞沿着位移方向可滑动地移动。活塞包括至少一个密封元件，用于在密封元件的外圆周上的接触区域中与内周表面形成密封。当接触区域处于引导区域时，密封元件具有第一压缩状态，当接触区域处于密封区域时，密封元件具有第二压缩状态。第二阻挡装置防止接触区从密封区域移动到引导区域。

4. 发明申请

US20130086871A1 STERILIZABLE BIOPHARMACEUTICAL PACKAGING 有权
标题翻译：无菌生物包装
公开(公告)号：US20130086871A1
公开(公告)日：2013-04-11
申请号：US13642593
申请日：2011-02-11
申请人： Isabelle Gay , Gaelle Nodin , Nicolas Mendyk , Stephanie Armau
发明人： Isabelle Gay , Gaelle Nodin , Nicolas Mendyk , Stephanie Armau
IPC分类号： B65B17/00
CPC分类号： B65B55/18 , A61L2/0094 , A61L2/20 , A61L2/204 , A61L2/206 , A61L2/208 , A61L2/26 , A61L2202/181 , B65B55/02 , B65D81/245
摘要： A sterilizable biopharmaceutical packaging includes an opening for inserting biopharmaceutical contents to be sterilized, the opening being separate from a sterilization gas conveyance channel so that the opening can be closed independently and before closing the sterilization gas conveyance channel. The opening is directly adjacent to an inner space for receiving the biopharmaceutical contents so that the contents to be sterilized are inserted directly into the inner space from outside the packaging. The elements for controlling the distribution of the sterilization gas open/close the sterilization gas conveyance channel independently of the opening or closing of the insertion opening. After sterilization, the outer wall, the sterilization gas conveyance channel, and the opening/closing element are capable of remaining rigidly connected therebetween so as to form a sterilized biopharmaceutical packaging that contains the sterilized biopharmaceutical contents and can be subjected to one or more integrity tests at any desired time after the sterilization.
摘要翻译：可灭菌的生物药物包装包括用于插入要灭菌的生物制药内容物的开口，所述开口与灭菌气体输送通道分开，使得开口可以独立地关闭并且在关闭灭菌气体输送通道之前。开口直接邻近用于接收生物药物内容物的内部空间，使得待消毒的内容物从包装外部直接插入内部空间。用于控制灭菌气体的分配的元件独立于插入开口的打开或关闭来打开/关闭灭菌气体输送通道。灭菌后，外壁，灭菌气体输送通道和打开/关闭元件能够保持其间的刚性连接，从而形成包含灭菌的生物药物内容物并可进行一次或多次完整性测试的无菌生物药物包装灭菌后任何所需时间。

5. 发明申请

US20100196196A1 METHOD FOR RADIOCHEMICAL STERILIZATION 有权
标题翻译：放射化学灭菌方法
公开(公告)号：US20100196196A1
公开(公告)日：2010-08-05
申请号：US12658956
申请日：2010-02-18
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61L2/20 , A61L2/08 , A61L2/26
CPC分类号： A61L2/204 , A61L2/08 , B65D75/14 , B65D2205/025
摘要： This invention deals with package components for radiochemical sterilization of medical or pharmaceutical products consisting of a hermetically sealed foil pack containing (1) a solid device, as in absorbable sutures and meshes, in a perforated holder or a liquid formulation in a sealed, flexible dispenser, as in absorbable cyanoacrylate-based tissue adhesive; (2) a microparticulate, unstabilized polyformaldehyde as a source of radiolytically generated formaldehyde encased in a sealed pouch comprising a porous, non-woven or woven fabric; and (3) a nitrogenous compound capable of reacting with residual formaldehyde, such as melamine or urea, that is encased in a sealed pouch comprising a porous, non-woven or woven fabric.
摘要翻译：本发明涉及医疗或药物产品的放射化学灭菌的包装组件，其由密封的箔包组成，其包含（1）在可吸收的缝合线和网眼中的固体装置，在穿孔保持器或密封的柔性分配器中的液体制剂中，如可吸收的氰基丙烯酸酯基组织粘合剂; （2）微囊化，未稳定的聚甲醛，作为包含在密封袋中的放射性产生的甲醛的源，其包含多孔，无纺布或机织织物; 和（3）能够与残留的甲醛反应的含氮化合物，例如三聚氰胺或尿素，其被封装在包含多孔，无纺布或机织织物的密封袋中。

6. 发明授权

US07709556B2 Radiation and radiochemically sterilized absorbable devices with dose-controlled functional strength retention 失效
标题翻译：具有剂量控制功能强度保持的辐射和放射化学灭菌吸收性设备
公开(公告)号：US07709556B2
公开(公告)日：2010-05-04
申请号：US10683060
申请日：2003-10-09
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： C08J3/28 , C08F2/48 , C08F2/42 , A61K47/00
CPC分类号： A61L24/0042 , A61L2/08 , A61L2/204 , A61L17/12 , A61L17/14 , A61L24/001
摘要： Absorbable radiation or radiochemically sterilized medical devices, including sutures, whose breaking strength and absorption profile can be modulated by controlling the total dose received during sterilization are disclosed.
摘要翻译：公开了可吸收辐射或放射化学消毒的医疗装置，包括缝合线，其断裂强度和吸收曲线可通过控制灭菌期间接收的总剂量来调节。

7. 发明授权

US07694813B2 Package components for radiochemical sterilization 失效
标题翻译：用于放射化学灭菌的包装组件
公开(公告)号：US07694813B2
公开(公告)日：2010-04-13
申请号：US11228719
申请日：2005-09-16
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61L2/08
CPC分类号： A61L2/204 , A61L2/08 , B65D75/14 , B65D2205/025
摘要： This invention deals with package components for radiochemical sterilization of medical or pharmaceutical products consisting of a hermetically sealed foil pack containing (1) a solid device, as in absorbable sutures and meshes, in a perforated holder or a liquid formulation in a sealed, flexible dispenser, as in absorbable cyanoacrylate-based tissue adhesive; (2) a microparticulate, unstabilized polyformaldehyde as a source of radiolytically generated formaldehyde encased in a sealed pouch comprising a porous, non-woven or woven fabric; and (3) a nitrogenous compound capable of reacting with residual formaldehyde, such as melamine or urea, that is encased in a sealed pouch comprising a porous, non-woven or woven fabric.
摘要翻译：本发明涉及医疗或药物产品的放射化学灭菌的包装组件，其由密封的箔包组成，其包含（1）在可吸收的缝合线和网眼中的固体装置，在穿孔保持器或密封的柔性分配器中的液体制剂中，如可吸收的氰基丙烯酸酯基组织粘合剂; （2）微囊化，未稳定的聚甲醛，作为包含在密封袋中的放射性产生的甲醛的源，其包含多孔，无纺布或机织织物; 和（3）能够与残留的甲醛反应的含氮化合物，例如三聚氰胺或尿素，其被封装在包含多孔，无纺布或机织织物的密封袋中。

8. 发明申请

US20080286144A1 Package components for radiochemical sterilization 失效
标题翻译：用于放射化学灭菌的包装组件
公开(公告)号：US20080286144A1
公开(公告)日：2008-11-20
申请号：US12157516
申请日：2008-06-11
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61L2/00 , B01J19/00
CPC分类号： A61L2/08 , A61L2/204 , B65D81/18
摘要： Package components for the radiochemical sterilization of medical devices contain paraformaldehyde as the precursor of the radiolytically generated, sterilizing dose of formaldehyde, premixed with a particulate solid dispersant of, preferably, polyethylene or silica gel, which facilitates the free passage of the formaldehyde to the package gaseous environment or additionally, absorbs trace amounts of moisture in the package, thus, facilitating the device manufacturing process and increasing shelf-stability.
摘要翻译：用于医疗器械放射化学灭菌的包装组件含有多聚甲醛作为放射学产生的灭菌剂量的甲醛的前体，与优选聚乙烯或硅胶的颗粒固体分散剂预混合，这有助于甲醛自由通过包装气体环境或附加地，吸收包装中的痕量水分，从而便于装置制造过程和增加货架稳定性。

9. 发明授权

US5422068A Radiochemical sterilization 失效
标题翻译：放射化学灭菌
公开(公告)号：US5422068A
公开(公告)日：1995-06-06
申请号：US177872
申请日：1994-01-05
申请人： Shalaby W. Shalaby , Charles L. Linden, Jr.
发明人： Shalaby W. Shalaby , Charles L. Linden, Jr.
IPC分类号： A61L2/20 , A61L2/00 , A61L2/08
CPC分类号： A61L2/204 , A61L2/20
摘要： Radiochemical sterilization is accomplished by exposing a sterilant gas releasing substrate to an effective gas releasing amount of ionizing radiation and contacting an object to be sterilized with the released sterilant gas. Objects to be sterilized may be subjected to a combination of ionizing radiation and gas sterilant which is released by the ionizing radiation.
摘要翻译：通过将灭菌剂气体释放衬底暴露于有效气体释放量的电离辐射并使待消毒物体与释放的灭菌剂气体接触来实现放射化学灭菌。要灭菌的物体可以经受电离辐射和由电离辐射释放的气体灭菌剂的组合。

10. 发明授权

US5252304A Formalin sterilization apparatus 失效
标题翻译：福尔马林灭菌装置
公开(公告)号：US5252304A
公开(公告)日：1993-10-12
申请号：US781382
申请日：1991-10-23
申请人： Tetsuo Miyoshi
发明人： Tetsuo Miyoshi
IPC分类号： A61L2/20
CPC分类号： A61L2/204
摘要： A reaction chamber is disposed between a heating chamber and an outlet line of the heating chamber, and performs a reaction of ammonia gas vaporized in the heating chamber with formaldehyde circulated from a room to be sterilized. A filter is disposed between the reaction chamber and the outlet line.

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