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1. 发明授权

US5990286A Antibodies with reduced net positive charge 失效
标题翻译：具有减少净正电荷的抗体
公开(公告)号：US5990286A
公开(公告)日：1999-11-23
申请号：US781449
申请日：1997-01-10
申请人： Leslie A. Khawli , Alan L. Epstein
发明人： Leslie A. Khawli , Alan L. Epstein
IPC分类号： A61K38/00 , A61K51/10 , A61P37/02 , C07K16/30 , A61K39/395 , C07K16/00
CPC分类号： C07K16/3046 , A61K51/1045 , C07K16/30 , C07K16/3061 , A61K38/00 , C07K2317/54
摘要： Modified antibodies which have been by chemical conjugation with agents reactive with free amino groups are disclosed. Among the chemical agents disclosed for use in connection with the invention are heterobifunctional reagents and biotin. The use of these modified antibodies in the diagnosis and therapy of cancer and other mammalian disease is also disclosed. Diagnostic uses include immunoscintography. The modified antibodies may be further conjugated with labels or biologically active molecules for use in diagnosis and therapy. The modified antibodies may also be formulated into pharmaceutical compositions for these purposes.
摘要翻译：公开了通过与与游离氨基反应的试剂化学共轭的修饰抗体。公开的与本发明有关的化学试剂是异双功能试剂和生物素。还公开了这些修饰的抗体在癌症和其它哺乳动物疾病的诊断和治疗中的用途。诊断用途包括免疫印迹。修饰的抗体可以进一步与标记或生物活性分子缀合用于诊断和治疗。为了这些目的，修饰的抗体也可以配制成药物组合物。

2. 发明授权

US6017514A Detection of necrotic malignant tissue and associated therapy 失效
标题翻译：检测坏死性恶性组织及相关治疗
公开(公告)号：US6017514A
公开(公告)日：2000-01-25
申请号：US268543
申请日：1999-03-11
申请人： Alan L. Epstein , Clive R. Taylor
发明人： Alan L. Epstein , Clive R. Taylor
IPC分类号： A61K38/00 , A61K47/48 , A61K49/04 , A61K49/16 , A61K51/10 , C07K16/30 , G01N33/574 , A61K49/00 , G01N31/00 , G01N33/48
CPC分类号： G01N33/57496 , A61K47/48384 , A61K47/48569 , A61K49/04 , A61K49/16 , A61K51/1018 , A61K51/1045 , C07K16/30 , C07K16/3061 , A61K2121/00 , A61K2123/00 , A61K38/00 , C07K2317/54
摘要： Disclosed is a method for measuring the effectiveness of therapy intended to kill malignant cells in vivo in a mammal, comprising the steps of obtaining monoclonal antibody that is specific to an internal cellular component of the mammal but not to external cellular components, wherein the monoclonal antibody is labeled; contacting the labeled antibody with tissue of a mammal that has received therapy to kill malignant cells in vivo, and determining the effectiveness of the therapy by measuring the binding of the labeled antibody to the internal cellular component. The internal cellular component is preferably insoluble intracellular antigen, and the label is preferably a radionuclide, a radiopaque material, or a magnetic resonance-enhancing material. Also disclosed is a method whereby the antibody to insoluble intracellular antigen is conjugated to an antineoplastic agent, so that upon administration of the antibody-antineoplastic agent conjugate, antineoplastic agent may be delivered to the tumor. Also disclosed are antibodies for use with the foregoing methods.
摘要翻译：公开了一种测量用于在哺乳动物体内杀死恶性细胞的治疗效果的方法，包括以下步骤：获得对哺乳动物的内部细胞成分特异但不与外部细胞成分特异的单克隆抗体，其中单克隆抗体被标记使标记的抗体与已经接受治疗以在体内杀死恶性细胞的哺乳动物的组织接触，并通过测量标记的抗体与内部细胞组分的结合来确定治疗的有效性。内部细胞组分优选为不溶性细胞内抗原，并且标记物优选为放射性核素，不透射线材料或磁共振增强材料。还公开了一种使不溶性细胞内抗原的抗体与抗肿瘤剂缀合的方法，使得在施用抗体 - 抗肿瘤剂缀合物时，可将抗肿瘤药递送至肿瘤。还公开了与上述方法一起使用的抗体。

3. 发明授权

US6071491A Detection of necrotic malignant tissue and associated therapy 失效
标题翻译：检测坏死性恶性组织及相关治疗
公开(公告)号：US6071491A
公开(公告)日：2000-06-06
申请号：US370367
申请日：1999-08-09
申请人： Alan L. Epstein , Clive R. Taylor
发明人： Alan L. Epstein , Clive R. Taylor
IPC分类号： A61K38/00 , A61K47/48 , A61K49/04 , A61K49/16 , A61K51/10 , C07K16/30 , G01N33/574 , A61K51/00 , A61M36/14
CPC分类号： G01N33/57496 , A61K47/48384 , A61K47/48569 , A61K49/04 , A61K49/16 , A61K51/1018 , A61K51/1045 , C07K16/30 , C07K16/3061 , A61K2121/00 , A61K2123/00 , A61K38/00 , C07K2317/54
摘要： Disclosed are methods for identifying the presence of a tumor in a mammal, comprising the steps of obtaining an antibody against cell ghosts, wherein the antibody is specific to an intracellular antigen not present on the cell surface of normal or neoplastic cells, and wherein the antibody is labeled with a label capable of being imaged; administering the antibody to the mammal, thereby permitting the antibody to bind preferentially to necrotic tissue; and imaging the binding of the antibody to the necrotic tissue, wherein a localized concentration of said antibody is indicative of the presence of a tumor. The antibodies used in these methods are preferably monoclonal antibodies, are also preferably specific for one or more nuclear proteins, and are also preferably labeled with one or more radionuclides. Also disclosed are antibodies for use with the foregoing methods.
摘要翻译：公开了用于鉴定哺乳动物肿瘤存在的方法，包括以下步骤：获得针对细胞重影的抗体，其中所述抗体对于不存在于正常或肿瘤细胞的细胞表面上的细胞内抗原是特异性的，并且其中所述抗体标有能够成像的标签; 向哺乳动物施用抗体，从而允许抗体优先结合坏死组织; 以及成像抗体与坏死组织的结合，其中所述抗体的局部浓度指示肿瘤的存在。这些方法中使用的抗体优选是单克隆抗体，也优选对一种或多种核蛋白是特异性的，并且还优选用一种或多种放射性核素标记。还公开了与上述方法一起使用的抗体。

4. 发明授权

US5194594A Modified antibodies 失效
标题翻译：改良抗体
公开(公告)号：US5194594A
公开(公告)日：1993-03-16
申请号：US579375
申请日：1990-09-07
申请人： Leslie A. Khawli , Alan L. Epstein
发明人： Leslie A. Khawli , Alan L. Epstein
IPC分类号： G01N33/532 , A61K39/395 , A61K45/00 , A61K47/48 , A61K51/00 , A61K51/10 , A61P35/00 , A61P35/02 , A61P37/00 , C07K16/00 , C07K16/18 , C07K16/30
CPC分类号： C07K16/00 , A61K47/48369 , A61K47/48715 , A61K51/10 , A61K51/1063 , A61K51/1069 , C07K16/30 , C07K16/3046 , C07K16/3061 , A61K2121/00 , A61K2123/00
摘要： Modified antibodies are disclosed which have been modified by chemical conjugation with a heterobifunctional reagent, such as SPDP. The use of these modified antibodies in the diagnosis and therapy of cancer and other mammalian disease is also disclosed. Diagnostic uses include immunoscintography. The modified antibodies may be further conjugated with labels or biologically active molecules for use in such diagnosis and therapy. The modified antibodies may also be formulated into pharmaceutical compositions for these purposes.
摘要翻译：公开了已经通过与异双功能试剂如SPDP化学共轭修饰的修饰抗体。还公开了这些修饰的抗体在癌症和其它哺乳动物疾病的诊断和治疗中的用途。诊断用途包括免疫印迹。修饰的抗体可以进一步与标记或生物活性分子缀合用于这种诊断和治疗。为了这些目的，修饰的抗体也可以配制成药物组合物。

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