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    • 2. 发明授权
    • Therapeutic copolymer
    • 治疗性共聚物
    • US3849550A
    • 1974-11-19
    • US24024472
    • 1972-03-31
    • YEDA RES & DEV
    • TEITELBAUM DSELA MMESHORER AARNON R
    • C08G69/10A61K27/00
    • C08G69/10
    • 1. A THERAPEUTIC PREPARATION FOR USE IN THE TREATMENT OF PREVENTION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS, COMPRISING A WATER-SOLUBLE COMPOLYMER HAVING A MOLECULAR WEIGHT IN EXCESS OF 15,000 AND UP TO 25,000, A NET POSITIVE ELECTRICAL CHARGE, AND BEING SELECTED FROM THE GROUP CONSISTING OF A COPOLYMER OF A MIXTURE CONSISTING ESSENTIALLY OF (1) ALANINE, GLUTAMIC ACID, LYSINE AND TYROSINE IN HE MOLAR RATIO OF ABOUT 6 PARTS ALANINE TO 2 PARTS GLUTAMIC ACID TO 4.5 PARTS LYSINE TO 1 PART TYROSINE; (2) ALANINE, ASPARTIC ACID, LYSINE AND TYROSINE IN THE MOLAR RATIO OF ABOUT 5 PARTS ALANINE TO 1.5 PARTS ASPARTIC ACID TO 3.5 PARTS LYSINE TO 1 PART TYROSINE; AND (3) ALANINE, GLUTAMIC ACID AND LYSINE IN THE MOLAR RATIO OF ABOUT 5 PARTS ALANINE TO 1.5 PARTS GLUTAMIC ACID TO 3.5 PARTS LYSINE; IN AN AMOUNT EFFECT FOR TREATMENT OR PREVENTION OF THE SAID DISEASE, DISPERSED IN A PHARMACEUTICALLY ACCEPTABLE CARRIER FOR INJECTABLE ADMINISTRATION.