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1. 发明授权

US10745730B2 Modified bacterial protein expression system 有权
公开(公告)号：US10745730B2
公开(公告)日：2020-08-18
申请号：US15764070
申请日：2016-09-28
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： Maxwell Gottesman
IPC分类号： C12N9/52 , C12P21/02 , C07K14/245 , C12N15/10 , C12N15/70
摘要： The present invention describes host cells for reliable, high yield recombinant protein production, including unstable proteins. The present host cell (e.g., a bacterial cell) is deficient in at least one protease (or a subunit of a protease) such as Clp or ClpP. The host cell may also contain an expression vector that encodes a protein or polypeptide for overexpression.

2. 发明授权

US5705532A Triple antimicrobial composition 失效
标题翻译：三重抗菌组成
公开(公告)号：US5705532A
公开(公告)日：1998-01-06
申请号：US556256
申请日：1995-11-13
申请人： Shanta Modak , Lester Sampath
发明人： Shanta Modak , Lester Sampath
IPC分类号： A01N47/44 , A01N31/08 , A01N33/12 , A01N37/52
CPC分类号： A01N47/44
摘要： The present invention relates to antimicrobial compositions comprising (i) less than or equal to two percent by weight chlorhexidine or chlorhexidine salt; (ii) less than or equal to 0.1 percent by weight of a quaternary ammonium compound such as benzalkonium chloride; and (iii) less than or equal to two percent by weight of parachlorometaxylenol. The antimicrobial compositions of the invention may be utilized in antimicrobial detergents, soaps, creams, rinses, and emulsions for use in the medical community as well as general public use.
摘要翻译：本发明涉及抗微生物组合物，其包含（i）小于或等于2重量％的氯己定或氯己定盐; （ii）小于或等于0.1重量％的季铵化合物如苯扎氯铵; 和（iii）小于或等于2％（重量）的对氯甲ax en酚。本发明的抗微生物组合物可以用于医学界中使用的抗微生物洗涤剂，肥皂，乳膏，漂洗剂和乳剂，以及一般公众使用。

3. 发明授权

US5374432A Topical anti-infective ointment containing silver or silver salts and antibiotics 失效
标题翻译：含有银或银盐和抗生素的局部抗感染软膏
公开(公告)号：US5374432A
公开(公告)日：1994-12-20
申请号：US387211
申请日：1989-07-28
申请人： Charles L. Fox, Jr., deceased , by Alan F. Ruf, legal representative , Shanta M. Modak
发明人： Charles L. Fox, Jr., deceased , by Alan F. Ruf, legal representative , Shanta M. Modak
IPC分类号： A61K31/635 , A61K33/38
CPC分类号： A61K31/70 , A61K31/635 , A61K33/38
摘要： Topical compositions for use in the treatment of burns and other infection-prone wounds and of ocular infection are provided. These compositions comprise silver or a silver salt, an antibiotic selected from among aminoglycoside antibiotics and quinolone antibiotics, with the proviso that the antibiotic is not norfloxacin; and a sterile carrier, such as water or an ointment base.
摘要翻译：提供了用于治疗烧伤和其他易感染的伤口和眼睛感染的局部组合物。这些组合物包含银或银盐，选自氨基糖苷类抗生素和喹诺酮抗生素的抗生素，条件是抗生素不是诺氟沙星; 和无菌载体，例如水或软膏基质。

4. 发明授权

US06861896B2 Circuits with dynamic biasing 有权
标题翻译：具有动态偏置电路
公开(公告)号：US06861896B2
公开(公告)日：2005-03-01
申请号：US10353200
申请日：2003-01-28
申请人： Yannis P. Tsividis , Nagendra Krishnapura
发明人： Yannis P. Tsividis , Nagendra Krishnapura
IPC分类号： H03F1/02 , H03F1/30 , H03F3/45 , H03H11/12 , H03B1/00
CPC分类号： H03F1/301 , H03F1/0266 , H03F3/45098 , H03F2203/45454 , H03H11/1213
摘要： Techniques are provided for the implementation of dynamically biased circuits. In these circuits, bias currents are varied according to signal amplitude. Benefits include reduced power dissipation, reduced noise, and increased dynamic range. The techniques can be employed in various types of circuits such as, for example, amplifiers, log-domain circuits, and filters.
摘要翻译：为实现动态偏置电路提供技术。在这些电路中，偏置电流根据信号幅度而变化。优点包括降低功耗，降低噪音，增加动态范围。这些技术可以用在各种类型的电路中，例如放大器，对数域电路和滤波器。

5. 发明授权

US5772640A Triclosan-containing medical devices 失效
标题翻译：含三氯生的医疗器械
公开(公告)号：US5772640A
公开(公告)日：1998-06-30
申请号：US583239
申请日：1996-01-05
申请人： Shanta Modak , Lester Sampath
发明人： Shanta Modak , Lester Sampath
IPC分类号： A61L15/44 , A61L27/00 , A61L27/34 , A61L27/54 , A61L29/00 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61M5/32
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/104 , A61L2300/202 , A61L2300/206 , A61L2300/404 , A61L2300/45 , Y10T428/1331 , Y10T428/1352
摘要： The present invention relates to polymeric medical articles contained the antiinfective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are contained in either hydrophilic or hydrophobic polymers.
摘要翻译：本发明涉及含有抗感染剂氯己定和三氯生的聚合物医疗制品。至少部分地基于以下发现：这些化合物之间的协同关系允许使用相对低水平的两种试剂，并且发现当这些化合物包含在亲水性或亲水性中时，可以实现有效的抗微生物活性疏水聚合物。

6. 发明授权

US07049076B2 Method for assaying protein—protein interaction 有权
公开(公告)号：US07049076B2
公开(公告)日：2006-05-23
申请号：US10888313
申请日：2004-07-09
申请人： Kevin J. Lee , Richard Axel , Walter Strapps , Gilad Barnea
发明人： Kevin J. Lee , Richard Axel , Walter Strapps , Gilad Barnea
IPC分类号： C07H21/04 , C12Q1/68 , G01N33/53 , G01N33/567 , C12N15/63 , C12Q1/60
CPC分类号： G01N33/6845 , C12N15/1055 , G01N33/9406 , G01N2333/726 , G01N2500/10
摘要： The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the use of two recombinant molecules, one of which contains the first protein a cleavage site for a proteolytic molecules, and an activator of a gene. The second recombinant molecule includes the second protein and the proteolytic molecule. If the test compound binds to the first protein, a reaction is initiated whereby the activator is cleaved, and activates a reporter gene.

7. 发明授权

US06879703B2 Method and apparatus for watermarking images 失效
标题翻译：水印图像的方法和装置
公开(公告)号：US06879703B2
公开(公告)日：2005-04-12
申请号：US10220776
申请日：2002-01-10
申请人： Ching-Yung Lin , Shih-Fu Chang
发明人： Ching-Yung Lin , Shih-Fu Chang
IPC分类号： G06T1/00 , H04N1/32 , G06K9/10
CPC分类号： G06T1/0057 , G06T1/0042 , G06T1/005 , G06T2201/0052 , G06T2201/0061 , H04N1/32165 , H04N1/32187 , H04N1/32277 , H04N1/3232 , H04N2201/3236 , H04N2201/327
摘要： Digital watermarks are embedded in image data (102)in order to enable authentication of the image data and/or replacement of rejected portions of the image data. Authentication codes are derived by comparing selected discrete cosine transform (DCT) (104) coefficients within DCT data (106) derived from the original, spatial-domain image data. The authentication codes thus generated are embedded in DCT coefficients (612) other than the ones which were used to derive the authentication codes. The resulting, watermarked data can be sent or made available to one or more recipients who can compress or otherwise use the watermarked data. Image data derived from the watermarked data—e.g, compressed versions of the watermarked data—can be authenticated by: extracting the embedded authentication codes, comparing DCT coefficients derived from the coefficients from which the original authentication codes were generated; and determining whether the compared DCT coefficients are consistent with the extracted authentication codes.
摘要翻译：数字水印被嵌入在图像数据（102）中，以便能够对图像数据进行认证和/或替换图像数据的被拒绝的部分。通过比较从原始的空间域图像数据导出的DCT数据（106）内的选定的离散余弦变换（DCT）（104）系数，导出认证码。这样生成的认证码被嵌入除了用于导出认证码的那些之外的DCT系数（612）中。所得到的水印数据可以被发送或使其可用于可压缩或以其他方式使用水印数据的一个或多个接收者。从水印数据导出的图像数据（例如，水印数据的压缩版本）可以通过以下方式来认证：提取嵌入的认证码，比较从产生原始认证码的系数导出的DCT系数; 以及确定所述比较的DCT系数是否与所提取的认证码一致。

8. 发明授权

US6106505A Triclosan-containing medical devices 失效
标题翻译：含三氯生的医疗器械
公开(公告)号：US6106505A
公开(公告)日：2000-08-22
申请号：US101129
申请日：1998-06-30
申请人： Shanta Modak , Lester Sampath
发明人： Shanta Modak , Lester Sampath
IPC分类号： A61L15/44 , A61L27/00 , A61L27/34 , A61L27/54 , A61L29/00 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61M5/32
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/104 , A61L2300/202 , A61L2300/206 , A61L2300/404 , A61L2300/45 , Y10T428/1331 , Y10T428/1352
摘要： The present invention relates to polymeric medical articles comprising the antiinfective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of antiinfective agent, for example into the bloodstream of a subject.
摘要翻译： PCT No.PCT / US96 / 20932 Sec。 371日期1998年6月30日第 102（e）日期1998年6月30日PCT 1996年12月23日PCT PCT。公开号WO97 / 25085 日期1997年7月17日本发明涉及包含抗感染剂氯己定和三氯生的聚合物医疗制品。至少部分地基于以下发现：这些化合物之间的协同关系允许使用相对低水平的两种试剂，并且发现当这些化合物包括在亲水性或亲水性中时，可以实现有效的抗微生物活性疏水聚合物。也是基于以下发现：一起使用氯己定游离碱和三氯生，更有效地掺入到聚合物医疗用品中。根据本发明制备的医疗制品提供了预防或抑制感染的优点，同时避免了抗感染剂的不期望的高释放，例如进入受试者的血液中。

9. 发明授权

US6083208A Triclosan-containing medical devices 失效
标题翻译：含三氯生的医疗器械
公开(公告)号：US6083208A
公开(公告)日：2000-07-04
申请号：US062411
申请日：1998-04-17
申请人： Shanta Modak , Sampath Lester
发明人： Shanta Modak , Sampath Lester
IPC分类号： A61L15/44 , A61L27/00 , A61L27/34 , A61L27/54 , A61L29/00 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61M25/00
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/104 , A61L2300/202 , A61L2300/206 , A61L2300/404 , A61L2300/45 , Y10T428/1331 , Y10T428/1352
摘要： The present invention relates to polymeric medical articles comprising the antiinfective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers.
摘要翻译：本发明涉及包含抗感染剂氯己定和三氯生的聚合物医疗制品。至少部分地基于以下发现：这些化合物之间的协同关系允许使用相对低水平的两种试剂，并且发现当这些化合物包括在亲水性或亲水性中时，可以实现有效的抗微生物活性疏水聚合物。

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