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1. 发明授权

US09336916B2 Tc-99m produced by proton irradiation of a fluid target system 有权
标题翻译：通过流体靶系统的质子照射产生的Tc-99m
公开(公告)号：US09336916B2
公开(公告)日：2016-05-10
申请号：US13106634
申请日：2011-05-12
申请人： Nigel R. Stevenson
发明人： Nigel R. Stevenson
IPC分类号： G21G1/10 , G21G1/00
CPC分类号： G21G1/001 , G21G1/10 , G21G2001/0042
摘要： Methods for producing Tc-99m radioisotope by proton irradiation of a fluid target matrix. A method of producing Tc-99m includes irradiating a fluid target matrix comprising Mo-100 with a proton beam to transform at least a portion of Mo-100 to Tc-99m. Optionally, the fluid target matrix further includes at least one of O-18, O-16, or N-14, which upon exposure to the proton beam concurrently transform at least a portion of O-18 to F-18, at least a portion of O-16 to N-13, at least a portion of the O-16 to O-15, or at least a portion of N-14 to C-11. The method further includes isolating Tc-99m and optionally at least one of F-18, N-13, O-15, or C-11 from the irradiated fluid target matrix. An additional source of Tc-99m is available from the decay of Mo-99 that is co-produced from the Mo-100 during irradiation with the proton beam.
摘要翻译：通过流体靶基质的质子照射来生产Tc-99m放射性同位素的方法。制备Tc-99m的方法包括用质子束照射包含Mo-100的流体靶基质以将至少一部分Mo-100转化为Tc-99m。任选地，流体目标基质还包括O-18，O-16或N-14中的至少一种，其在暴露于质子束时同时将至少一部分O-18转化为F-18，至少一种 O-16至N-13的部分，O-16至O-15的至少一部分，或N-14至C-11的至少一部分。该方法还包括从照射的流体靶基质中分离出Tc-99m和任选的F-18，N-13，O-15或C-11中的至少一种。从质子束照射期间Mo-100共同生产的Mo-99的衰变可获得额外的Tc-99m源。

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