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1. 发明申请

US20130315783A1 SENSOR 有权
标题翻译：传感器
公开(公告)号：US20130315783A1
公开(公告)日：2013-11-28
申请号：US13954582
申请日：2013-07-30
申请人： Vivacta Limited
发明人： Timothy Joseph Nicholas Carter , Steven Andrew Ross
IPC分类号： G01N33/53
CPC分类号： G01N33/5302 , G01N21/1702 , G01N21/171 , G01N33/54373 , G01N2021/1708 , G01N2201/062
摘要： A device for detecting an analyte in a sample, which includes a radiation source adapted to generate electromagnetic radiation; a transducer capable of transducing a change in energy to an electrical signal; at least one tethered reagent on or proximal to the transducer, the tethered reagent having a binding site which is capable of binding the analyte; a chamber for holding the sample in fluid contact with transducer, wherein the chamber is adapted to contain the sample on inversion, partial inversion or agitation of the device; and a detector which is capable of detecting the electrical signal generated by the transducer.
摘要翻译：一种用于检测样品中的分析物的装置，其包括适于产生电磁辐射的辐射源; 能够将电能变化转换为电信号的换能器; 所述连接试剂具有能够结合所述分析物的结合位点;所述连接的试剂具有能够结合所述分析物的结合位点; 用于保持样品与换能器流体接触的室，其中所述室适于在所述装置反转，部分反转或搅动时容纳所述样品; 以及能够检测由换能器产生的电信号的检测器。

2. 发明授权

US08524504B2 Sensor 有权
标题翻译：传感器
公开(公告)号：US08524504B2
公开(公告)日：2013-09-03
申请号：US12675684
申请日：2008-08-13
申请人： Timothy Joseph Nicholas Carter , Steven Andrew Ross
发明人： Timothy Joseph Nicholas Carter , Steven Andrew Ross
IPC分类号： G01N25/18
CPC分类号： G01N33/5302 , G01N21/1702 , G01N21/171 , G01N33/54373 , G01N2021/1708 , G01N2201/062
摘要： This invention relates to a method for detecting an analyte in a sample, comprising the steps of exposing the sample to a transducer which is capable of transducing a change in energy to an electrical signal, the transducer having at least one tethered reagent on or proximal thereto, the at least one tethered reagent having a binding site which is capable of binding the analyte; introducing a labelled reagent into the sample, wherein the labelled reagent contains a binding site for the analyte or the tethered reagent and a label which is capable of absorbing electromagneticradiation generated by a radiation source to generate energy; allowing the labelled reagent to bind to the analyte or tethered reagent in a first period in which the transducer is oriented such that the labelled reagent is caused to settle, at least in part, on the transducer; subsequently, in a second period, causing the labelled reagent to become unsettled; irradiating the sample with electromagnetic radiation during the first and second periods, transducing the energy generated into an electrical signal; detecting the electrical signal. A device for performing the method is also provided.
摘要翻译：本发明涉及一种用于检测样品中的分析物的方法，包括以下步骤：将样品暴露于能够将能量变化转换为电信号的换能器，换能器在其上或其上具有至少一个系留试剂所述至少一种系留试剂具有能够结合分析物的结合位点; 将标记的试剂引入样品中，其中标记的试剂含有分析物或系留试剂的结合位点和能够吸收由辐射源产生的电磁辐射以产生能量的标签; 允许标记的试剂在换能器定向的第一时段内结合分析物或系留试剂，使得标记的试剂至少部分地沉积在换能器上; 随后，在第二时间段内，使标记的试剂变得不稳定; 在第一和第二周期期间用电磁辐射照射样品，将产生的能量转换成电信号; 检测电信号。还提供了一种用于执行该方法的装置。

3. 发明申请

US20080199970A1 Chemical Sensing Device 有权
标题翻译：化学传感装置
公开(公告)号：US20080199970A1
公开(公告)日：2008-08-21
申请号：US11814767
申请日：2006-01-24
申请人： Timothy Joseph Nicholas Carter , Florence Colin , Steven Andrew Ross , John Dalton Wright
发明人： Timothy Joseph Nicholas Carter , Florence Colin , Steven Andrew Ross , John Dalton Wright
IPC分类号： G01N21/76 , C12M1/34
CPC分类号： G01N25/4813 , G01N21/6428 , G01N21/77 , G01N25/482 , G01N2021/6432
摘要： This invention relates to a chemical sensing device for detecting an analyte. The device comprises a light source; at least one luminescent reagent which is capable of luminescing when irradiated by the light source wherein the luminescence of the luminescent reagent is modifiable by the analyte thereby changing the generation of heat, which change in heat generation is proportional to the concentration of the analyte, a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing the change in heat to an electrical signal, and a detector which is capable of converting the electrical signal into an indication of the concentration of the analyte. The invention also relates to a method for detecting an analyte.
摘要翻译：本发明涉及一种用于检测分析物的化学感测装置。该装置包括光源; 至少一种发光试剂，其在被光源照射时能够发光，其中发光试剂的发光可由分析物改变，从而改变发热，其发热变化与分析物的浓度成比例，具有热电或压电元件的换能器和能够将热变化转换为电信号的电极，以及能够将电信号转换成分析物浓度的指示的检测器。本发明还涉及检测分析物的方法。

4. 发明授权

US08758686B2 Optical chemical sensing device with pyroelectric or piezoelectric transducer 有权
标题翻译：具有热电或压电传感器的光学化学感测装置
公开(公告)号：US08758686B2
公开(公告)日：2014-06-24
申请号：US10552702
申请日：2004-04-08
申请人： Timothy Joseph Nicholas Carter , Steven Andrew Ross
发明人： Timothy Joseph Nicholas Carter , Steven Andrew Ross
IPC分类号： G01N21/63 , G01J5/00
CPC分类号： G01N21/63 , G01J5/00 , G01N21/1702 , G01N21/171 , G01N25/482 , G01N29/2418 , G01N33/54366 , G01N2021/1708
摘要： This invention relates to a device (1) for detecting energy generated by non-radiative decay generated in a substance (2) on irradiation with electromagnetic radiation. The device (1) comprises a radiation source (6) adapted to generate a series of pulses of electromagnetic radiation, a transducer (3) having a pyroelectric or piezoelectric element and electrodes (4, 5) which is capable of transducing the energy generated by the substance (2) into an electrical signal, and a detector (7) which is capable of detecting the electrical signal generated by the transducer (3). The detector (7) is adapted to determine the time delay between each pulse of electromagnetic radiation from the radiation source (6) and the generation of the electric signal. The device (1) has a wide applicability in the fields of assays and monitoring.
摘要翻译：本发明涉及一种用于在用电磁辐射照射时检测在物质（2）中产生的非辐射衰减产生的能量的装置（1）。设备（1）包括适于产生一系列电磁辐射脉冲的辐射源（6），具有热电或压电元件的换能器（3）和能够传导由物质（2）变成电信号，以及能够检测由换能器（3）产生的电信号的检测器（7）。检测器（7）适于确定来自辐射源（6）的电磁辐射的每个脉冲与电信号的产生之间的时间延迟。装置（1）在测定和监测领域具有广泛的适用性。

5. 发明申请

US20120034636A1 CHEMICAL SENSING DEVICE 审中-公开
标题翻译：化学传感装置
公开(公告)号：US20120034636A1
公开(公告)日：2012-02-09
申请号：US13279789
申请日：2011-10-24
申请人： Timothy Joseph Nicholas Carter , Florence Colin , Steven Andrew Ross , John Dalton Wright
发明人： Timothy Joseph Nicholas Carter , Florence Colin , Steven Andrew Ross , John Dalton Wright
IPC分类号： C12Q1/54 , C12M1/34 , G01N25/20
CPC分类号： G01N25/4813 , G01N21/6428 , G01N21/77 , G01N25/482 , G01N2021/6432
摘要： This invention relates to a chemical sensing device for detecting an analyte. The device comprises a light source, at least one luminescent reagent which is capable of luminescing when irradiated by the light source wherein the luminescence of the luminescent reagent is modifiable by the analyte thereby changing the generation of heat, which change in heat generation is proportional to the concentration of the analyte, a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing the change in heat to an electrical signal, and a detector which is capable of converting the electrical signal into an indication of the concentration of the analyte. The invention also relates to a method for detecting an analyte.
摘要翻译：本发明涉及一种用于检测分析物的化学感测装置。该装置包括光源，至少一种发光试剂，其在被光源照射时能够发光，其中发光试剂的发光可被分析物修饰，从而改变发热，其发热变化与分析物的浓度，具有热电或压电元件的换能器和能够将热变化转换成电信号的电极以及能够将电信号转换成分析物浓度的指示的检测器。本发明还涉及检测分析物的方法。

6. 发明授权

US10078079B2 Device for detecting an analyte 有权
公开(公告)号：US10078079B2
公开(公告)日：2018-09-18
申请号：US14110033
申请日：2012-04-05
申请人： Steve Ross , Julie Richards , Tim Carter
发明人： Steve Ross , Julie Richards , Tim Carter
IPC分类号： G01N33/543 , G01N21/17 , G01N29/02 , G01N33/542 , G01N33/53 , G01N21/64 , G01N33/58
CPC分类号： G01N33/54373 , G01N21/171 , G01N21/6428 , G01N29/022 , G01N33/5302 , G01N33/542 , G01N33/582 , G01N2021/6439 , G01N2201/062 , G01N2291/02433 , G01N2291/0255 , G01N2291/0256
摘要： This invention relates to a device for detecting an analyte in a sample comprising: a radiation source adapted to generate a series of pulses of electromagnetic radiation; a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing energy generated by non-radiative decay into an electrical signal; a detector which is capable of detecting the electrical signal generated by the transducer; a first reagent proximal to the transducer, the first reagent having a binding site which is capable of binding a labelled reagent proportionally to the concentration of the analyte in the sample, which labelled reagent being capable of absorbing the electromagnetic radiation generated by the radiation source to generate energy by non-radiative decay; a second reagent proximal to the transducer, the second reagent having a lower affinity for the labelled reagent under the conditions of the assay than the first reagent; and a third reagent proximal to the transducer, the third reagent having a binding site which is capable of binding the labelled reagent, wherein the third reagent has an affinity for the labelled reagent which is less influenced than the first reagent by the concentration of the analyte or the complex or derivative of the analyte.

7. 发明申请

US20140119995A1 DEVICE FOR DETECTING AN ANALYTE 审中-公开
标题翻译：用于检测分析仪的装置
公开(公告)号：US20140119995A1
公开(公告)日：2014-05-01
申请号：US14110033
申请日：2012-04-05
申请人： Steve Ross , Julie Richards , Tim Carter
发明人： Steve Ross , Julie Richards , Tim Carter
IPC分类号： G01N33/53
CPC分类号： G01N33/54373 , G01N21/171 , G01N21/6428 , G01N29/022 , G01N33/5302 , G01N33/542 , G01N33/582 , G01N2021/6439 , G01N2201/062 , G01N2291/02433 , G01N2291/0255 , G01N2291/0256
摘要： This invention relates to a device for detecting an analyte in a sample comprising: a radiation source adapted to generate a series of pulses of electromagnetic radiation; a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing energy generated by non-radiative decay into an electrical signal; a detector which is capable of detecting the electrical signal generated by the transducer; a first reagent proximal to the transducer, the first reagent having a binding site which is capable of binding a labelled reagent proportionally to the concentration of the analyte in the sample, which labelled reagent being capable of absorbing the electromagnetic radiation generated by the radiation source to generate energy by non-radiative decay; a second reagent proximal to the transducer, the second reagent having a lower affinity for the labelled reagent under the conditions of the assay than the first reagent; and a third reagent proximal to the transducer, the third reagent having a binding site which is capable of binding the labelled reagent, wherein the third reagent has an affinity for the labelled reagent which is less influenced than the first reagent by the concentration of the analyte or the complex or derivative of the analyte.
摘要翻译：本发明涉及一种用于检测样品中分析物的装置，包括：辐射源，适于产生一系列电磁辐射脉冲; 具有热电或压电元件的传感器和能够将由非辐射衰减产生的能量转换成电信号的电极; 检测器，其能够检测由换能器产生的电信号; 靠近换能器的第一试剂，第一试剂具有结合位点，其能够将标记的试剂与样品中分析物的浓度成比例地结合，该标记试剂能够吸收由辐射源产生的电磁辐射，通过非辐射衰减产生能量; 靠近换能器的第二试剂，所述第二试剂在所述测定条件下对所述标记试剂的亲和力低于所述第一试剂; 以及靠近所述换能器的第三试剂，所述第三试剂具有能够结合所述标记试剂的结合位点，其中所述第三试剂对所述标记试剂具有亲和性，所述试剂比所述第一试剂的浓度受到分析物的浓度影响小或分析物的复合物或衍生物。

8. 发明申请

US20130052632A1 METHOD FOR SENSING A CHEMICAL 审中-公开
标题翻译：感应化学品的方法
公开(公告)号：US20130052632A1
公开(公告)日：2013-02-28
申请号：US13520484
申请日：2011-01-04
申请人： Timothy Joseph Nicholas Carter , Steven Andrew Ross
发明人： Timothy Joseph Nicholas Carter , Steven Andrew Ross
IPC分类号： G01N25/20 , C12M1/42 , B82Y15/00
CPC分类号： G01N25/20 , B82Y15/00 , G01N33/54373
摘要： This invention relates to a method for detecting an analyte in a sample. The method comprises the steps of exposing the sample to a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing a change in energy to an electrical signal, the transducer having at least one reagent proximal thereto, the reagent having a binding site which is capable of binding the analyte or a complex or derivative of the analyte, wherein at least one of the analyte or the complex or derivative of the analyte has a label attached thereto which is capable of absorbing the electromagnetic radiation generated by the radiation source to generate energy by non-radiative decay; irradiating the reagent with a series of pulses of electromagnetic radiation, transducing the energy generated into an electrical signal, detecting the electrical signal and the time delay between each pulse of electromagnetic radiation from the radiation source and the generation of the electric signal. The time delay between each of the pulses of electromagnetic radiation and the generation of the electric signal corresponds to the position of the analyte at any of one or more positions at different distances from the surface of the transducer. The label is a nanoparticle comprising polypyrrole or a derivative thereof. The invention also provides a kit suitable for performing this method.
摘要翻译：本发明涉及一种用于检测样品中分析物的方法。该方法包括以下步骤：将样品暴露于具有热电或压电元件的换能器和能够将能量变化转换为电信号的电极，所述换能器具有至少一个接近其的试剂，所述试剂具有结合位点其能够结合分析物或分析物的复合物或衍生物，其中分析物或分析物的复合物或衍生物中的至少一种具有附着于其上的标签，其能够吸收由辐射源产生的电磁辐射，通过非辐射衰减产生能量; 用一系列电磁辐射脉冲照射试剂，将产生的能量转换成电信号，检测电信号和来自辐射源的每个电磁辐射脉冲之间的时间延迟和电信号的产生。电磁辐射的每个脉冲和电信号的产生之间的时间延迟对应于分析物在与换能器表面不同距离处的一个或多个位置的任何位置处的位置。该标签是包含聚吡咯或其衍生物的纳米颗粒。本发明还提供适用于执行该方法的试剂盒。

9. 发明授权

US08066944B2 Chemical sensing device 有权
标题翻译：化学传感装置
公开(公告)号：US08066944B2
公开(公告)日：2011-11-29
申请号：US11814767
申请日：2006-01-24
申请人： Timothy Joseph Nicholas Carter , Florence Colin , Steven Andrew Ross , John Dalton Wright
发明人： Timothy Joseph Nicholas Carter , Florence Colin , Steven Andrew Ross , John Dalton Wright
IPC分类号： G01N15/06 , G01N21/00 , G01N25/20 , G01N21/75 , C12M1/34
CPC分类号： G01N25/4813 , G01N21/6428 , G01N21/77 , G01N25/482 , G01N2021/6432
摘要： This invention relates to a chemical sensing device for detecting an analyte. The device comprises a light source; at least one luminescent reagent which is capable of luminescing when irradiated by the light source wherein the luminescence of the luminescent reagent is modifiable by the analyte thereby changing the generation of heat, which change in heat generation is proportional to the concentration of the analyte, a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing the change in heat to an electrical signal, and a detector which is capable of converting the electrical signal into an indication of the concentration of the analyte. The invention also relates to a method for detecting an analyte.
摘要翻译：本发明涉及一种用于检测分析物的化学感测装置。该装置包括光源; 至少一种发光试剂，其在被光源照射时能够发光，其中发光试剂的发光可由分析物改变，从而改变发热，其发热变化与分析物的浓度成比例，具有热电或压电元件的换能器和能够将热变化转换为电信号的电极，以及能够将电信号转换成分析物浓度的指示的检测器。本发明还涉及检测分析物的方法。

10. 发明申请

US20160209408A1 DEVICE FOR DETECTING AN ANALYTE 审中-公开
标题翻译：用于检测分析仪的装置
公开(公告)号：US20160209408A1
公开(公告)日：2016-07-21
申请号：US15082417
申请日：2016-03-28
申请人： VIVACTA LIMITED
发明人： Steve ROSS , Julie RICHARDS , Tim CARTER
IPC分类号： G01N33/543 , G01N33/542 , G01N21/64 , G01N33/58
CPC分类号： G01N33/54373 , G01N21/171 , G01N21/6428 , G01N29/022 , G01N33/5302 , G01N33/542 , G01N33/582 , G01N2021/6439 , G01N2201/062 , G01N2291/02433 , G01N2291/0255 , G01N2291/0256
摘要： This invention relates to a device for detecting an analyte in a sample comprising: a radiation source adapted to generate a series of pulses of electromagnetic radiation; a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing energy generated by non-radiative decay into an electrical signal; a detector which is capable of detecting the electrical signal generated by the transducer; a first reagent proximal to the transducer, the first reagent having a binding site which is capable of binding a labelled reagent proportionally to the concentration of the analyte in the sample, which labelled reagent being capable of absorbing the electromagnetic radiation generated by the radiation source to generate energy by non-radiative decay; a second reagent proximal to the transducer, the second reagent having a lower affinity for the labelled reagent under the conditions of the assay than the first reagent; and a third reagent proximal to the transducer, the third reagent having a binding site which is capable of binding the labelled reagent, wherein the third reagent has an affinity for the labelled reagent which is less influenced than the first reagent by the concentration of the analyte or the complex or derivative of the analyte.
摘要翻译：本发明涉及一种用于检测样品中分析物的装置，包括：辐射源，适于产生一系列电磁辐射脉冲; 具有热电或压电元件的传感器和能够将由非辐射衰减产生的能量转换成电信号的电极; 检测器，其能够检测由换能器产生的电信号; 靠近换能器的第一试剂，第一试剂具有结合位点，其能够将标记的试剂与样品中分析物的浓度成比例地结合，该标记试剂能够吸收由辐射源产生的电磁辐射，通过非辐射衰减产生能量; 靠近换能器的第二试剂，所述第二试剂在所述测定条件下对所述标记试剂的亲和力低于所述第一试剂; 以及靠近所述换能器的第三试剂，所述第三试剂具有能够结合所述标记试剂的结合位点，其中所述第三试剂对所述标记试剂具有亲和性，所述试剂比所述第一试剂的浓度受到分析物的浓度影响小或分析物的复合物或衍生物。

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