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1. 发明授权

US08747317B2 Full-field breast ultrasound system and architechture 有权
标题翻译：全场乳房超声系统和体系结构
公开(公告)号：US08747317B2
公开(公告)日：2014-06-10
申请号：US13685064
申请日：2012-11-26
申请人： U-Systems, Inc.
发明人： Zengpin Yu , Danhua Zhao , Thomas P. Neff , Wei Zhang , Shih-Ping Wang
IPC分类号： A61B8/00
CPC分类号： A61B8/4477 , A61B8/0825 , A61B8/4281 , A61B8/4405 , A61B8/5238 , Y10T29/49005
摘要： A modular, flexible architecture for offering full-field breast ultrasound (FFBU) functionality and general-purpose ultrasound functionality in a single system is described. A conventional, general-purpose ultrasound system is modified with an FFBU toolkit to create a dual-capability ultrasound system, the dual-capability ultrasound system being able to accommodate both general-purpose ultrasound functionality and FFBU functionality, using a single ultrasound engine. Among other advantages, real-world clinical environments may enjoy cost savings for initial system procurement, space savings on clinic floors, easier and less expensive system upgrades, and the ability to use a single system and user interface for both FFBU screening and for follow-up diagnosis, biopsy, etc. Among other advantages from an ultrasound manufacturer's perspective are the ability to quickly and/or more easily come to market with an FFBU-related offering by modifying their existing general-purpose ultrasound systems with FFBU toolkits to quickly create dual-capability ultrasound systems.
摘要翻译：描述了在单个系统中提供全场乳房超声（FFBU）功能和通用超声功能的模块化，灵活的架构。使用FFBU工具包修改常规的通用超声系统，以创建双能力超声系统，双能力超声系统能够使用单个超声引擎来兼容通用超声功能和FFBU功能。除了其他优点之外，现实世界的临床环境可以节省初始系统采购成本，临床楼层节省空间，更便宜和更便宜的系统升级，以及使用单个系统和用户界面进行FFBU筛选和跟踪的功能，超声波诊断，活检等。超声波制造商的观点还有其他优点，即通过使用FFBU工具包修改现有的通用超声波系统，快速和/或更容易地与FFBU相关的产品上市，以快速创建双重能力超声系统。

2. 发明授权

US08241219B2 Compressive surfaces for ultrasonic tissue scanning 有权
标题翻译：用于超声波组织扫描的压缩表面
公开(公告)号：US08241219B2
公开(公告)日：2012-08-14
申请号：US12769440
申请日：2010-04-28
申请人： Tor C. Anderson , Jiaya Chen , Shih-Ping Wang
发明人： Tor C. Anderson , Jiaya Chen , Shih-Ping Wang
IPC分类号： A61B8/00
CPC分类号： A61B8/0825 , A61B8/406 , A61B8/4218 , A61B8/4281 , A61B8/4405 , A61B8/462 , A61B8/483
摘要： Automated ultrasonic scanning of a chestwardly compressed breast of a supine patient uses a scanning assembly that moves down to compress the breast through a membrane that is secured to the assembly across a bottom opening. A motorized ultrasound transducer moves across the breast while the breast remains downwardly compressed against the patient's chest, sending and receiving ultrasound energy through the membrane. The membrane is porous with respect to an acoustic coupling liquid that impregnates it. The transducer outputs ultrasound information that is processed to form initial planar images and then reconstructed slice images of breast tissue.
摘要翻译：仰卧患者胸部压缩乳房的自动超声波扫描使用向下移动的扫描组件，以通过穿过底部开口固定到组件的膜来压缩乳房。电动超声波换能器穿过乳房，同时乳房保持向下压迫患者的胸部，通过膜发送和接收超声能量。相对于浸渍它的声耦合液体，膜是多孔的。传感器输出被处理以形成初始平面图像，然后重建乳腺组织切片图像的超声信息。

3. 发明授权

US08162833B2 Thick-slice ultrasound images derived from ultrasonic scans of a chestwardly-compressed breast of a supine patient 有权
标题翻译：来自仰卧患者胸部压缩乳房超声扫描的厚片超声图像
公开(公告)号：US08162833B2
公开(公告)日：2012-04-24
申请号：US12890374
申请日：2010-09-24
申请人： Wei Zhang , Shih-Ping Wang , Jiayu Chen , Zengpin Yu , Tommy Earl Cupples , Thomas P. Neff , Michael E. Reed
发明人： Wei Zhang , Shih-Ping Wang , Jiayu Chen , Zengpin Yu , Tommy Earl Cupples , Thomas P. Neff , Michael E. Reed
IPC分类号： A61B8/00
CPC分类号： A61B8/5238 , A61B6/463 , A61B6/502 , A61B6/5247 , A61B6/563 , A61B8/0825 , A61B8/13 , A61B8/406 , A61B8/4281 , A61B8/4405 , A61B8/462 , A61B8/463 , A61B8/465 , A61B8/466 , A61B8/467 , A61B8/565
摘要： Displaying breast ultrasound information on an interactive user interface is described, the user interface being useful in adjunctive ultrasound mammography environments and/or ultrasound-only mammography environments. Bilateral comparison is facilitated by a pairwise display of thick-slice images corresponding to analogous slab-like subvolumes in the left and right breasts. Coronal thick-slice imaging and convenient navigation on and among coronal thick-slice images is described. In one preferred embodiment, a nipple marker is displayed the coronal thick-slice image representing a projection of a nipple location thereupon. A convenient breast icon is also displayed including a cursor position indicator variably disposed thereon in a manner that reflects a relative position between the cursor and the nipple marker. Preferably, the breast icon is configured to at least roughly resemble a clock face, the center of the clock face representing the nipple marker location. Bookmark-centric and CAD-marker-centric navigation within and among thick-slice images is also described.
摘要翻译：描述了在交互式用户界面上显示乳房超声信息，用户界面在辅助超声乳腺X线照相术环境和/或仅超声乳腺X线照相术环境中有用。通过成对显示对应于左乳房和右乳房中类似的板状子体积的双层比较来促进双边比较。描述了冠状厚片成像和冠状厚片图像之间和之间方便的导航。在一个优选实施例中，乳头标记被显示为表示其上的乳头位置的投影的冠状厚片图像。还显示方便的胸部图标，包括以反映光标和乳头标记之间的相对位置的方式可变地设置在其上的光标位置指示器。优选地，乳房图标被配置为至少大致类似于时钟面，时钟面的中心表示乳头标记位置。还描述了厚片图像内和书签中心和CAD标记为中心的导航。

4. 发明申请

US20110288414A1 FULL-FIELD BREAST IMAGE DATA PROCESSING AND ARCHIVING 有权
标题翻译：全场BREAST图像数据处理和存档
公开(公告)号：US20110288414A1
公开(公告)日：2011-11-24
申请号：US13072006
申请日：2011-03-25
申请人： Zengpin YU , Shih-Ping Wang
发明人： Zengpin YU , Shih-Ping Wang
IPC分类号： A61B8/00 , A61B6/04
CPC分类号： G06K9/00 , A61B6/502 , A61B6/5235 , A61B6/5247 , A61B8/0825 , A61B8/4405 , A61B8/5238 , G06F19/00 , G06Q10/06311 , G06Q10/063116 , G06Q50/22 , G06Q50/24
摘要： A system, computer program product, and related methods are described for obtaining, processing, and/or and archiving full-field breast image data, such as full-field breast ultrasound (FFBU) data, in a manner that promotes ready integration with current x-ray mammogram-based breast cancer screening methodologies, and which can alternatively be used to support a full-field-only environment. Two-dimensional thick-slice images computed from a three-dimensional data volume are used to facilitate efficient archiving for a breast imaging session, the two-dimensional thick-slice images corresponding to slab-like subvolumes of the breast. Clinician data overload problems that can arise from the existence of large amounts of three-dimensional full-field breast image data are reduced. Archive space is also preserved while still providing sufficient information data for future reference purposes. Related adjunctive full-field workflow methods are also described. The described embodiments are applicable to FFBU imaging and other full-field breast imaging modalities such as MRI, CT, PET, and others.
摘要翻译：描述了用于获得，处理和/或归档全场乳房图像数据（例如全场乳房超声（FFBU）数据）的系统，计算机程序产品和相关方法，以促进与当前的现场集成的方式基于X射线乳腺X线摄影的乳腺癌筛查方法，可替代地可用于支持全场仅有的环境。使用从三维数据体积计算的二维厚片图像来促进乳房成像会话的有效归档，对应于乳房的板状子体积的二维厚片图像。减少了由存在大量三维全场乳房图像数据引起的临床医生数据过载问题。存档空间也得到保留，同时仍然提供足够的信息数据以备将来参考。还描述了相关的辅助全字段工作流程方法。所描述的实施例可应用于FFBU成像和其他全场乳房成像模式，例如MRI，CT，PET等。

5. 发明授权

US07940966B2 Full-field breast image data processing and archiving 有权
标题翻译：全场乳房图像数据处理和归档
公开(公告)号：US07940966B2
公开(公告)日：2011-05-10
申请号：US10530447
申请日：2003-11-25
申请人： Zengpin Yu , Shih-Ping Wang
发明人： Zengpin Yu , Shih-Ping Wang
IPC分类号： G06K9/00
CPC分类号： G06K9/00 , A61B6/502 , A61B6/5235 , A61B6/5247 , A61B8/0825 , A61B8/4405 , A61B8/5238 , G06F19/00 , G06Q10/06311 , G06Q10/063116 , G06Q50/22 , G06Q50/24
摘要： A system, computer program product, and related methods are described for obtaining, processing, and/or and archiving full-field breast image data, such as full-field breast ultrasound (FFBU) data, in a manner that promotes ready integration with current x-ray mammogram-based breast cancer screening methodologies, and which can alternatively be used to support a full-field-only environment. Two-dimensional thick-slice images computed from a three-dimensional data volume are used to facilitate efficient archiving for a breast imaging session, the two-dimensional thick-slice images corresponding to slab-like subvolumes of the breast. Clinician data overload problems that can arise from the existence of large amounts of three-dimensional full-field breast image data are reduced. Archive space is also preserved while still providing sufficient information data for future reference purposes. Related adjunctive full-field workflow methods are also described. The described embodiments are applicable to FFBU imaging and other full-field breast imaging modalities such as MRI, CT, PET, and others.
摘要翻译：描述了用于获得，处理和/或归档全场乳房图像数据（例如全场乳房超声（FFBU）数据）的系统，计算机程序产品和相关方法，以促进与当前的现场集成的方式基于X射线乳腺X线摄影的乳腺癌筛查方法，可替代地可用于支持全场仅有的环境。使用从三维数据体积计算的二维厚片图像来促进乳房成像会话的有效归档，对应于乳房的板状子体积的二维厚片图像。减少了由存在大量三维全场乳房图像数据引起的临床医生数据过载问题。存档空间也得到保留，同时仍然提供足够的信息数据以备将来参考。还描述了相关的辅助全字段工作流程方法。所描述的实施例可应用于FFBU成像和其他全场乳房成像模式，例如MRI，CT，PET等。

6. 发明授权

US07828733B2 Coronal and axial thick-slice ultrasound images derived from ultrasonic scans of a chestwardly-compressed breast 有权
标题翻译：冠状和轴向厚片超声图像来自胸部压缩乳房的超声波扫描
公开(公告)号：US07828733B2
公开(公告)日：2010-11-09
申请号：US12545201
申请日：2009-08-21
申请人： Wei Zhang , Shih-Ping Wang , Jiayu Chen , Zengpin Yu , Tommy Earl Cupples , Thomas P. Neff , Michael E. Reed
发明人： Wei Zhang , Shih-Ping Wang , Jiayu Chen , Zengpin Yu , Tommy Earl Cupples , Thomas P. Neff , Michael E. Reed
IPC分类号： A61B8/00
CPC分类号： A61B8/5238 , A61B6/463 , A61B6/502 , A61B6/5247 , A61B6/563 , A61B8/0825 , A61B8/13 , A61B8/406 , A61B8/4281 , A61B8/4405 , A61B8/462 , A61B8/463 , A61B8/465 , A61B8/466 , A61B8/467 , A61B8/565
摘要： Displaying breast ultrasound information on an interactive user interface is described, the user interface being useful in adjunctive ultrasound mammography environments and/or ultrasound-only mammography environments. Bilateral comparison is facilitated by a pairwise display of thick-slice images corresponding to analogous slab-like subvolumes in the left and right breasts. Coronal thick-slice imaging and convenient navigation on and among coronal thick-slice images is described. In one preferred embodiment, a nipple marker is displayed the coronal thick-slice image representing a projection of a nipple location thereupon. A convenient breast icon is also displayed including a cursor position indicator variably disposed thereon in a manner that reflects a relative position between the cursor and the nipple marker. Preferably, the breast icon is configured to at least roughly resemble a clock face, the center of the clock face representing the nipple marker location. Bookmark-centric and CAD-marker-centric navigation within and among thick-slice images is also described.
摘要翻译：描述了在交互式用户界面上显示乳房超声信息，用户界面在辅助超声乳腺X线照相术环境和/或仅超声乳腺X线照相术环境中有用。通过成对显示对应于左乳房和右乳房中类似的板状子体积的双层比较来促进双边比较。描述了冠状厚片成像和冠状厚片图像之间和之间方便的导航。在一个优选实施例中，乳头标记被显示为表示其上的乳头位置的投影的冠状厚片图像。还显示方便的胸部图标，包括以反映光标和乳头标记之间的相对位置的方式可变地设置在其上的光标位置指示器。优选地，乳房图标被配置为至少大致类似于时钟面，时钟面的中心表示乳头标记位置。还描述了厚片图像内和书签中心和CAD标记为中心的导航。

7. 发明授权

US07828732B2 Breast cancer screening with adjunctive ultrasound mammography 有权
标题翻译：乳腺癌筛查与辅助超声乳房X线照相术
公开(公告)号：US07828732B2
公开(公告)日：2010-11-09
申请号：US12479468
申请日：2009-06-05
申请人： Shih-Ping Wang , Donald Chin , Fangyi Rao
发明人： Shih-Ping Wang , Donald Chin , Fangyi Rao
IPC分类号： A61B8/00
CPC分类号： A61B6/463 , A61B6/4423 , A61B6/502 , A61B6/5247 , A61B6/563 , A61B8/0825 , A61B8/406 , A61B8/462 , A61B8/463 , A61B8/464 , A61B8/465 , A61B8/467 , A61B8/469 , A61B8/5238 , A61B8/565 , G06F19/00
摘要： An adjunctive ultrasound mammography system and associated methods are described, comprising a scanning apparatus for facilitating standardized, repeatable breast ultrasound scans, and further comprising an adjunctive ultrasound display apparatus configured for fast, intuitive viewing of adjunctive ultrasound data concurrently with x-ray mammogram information. In one preferred embodiment, thick-slice ultrasound images are displayed near an x-ray mammogram such that a screening radiologist can quickly view the thick-slice images for assistance in interpreting the x-ray mammogram. Methods for concurrently acquiring and displaying vibrational resonance image (VDI) data are described. Computer-aided diagnosis (CAD) algorithms that incorporate acoustically-based feature vectors are described, the feature vectors including lateral shadow metrics, vertical shadow metrics, posterior enhancement metrics, and VDI-based metrics. Algorithms are also described that combine x-ray mammogram CAD results with adjunctive ultrasound CAD results without requiring complex image registrations therebetween. Many of the practical, economic, and political barriers to acceptance and integration of ultrasound mammography into existing mass breast cancer screening environments are mitigated.
摘要翻译：描述了辅助超声乳腺摄影系统和相关方法，其包括用于促进标准化，可重复的乳房超声扫描的扫描装置，并且还包括辅助超声显示装置，其配置为与X射线乳腺X线照相信息同时快速，直观地观看辅助超声数据。在一个优选实施例中，在x射线乳房X线照片附近显示厚片超声图像，使得筛选放射科医师可以快速查看厚切片图像以辅助解释X射线乳腺X线照片。描述了同时获取和显示振动共振图像（VDI）数据的方法。描述了包含声学特征向量的计算机辅助诊断（CAD）算法，其特征向量包括横向阴影度量，垂直阴影度量，后验增强度量和基于VDI的度量。还描述了将x射线乳房X线照片CAD结果与辅助超声CAD结果相结合的算法，而不需要它们之间的复杂图像注册。超声乳房X线照相术在现有的大规模乳腺癌筛查环境中接受和整合的许多实际，经济和政治障碍得到缓解。

8. 发明申请

US20100076311A1 THICK-SLICE PROCESSING AND DISPLAY OF INFORMATION FROM A VOLUMETRIC ULTRASOUND SCAN OF A CHESTWARDLY COMPRESSED BREAST 审中-公开
标题翻译：厚片加工和信息显示从一个西门子压缩乳头的体积超声波扫描
公开(公告)号：US20100076311A1
公开(公告)日：2010-03-25
申请号：US12441975
申请日：2007-09-21
申请人： Laszlo Tabar , Shih-Ping Wang , Tor C. Anderson , Jiayu Chen
发明人： Laszlo Tabar , Shih-Ping Wang , Tor C. Anderson , Jiayu Chen
IPC分类号： A61B8/14 , G06K9/00
CPC分类号： A61B8/0825 , A61B8/523
摘要： Systems, methods, and related computer program products for acquiring, processing, and displaying breast ultrasound information are described. In one preferred embodiment, a three-dimensional data volume of a sonographic property of a chestwardly compressed breast is acquired, and the data volume is processed to generate a plurality of two-dimensional coronal thick-slice images. Each coronal thick-slice image is representative of the sonographic property within a thick-slice subvolume of the breast substantially parallel to a coronal plane. The thick-slice subvolume has a thickness selected for optimal viewing of terminal ductal lobular unit (TDLU) patterns in a display of the thick-slice images.
摘要翻译：描述了用于获取，处理和显示乳房超声信息的系统，方法和相关的计算机程序产品。在一个优选实施例中，获取胸部压缩乳房的超声波特性的三维数据体积，并处理数据体积以产生多个二维冠状厚片图像。每个冠状厚片图像代表基本上平行于冠状面的乳房的厚切片子体积内的超声波特性。厚片子体积具有选择用于在厚片图像的显示器中最佳观看末端导管小叶单元（TDLU）图案的厚度。

9. 发明授权

US07597663B2 Adjunctive ultrasound processing and display for breast cancer screening 有权
标题翻译：辅助超声处理和显示乳腺癌筛查
公开(公告)号：US07597663B2
公开(公告)日：2009-10-06
申请号：US10305936
申请日：2002-11-27
申请人： Shih-Ping Wang , Donald Chin , Fangyi Rao , Nico Karssemeijier
发明人： Shih-Ping Wang , Donald Chin , Fangyi Rao , Nico Karssemeijier
IPC分类号： A61B8/00
CPC分类号： A61B8/5215 , A61B6/463 , A61B6/502 , A61B6/5241 , A61B6/5247 , A61B6/563 , A61B8/0825 , A61B8/406 , A61B8/4281 , A61B8/4405 , A61B8/463 , A61B8/464 , A61B8/465 , A61B8/466 , A61B8/467 , A61B8/5238 , A61B8/565 , G06F19/00
摘要： An adjunctive ultrasound mammography system and associated methods are described comprising an adjunctive ultrasound display configured for quick, intuitive, interactive viewing of data derived from volumetric ultrasound scans, the data being displayed near a conventional x-ray mammogram display. Preferred embodiments for navigating among a thick-slice image array, a selected enlarged thick-slice image, and planar ultrasound views are described, including a preferred embodiment in which the planar ultrasound views are updated in real time as a cursor is moved across an active thick-slice image. In one preferred embodiment the thick-slice images are inverted prior to display, with non-breast areas of the image preferably segmented out and reset to dark. The inverted thick-slice images are of more familiar significance to radiologists having years of expertise in analyzing conventional x-ray mammograms. For example, the inverted thick-slice images allow benign features to be more easily dismissed as compared to non-inverted thick-slice images. Preferred embodiments for computing thick-slice image values from the volumetric scan data are also described that emphasize larger mass lesions in the resulting thick-slice images, and that compensate for mass lesions that straddle thick-slice region borders.
摘要翻译：描述了一种辅助超声乳腺摄影系统和相关方法，其包括辅助性超声显示器，其配置用于快速，直观，互动地观看从体积超声扫描获得的数据，该数据显示在常规x射线乳房X线照片显示附近。描述了用于在厚片图像阵列，选定的放大的厚片图像和平面超声波视图之间导航的优选实施例，包括优选实施例，其中当光标移动到活动的时候，平面超声波视图被实时地更新厚片图像。在一个优选实施例中，厚片图像在显示之前被反转，其中图像的非乳房区域优选地被分割出并且重新设置为暗。倒置的厚片图像对于在分析常规x射线乳房X线照片方面具有多年专业知识的放射科医师更为重要。例如，与非倒置厚片图像相比，反向厚片图像允许更容易地解除良性特征。还描述了用于从体积扫描数据计算厚片图像值的优选实施例，其强调所得厚片图像中的较大质量损伤，并补偿跨越厚片区域边界的质量损伤。

10. 发明申请

US20020173719A1 METHOD AND SYSTEM FOR ULTRASOUND IMAGING OF A BIOPSY NEEDLE 有权
标题翻译：用于生物针头超声成像的方法和系统
公开(公告)号：US20020173719A1
公开(公告)日：2002-11-21
申请号：US09858221
申请日：2001-05-15
申请人： U-Systems, Inc.
发明人： Danhua Zhao , Tommy Earl Cupples , Zengpin Yu
IPC分类号： A61B008/12
CPC分类号： A61B8/0841 , A61B8/0833 , A61B2017/3413
摘要： A method, system, computer program product, and user interface for real-time ultrasonic visualization enhancement of a biopsy needle are disclosed in which a wide range of needle positions with respect to the ultrasound probe axis and with respect to the imaged plane are accommodated. Ordinary frames are compounded with special purpose frames, the special purpose frames having transmit and receive parameters adapted to highlight reception of echoes from the biopsy needle. Preferably, an elevation beam width associated with the special purpose ultrasound frames is wider than an elevation beam width associated with the ordinary ultrasound frames. Preferably, the beams of the special purpose ultrasound frames are steered such that they are incident upon the biopsy needle at an increased angle as compared to the angle of incidence for ordinary ultrasound frames. A method for automatically and adaptively determining the depth and orientation of a biopsy needle is also described, whereby beam steering parameters, focus parameters, etc. may be automatically and adaptively computed. The user may optionally provide selected beam steering parameters to the ultrasound imaging system using a simple, intuitive user interface.
摘要翻译：公开了一种用于活检针的实时超声可视化增强的方法，系统，计算机程序产品和用户界面，其中容纳相对于超声探针轴线和相对于成像平面的宽范围的针位置。普通帧与专用帧相结合，专用帧具有适于突出从活检针接收回波的发射和接收参数。优选地，与专用超声波帧相关联的仰角波束宽度比与普通超声波帧相关联的仰角波束宽度宽。优选地，专用超声波框架的梁被转向，使得它们与普通超声波框架的入射角相比以更大的角度入射到活检针上。还描述了一种用于自动和自适应地确定活检针的深度和取向的方法，由此可以自动和自适应地计算光束转向参数，聚焦参数等。使用者可以使用简单直观的用户界面来选择性地向超声成像系统提供选择的波束操纵参数。

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