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1. 发明授权

US5217953A Vasoactive intestinal peptide antagonist 失效
标题翻译：血管活性肠肽拮抗剂
公开(公告)号：US5217953A
公开(公告)日：1993-06-08
申请号：US620410
申请日：1990-11-30
申请人： Illana Gozes , Douglas E. Brenneman , Mati M. Fridkin , Terry Moody
发明人： Illana Gozes , Douglas E. Brenneman , Mati M. Fridkin , Terry Moody
IPC分类号： A61K38/00 , C07K7/08 , C07K14/575
CPC分类号： C07K7/083 , C07K14/57563 , A61K38/00 , Y10S930/17
摘要： The present invention relates to a peptide encoding an antagonist of VIP. The invention also relates to a method of using said peptide to antagonize VIP function. The invention further relates to a pharmaceutical composition.
摘要翻译：本发明涉及编码VIP拮抗剂的肽。本发明还涉及使用所述肽拮抗VIP功能的方法。本发明还涉及药物组合物。

2. 发明授权

US4341870A Cultivatable human rotavirus type 2 失效
标题翻译：可培养人类轮状病毒2型
公开(公告)号：US4341870A
公开(公告)日：1982-07-27
申请号：US208389
申请日：1980-11-19
申请人： Richard G. Wyatt , Walter D. James , Edward H. Bohl , Kenneth W. Theil , Linda J. Saif , Anthony R. Kalica , Harry B. Greenberg , Albert Z. Kapikian , Robert M. Chanock
发明人： Richard G. Wyatt , Walter D. James , Edward H. Bohl , Kenneth W. Theil , Linda J. Saif , Anthony R. Kalica , Harry B. Greenberg , Albert Z. Kapikian , Robert M. Chanock
IPC分类号： A61K39/15 , C12N7/08 , A61K39/12
CPC分类号： C12N7/00 , A61K39/12 , A61K39/15 , C12N2720/12334 , C12N2720/12364
摘要： This invention relates to a precursor or intermediate for a rotavirus vaccine to protect infants and young children against diarrhea caused by rotavirus. The invention is the efficient propagation of a strain of human rotavirus type 2 prepared by a method of cultivation by multiple passages in vivo in gnotobiotic piglets and by multiple passages in vitro subsequently in AGMK (African green monkey kidney) cell cultures. Additionally, rotavirus is treated with a biologically active amount of trypsin prior to growth in AGMK cells, and the inoculated cell cultures are centrifuged at a low centrifugal force before incubation.
摘要翻译：本发明涉及轮状病毒疫苗的前体或中间体，用于保护婴儿和幼儿免受由轮状病毒引起的腹泻。本发明是在AGMK（非洲绿猴肾）细胞培养物中，通过在体内多次通过生物体仔猪和体外多次传代培养的方法制备的人轮状病毒2型菌株的有效繁殖。另外，轮状病毒在AGMK细胞中生长之前用生物活性量的胰蛋白酶处理，接种的细胞培养物在孵育前以低离心力离心。

3. 发明授权

US09090873B2 Development of dengue virus vaccine components 有权
标题翻译：发展登革热病毒疫苗组件
公开(公告)号：US09090873B2
公开(公告)日：2015-07-28
申请号：US13692557
申请日：2012-12-03
申请人： The United States of America, as represented by the Secretary of the Department of Health and Human Services
发明人： Stephen S. Whitehead , Joseph E. Blaney , Brian R. Murphy , Ching-Juh Lai
IPC分类号： A61K39/12 , A61K39/295 , A61K48/00 , C12N7/01 , C12N7/04 , C12N15/40 , C12N15/83 , C07K14/005 , C07K14/18 , C12N7/00 , A61K39/00
CPC分类号： C12N7/045 , A61K2039/5254 , C07K14/005 , C07K14/1825 , C12N7/00 , C12N2770/24122 , C12N2770/24162 , Y02A50/386
摘要： The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3′untranslated region (3′-UTR) comprising a Δ30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR that removes sequence in the 5′direction as far as the 5′boundary of the TL-3 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, or a replacement of the 3′-UTR of a dengue virus of a first serotype with the 3′-UTR of a dengue virus of a second serotype, optionally containing the Δ30 mutation and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR; and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus.
摘要翻译：本发明涉及包含在每个登革热病毒血清型1中除去TL-2同源结构的＆Dgr 30突变的3'非翻译区（3'-UTR）中的突变的登革热病毒或嵌合登革热病毒，2,3和4，以及从3'-UTR缺失的＆Dgr 30突变体附加的核苷酸，其除去在每个的TL-3同源结构中的5'方向上的序列登革热病毒血清型1,2,3和4，或用第二血清型登革病毒的3'-UTR替换第一血清型登革病毒的3'-UTR，任选含有'Dgr 30 来自3'-UTR缺失的＆Dgr 30突变的突变和核苷酸; 和免疫原性组合物，诱导免疫应答的方法，以及产生登革热病毒或嵌合登革病毒的方法。

4. 发明授权

US08778671B2 Construction of West Nile virus and dengue virus chimeras for use in a live virus vaccine to prevent disease caused by West Nile virus 有权
标题翻译：建立西尼罗病毒和登革热病毒嵌合体，用于活病毒疫苗，以预防西尼罗病毒引起的疾病
公开(公告)号：US08778671B2
公开(公告)日：2014-07-15
申请号：US10871775
申请日：2004-06-18
申请人： Alexander G. Pletnev , Joseph R. Putnak , Robert M. Chanock , Brian R. Murphy , Stephen S. Whitehead , Joseph E. Blaney, Jr.
发明人： Alexander G. Pletnev , Joseph R. Putnak , Robert M. Chanock , Brian R. Murphy , Stephen S. Whitehead , Joseph E. Blaney, Jr.
IPC分类号： C07H21/04 , A61K39/00
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2770/24122 , C12N2770/24134 , C12N2770/24143 , C12N2770/24162 , C12Q1/6888 , Y02A50/386 , Y02A50/394
摘要： The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines.
摘要翻译：本发明涉及建立在用于产生免疫原性，活的，减毒的西尼罗病毒疫苗的登革病毒骨架上的减毒，免疫原性的西尼罗病毒嵌合体。

5. 发明授权

US06900024B2 T cell receptor ligands and methods of using same 失效
标题翻译： T细胞受体配体及其使用方法
公开(公告)号：US06900024B2
公开(公告)日：2005-05-31
申请号：US10193473
申请日：2002-07-10
申请人： Ronald N. Germain , Luigi Racioppi , Franca Ronchese-Le Gros
发明人： Ronald N. Germain , Luigi Racioppi , Franca Ronchese-Le Gros
IPC分类号： A61K38/00 , A61K39/12 , A61K39/395 , A61P37/02 , C07K14/725 , C07K14/74 , C07K14/80 , C07K16/28 , G01N33/567 , G01N33/53
CPC分类号： C07K14/80 , A61K38/00 , C07K14/70539 , Y10S530/868
摘要： The present invention concerns TCR ligands with immunomodulatory properties, as well as methods of identifying such ligands and of using such ligands to modulate T cell effector responses.
摘要翻译：本发明涉及具有免疫调节特性的TCR配体，以及鉴定此类配体和使用这些配体调节T细胞效应物应答的方法。

6. 发明授权

US5672354A Treated bird seed preferentially palatable to birds but not palatable to animals having capsaicin sensitive receptors 失效
标题翻译：经过处理的鸟类种子优先适合鸟类，但对具有辣椒素敏感性受体的动物无法适应
公开(公告)号：US5672354A
公开(公告)日：1997-09-30
申请号：US596807
申请日：1996-02-05
申请人： Peter M. Blumberg
发明人： Peter M. Blumberg
IPC分类号： A01N37/40 , A01N37/10 , A01N43/90 , A23K1/16 , A23K1/18 , A61K36/81
CPC分类号： A23K50/70 , A23K20/111 , Y10S426/805 , Y10S514/918
摘要： The present invention is directed to preparations of birdseed treated with capsaicin or capsaicin derivatives or analogues thereof in an amount sufficient to be unpalatable to animals having capsaicin sensitive receptors, and more specifically to mammals such as rodents. These "hot" compounds, extracts or whole plant material containing these compounds may be coated on, impregnated in or combined (e.g., mixed) with birdseed to repel troublesome mammals which recognize these compounds as "hot". These "hot" compounds, in contrast, will not repel birds because birds do not recognize these compounds as "hot" since they do not have capsaicin sensitive receptors. The invention is further directed to a method of selectively repelling animals having capsaicin sensitive receptors, which comprises feeding the treated birdseed of the invention to birds, in an amount effective for repelling animals having capsaicin sensitive receptors, thereby discouraging said animals from eating the treated birdseed.
摘要翻译：本发明涉及用辣椒素或辣椒素衍生物或其类似物处理的足以使具有辣椒素敏感性受体的动物具有足够好的量的鸟类制品，更具体地说涉及哺乳动物如啮齿动物。这些“热”化合物，提取物或含有这些化合物的整个植物材料可以被涂覆，浸渍或与鸟or组合（例如混合）以排斥将这些化合物识别为“热”的麻烦的哺乳动物。相比之下，这些“热”化合物不会排斥鸟类，因为鸟类不会将这些化合物识别为“热”，因为它们没有辣椒素敏感受体。本发明进一步涉及一种选择性排斥具有辣椒素敏感性受体的动物的方法，其包括将经治疗的本发明鸟类给予鸟类，其量可有效地排斥具有辣椒素敏感性受体的动物，从而阻止所述动物进食经过治疗的bird鸟。

7. 发明授权

US5258627A Semiconductor structure using protein as its active element 失效
标题翻译：使用蛋白质作为其活性元素的半导体结构
公开(公告)号：US5258627A
公开(公告)日：1993-11-02
申请号：US802305
申请日：1991-12-04
申请人： Luca Turin
发明人： Luca Turin
IPC分类号： G01R31/26 , H01L51/30 , H01L29/28
CPC分类号： G01R31/2648 , B82Y10/00 , H01L51/0093
摘要： A method and apparatus of testing semiconductor properties of a protein. Mercury electrodes are formed in an aqueous solution of protein and protein is adsorbed of the surface of the mercury electrodes. The electrical properties of the protein adsorbed thereon can be determined by applying current and voltage thereto.
摘要翻译：测试蛋白质的半导体性质的方法和装置。汞电极在蛋白质水溶液中形成，蛋白质被吸附在汞电极表面。可以通过向其上施加电流和电压来确定吸附在其上的蛋白质的电学性质。

8. 发明授权

US5221693A Antimicrobial and antiviral bis-adamantanamine compounds 失效
标题翻译：抗微生物和抗病毒双金刚烷胺化合物
公开(公告)号：US5221693A
公开(公告)日：1993-06-22
申请号：US888438
申请日：1992-05-28
申请人： B. Vithal Shetty
发明人： B. Vithal Shetty
IPC分类号： C07C279/26
CPC分类号： C07C279/265 , C07C2103/74
摘要： Several bis-adamantanamine compounds have been found to have a broad range of antiviral and antibacterial activities. Demonstrated activity against enveloped viruses, yeasts, fungi, gram positive and gram negative bacteria is shown.
摘要翻译：已经发现几种双金刚烷胺化合物具有广泛的抗病毒和抗菌活性。显示了对包膜病毒，酵母菌，真菌，革兰氏阳性菌和革兰氏阴性菌的活性。

9. 发明授权

US5126129A Cancer therapy using interleukin-2 and flavone compounds 失效
标题翻译：使用白介素-2和黄酮化合物的癌症治疗
公开(公告)号：US5126129A
公开(公告)日：1992-06-30
申请号：US649182
申请日：1991-02-04
申请人： Robert H. Wiltrout , Ronald Hornung
发明人： Robert H. Wiltrout , Ronald Hornung
IPC分类号： A61K38/20
CPC分类号： A61K38/2013
摘要： Treatment of Cancer with Flavones and Interleukin 2.
摘要翻译：用黄酮和白细胞介素2治疗癌症。

10. 发明授权

US5120720A Preparation of lipophile:hydroxypropylcyclodextrin complexes by a method using co-solubilizers 失效
标题翻译：通过使用CO溶剂的方法制备脂质：羟丙基胆碱酯复合物
公开(公告)号：US5120720A
公开(公告)日：1992-06-09
申请号：US585792
申请日：1990-09-20
申请人： Josef Pitha , Juan J. Torres-Labandeira , Tetsumi Irie
发明人： Josef Pitha , Juan J. Torres-Labandeira , Tetsumi Irie
IPC分类号： A61K9/18 , A61K47/48
CPC分类号： B82Y5/00 , A61K47/48969
摘要： The dissolution of lipophilic compounds in aqueous solutions of hydroxypropylcyclodextrins can be accelerated by the addition of co-solubilizers, such as ethanol or ammonia, which again can be removed, together with water, by evaporation or by freeze-drying leaving lipophile: hydroxypropylcyclodextrin complexes as a residue. The co-solubilizer method was used successfully with steroid drugs (5-androstene-3.beta.,17.beta.-diol, 4-androstene-3,17-dione, dehydroepiandrosterone, dexamethasone, 5-.alpha.-dihydro-testosterone, 6-methylprednisolone, and testosterone), peptides (gramicidin S) and a macrocyclic antibiotic (amphotericin B). The complexes prepared in this manner were amorphous and possessed satisfactory stability.
摘要翻译：亲水性化合物在羟丙基环糊精的水溶液中的溶解可以通过加入共增溶剂如乙醇或氨来加速，这可以通过蒸发或通过冷冻干燥再次与水一起除去，使亲脂性：羟丙基环糊精复合物作为一个残留物使用辅助增溶剂方法，使用类固醇药物（5-雄甾烯-3β，17β-二醇，4-雄甾烯-3,17-二酮，脱氢表雄酮，地塞米松，5α-二氢睾酮，6-甲基泼尼松龙，和睾丸激素），肽（短杆菌肽S）和大环抗生素（两性霉素B）。以这种方式制备的络合物是无定形的并且具有令人满意的稳定性。

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