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1. 发明申请

US20090287141A1 Device and method for delivering therapeutic agents to an area of the body 有权
标题翻译：将治疗剂递送到身体区域的装置和方法
公开(公告)号：US20090287141A1
公开(公告)日：2009-11-19
申请号：US12152280
申请日：2008-05-13
申请人： Matthew S. Solar , Chris Ross , Martin L. Brady , Raghu Raghavan
发明人： Matthew S. Solar , Chris Ross , Martin L. Brady , Raghu Raghavan
IPC分类号： A61M5/32 , A61N1/30
CPC分类号： A61B17/34 , A61B17/3478 , A61B2017/00247 , A61B2017/00331 , A61B2018/00392 , A61M37/00 , A61M37/0069
摘要： A device, system and method deliver an agent to a soft mass, such as an area of the body, and more specifically the brain. One aspect includes creation of one or more channels, tunnels or grooves in tissue using a relatively small diameter, minimally-invasive stylet and then removing the stylet prior to infusion. The stylet-created channels become paths of increased hydraulic conductivity, through which the infusate will tend to flow and produce a predictable infusion pattern. Infusate will be carried into these channels with relatively low resistance, and then infuse outward from these channels into the surrounding tissue. By carefully positioning these channels, one can control and modify the preferred paths and duration of distribution.
摘要翻译：装置，系统和方法将药剂递送到软质量体，例如身体的区域，更具体地是脑。一个方面包括使用相对较小直径的微创管心针产生组织中的一个或多个通道，隧道或凹槽，然后在输注之前去除探针。探针创造的通道成为增加水力传导性的途径，通过该途径，输注物将倾向于流动并产生可预测的输注模式。输液将以相对较低的阻力进入这些通道，然后从这些通道向外注入周围组织。通过仔细定位这些通道，可以控制和修改分配的首选路径和持续时间。

2. 发明授权

US08582397B2 Creating, directing and steering regions of intensity of wave propagation in inhomogeneous media 有权
标题翻译：在不均匀介质中创建，指导和指导波传播强度的区域
公开(公告)号：US08582397B2
公开(公告)日：2013-11-12
申请号：US12945048
申请日：2010-11-12
申请人： Raghu Raghavan , Timothy Poston
发明人： Raghu Raghavan , Timothy Poston
IPC分类号： G10K11/34
CPC分类号： G10K11/346 , A61M37/00 , Y10T137/206
摘要： Known time reversal methods consist of three steps which may be listed as (i) the recording of signals and (ii) the time reversing of the recorded signals, and (iii) the transmission of the time-reversed signals. The first and third steps of the above process are retained, but the second step is modified. The empirical signal is transformed to fit mathematical forms taught by the mathematics of singularity and catastrophe theory that ensure a structural stability to the waveforms that will be received, when the time reversed signals are transmitted again. This structural stability ensures robustness of the waveform and the predominant direction of the flux of energy of the waveform, and improves controllability of the location of the high magnitude regions of the energy flux despite limited knowledge of the exact properties of the medium. Applications to drug delivery in the brain, and geophysical applications are envisaged.
摘要翻译：已知的时间反转方法由三个步骤组成，可以列为：（i）信号的记录和（ii）记录信号的时间反转，以及（iii）时间反转信号的传输。上述过程的第一和第三步骤被保留，但第二步被修改。经验信号被转换为适合数学形式教授的奇点和灾难理论的数学，确保结构稳定的波形将被接收，当时间反转信号被再次传输。这种结构稳定性确保波形的鲁棒性和波形能量通量的主要方向，并且尽管对介质的确切性质有所了解，但是提高了能量通量的高幅度区域的位置的可控性。应用于大脑中的药物递送以及地球物理应用。

3. 发明授权

US08545405B2 Device, methods, and control for sonic guidance of molecules and other material utilizing time-reversal acoustics 有权
标题翻译：使用时间反转声学的分子和其他材料的声波引导的装置，方法和控制
公开(公告)号：US08545405B2
公开(公告)日：2013-10-01
申请号：US12319311
申请日：2009-01-06
申请人： Raghu Raghavan , Armen P. Sarvazyan
发明人： Raghu Raghavan , Armen P. Sarvazyan
IPC分类号： A61B8/00
CPC分类号： A61M37/00 , A61B8/0816 , A61B8/445
摘要： Acoustic waves exhibit force that pushes objects along the direction of sound propagation. Precise motions require well-focused beams. The technique of time-reversal acoustics (TRA) overcomes beam distortions introduced by propagation along irregular paths to focus sound without knowledge of the medium properties. TRA requires a small receiver to be placed at a point of desired focus. The invention disclosed refines TRA by introducing data matching schemes to extend the points of focus beyond the location points of the receivers. With as few as two receivers, a large region can be manipulated with well-focused acoustic beams and with no receiver at a desired point of focus. Applications are described in drug delivery in medicine; environmental fluid contaminant control; and in oil exploration, for retrieving oil stuck in underground pockets.
摘要翻译：声波表现出沿声音传播方向推动物体的力。精确的运动需要聚焦良好的光束。时间反射声学（TRA）的技术克服了通过不规则路径传播引起的波束失真，以聚焦声音而不知道介质属性。 TRA需要将小型接收器放置在所需焦点的位置。公开的发明通过引入数据匹配方案来提炼TRA，以将焦点扩展到接收器的位置点之外。使用少至两个接收器，可以使用良好聚焦的声束并且没有接收器在期望的焦点处操纵大的区域。药物中药物描述的应用; 环境流体污染物控制; 并在石油勘探中，用于检索卡在地下袋中的油。

4. 发明授权

US07998128B2 Active delivery and flow redirection: novel devices and method of delivery of materials to patients 有权
标题翻译：主动输送和流向重定向：新型装置和向患者输送材料的方法
公开(公告)号：US07998128B2
公开(公告)日：2011-08-16
申请号：US11434080
申请日：2006-05-15
申请人： David Poston , Raghu Raghavan , Martin L. Brady
发明人： David Poston , Raghu Raghavan , Martin L. Brady
IPC分类号： A61M31/00
CPC分类号： A61M25/0026 , A61B17/3401 , A61B17/3421 , A61B2017/3419 , A61F2/82 , A61F2002/826 , A61M25/0021 , A61M25/0068 , A61M25/0069 , A61M25/0074 , A61M2025/0042 , A61M2025/0096 , A61M2025/0681
摘要： A medical device for delivering material through tissue into a defined area of a patient may comprise: a material delivery element through which the material may flow out of a delivery end; the delivery end having an opening that can be inserted through a surface of the tissue; and a sealing system proximal to the delivery end that can extend away from the material delivery element along the surface of the tissue and apply pressure to the tissue after the material delivery element has been inserted through the surface of the tissue. A physical barrier may be provided on the material delivery device to reduce back flow loss of delivered material.
摘要翻译：用于将材料通过组织输送到患者的限定区域中的医疗装置可以包括：材料递送元件，材料可以通过该材料输送元件从输送端流出; 所述输送端具有能够穿过所述组织的表面插入的开口; 以及靠近输送端的密封系统，其可以沿着组织的表面远离材料输送元件延伸，并且在材料输送元件已经穿过组织的表面插入之后对组织施加压力。可以在材料输送装置上提供物理屏障以减少输送材料的回流损失。

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