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    • 4. 发明申请
    • Combination cancer therapy with a GST-activated anticancer compound and another anticancer therapy
    • 组合癌症治疗与GST活化的抗癌化合物和另一种抗癌疗法
    • US20080159980A1
    • 2008-07-03
    • US11872659
    • 2007-10-15
    • Hua XuGail L. BrownSteven R. SchowJames G. Keck
    • Hua XuGail L. BrownSteven R. SchowJames G. Keck
    • A61K31/664A61K38/20A61K38/21A61K39/395A61K31/704A61P35/00
    • A61K45/06A61K31/282A61K31/337A61K31/475A61K31/5377A61K31/70A61K38/05A61K2300/00
    • A method of combination cancer therapy in a mammal, especially a human, by administering a therapeutically effective amount of a GST-activated anticancer compound and a therapeutically effective amount of another anticancer therapy, that is, an anticancer therapy that is not a treatment with a GST- activated anticancer compound (including chemotherapy; molecular targeted therapy; biologic therapy; and radiotherapy, used as monotherapy or in combination). Pharmaceutical compositions, products, and kits for the method. The use of a GST-activated anticancer compound in the manufacture of a medicament for the method. A method of potentiating an anticancer therapy in a mammal, especially a human, comprising administering a therapeutically effective amount of a GST-activated anticancer compound to the mammal being treated with the anticancer therapy. The use of a GST-activated anticancer compound in the manufacture of a medicament for the method. The GST-activated anticancer compound is preferably a compound of U.S. Pat. No. 5,556,942, and more preferably TLK286, especially as the hydrochloride salt.
    • 通过施用治疗有效量的GST活化的抗癌化合物和治疗有效量的另一种抗癌疗法,即哺乳动物,特别是人的组合癌症治疗的方法,即不是治疗的抗癌疗法 GST活化的抗癌化合物(包括化学疗法;分子靶向治疗;生物治疗和放疗,用作单一疗法或组合)。 用于该方法的药物组合物,产品和试剂盒。 使用GST活化的抗癌化合物在制备该方法的药物中的用途。 一种增强哺乳动物,特别是人类抗癌疗法的方法,包括向用抗癌疗法治疗的哺乳动物施用治疗有效量的GST活化抗癌化合物。 使用GST活化的抗癌化合物在制备该方法的药物中的用途。 GST活化的抗癌化合物优选为美国专利No. 更优选TLK 286,特别是作为盐酸盐。