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1. 发明授权

US3914293A Naphthyl acetaldehyde derivatives; methods of use thereof; and processes for the preparation thereof 失效
标题翻译：萘乙醛衍生物; 使用方法; 及其制备方法
公开(公告)号：US3914293A
公开(公告)日：1975-10-21
申请号：US49238174
申请日：1974-07-29
申请人： SYNTEX CORP
发明人： FRIED JOHN H , HARRISON IAN T
IPC分类号： C07C57/40 , C07C57/42 , C07C57/46 , C07C57/50 , C07C57/58 , C07C57/60 , C07C59/64 , C07C59/84 , C07C309/24 , C07C309/41 , C07D317/22 , C07C143/42
CPC分类号： C07C45/41 , C07C45/673 , C07C57/40 , C07C57/42 , C07C57/46 , C07C57/50 , C07C57/58 , C07C57/60 , C07C59/64 , C07C59/84 , C07C251/72 , C07C309/24 , C07D317/22 , C07C47/277 , C07C47/27
摘要： 2-(2''-Naphthyl) acetaldehyde derivatives optionally substituted at the 2 position and/or positions C-1'', 4'', 5'', 7'' or 8''; and/or position C-6'' or positions C-5'' and 7'' exhibit anti-inflammatory, analgesic, antipyretic and anti-pruritic activity.
摘要翻译：任选在2位和/或C-1'，4'，5'，7'或8'位置取代的2-（2'-萘基）乙醛衍生物; 和/或位置C-6'或位置C-5'和7'表现出抗炎，镇痛，解热和抗瘙痒活性。

2. 发明授权

US3898281A Naphthyl acetaldehyde imines 失效
标题翻译：萘乙醛亚胺
公开(公告)号：US3898281A
公开(公告)日：1975-08-05
申请号：US46401774
申请日：1974-04-25
申请人： SYNTEX CORP
发明人： FRIED JOHN H , HARRISON IAN T
IPC分类号： C07C43/20 , C07C45/46 , C07C57/46 , C07C57/58 , C07C57/60 , C07C119/00
CPC分类号： C07C251/72 , C07C43/202 , C07C45/41 , C07C45/46 , C07C57/46 , C07C57/58 , C07C57/60 , C07C47/277 , C07C49/84
摘要： 2-(2''-Naphthyl) acetaldehyde derivatives optionally substituted at the 2 position and/or positions C-1'', 4'',5'',7'' or 8''; and/or position C-6'' or positions C-5'' and 7'' exhibit anti-inflammatory, analgesic, antipyretic and anti-pruritic activity.
摘要翻译：任选在2位和/或C-1'，4'，5'，7'或8'位置取代的2-（2'-萘基）乙醛衍生物; 和/或位置C-6'或位置C-5'和7'表现出抗炎，镇痛，解热和抗瘙痒活性。

3. 发明授权

US3865883A 1,2,3,4,9,12-Hexahydrophenanthrenes 失效
标题翻译： 1,2,3,4,9,12-六氢卟吩
公开(公告)号：US3865883A
公开(公告)日：1975-02-11
申请号：US23580872
申请日：1972-03-17
申请人： SYNTEX CORP
发明人： EDWARDS JOHN A , FRIED JOHN H
IPC分类号： C07C49/755 , C07C51/09 , C07C51/235 , C07C51/29 , C07C51/36 , C07C51/377 , C07C51/41 , C07C57/44 , C07C59/68 , C07C59/90 , C07C171/07
CPC分类号： C07C59/90 , C07C49/755 , C07C51/09 , C07C51/235 , C07C51/29 , C07C51/36 , C07C51/377 , C07C51/41 , C07C57/44 , C07C59/68 , C07C2603/26 , C07C62/34 , C07C62/32 , C07C62/38
摘要： New compounds of the 1,2,3,4,9,12-hexahydrophenanthrene class, useful as estrogenic and anti-fertility agents, and methods for their preparation. 1 Alpha -Ethyl-2 Alpha -carboxy-2 Beta methyl-7-methoxy-1,2,3,4,9,12-hexahydrophenanthrene is exemplified as illustrative of the class.
摘要翻译：可用作雌激素和抗生育剂的1,2,3,4,9,12-六氢菲类的新化合物及其制备方法。 1个α-乙基-2α-羧基-2β-甲基-7-甲氧基-1,2,3,4,9,12-六氢菲作为该类的说明。

4. 发明授权

US3859309A Production of unsaturated carbocyclic ketones 失效
标题翻译：生产不饱和碳氢化合物
公开(公告)号：US3859309A
公开(公告)日：1975-01-07
申请号：US19938971
申请日：1971-11-16
申请人： SYNTEX CORP
发明人： FRIED JOHN H
IPC分类号： C07C45/59 , C07C49/603 , C07C49/67 , C07C59/64 , C07C59/90 , C07D261/08 , C07D261/18 , C07D295/084 , C07D309/10 , C07D309/12 , C07D311/94 , C07D317/16 , C07F9/535 , C07F9/54 , C07F9/653 , C07F9/655 , C07D13/04
CPC分类号： C07D295/084 , C07C45/59 , C07C59/64 , C07C59/90 , C07C2603/16 , C07D261/08 , C07D261/18 , C07D309/10 , C07D309/12 , C07D311/94 , C07D317/16 , C07F9/5352 , C07F9/5442 , C07F9/653 , C07F9/65515 , C07F9/65586 , C07C49/67
摘要： Preparation of Alpha , Beta -unsaturated carbocyclic ketones by reacting a methylene phosphonium ylid or a mono-substituted methylene phosphonium ylid with an enol lactone.

5. 发明授权

US3855247A Production of unsaturated carbocyclic ketones 失效
标题翻译：生产不饱和碳氢化合物
公开(公告)号：US3855247A
公开(公告)日：1974-12-17
申请号：US19847671
申请日：1971-11-12
申请人： SYNTEX CORP
发明人： FRIED J
IPC分类号： C07C45/59 , C07C49/597 , C07C49/683 , C07C59/215 , C07C59/68 , C07D311/94 , C07D317/20 , C07D317/72 , C07F9/653 , C07F9/655 , C07F9/6558 , C07D13/08
CPC分类号： C07D317/72 , C07C45/60 , C07C59/215 , C07C59/68 , C07C2603/16 , C07D311/94 , C07D317/20 , C07F9/653 , C07F9/655 , C07F9/65586 , C07C49/597
摘要： Preparation of Alpha , Beta -unsaturated carbocyclic ketones by reacting an enol lactone with a carbanion generated by treatment of a methylphosphonate or a mono-substituted methylphosphonate with base.
摘要翻译：通过使烯醇内酯与通过用碱处理甲基膦酸酯或单取代的甲基膦酸酯产生的碳负离子反应来制备α，β-不饱和碳环酮。

6. 发明授权

US3852363A Naphthyl acetaldehyde derivatives; method of use thereof; and processes for the preparation thereof 失效
标题翻译：萘甲醛衍生物使用方法及其制备方法
公开(公告)号：US3852363A
公开(公告)日：1974-12-03
申请号：US25073372
申请日：1972-05-05
申请人： SYNTEX CORP
发明人： FRIED J , HARRISON I
IPC分类号： C07C43/20 , C07C57/40 , C07C57/42 , C07C57/46 , C07C57/50 , C07C57/60 , C07C59/64 , C07C59/84
CPC分类号： C07C43/315 , C07C43/303 , C07C45/41 , C07C45/673 , C07C57/40 , C07C57/42 , C07C57/46 , C07C57/50 , C07C57/60 , C07C59/64 , C07C59/84 , C07C251/72 , C07C47/277 , C07C47/27
摘要： 2-(2''-Napthyl) acetaldehyde derivatives optionally substituted at the 2 position and/or positions C-1'',4'',5'',7'' or 8''; and/or position C-6'' or positions C-5'' and 7'' exhibit anti-inflammatory, analgesic, antipyretic and anti-pruritic activity.
摘要翻译：任选在2位和/或C-1'，4'，5'，7'或8'位置取代的2-（2'-萘基）乙醛衍生物; 和/或位置C-6'或位置C-5'和7'表现出抗炎，镇痛，解热和抗瘙痒活性。

7. 发明授权

US3803245A Process for preparing 2-(6-methoxy-2-naphthyl)propionic acid,and intermediate therefor 失效
标题翻译：制备2-（6-甲氧基-2-萘基）丙酸及其中间体的方法
公开(公告)号：US3803245A
公开(公告)日：1974-04-09
申请号：US25229172
申请日：1972-05-11
申请人： SYNTEX CORP
发明人： LODEWIJK E
IPC分类号： C07C59/64 , B01J27/00 , C07C45/46 , C07C51/00 , C07C67/00 , C07C43/20 , C07C43/28
CPC分类号： C07C45/46 , C07C49/84
摘要： 2- (6 - METHOXY -2 - NAPHTHYL)PROPIONIC ACID IS PREPARED BY TREATING 6-METHOXY-2-(1-PROPYNYL) NAPHTHALENE WITH A THALLIC SALT, SUCH AS THALLIUM TRINITRATE, AND A LOWER ALKANOL TO YIELD THE CORRESPONDING ESTER OF 2-(6-METHOXY2-NAPHTHYL)PROPINOIC ACID WHICH IS HYDROLYZED TO THE DESIRED PROPIONIC ACID COMPOUND. THE COMPOUND IS, PREFERABLY, RESOLVED TO YIELD THE BIOLOGICALLY ACTIVE D ISOMER, THE PRODUCT HAS ANTI-INFLAMMATORY, ANALGESIC AND ANTIPYRETIC ACTIVITIES.

8. 发明授权

US3795244A Inhalation device 失效
标题翻译：吸入装置
公开(公告)号：US3795244A
公开(公告)日：1974-03-05
申请号：US3795244D
申请日：1973-02-02
申请人： SYNTEX CORP
发明人： LAX R , HERD A
IPC分类号： A61M15/00 , A61M15/06
CPC分类号： A61M15/0028 , A61M15/0033 , A61M2202/064 , A61M2206/16
摘要： An inhalation device having means to engage the free end of a powdered medicament-holding capsule as the capsule is pierced to provide outlet ports for the powdered medicament held therein. Such engagement ensures that the capsule is completely seated in the rotary member on which it is supported and thus ensures that the outlet ports are positioned at the desired locations adjacent the shoulder of the capsule. Additionally, such engagement enables the piercing operation to be conducted in any orientation of the inhalation device. The rotary member, which supports the capsule during inhalation, is itself supported by a shaft having a polygon shaped base having n sides. The rotary member has a hollow sleeve which fits over the shaft, the sleeve having a polygon shaped inner surface having at least n + 1 sides. During inhalation which causes the rotary member to spin about the supporting shaft, contact of the adjacent polygon shaped surfaces with each other positively causes the walls of the capsule to undergo repeated changes or radial acceleration whereby the powdered medicament is dispersed from the capsule.
摘要翻译：一种吸入装置，其具有在胶囊被刺穿时接合粉末状药物保持胶囊的自由端的装置，以提供保持在其中的粉末状药物的出口。这种接合确保胶囊完全就位于其所支撑的旋转构件中，从而确保出口端口位于邻近胶囊肩部的所需位置。此外，这种接合使得能够在吸入装置的任何取向上进行刺穿操作。在吸入期间支撑胶囊的旋转部件本身由具有n个侧面的多边形基部的轴支撑。旋转构件具有装配在轴上的中空套筒，套筒具有至少n + 1个侧面的多边形形状的内表面。在使旋转构件围绕支撑轴旋转的吸入期间，相邻的多边形形状的表面彼此接触积极地导致胶囊的壁经历反复的变化或径向加速，由此粉末状药物从胶囊中分散。

9. 发明授权

US3793148A Microbiological reduction of 1,3,-dioxo-2-alkylcycloalkanes 失效
标题翻译： 1,3-二氧代-2-烷基胆碱的微生物降解
公开(公告)号：US3793148A
公开(公告)日：1974-02-19
申请号：US3793148D
申请日：1972-07-24
申请人： SYNTEX CORP
发明人： LANZILOTTA R
IPC分类号： C12P7/26 , C12P7/38 , C12B1/00
CPC分类号： C12R1/645 , C12P7/26 , C12P7/38 , C12R1/85 , Y10S435/911 , Y10S435/94 , Y10S435/942
摘要： An improved method of microbiologically reducing a 1,3-dioxo-2alkylcycloalkane using members of a group of compounds which increase the production of the 1 Beta -hydroxy-2 Beta -alkyl-3oxocycloalkane product. The products are useful as intermediates in the total synthesis of useful steroid compounds. Alkyl alcohol and acrylonitrile are illustrated as representative of the useful group of compounds.
摘要翻译：使用增加1β-羟基-2β-烷基-3-氧代环烷烃产物产生的一组化合物的成员来微生物还原1,3-二氧代-2-烷基环烷烃的改进方法。该产品可用作有用类固醇化合物的全合成中的中间体。示出了烷基醇和丙烯腈作为有用的化合物组的代表。

10. 发明授权

US3744493A Implanter having an improved cartridge ejector 失效
标题翻译：具有改进的盒式喷枪的植绒
公开(公告)号：US3744493A
公开(公告)日：1973-07-10
申请号：US3744493D
申请日：1972-01-10
申请人： SYNTEX CORP
发明人： BOOHER K , VAN LOOZEN G
IPC分类号： A61M37/00 , A61D7/00 , A61M5/00
CPC分类号： A61M37/0069
摘要： A pellet implanter includes a tubular body having a movable plunger therein extending from the rear end thereof through a hollow needle at the forward end thereof for pushing pellets from a pellet cartridge through the cartridge and through the hollow needle into the animal being treated. A side breech opening is provided in the body of the implanter. A cartridge ejector and stripper is provided proximate the rear end of the breech opening. The cartridge stripper and ejector includes a plug having a central bore for retaining the plunger therein against transverse translation. A forwardly projecting eccentric end portion of the ejector and stripper plug engages the rearwardly moving cartridge for stripping the cartridge from the plunger and for flipping the spent cartridge through the side breech opening, thereby ejecting same.

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