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1. 发明申请

US20110280357A1 Tc-99m PRODUCED BY PROTON IRRADIATION OF A FLUID TARGET SYSTEM 有权
标题翻译： Tc-99m由流体目标系统的原子辐照产生
公开(公告)号：US20110280357A1
公开(公告)日：2011-11-17
申请号：US13106634
申请日：2011-05-12
申请人： Nigel R. Stevenson
发明人： Nigel R. Stevenson
IPC分类号： G21G1/10
CPC分类号： G21G1/001 , G21G1/10 , G21G2001/0042
摘要： Methods for producing Tc-99m radioisotope by proton irradiation of a fluid target matrix. A method of producing Tc-99m includes irradiating a fluid target matrix comprising Mo-100 with a proton beam to transform at least a portion of Mo-100 to Tc-99m. Optionally, the fluid target matrix further includes at least one of O-18, O-16, or N-14, which upon exposure to the proton beam concurrently transform at least a portion of O-18 to F-18, at least a portion of O-16 to N-13, at least a portion of the O-16 to O-15, or at least a portion of N-14 to C-11. The method further includes isolating Tc-99m and optionally at least one of F-18, N-13, O-15, or C-11 from the irradiated fluid target matrix. An additional source of Tc-99m is available from the decay of Mo-99 that is co-produced from the Mo-100 during irradiation with the proton beam.
摘要翻译：通过流体靶基质的质子照射来生产Tc-99m放射性同位素的方法。制备Tc-99m的方法包括用质子束照射包含Mo-100的流体靶基质以将至少一部分Mo-100转化为Tc-99m。任选地，流体目标基质还包括O-18，O-16或N-14中的至少一种，其在暴露于质子束时同时将至少一部分O-18转化为F-18，至少一种 O-16至N-13的部分，O-16至O-15的至少一部分，或N-14至C-11的至少一部分。该方法还包括从照射的流体靶基质中分离出Tc-99m和任选的F-18，N-13，O-15或C-11中的至少一种。从质子束照射期间Mo-100共同生产的Mo-99的衰变可获得额外的Tc-99m源。

2. 发明授权

US06750756B2 Use of isotopes to provide information to an article 失效
标题翻译：使用同位素向文章提供信息
公开(公告)号：US06750756B2
公开(公告)日：2004-06-15
申请号：US10213917
申请日：2002-08-07
申请人： Nigel R. Stevenson , John M. Dawson , Lee Heflinger
发明人： Nigel R. Stevenson , John M. Dawson , Lee Heflinger
IPC分类号： G08B1314
CPC分类号： G01N24/08 , G01R33/441 , G07D7/14 , G07F7/086
摘要： A method for associating information with an article, an isotopic labeling composition to label an article with information using at least two different isotopes of an element, and an article labeled with the labeling composition. In the labeling composition, the isotopes of the labeling composition have an abundance ratio that is detectably different from the natural abundance ratio thereof. By detecting the abundance ratio(s) of the isotopes in the labeling composition, via laser ablation/magnetic spectroscopy, an NQR spectrometer, an NMR spectrometer, an IR spectrometer, or a microwave spectrometer, information about the article can be determined. The method and labeling composition may be used to identify, authenticate or determine the source or origin of an article or to provide detailed information about an article.
摘要翻译：用于将信息与物品相关联的方法，使用至少两种元素的不同同位素标记具有信息的物品的同位素标记组合物和用标记组合物标记的物品的方法。在标记组合物中，标记组合物的同位素具有与其天然丰度比可检测地不同的丰度比。通过检测标记组合物中的同位素的丰度比例，通过激光烧蚀/磁光谱，NQR光谱仪，NMR光谱仪，IR光谱仪或微波光谱仪，可以确定关于该物品的信息。方法和标签组合物可用于识别，鉴定或确定物品的来源或来源，或提供有关物品的详细信息。

3. 发明授权

US09336916B2 Tc-99m produced by proton irradiation of a fluid target system 有权
标题翻译：通过流体靶系统的质子照射产生的Tc-99m
公开(公告)号：US09336916B2
公开(公告)日：2016-05-10
申请号：US13106634
申请日：2011-05-12
申请人： Nigel R. Stevenson
发明人： Nigel R. Stevenson
IPC分类号： G21G1/10 , G21G1/00
CPC分类号： G21G1/001 , G21G1/10 , G21G2001/0042
摘要： Methods for producing Tc-99m radioisotope by proton irradiation of a fluid target matrix. A method of producing Tc-99m includes irradiating a fluid target matrix comprising Mo-100 with a proton beam to transform at least a portion of Mo-100 to Tc-99m. Optionally, the fluid target matrix further includes at least one of O-18, O-16, or N-14, which upon exposure to the proton beam concurrently transform at least a portion of O-18 to F-18, at least a portion of O-16 to N-13, at least a portion of the O-16 to O-15, or at least a portion of N-14 to C-11. The method further includes isolating Tc-99m and optionally at least one of F-18, N-13, O-15, or C-11 from the irradiated fluid target matrix. An additional source of Tc-99m is available from the decay of Mo-99 that is co-produced from the Mo-100 during irradiation with the proton beam.
摘要翻译：通过流体靶基质的质子照射来生产Tc-99m放射性同位素的方法。制备Tc-99m的方法包括用质子束照射包含Mo-100的流体靶基质以将至少一部分Mo-100转化为Tc-99m。任选地，流体目标基质还包括O-18，O-16或N-14中的至少一种，其在暴露于质子束时同时将至少一部分O-18转化为F-18，至少一种 O-16至N-13的部分，O-16至O-15的至少一部分，或N-14至C-11的至少一部分。该方法还包括从照射的流体靶基质中分离出Tc-99m和任选的F-18，N-13，O-15或C-11中的至少一种。从质子束照射期间Mo-100共同生产的Mo-99的衰变可获得额外的Tc-99m源。

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