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1. 发明授权

US4336809A Human and animal tissue photoradiation system and method 失效
标题翻译：人和动物组织照射系统和方法
公开(公告)号：US4336809A
公开(公告)日：1982-06-29
申请号：US131022
申请日：1980-03-17
申请人： William G. Clark
发明人： William G. Clark
IPC分类号： A61B5/00 , A61B10/00 , A61B18/20 , A61B18/22 , A61N5/06 , A61B6/00
CPC分类号： A61B5/0084 , A61B10/00 , A61B18/22 , A61N5/0601 , A61N5/062 , A61B2018/204 , A61B2018/2045 , A61B5/0071 , A61N2005/0644
摘要： A tissue photoradiation system uses a hematoporphyrin or hematoporphyrin derivative dye in tissue to be irradiated and arranges a xenon ion laser 10 for simultaneous lasing. Deep blue light is produced at wavelengths of about 406-427 nanometers and red light at a wavelength of about 627 nanometers by using partially transmitting mirrors 12 and 13 arranged at opposite ends of the laser resonator. Mirror 12 has a coating 14 that substantially reflects blue light and partially transmits red light to produce a red light output, and the coating 15 of mirror 13 substantially reflects red light and partially transmits blue light producing a blue light output. The blue light output is transmitted to a diagnostic tissue irradiator 21 to illuminate the tissue and diagnose its condition. A transmission system using an optical fiber 25 delivers the red light to the tissue for treatment purposes. The red light is radiated out the side of an optical fiber region 30a to be directed into large area of tissue.
摘要翻译：组织射线照射系统使用组织中的血卟啉或血卟啉衍生物染料进行照射，并且安排用于同时激光的氙离子激光器10。通过使用布置在激光谐振器的相对端的部分透射反射镜12和13，在约406-427纳米的波长和约627纳米波长的红光下产生深蓝光。反射镜12具有基本上反射蓝光并部分透射红光以产生红光输出的涂层14，反射镜13的涂层15基本上反射红光并部分透射产生蓝光输出的蓝光。蓝光输出被传送到诊断组织照射器21以照亮组织并诊断其状况。使用光纤25的传输系统将红光传送到组织用于处理目的。红光从光纤区域30a的一侧辐射出来，进入大面积的组织。

2. 发明授权

US4592361A Electro-optical device and method for monitoring instantaneous singlet oxygen concentration produced during photoradiation using pulsed excitation and time domain signal processing 失效
标题翻译：使用脉冲激励和时域信号处理来监测光辐射期间产生的瞬时单线态氧浓度的电光装置和方法
公开(公告)号：US4592361A
公开(公告)日：1986-06-03
申请号：US629879
申请日：1984-07-11
申请人： John G. Parker , William D. Stanbro
发明人： John G. Parker , William D. Stanbro
IPC分类号： A61B10/00 , A61B5/00 , A61B17/00 , A61B18/20 , A61B19/00 , A61F9/007 , A61F9/009 , A61N5/00 , A61N5/06 , G01N21/64 , A61B6/00
CPC分类号： A61B5/0059 , A61B90/06 , A61F9/007 , A61F9/00821 , A61N5/062 , G01N21/6408 , G01N21/6428 , A61B2017/00057 , A61B2018/2045 , A61F2009/00897 , A61F9/009 , A61N2005/0644 , G01N2021/6432
摘要： A method and apparatus is disclosed for optically monitoring the concentration of singlet oxygen produced during photoradiation. A composite optical emission in the 1.27 micron frequency band is detected and electrically processed to separate a first component due to the decay of singlet oxygen from a second unwanted component due to the fluorescence of the photosensitizing dye.A pulsed excitation source is used to excite the photosensitizing dye and a time domain signal processor, such as a box-car integrator, is used to separate and process the singlet oxygen emission component in the time domain.The magnitude and/or other characteristics of the singlet oxygen emission component can be used to determine properties of complex biological or other media. In a therapeutic environment the magnitude and/or other characteristics of the singlet oxygen emission can be used by the treating physician to set a therapeutic light dosimetry.
摘要翻译：公开了用于光学监测在放射照射期间产生的单线态氧的浓度的方法和装置。检测到1.27微米频带中的复合光发射，并且由于光敏染料的荧光，由于单线态氧从第二不需要的分量的衰减而被电处理以分离第一分量。使用脉冲激发源来激发光敏染料，并且使用时域信号处理器（例如盒车积分器）在时域中分离和处理单重态氧发射成分。单重态氧排放组分的大小和/或其他特征可用于确定复杂生物或其他介质的性质。在治疗环境中，单线态氧发射的大小和/或其它特征可被治疗医师用来设定治疗性光剂量测定法。

3. 发明申请

US20100137848A1 LASER SYSTEM FOR HUMAN SKIN SURFACE TREATMENTS 审中-公开
标题翻译：人体皮肤表面处理激光系统
公开(公告)号：US20100137848A1
公开(公告)日：2010-06-03
申请号：US12451893
申请日：2008-06-10
申请人： Dante Marchi
发明人： Dante Marchi
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B2018/00452 , A61B2018/20351 , A61B2018/2045
摘要： The present invention relates to a field of systems for human skin medical treatments. The present system consists of a continuous wave-operated laser source (2) and of a biomedical laser system (1) connected to a scanning device (5) by means of an articulated transmission system (4) said laser being adapted to radiate a continuous CO2 laser beam.
摘要翻译：本发明涉及一种人皮肤医学治疗系统领域。本系统由连续波动激光源（2）和通过铰接式传输系统（4）连接到扫描装置（5）的生物医学激光系统（1）组成，所述激光器适于辐射连续的 CO2激光束。

4. 发明授权

US4576173A Electro-optical device and method for monitoring instanteous singlet oxygen concentration produced during photoradiation using a CW excitation source 失效
标题翻译：用于监测使用CW激发源的光辐射期间产生的特征单线态氧浓度的电光装置和方法
公开(公告)号：US4576173A
公开(公告)日：1986-03-18
申请号：US629854
申请日：1984-07-11
申请人： John G. Parker , William D. Stanbro
发明人： John G. Parker , William D. Stanbro
IPC分类号： A61B10/00 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B17/00 , A61B18/20 , A61B19/00 , A61F9/007 , A61F9/009 , A61N5/00 , A61N5/06 , G01N21/64 , G01N21/76 , A61B6/00
CPC分类号： G01N21/6408 , A61B5/0059 , A61B90/06 , A61F9/007 , A61F9/00821 , A61N5/062 , G01N21/6428 , A61B2017/00057 , A61B2018/2045 , A61F2009/00897 , A61F9/009 , A61N2005/0644 , G01N2021/6432
摘要： A method and apparatus is disclosed for optically monitoring the concentration of singlet oxygen produced during photoradiation. A composite optical emission in the 1.27 micron frequency band is detected and electrically processed to separate a first component due to the decay of singlet oxygen from a second unwanted component due to the fluorescence of the photosensitizing dye.A chopped CW excitation source is used to excite the photosensitizing dye and a signal processing means such as a lock-in amplifier is used to separate the singlet oxygen emission component which appears out of phase from the chopped excitation signal and the in-phase photosensitizer fluorescence.The magnitude and/or other characteristics of the singlet oxygen emission component can be used to determine properties of complex biological or other media. In a therapeutic environment the magnitude and/or other characteristics of the singlet oxygen emission can be used by the treating physician to set a therapeutic light dosimetry.
摘要翻译：公开了用于光学监测在放射照射期间产生的单线态氧的浓度的方法和装置。检测到1.27微米频带中的复合光发射，并且由于光敏染料的荧光，由于单线态氧从第二不需要的分量的衰减而被电处理以分离第一分量。使用切碎的CW激发源来激发光敏染料，并且使用诸如锁定放大器的信号处理装置来分离出与切断的激发信号和同相光敏剂荧光相出现的单线态氧发射分量。单重态氧排放组分的大小和/或其他特征可用于确定复杂生物或其他介质的性质。在治疗环境中，单线态氧发射的大小和/或其它特征可被治疗医师用来设定治疗性光剂量测定法。

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