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    • 1. 发明申请
    • Genetic Regulation of Bone and Cells by Electromagnetic Stimulation Fields and Uses thereof
    • 通过电磁刺激场对骨细胞进行遗传调控及其应用
    • US20140342428A1
    • 2014-11-20
    • US14445995
    • 2014-07-29
    • Thomas J. GoodwinLinda C. Shackelford
    • Thomas J. GoodwinLinda C. Shackelford
    • C12N13/00
    • C12N13/00A61N2/02
    • The present invention provides methods to modify the genetic regulation of mammalian tissue, bone, cells or any combination thereof by preferential activation, up-regulation and/or down-regulation. The method comprises steps of tuning the predetermined profiles of one or more time-varying stimulation fields by manipulating the B-Field magnitude, rising slew rate, rise time, falling slew rate, fall time, frequency, wavelength, and duty cycle, and exposing mammalian cells or tissues to one or more tuned time-varying stimulation fields with predetermined profiles. Examples of mammalian cells or tissues are chondrocytes, osteoblasts, osteocytes, osteoclasts, nucleus pulposus, associated tissue, or any combination. The resulted modification on gene regulation of these cells, tissues or bones may promote the retention, repair of and reduction of compromised mammalian cartilage, bone, and associated tissue.
    • 本发明提供了通过优先活化,上调和/或下调来修饰哺乳动物组织,骨,细胞或其任何组合的遗传调控的方法。 该方法包括以下步骤:通过操纵B场幅度,上升转换速率,上升时间,下降转换速率,下降时间,频率,波长和占空比来调谐一个或多个时变刺激场的预定曲线,并且曝光 哺乳动物细胞或组织移动到具有预定特征的一个或多个调谐的时变刺激场。 哺乳动物细胞或组织的实例是软骨细胞,成骨细胞,骨细胞,破骨细胞,髓核,相关组织或任何组合。 对这些细胞,组织或骨骼的基因调控的所得到的修饰可以促进受损的哺乳动物软骨,骨骼和相关组织的保留,修复和减少。
    • 3. 发明申请
    • DEVICE AND METHOD FOR GATHERING ENSEMBLE DATA SETS
    • 用于创建数据集的设备和方法
    • US20110299640A1
    • 2011-12-08
    • US13154599
    • 2011-06-07
    • PAUL E. RACETTE
    • PAUL E. RACETTE
    • H04L27/08
    • H04L27/08G01S13/951G01S2007/2886Y02A90/18
    • An ensemble detector uses calibrated noise references to produce ensemble sets of data from which properties of non-stationary processes may be extracted. The ensemble detector comprising: a receiver; a switching device coupled to the receiver, the switching device configured to selectively connect each of a plurality of reference noise signals to the receiver; and a gain modulation circuit coupled to the receiver and configured to vary a gain of the receiver based on a forcing signal; whereby the switching device selectively connects each of the plurality of reference noise signals to the receiver to produce an output signal derived from the plurality of reference noise signals and the forcing signal.
    • 综合检测器使用校准的噪声参考来产生集合的数据,从中可以提取非平稳过程的特性。 所述集合检测器包括:接收器; 耦合到所述接收器的开关装置,所述开关装置被配置为选择性地将多个参考噪声信号中的每一个连接到所述接收器; 以及增益调制电路,其耦合到所述接收器并且被配置为基于强制信号来改变所述接收机的增益; 由此,开关装置选择性地将多个参考噪声信号中的每一个连接到接收器,以产生从多个参考噪声信号和强制信号导出的输出信号。
    • 4. 发明申请
    • Method for Producing Heavy Electrons
    • 生产重电子的方法
    • US20110255645A1
    • 2011-10-20
    • US13070552
    • 2011-03-24
    • Joseph M. Zawodny
    • Joseph M. Zawodny
    • G21B1/00
    • G21B3/00Y02E30/18
    • A method for producing heavy electrons is based on a material system that includes an electrically-conductive material is selected. The material system has a resonant frequency associated therewith for a given operational environment. A structure is formed that includes a non-electrically-conductive material and the material system. The structure incorporates the electrically-conductive material at least at a surface thereof. The geometry of the structure supports propagation of surface plasmon polaritons at a selected frequency that is approximately equal to the resonant frequency of the material system. As a result, heavy electrons are produced at the electrically-conductive material as the surface plasmon polaritons propagate along the structure.
    • 制造重电子的方法是基于选择包括导电材料的材料系统。 对于给定的操作环境,材料系统具有与其相关联的谐振频率。 形成包括非导电材料和材料体系的结构。 该结构至少在其表面上并入导电材料。 该结构的几何结构支持表面等离子体激元的传播,所选频率大约等于材料系统的谐振频率。 结果,当表面等离子体激元极化子沿结构传播时,导电材料产生重的电子。
    • 6. 发明申请
    • Use of Beam Deflection to Control an Electron Beam Wire Deposition Process
    • 使用光束偏转来控制电子束线沉积过程
    • US20100270274A1
    • 2010-10-28
    • US12751075
    • 2010-03-31
    • Karen M. TamingerWilliam H. HofmeisterRobert A. Hafley
    • Karen M. TamingerWilliam H. HofmeisterRobert A. Hafley
    • B23K15/00
    • B23K15/02
    • A method for controlling an electron beam process wherein a wire is melted and deposited on a substrate as a molten pool comprises generating the electron beam with a complex raster pattern, and directing the beam onto an outer surface of the wire to thereby control a location of the wire with respect to the molten pool. Directing the beam selectively heats the outer surface of the wire and maintains the position of the wire with respect to the molten pool. An apparatus for controlling an electron beam process includes a beam gun adapted for generating the electron beam, and a controller adapted for providing the electron beam with a complex raster pattern and for directing the electron beam onto an outer surface of the wire to control a location of the wire with respect to the molten pool.
    • 一种用于控制电子束工艺的方法,其中将熔丝熔化并沉积在作为熔池的衬底上的方法包括以复杂光栅图案生成电子束,并将光束引导到电线的外表面上,由此控制位置 电线相对于熔池。 引导梁选择性地加热线的外表面并且保持线相对于熔池的位置。 一种用于控制电子束处理的装置包括适于产生电子束的束枪,以及用于向电子束提供复杂光栅图案并用于将电子束引导到线的外表面以控制位置的控制器 的电线相对于熔池。
    • 10. 发明申请
    • Magnetic Field Response Sensor For Conductive Media
    • 用于导电介质的磁场响应传感器
    • US20090315546A1
    • 2009-12-24
    • US12533520
    • 2009-07-31
    • Stanley E. WoodardBryant Douglas Taylor
    • Stanley E. WoodardBryant Douglas Taylor
    • G01R33/12
    • G01L1/14
    • A magnetic field response sensor comprises an inductor placed at a fixed separation distance from a conductive surface to address the low RF transmissivity of conductive surfaces. The minimum distance for separation is determined by the sensor response. The inductor should be separated from the conductive surface so that the response amplitude exceeds noise level by a recommended 10 dB. An embodiment for closed cavity measurements comprises a capacitor internal to said cavity and an inductor mounted external to the cavity and at a fixed distance from the cavity's wall. An additional embodiment includes a closed cavity configuration wherein multiple sensors and corresponding antenna are positioned inside the cavity, with the antenna and inductors maintained at a fixed distance from the cavity's wall.
    • 磁场响应传感器包括设置在与导电表面固定间隔距离处的电感器,以解决导电表面的低RF透射率。 分离的最小距离由传感器响应决定。 电感应与导电表面分离,使得响应幅度超过噪声电平推荐的10 dB。 用于闭合腔测量的实施例包括在所述空腔内部的电容器和安装在空腔外部且距空腔壁的固定距离处的电感器。 另外的实施例包括封闭的腔体结构,其中多个传感器和相应的天线位于空腔内部,天线和电感器保持在离空腔壁的固定距离处。