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1. 发明授权

US10898307B2 System and method for fowl vaccination 有权
公开(公告)号：US10898307B2
公开(公告)日：2021-01-26
申请号：US15538630
申请日：2015-12-21
申请人： The University of Georgia Research Foundation, Inc
发明人： Mark W Jackwood , Brian Jordan
IPC分类号： A61D7/00 , A61D1/02 , A61M11/00
摘要： A method, apparatus and system for delivery of live or attenuated viral and bacterial vaccines to fowl are described.

2. 发明申请

US20140065690A1 Avian Transgenesis and Exogenous Proteins 审中-公开
标题翻译：禽类转基因和外源蛋白
公开(公告)号：US20140065690A1
公开(公告)日：2014-03-06
申请号：US13938015
申请日：2013-07-09
申请人： The University of Georgia Research Foundation, Inc , Synageva BioPharma Corp.
发明人： Robert D. Ivarie , Alex J. Harvey , Julie A. Morris , Guodong Liu , Jeffrey C. Rapp
IPC分类号： C12N9/00 , C07K16/00
CPC分类号： C12N9/00 , A01K67/0275 , A01K2217/05 , A01K2217/072 , A01K2227/30 , A01K2267/01 , A01K2267/025 , C07K14/77 , C07K16/00 , C12N15/8509 , C12N15/86 , C12N15/902 , C12N2740/11043 , C12N2799/027 , C12N2800/30 , C12N2800/90 , C12N2830/00 , C12N2830/008 , C12N2830/40 , C12N2830/42 , C12N2830/90 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of a bird and for expressing said exogenous sequences to alter the phenotype of the bird or to produce desired proteins. In particular, transgenic chickens are produced which express exogenous sequences in their oviducts. Eggs which contain exogenous proteins are also produced.
摘要翻译：本发明提供用于将外源核酸序列稳定引入鸟类基因组并用于表达所述外源序列以改变鸟的表型或产生所需蛋白质的载体和方法。特别地，产生在其输卵管中表达外源序列的转基因鸡。也产生含有外源蛋白质的蛋。

3. 发明授权

US08030464B2 Stabilized bioactive peptides and methods of identification, synthesis, and use 有权
标题翻译：稳定的生物活性肽和鉴定，合成和使用的方法
公开(公告)号：US08030464B2
公开(公告)日：2011-10-04
申请号：US12074357
申请日：2008-03-03
申请人： Elliot Altman
发明人： Elliot Altman
IPC分类号： C07H21/02 , A61K38/00
CPC分类号： G01N33/5008 , C07K7/06 , C07K7/08 , C07K7/14 , C07K14/195 , C07K14/245 , C07K14/425 , C07K14/435 , C07K14/43536 , C07K14/43568 , C07K14/43572 , C07K14/463 , C07K14/575 , C07K14/58 , C07K14/585 , C07K14/59 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/63 , C07K14/645 , C07K14/655 , C07K14/665 , C07K2319/00 , C12N15/1037 , C12N15/62 , C12N15/635 , C12N15/67 , C12N15/72 , C40B40/02 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N33/68 , G01N33/6845
摘要： An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon. Bioactive peptides thus identified are inherently protease- and peptidase-resistant. Also provided are bioactive peptides stabilized by a stabilizing group at the N-terminus, the C-terminus, or both. The stabilizing group can be a small stable protein, such as the Rop protein, glutathione sulfotransferase, thioredoxin, maltose binding protein, or glutathione reductase, an α-helical moiety, or one or more proline residues.
摘要翻译：细胞内选择系统允许筛选肽的生物活性和稳定性。在紧密调节的表达系统中筛选随机重组肽的生物活性，优选衍生自野生型lac操纵子。因此鉴定的生物活性肽本身就是蛋白酶和肽酶抗性。还提供了在N末端，C末端或两者均由稳定基团稳定的生物活性肽。稳定基团可以是小的稳定蛋白质，例如Rop蛋白质，谷胱甘肽磺基转移酶，硫氧还蛋白，麦芽糖结合蛋白或谷胱甘肽还原酶，α-螺旋部分或一个或多个脯氨酸残基。

4. 发明申请

US20110201549A1 Enhancement of Bacillus Thuringiensis Cry Toxicities to Lesser Mealworm Alphitobius Diaperinus 审中-公开
标题翻译：苏云金芽孢杆菌对小orm ius ius ensis ry ry us us us us us us us us
公开(公告)号：US20110201549A1
公开(公告)日：2011-08-18
申请号：US13056380
申请日：2009-07-30
申请人： Michael J. Adang
发明人： Michael J. Adang
IPC分类号： A01N37/18 , A01P7/04
CPC分类号： A01N63/02 , A01N2300/00
摘要： The subject invention relates in part to the discovery that BtBooster (BtB) peptides enhance Bt strain and Cry protein toxicity to the lesser mealworm. The subject invention also relates in part to the discovery that Bt tenebrionis producing Cry3Aa crystals and Bt japonensis BuiBui producing Cry8Ca crystals are insecticidal to A. diperinus larvae (darkling beetle or lesser mealworm). The subject invention also relates in part to the discovery that fragments from cadherins of the western corn rootworm and the yellow mealworm enhance the toxicities of Bt tenebrionis and Bt japonensis BuiBui toxicity to coleopteran larvae of the genus Alphitobius. In addition, the subject invention relates in part to the use of cadherin fragments to enhance the toxicities of Cry3Aa, Cry3Bb and Cry8Ca to coleopteran larvae of the genus Alphitobius. The subject invention also relates in part to screening Bt strains and Cry proteins for toxicity to larvae of darkling beetles or lesser mealworm, Alphitobius diaperinus.
摘要翻译：本发明部分地涉及BtBooster（BtB）肽增强Bt毒株和Cry蛋白毒性对小虫虫的发现的发现。本发明还部分涉及产生Cry3Aa晶体的Bt tenebrionis和生产Cry8Ca晶体的Bt japonensis BuiBui对A.perperinus幼虫（暗甲虫或较小的蛔虫）具有杀虫作用的发现。本发明还部分涉及西方玉米根虫和黄粉虫的钙粘蛋白片段，增强了白纹枯病和Bt japonensis BuiBui对Alphitobius属鞘翅目幼虫毒性的毒性。此外，本发明部分地涉及钙粘蛋白片段用于增强Cry3Aa，Cry3Bb和Cry8Ca对Alphitobius属鞘翅目幼虫的毒性的用途。本发明还部分地涉及筛选Bt菌株和Cry蛋白质，以对于暗甲虫或更少的蛔虫Alphitobius diaperinus的幼虫具有毒性。

5. 发明授权

US07679058B2 Systems and method for predicting the lime requirement in soils 失效
标题翻译：用于预测土壤中石灰需求的系统和方法
公开(公告)号：US07679058B2
公开(公告)日：2010-03-16
申请号：US11792807
申请日：2005-12-15
申请人： David E. Kissel , Miguel L. Cabrera
发明人： David E. Kissel , Miguel L. Cabrera
IPC分类号： G01J5/02
CPC分类号： G01N21/359 , G01N21/274 , G01N21/3563 , G01N21/80 , G01N33/24
摘要： Methods and systems related to soil testing are disclosed. One exemplary embodiment of a system of the present disclosure includes a calibrated near-infrared (NIR) spectrophotometer and a soil sample with an unknown value of at least one of pH and b disposed in proximity to the calibrated NIR spectrophotometer, the NIR spectrophotometer configured to produce a spectrum from a reading of the sample.
摘要翻译：公开了与土壤测试相关的方法和系统。本公开的系统的一个示例性实施例包括校准的近红外（NIR）分光光度计和具有未知值的pH和b中至少一个的土壤样品，其设置在校准的近红外分光光度计附近，所述NIR分光光度计被配置为从样品的读数产生光谱。

6. 发明申请

US20090297913A1 Nanostructure-Enhanced stereo-electrodes for fuel cells and biosensors 审中-公开
标题翻译：纳米结构 - 用于燃料电池和生物传感器的增强立体电极
公开(公告)号：US20090297913A1
公开(公告)日：2009-12-03
申请号：US12382861
申请日：2009-03-25
申请人： Guigen Zhang , Venkataramani Anandan
发明人： Guigen Zhang , Venkataramani Anandan
IPC分类号： H01M8/10 , H01M8/00 , H01M4/86 , H01M2/02 , G01N27/26 , C25D5/02
CPC分类号： H01M4/8626 , B82Y30/00 , C12Q1/001 , C23C18/54 , C25D1/02 , C25D1/04 , C25D3/34 , C25D3/48 , C25D5/48 , C25D11/045 , C25D11/20 , H01M4/8803 , H01M4/8817 , H01M4/8853 , H01M4/9016 , H01M4/92 , H01M4/921 , H01M8/0297 , H01M8/08 , H01M8/10 , H01M8/1004 , H01M2300/0011 , H01M2300/0068 , Y02P70/56
摘要： This application provides nanostructure-enhanced stereo-electrodes. The application also provides novel ways to manufacture nanostructure-enhanced electrodes. In some embodiments, the invention also provides methods of use for devices equipped with the nanostructure-enhanced stereo-electrodes.
摘要翻译：该应用提供纳米结构增强的立体电极。该应用还提供了制造纳米结构增强电极的新方法。在一些实施例中，本发明还提供了装备有纳米结构增强立体电极的器件的使用方法。

7. 发明申请

US20060078920A1 Methods to identify and quantify oligosaccharide modifications of glycoproteins 有权
标题翻译：鉴定和定量糖蛋白寡糖修饰的方法
公开(公告)号：US20060078920A1
公开(公告)日：2006-04-13
申请号：US11223323
申请日：2005-09-08
申请人： J. Pierce
发明人： J. Pierce
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6804 , C12Q2561/125 , C12Q2531/113
摘要： Methods are disclosed for identifying oligosaccharides found on proteins and identifying those that are modified in disease states.
摘要翻译：公开了用于鉴定在蛋白质上发现的寡糖并鉴定在疾病状态中被修饰的寡糖的方法。

8. 植物专利

USPP15798P2 Goatsbeard plant named ‘Misty Lace’ 有权
标题翻译：山羊植物名为“迷雾蕾丝”
公开(公告)号：USPP15798P2
公开(公告)日：2005-06-14
申请号：US10738072
申请日：2003-12-17
申请人： Allan M. Armitage , Hazel Y. Wetzstein
发明人： Allan M. Armitage , Hazel Y. Wetzstein
IPC分类号： A01H5/00 , A01H5/02
CPC分类号： A01H5/02
摘要： A Goatsbeard Plant named ‘Misty Lace’ is a hybrid between Aruncus dioicus and Aruncus aethusifolius, and bears distinct habit, having perfect flowers that are borne in feathery, elongate terminal panicles.
摘要翻译：名为“薄雾蕾丝”的山羊皮植物是云杉（Aruncus dioicus）和亚麻（Aruncus aethusifolius）之间的混合物，具有独特的习惯，具有完美的花朵，其羽毛状，细长的末端圆锥花序。

9. 发明申请

US20040158882A1 Novel vectors in avian transgenesis 有权
标题翻译：鸟类转基因新型载体
公开(公告)号：US20040158882A1
公开(公告)日：2004-08-12
申请号：US10696671
申请日：2003-10-28
申请人： AviGenics, Inc. , The University of Georgia Research Foundation, Inc
发明人： Robert D. Ivarie , Alex J. Harvey , Julie A. Morris , Guodong Liu
IPC分类号： C12Q001/68 , A01K067/027 , C12N015/86
CPC分类号： C12N9/00 , A01K67/0275 , A01K2217/05 , A01K2217/072 , A01K2227/30 , A01K2267/01 , A01K2267/025 , C07K14/77 , C07K16/00 , C12N15/8509 , C12N15/86 , C12N15/902 , C12N2740/11043 , C12N2799/027 , C12N2800/30 , C12N2800/90 , C12N2830/00 , C12N2830/008 , C12N2830/40 , C12N2830/42 , C12N2830/90 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of a bird and for expressing said exogenous sequences to alter the phenotype of the bird or to produce desired proteins. In particular, transgenic chickens are produced which express exogenous sequences in their oviducts. Eggs which contain exogenous proteins are also produced.
摘要翻译：本发明提供用于将外源核酸序列稳定引入鸟类基因组并用于表达所述外源序列以改变鸟的表型或产生所需蛋白质的载体和方法。特别地，产生在其输卵管中表达外源序列的转基因鸡。也产生含有外源蛋白质的蛋。

10. 发明申请

US20030022156A2 Transducing Phages 有权
标题翻译：转化噬菌体
公开(公告)号：US20030022156A2
公开(公告)日：2003-01-30
申请号：US09796318
申请日：2001-02-28
申请人： The University of Georgia Research Foundation, Inc.
发明人： Dr. Janet Westpheling , Julie A. Burke
IPC分类号： C12Q001/70 , C12N015/86 , C12N015/74
CPC分类号： C12R1/465 , C12N15/76 , C12R1/91
摘要： Abstract of DisclosureThe present invention is directed to isolated transducing phages, methods of isolating transducing phages, and methods of using transducing phages including, for instance, transferring at least one nucleic acid fragment from a donor microbe to a recipient microbe, and producing a secondary metabolite from a microbe. The transducing phages typically have a broad host range, and transduce microbes in the Order Actinomycetales, in particular in the Family Streptomycetaceae, including Streptomyces coelicolor, Streptomyces lividans, Streptomyces venezuelae, Streptomyces avermitilis, and Saccharopolyspora erythraea. The transducing phages can be specialized transducing phages or generalized transducing phages.
摘要翻译：公开摘要本发明涉及分离的转导噬菌体，分离转导噬菌体的方法，以及使用转导噬菌体的方法，包括例如将至少一个核酸片段从给受体微生物的供体微生物，并从微生物产生次级代谢物。转导噬菌体通常具有广泛的宿主范围，并且在放线菌纲中转导微生物，特别是在家族链霉菌科，包括天蓝色链霉菌（Streptomyces coelicolor），变形链霉菌（Streptomyces lividans），维生素链霉菌（Streptomyces venezuelae），阿维链霉菌（Streptomyces avermitilis）和糖酵母（Saccharopolyspora erythraea）中。转导噬菌体可以是专门的转化噬菌体或广泛转导的噬菌体。

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