专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110318770A1 COMPOSITIONS, KITS AND METHODS FOR DETERMINING PLASMIN ACTIVITY 审中-公开
标题翻译：组合物，用于测定血浆活性的试剂盒和方法
公开(公告)号：US20110318770A1
公开(公告)日：2011-12-29
申请号：US13145875
申请日：2010-02-05
申请人： Kevin Yarbrough , Maria Cruz , Pete Vandeberg
发明人： Kevin Yarbrough , Maria Cruz , Pete Vandeberg
IPC分类号： C12Q1/37 , C07K5/093
CPC分类号： G01N33/582 , C07K5/0812 , C12Q1/56 , G01N33/52 , G01N2333/968 , G01N2500/02
摘要： Compositions, kits, and methods for determining plasmin activity using a fluorogenic peptide substrate are provided.
摘要翻译：提供了使用荧光肽底物测定纤溶酶活性的组合物，试剂盒和方法。

2. 发明申请

US20110213126A1 TWO-STAGE ULTRAFILTRATION/DIAFILTRATION 有权
标题翻译：两级超声波/双相
公开(公告)号：US20110213126A1
公开(公告)日：2011-09-01
申请号：US12937454
申请日：2009-04-14
申请人： Martin Gonzalez , Woody D. Wood , Fred H. Earp
发明人： Martin Gonzalez , Woody D. Wood , Fred H. Earp
IPC分类号： C07K1/34
CPC分类号： C07K16/065 , C07K1/30 , C07K1/34 , C07K1/36
摘要： The present invention provides a method for concentrating a protein, in particular a method for concentrating a plasma product, in particular IgG, using glycine in a (two-stage ultrafiltration/diafiltration approach.
摘要翻译：本发明提供了一种浓缩蛋白质的方法，特别是使用甘氨酸在（两级超滤/渗滤方法）中浓缩血浆产物，特别是IgG的方法。

3. 发明申请

US20120009650A1 COMPOSITIONS, METHODS AND KITS FOR PREPARING PLASMINOGEN AND PLASMIN PREPARED THEREFROM 有权
标题翻译：用于制备血浆和制剂的组合物，方法和试剂盒
公开(公告)号：US20120009650A1
公开(公告)日：2012-01-12
申请号：US13147491
申请日：2010-03-02
申请人： Edward Koepf , Myies Lindsay , Rebecca Silverstein , Jennifer Hunt , James Rebbeor , Thomas Zimmerman , Charles Miller , Anthony Caronna , Kenya Stokes
发明人： Edward Koepf , Myies Lindsay , Rebecca Silverstein , Jennifer Hunt , James Rebbeor , Thomas Zimmerman , Charles Miller , Anthony Caronna , Kenya Stokes
IPC分类号： C12N9/68 , C07K14/435 , C07K1/18
CPC分类号： C12N9/6435 , C12Y304/21007
摘要： Compositions and methods for preparing plasminogen, in particular recombinant plasminogen, and compositions and methods of utilizing same for preparing plasmin are provided.
摘要翻译：提供了制备纤溶酶原的组合物和方法，特别是重组纤溶酶原，以及其用于制备纤溶酶的组合物和方法。

4. 发明申请

US20100304465A1 Recombinantly Modified Plasmin 有权
标题翻译：重组改良的纤溶酶
公开(公告)号：US20100304465A1
公开(公告)日：2010-12-02
申请号：US11568023
申请日：2005-04-21
申请人： Jennifer A. Hunt , Valery Novokhatny
发明人： Jennifer A. Hunt , Valery Novokhatny
IPC分类号： C12N9/50 , C07H21/04 , C12N15/63 , C12N1/00
CPC分类号： C12N9/6435 , C12Y304/21007
摘要： Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme.
摘要翻译：提供了与重组修饰的纤溶酶（原）分子相关的多核苷酸和多肽。纤溶酶原（Ogen）分子在天然人纤溶酶原分子中存在活化位点的N-末端单个三环结构域，并显示与天然酶相关的赖氨酸结合和显着的酶特征。

5. 发明申请

US20110237781A1 METHOD OF PREPARING ALPHA-1 PROTEINASE INHIBITOR 审中-公开
标题翻译：制备ALPHA-1蛋白酶抑制剂的方法
公开(公告)号：US20110237781A1
公开(公告)日：2011-09-29
申请号：US13002429
申请日：2009-07-17
申请人： Wytold Lebing , Scott A. Cook , Christopher A. Dadd
发明人： Wytold Lebing , Scott A. Cook , Christopher A. Dadd
IPC分类号： C07K1/36
CPC分类号： C07K14/8125
摘要： Purification of α-1 proteinase inhibitor (α-1 PI) from solutions comprising α-1 PI is accomplished using hydrophobic interaction chromatography (HIC). In some embodiments, purification of α-1 PI is accomplished by precipitation of contaminating proteins from a starting solution comprising α-1 PI, such as human plasma, followed by anion exchange resin chromatography prior to HIC. Further purification may be accomplished by an optional cation exchange chromatography subsequent to anion exchange chromatography but prior to HIC. Some embodiments of the invention also include virus removal and/or inactivation by methods such as nano filtration and such as contact with a non-ionic detergent. The methods of the present invention result in greater yield, purity, and pathogenic clearance of plasma fractions than known methods.
摘要翻译：使用疏水相互作用色谱（HIC）实现从包含α-1 PI的溶液中纯化α-1蛋白酶抑制剂（α-1 PI）。在一些实施方案中，通过从包含α-1PI的起始溶液（例如人血浆）中沉淀污染性蛋白，然后在HIC之前进行阴离子交换树脂色谱来完成α-1 PI的纯化。进一步纯化可以通过阴离子交换层析之后但在HIC之前的任选的阳离子交换层析来完成。本发明的一些实施方案还包括通过诸如纳米过滤的方法和诸如与非离子型洗涤剂接触的病毒去除和/或灭活。与已知方法相比，本发明的方法产生更高的产量，纯度和血浆级分的致病性清除。

6. 发明申请

US20110201077A1 COMPOSITION, METHOD, AND KIT FOR PREPARING PLASMIN 有权
标题翻译：用于制备PLASMIN的组合物，方法和试剂盒
公开(公告)号：US20110201077A1
公开(公告)日：2011-08-18
申请号：US12995447
申请日：2009-06-03
申请人： Edward Koepf , Thomas Zimmerman
发明人： Edward Koepf , Thomas Zimmerman
IPC分类号： C12N11/00 , C12N9/68
CPC分类号： C12N11/10 , C07K14/3153 , C12N9/6435 , C12Y304/21007
摘要： A streptokinase immobilized on a surface, in particular an immobilized plasmin-resistant streptokinase, and compositions, methods and kits of utilizing same for preparing plasmin are provided.
摘要翻译：提供固定在表面上的链激酶，特别是固定的纤溶酶抗性链激酶，以及用于制备纤溶酶的组合物，方法和试剂盒。

7. 发明申请

US20110004411A1 METHOD FOR ADJUSTING RESULTS OF A POLYMERASE CHAIN REACTION (PCR) INSTRUMENT 有权
标题翻译：调整聚合酶链反应（PCR）仪器结果的方法
公开(公告)号：US20110004411A1
公开(公告)日：2011-01-06
申请号：US12742801
申请日：2008-11-11
申请人： Justin M. Paul , Burton D. Beames
发明人： Justin M. Paul , Burton D. Beames
IPC分类号： G06F19/00 , C12Q1/68
CPC分类号： C12Q1/6851 , C12Q1/686 , C12Q2537/165 , C12Q2561/113
摘要： Methods of managing results of a real-time polymerase chain reaction (PCR) instrument and software associated with such methods are described herein. One disclosed method, among others, comprises calculating, from results of the real-time PCR instrument, a fluorescence signal of a sample during a cycle of a baseline period of the real-time PCR instrument. The method further comprises determining whether or not the fluorescence signal during the baseline period increases by at least a certain percentage compared to cycles outside the baseline period. The sample is flagged as a potentially high-titer sample when the fluorescence signal increases by at least the certain percentage.
摘要翻译：本文描述了管理实时聚合酶链式反应（PCR）仪器和与这些方法相关的软件的结果的方法。一种公开的方法，其中包括从实时PCR仪器的结果计算在实时PCR仪器的基线周期的循环期间样品的荧光信号。该方法还包括确定基线期间内的荧光信号是否与基线周期之外的周期相比增加至少一定百分比。当荧光信号增加至少一定百分比时，样品被标记为潜在的高滴度样品。

8. 发明申请

US20100093982A1 DEVICE AND METHOD FOR PRECIPITATION OF PEPTIDES 失效
标题翻译：用于降解肽的装置和方法
公开(公告)号：US20100093982A1
公开(公告)日：2010-04-15
申请号：US12520117
申请日：2007-11-27
申请人： Hans-Jurgen Henzler , Stephan Kirchner , Dirk Havekost , Klaus Kaiser , Jörg Kauling , Richard Pasquinelli , Rolf Treckmann
发明人： Hans-Jurgen Henzler , Stephan Kirchner , Dirk Havekost , Klaus Kaiser , Jörg Kauling , Richard Pasquinelli , Rolf Treckmann
IPC分类号： C07K1/30
CPC分类号： C07K1/30
摘要： The present invention relates to a method for precipitation of peptide where the mixing step of the peptide with the precipitation aid and the precipitation itself are specially separated.
摘要翻译：本发明涉及肽的沉淀方法，其中肽与沉淀助剂的混合步骤和沉淀本身被特别分离。

9. 发明授权

US06969515B2 Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin 有权
标题翻译：通过局部递送可逆灭活的酸化纤溶酶进行溶栓治疗的方法
公开(公告)号：US06969515B2
公开(公告)日：2005-11-29
申请号：US10280444
申请日：2002-10-25
申请人： Gary J. Jesmok , Kyle A. Landskroner
发明人： Gary J. Jesmok , Kyle A. Landskroner
IPC分类号： A61K20060101 , A61K38/00 , A61K38/48 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/26 , C12N9/68
CPC分类号： C12N9/6435 , A61K9/0019 , A61K38/4833 , A61K38/484 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/26 , C12Y304/21007
摘要： Methods of thrombolysis that allow the use of a fibrinolytic composition comprising reversibly inactivated acidified plasmin and the localized delivery of the plasmin to a vascular thrombotic occlusion are disclosed. Further disclosed is a method for administering a therapeutic dose of a fibrinolytic composition substantially free of plasminogen activator to a human or animal having a vascular thrombotic occlusion. The fibrinolytic composition includes a reversibly inactivated acidified plasmin substantially free of plasminogen activator. Intravascular catheter delivery of the fibrinolytic composition directly into or in the immediate vicinity of the thrombus is disclosed to minimize the systemic degradation of fibrin while retaining the maximum plasmin activity against the thrombus. The method is applicable to the dissolution of thrombi in artificial devices, e.g., hemodialysis grafts.
摘要翻译：公开了允许使用包含可逆灭活的酸化纤溶酶的纤维蛋白溶解组合物以及将纤溶酶局限性递送至血管性血栓闭塞的溶栓方法。进一步公开的是一种治疗剂量的基本上不含纤溶酶原激活剂的纤维蛋白溶解组合物给予具有血管性血栓闭塞的人或动物的方法。纤维蛋白溶解组合物包括基本上不含纤溶酶原激活物的可逆失活的酸化纤溶酶。公开了将纤维蛋白溶解组合物直接进入或紧邻血栓的血管内导管递送，以使纤维蛋白的全身降解最小化，同时保留针对血栓的最大纤溶酶活性。该方法适用于血栓在人造装置中的溶解，例如血液透析移植物。

10. 发明授权

US07871608B2 Reversibly inactivated acidified plasmin 有权
标题翻译：可逆灭活的酸化纤溶酶
公开(公告)号：US07871608B2
公开(公告)日：2011-01-18
申请号：US12197617
申请日：2008-08-25
申请人： Thomas P. Zimmerman , Valery Novokhatny , Shan Jiang , James Colandene
发明人： Thomas P. Zimmerman , Valery Novokhatny , Shan Jiang , James Colandene
IPC分类号： C12N9/48 , C12N9/72 , C13N9/68
CPC分类号： C12N9/6435 , A61K38/4833 , A61K38/484 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/26 , C12N9/96 , C12N9/99 , C12Y304/21007
摘要： A method of treating a subject, the method including administring a composition that includes a reversibly inactivated acidfied plasmin substantially free of a plasminogen activator, in a low buffering capacity buffer, wherein the composition is a solution suitable for pharmacenutical use that can be raised to physiological pH by adding no more than about 5 volumes of serum to the solution relative to a volume of the solution.
摘要翻译：一种治疗受试者的方法，所述方法包括在低缓冲容量缓冲液中施用包含基本上不含纤溶酶原激活物的可逆失活的酸性纤溶酶的组合物，其中所述组合物是适于药物使用的溶液，其可以升高至生理通过相对于一定体积的溶液向该溶液中加入不超过约5体积的血清的pH。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式