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1. 发明授权

US11661582B2 Method for producing sinoatrial node cells (pacemaker cells) from stem cells, and use of the produced sinoatrial node cells 有权
公开(公告)号：US11661582B2
公开(公告)日：2023-05-30
申请号：US15106388
申请日：2014-12-10
申请人： UNIVERSITAET ROSTOCK
发明人： Robert David , Julia Jung
IPC分类号： C12N15/85 , C12N5/077 , C12N5/10 , G01N33/50
CPC分类号： C12N5/0657 , C12N5/10 , C12N15/85 , G01N33/5061 , C12N2501/60 , C12N2506/02 , C12N2506/03 , C12N2506/04 , C12N2506/45 , C12N2510/00
摘要： The electrical pacemakers currently being used for the therapeutic approaches for treatment of “sick sinus syndrome” are not hormonally regulatable and entail risks through infections or premature battery discharge. These problems could be overcome by means of “biological cardiac pacemakers” obtained from pluripotent stem cells (PSCs). It has been shown that the controlled differentiation of stem cells with TBX, inductors of sinoatrial node cells, and an additional Myh6 promoter-specific antibiotic selection can give cardiomyocyte aggregates consisting to an extent of more than 80% of physiologically functional pacemaker cells. These induced sinoatrial bodies (“iSABs”) for the first time exhibited very high beat frequencies (300-400 bpm), similar to those in a murine heart, and were able to stably rhythmically stimulate heart muscle cells ex vivo. In the iSAB transcriptome decoded by means of RNA-seq, it was possible to assign almost all the genes to the ontologies of heart function/heart development and the structures of contractile cells. Overall, this is the first example of a high-purity functional sinoatrial tissue derived from stem cells, which means that a crucial step for future cell therapy and the testing of medicaments in vitro is being implemented.

2. 发明申请

US20160367403A1 GLAUCOMA DRAINAGE IMPLANT 审中-公开
标题翻译： GLAUCOMA排水植物
公开(公告)号：US20160367403A1
公开(公告)日：2016-12-22
申请号：US15121566
申请日：2015-02-23
申请人： UNIVERSITÄT ROSTOCK
发明人： Stefan SIEWERT , Frank LUDERER , Wolfram SCHMIDT , Marian LOEBLER , Rudolf GUTHOFF , Katrin STERNBERG , Klaus-Peter SCHMITZ
IPC分类号： A61F9/007 , D01D5/00
CPC分类号： A61F9/00781 , A61F2210/0004 , A61F2240/001 , A61F2250/0031 , A61F2250/0067 , D01D5/0007 , D10B2509/00
摘要： The invention relates to an ocular implant for treating glaucoma. The problem addressed by the invention is to make it possible to drain aqueous humor from the anterior chamber of the eye into the subconjunctival or suprachoroidal space in order to lower the intraocular pressure in glaucoma cases. The device is to do away with the drawbacks of known valve mechanisms and should be economical to produce. In order to solve said problem, the glaucoma drainage implant is composed of an elongate, hollow main member in which a flow-limiting membrane is arranged in the inflow region.
摘要翻译：本发明涉及用于治疗青光眼的眼部植入物。本发明所解决的问题是使得可以将房水从眼前房排出到结膜下或脉络膜上方，以降低青光眼患者的眼内压。该装置是消除已知阀机构的缺点，并且应该是经济的。为了解决上述问题，青光眼引流植入物由在流入区域配置有限流膜的细长中空主体构成。

3. 发明申请

US20160103116A1 Electrophysiological Measuring Arrangement, and Electrophysiological Measuring Method 审中-公开
标题翻译：电生理测量方法和电生理测量方法
公开(公告)号：US20160103116A1
公开(公告)日：2016-04-14
申请号：US14786855
申请日：2014-03-27
申请人： UNIVERSITAET ROSTOCK
发明人： Oliver Klink , Philipp Julian Koester , Carsten Tautorat , Uwe Scheffler
IPC分类号： G01N33/487 , G01N27/04
CPC分类号： G01N33/48728 , G01N27/04
摘要： The present invention relates to an electrophysiological measuring arrangement (100) and to an electrophysiological measuring method, in which a carrier (12) made of a carrier material (12′) and an aperture region (10) in the region of the carrier (12) are provided for the controlled sealing accumulation of a biological object (O). The aperture region (10) is formed with at least one aperture (14) and with a wall region (11) which, as the aperture inner wall (11i), surrounds the aperture (14), forming the latter. At least the wall region (11) is formed with a region (20) made of a material (12″) which, at least in terms of the composition thereof, substantially corresponds to the carrier material (12′) outside the aperture region (10) but has an increased concentration of at least one ion species in comparison therewith, with the result that the sealing accumulation of a biological object (O) in the aperture region (10) can be promoted by this increased concentration on or in at least the aperture inner wall (11i) of the aperture (14), wherein the concentration of the at least one material species or ion species is modified to a depth of approximately 10 nm from the top side (12a) or surface of the carrier (12) and, in particular, from the aperture inner wall (11i).
摘要翻译：本发明涉及电生理测量装置（100）和电生理测量方法，其中载体（12'）和载体（12'）的区域中的开口区域（10）构成的载体（12））用于生物体（O）的受控密封积聚。开口区域（10）形成有至少一个孔（14）和壁区域（11），壁区域（11）作为孔内壁（11i）围绕孔（14），形成孔。至少壁区域（11）形成有由材料（12“）制成的区域（20），其至少在其组成方面基本上对应于孔区域外的载体材料（12'） 10），但是与其相比具有增加的至少一种离子种类的浓度，结果是可以通过在至少一个或至少在该开口区域（10）中的这种增加的浓度来促进生物体（O）在开口区域（10）中的密封积聚孔（14）的孔径内壁（11i），其中至少一种材料种类或离子种类的浓度从载体（12）的顶侧（12a）或表面修饰至约10nm的深度），特别是从孔内壁（11i）。

4. 发明授权

US09138549B2 Insufflator 有权
标题翻译：吸入器
公开(公告)号：US09138549B2
公开(公告)日：2015-09-22
申请号：US13146500
申请日：2010-01-29
申请人： Lienhard Pagel , Stefan Gabmann , Johannes Tschepe
发明人： Lienhard Pagel , Stefan Gabmann , Johannes Tschepe
IPC分类号： A61M13/00 , H05K1/02 , A61B17/34 , H05K1/18
CPC分类号： A61M13/003 , A61B17/3474 , H05K1/0272 , H05K1/181 , H05K2201/10151
摘要： The invention relates to an insufflator with a supply connection (22) and a delivery connection (14) and a pressure and flow measuring device arranged between said connections (14, 22) for determining measured quantities characterizing a gas pressure at a delivery connection and a gas volume flow at the delivery connection. The pressure and flow measuring device comprises a multilayer board (20) which comprises on its interior at least one flow channel (26) that is connected at its input to the supply connection (22) and at its output (8) to the delivery connection (14). Arranged on the board (20) are pressure measurement sensors (32, 34) and electronic components (4, 6) for the wiring of the pressure measurement sensors. The pressure measurement sensors are each directly connected to the flow channel (26) via a corresponding opening of a board layer that otherwise tightly covers the flow channel (26) and are designed to provide an output value representing a static pressure at the point of the respective opening.
摘要翻译：本发明涉及具有供应连接件（22）和输送连接件（14）的吹入器，以及布置在所述连接件（14,22）之间的压力和流量测量装置，用于确定表征输送连接处气体压力的测量量，以及输送连接处的气体体积流量。所述压力和流量测量装置包括多层板（20），所述多层板（20）在其内部包括至少一个流动通道（26），所述至少一个流动通道（26）在其输入处连接到所述供应连接件（22），并在其输出端（8）连接到所述输送连接（14）。在板（20）上布置有用于压力测量传感器的布线的压力测量传感器（32,34）和电子部件（4,6）。压力测量传感器各自经由板层的相应开口直接连接到流动通道（26），否则其将紧密地覆盖流动通道（26），并被设计成提供表示静态压力的输出值各自开放。

5. 发明授权

US08211291B2 Sensor apparatus for an electrochemical measuring device and method for carrying out electrochemical measurements 有权
标题翻译：用于电化学测量装置的传感器装置和用于进行电化学测量的方法
公开(公告)号：US08211291B2
公开(公告)日：2012-07-03
申请号：US12278672
申请日：2007-02-06
申请人： Gerd-Uwe Flechsig , Jan Gimsa , Peter Gründler , Harald Grabow
发明人： Gerd-Uwe Flechsig , Jan Gimsa , Peter Gründler , Harald Grabow
IPC分类号： G01F1/64 , G01N17/00 , G01N27/26
CPC分类号： G01N27/286 , G01N27/3275
摘要： A sensor apparatus for an electrochemical measuring device. The apparatus has at least one electrode, which can be heated using a heating current in the form of an alternating current, and a first and a second connection for the supply line for the heating current. The electrochemical measuring device is connected to the electrode by a third connection. In this case, the apparatus has the third connection connected to the electrode by a bridge circuit, which is also connected to the first and second connections. There also is provided a method for carrying out electrochemical measurements at elevated temperature. The sensor apparatus and the method for carrying out electrochemical measurements enable electrochemical measurements with little interference and directly heated electrodes in conjunction with a simplified design of the electrodes.
摘要翻译：一种用于电化学测量装置的传感器装置。该装置具有至少一个电极，其可以使用交流电形式的加热电流加热，以及用于加热电流的供应管线的第一和第二连接。电化学测量装置通过第三连接连接到电极。在这种情况下，该装置具有通过桥接电路连接到电极的第三连接，桥接电路也连接到第一和第二连接。还提供了一种用于在升高的温度下进行电化学测量的方法。用于进行电化学测量的传感器装置和方法使得电化学测量具有很少的干扰和直接加热的电极以及电极的简化设计。

6. 发明授权

US08206333B2 Ocular implant 有权
标题翻译：眼部植入
公开(公告)号：US08206333B2
公开(公告)日：2012-06-26
申请号：US12524719
申请日：2008-01-25
申请人： Wolfram Schmidt , Katrin Sternberg , Detlef Behrend , Rudolf Guthoff , Klaus-Peter Schmitz
发明人： Wolfram Schmidt , Katrin Sternberg , Detlef Behrend , Rudolf Guthoff , Klaus-Peter Schmitz
IPC分类号： A61M5/00
CPC分类号： A61F9/00781
摘要： The present invention relates to an ocular implant, particularly a glaucoma stent.It is the object of the present invention to devise an ocular implant which allows the ocular eye pressure to be regulated, i.e., to be maintained at a desired level, while preventing the flow resistance from increasing over time, for example due to fibrosis.In order to achieve this object, the ocular implant according to the invention comprises a small tube (5), the wall surface (3) of which encloses a hollow duct that is open on both sides in the longitudinal direction of the hollow duct, wherein a first opening (1) allowing ocular humor to flow in and a second opening (2) allowing the ocular humor to be discharged is provided, and wherein the wall surface (3) is formed by a liquid-tight material, and wherein at least one pressure-controlled valve (4) is disposed in the area of the wall surface (3).
摘要翻译：本发明涉及眼部植入物，特别是青光眼支架。本发明的目的是设计一种允许眼睛压力被调节，即保持在期望水平的眼部植入物，同时防止流动阻力随时间增加，例如由于纤维化。为了实现该目的，根据本发明的眼部植入物包括小管（5），其壁表面（3）围绕中空管道，中空管道在中空管道的纵向两侧敞开，其中提供允许眼睛流入的第一开口（1）和允许眼睛被排出的第二开口（2），并且其中壁表面（3）由液体密封材料形成，并且其中至少一个压力控制阀（4）设置在壁表面（3）的区域中。

7. 发明申请

US20110042313A1 BIOEQUIVALENCE DIALYSIS 有权
标题翻译：生物平衡分析
公开(公告)号：US20110042313A1
公开(公告)日：2011-02-24
申请号：US12918425
申请日：2009-02-20
申请人： Steffen Mitzner
发明人： Steffen Mitzner
IPC分类号： A61M1/36 , B01D61/24
CPC分类号： A61M1/3633 , A61M1/34
摘要： The present invention relates to a method for treating blood composition disorders and blood function disorders. Said method comprises steps, in which blood or blood plasma of a patient is brought into extracorporeal contact with a second fluid (bioequivalent), wherein said second fluid is blood or modified blood, which comprises at least granulocytes, thrombocytes, and erythrocytes. Furthermore, the invention relates to devices for performing said method and to the use of such a device or blood or modified blood, which comprises granulocytes, thrombocytes, and erythrocytes, for treating blood composition disorders and blood function disorders.
摘要翻译：本发明涉及一种治疗血液成分紊乱和血液功能障碍的方法。所述方法包括以下步骤：使患者的血液或血浆与第二流体（生物等效物）体外接触，其中所述第二流体是包含至少粒细胞，血细胞和红细胞的血液或修饰的血液。此外，本发明涉及用于执行所述方法的装置，以及用于治疗血液成分紊乱和血液功能障碍的包含粒细胞，血小板和红细胞的这种装置或血液或改良血液的使用的装置。

8. 发明申请

US20100152870A1 METHOD AND DEVICE FOR CONTROLLING ROBOTS FOR WELDING WORKPIECES 有权
标题翻译：用于控制焊接工件的机器人的方法和装置
公开(公告)号：US20100152870A1
公开(公告)日：2010-06-17
申请号：US12449595
申请日：2008-02-19
申请人： Martin Christoph Wanner , Alexander Zych , Uwe Pfletscher
发明人： Martin Christoph Wanner , Alexander Zych , Uwe Pfletscher
IPC分类号： B25J9/22 , G06F15/18
CPC分类号： G05B19/4207 , B23K9/0256 , B23K31/02 , G01B11/2518 , G01B21/042 , G05B2219/36248 , G05B2219/37009 , G05B2219/37555 , G05B2219/37567 , G05B2219/45104 , G06T7/521
摘要： The invention relates to a method for controlling robots for welding three-dimensional workpieces, comprising the following steps: positioning and tacking profiles to a plate in order to form the workpiece to be welded, depicting the workpiece by means of a three-dimensional imaging system in the form of three-dimensional pixels, determining the geometric data of the plate and profiles, including the allocation of cutouts and final cutting shapes from the three-dimensional pixels, determining the weld seam data from the geometric data while considering the profile placement lines and the contact lines of profiles, allocating the weld seam data to parameterizable specifications for the weld plan into stored predefined movement patterns of the robot, and into commands for the control of the welding process.
摘要翻译：本发明涉及一种用于控制用于焊接三维工件的机器人的方法，包括以下步骤：将型材定位并固定到板上以形成待焊接的工件，通过三维成像系统描绘工件以三维像素的形式，确定板和轮廓的几何数据，包括从三维像素分配切割和最终切割形状，在考虑轮廓放置线的同时确定来自几何数据的焊缝数据以及型材的接触线，将焊缝数据分配给可焊接计划的可参数化规格，以保存在机器人的预定义的运动模式中，以及用于控制焊接过程的命令。

9. 发明授权

US10342703B2 Glaucoma drainage implant 有权
公开(公告)号：US10342703B2
公开(公告)日：2019-07-09
申请号：US15121566
申请日：2015-02-23
申请人： UNIVERSITAET ROSTOCK
发明人： Stefan Siewert , Frank Luderer , Wolfram Schmidt , Marian Loebler , Rudolf Guthoff , Katrin Sternberg , Klaus-Peter Schmitz
IPC分类号： A61F9/00 , A61F9/007 , D01D5/00
摘要： The invention relates to an ocular implant for treating glaucoma. The problem addressed by the invention is to make it possible to drain aqueous humor from the anterior chamber of the eye into the subconjunctival or suprachoroidal space in order to lower the intraocular pressure in glaucoma cases. The device is to do away with the drawbacks of known valve mechanisms and should be economical to produce. In order to solve said problem, the glaucoma drainage implant is composed of an elongate, hollow main member in which a flow-limiting membrane is arranged in the inflow region.

10. 发明授权

US10260948B2 Method and device for determining and calculating a scattered radiation spectrum and method for compressing data 有权
公开(公告)号：US10260948B2
公开(公告)日：2019-04-16
申请号：US14648010
申请日：2013-11-26
申请人： LEIBNIZ-INSTITUT FÜR ATMOSPHÄRENPHYSIK E.V. AN DER UNIVERSITÄT ROSTOCK
发明人： Josef Hoeffner
IPC分类号： G01J3/44 , G01J3/10 , G01S17/95 , G01S7/484 , G01S7/486 , G01S7/497 , G01N21/53 , G01S17/58
摘要： The invention relates to a device (1) and a method (20) for determining a spectrum (X) of scattered radiation (S). The invention further relates to a method (70) for calculating the spectrum (X) and a method for compressing unstructured data (60) of known distribution. To be able to determine the spectrum (X) as precisely as possible and to derive from this the characteristics of materials that scatter laser pulses (P), the invention proposes that at least one characteristic of the laser pulse (P) is determined and that a spectrum analyzer (5) is used for this. Frequencies (F) of laser pulses (P) and volumes (M) of backscattered radiation (S) are combined into frequency and volume values (F′, M′) to calculate the spectrum (X). The most frequent data values are deleted from the data to compress the data (60).

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