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1. 发明授权

US5260059A Treatment of open-angle glaucoma by modulation matrix metalloproteinases and their inhibitor 失效
标题翻译：通过调节基质金属蛋白酶及其抑制剂治疗开角型青光眼
公开(公告)号：US5260059A
公开(公告)日：1993-11-09
申请号：US338305
申请日：1989-04-14
申请人： Ted S. Acott , J. Preston Alexander , John M. B. Bradley
发明人： Ted S. Acott , J. Preston Alexander , John M. B. Bradley
IPC分类号： A61K31/00 , A61K31/12 , A61K31/31 , A61K33/06 , A61K33/30 , A61K38/18 , A61K38/20 , A61K38/48 , A61K38/55 , C07K16/38 , C07K16/40 , A61K37/54 , C12N9/64
CPC分类号： A61K31/31 , A61K31/00 , A61K31/12 , A61K33/06 , A61K33/30 , A61K38/1808 , A61K38/185 , A61K38/4886 , A61K38/49 , A61K38/55 , C07K16/38 , C07K16/40 , Y10S514/913
摘要： A method of treating open-angle glaucoma consisting of providing to the trabecular meshwork a substance such as MMP-1, MMP-2, MMP-3, basic heparin-binding growth factor, nerve growth factor, Interleukin-1, Interleukin-6, TPA, Ca++, Zn++, plasmin, trypsin, and APMA in effective amount to lower intraocular pressure is provided. A method of treating retinal disease such as; retinal degeneration, ocular neovascularization, and diabetic retinopathy consisting of providing to the optic cup a TIMP, retinoic acid, Razoxane, EDTA, EGTA or 1,10-phenanthrolie in an effective amount to ameliorate the retinal disease is also provided.
摘要翻译：一种治疗开角型青光眼的方法，其特征在于，向小梁网提供诸如MMP-1，MMP-2，MMP-3，碱性肝素结合生长因子，神经生长因子，白细胞介素-1，白细胞介素-6，提供有效量的降低眼内压的TPA，Ca ++，Zn ++，纤溶酶，胰蛋白酶和APMA。治疗视网膜疾病的方法如：视网膜变性，眼新生血管形成和糖尿病性视网膜病变由提供给视觉玻璃组成，还提供了有效量的用于改善视网膜疾病的TIMP，视黄酸，Razoxane，EDTA，EGTA或1,10-菲罗罗。

2. 发明授权

US5200508A Cell surface antigen that binds with L6 monoclonal antibody 失效
标题翻译：与L6单克隆抗体结合的细胞表面抗原
公开(公告)号：US5200508A
公开(公告)日：1993-04-06
申请号：US807787
申请日：1991-12-12
申请人： Gajanan Nilaver , Lawrence Rosenbaum , Edward A. Neuwelt
发明人： Gajanan Nilaver , Lawrence Rosenbaum , Edward A. Neuwelt
IPC分类号： A61K38/00 , A61K39/00 , C07K16/30
CPC分类号： A61K39/0005 , C07K16/30 , A61K38/00 , C07K2317/34
摘要： We disclose the discovery and purification of a tumor antigen that binds the mouse monoclonal antibody L6. Immunohistochemical analysis showed that the antigen is expressed on the membrane surface of LX-1 human lung tumor cells, which retain L6 binding activity when intracerebrally xenografted in nude rats. The antigen is also expressed in the cytoplasm of hypothalamic neurons. Inability of oxytocin and vasopressin hormones to block L6 binding showed that the antigenic epitope resides in neurophysin, the carrier protein associated with the two hormones. Porcine neurophysin did block L6 binding to the antigen. Western blot analysis confirmed that L6-immunoreactivity is neurophysin-related. Immunoaffinity chromatography and gel electrophoresis revealed the antigen molecular weight to be 45000 daltons. Amino-terminal sequencing revealed a 21-amino acid homology with the N-terminus of human pro-pressophysin.
摘要翻译：我们公开了结合小鼠单克隆抗体L6的肿瘤抗原的发现和纯化。免疫组织化学分析显示，抗原在LX-1人肺肿瘤细胞的膜表面表达，当在裸鼠中脑内异种移植时，其保留L6结合活性。抗原也在下丘脑神经元的细胞质中表达。催产素和加压素激素不能阻止L6结合显示抗原表位位于神经生物素，与两种激素相关的载体蛋白。猪神经生成素阻断L6与抗原的结合。 Western印迹分析证实，L6-免疫反应性是神经生物相关的。免疫亲和层析和凝胶电泳显示抗原分子量为45000道尔顿。氨基末端测序显示与人类前脂蛋白的N-末端具有21个氨基酸的同源性。

3. 发明授权

US4968137A Devices and procedures for in vitro testing of pulse oximetry monitors 失效
标题翻译：脉搏血氧饱和度监测仪的体外试验装置及程序
公开(公告)号：US4968137A
公开(公告)日：1990-11-06
申请号：US358794
申请日：1989-05-30
申请人： John E. Yount
发明人： John E. Yount
IPC分类号： A61B5/00 , G01N21/27 , G01N21/31
CPC分类号： A61B5/1495 , G01N21/274 , A61B2560/0233 , G01N2021/3144 , G01N2201/127
摘要： A device and method for calibration of pulse oximeters is disclosed. A standard specimen that has optical characteristics of hemoglobin of a known oxygen saturation is placed in the light path of a pulse oximeter probe. The image of a pulse is created by a filter that periodically increases and decreases the amount of light allowed to reach the sensor of the probe. In one embodiment, the filter comprises a pair of polarizing filters rotated with respect to one another under the control of a digital computer with a motor interface device. In another embodiment, a wedge of a light-attenuating medium, such as a cuvette containing oxygenated blood, is reciprocated in the light path, the wide portions of the wedge attenuating a greater amount of light than the narrow portions. Such a cuvette can include filler openings, with outwardly extending tubes at both the wide and narrow ends. For comparison testing, the cuvette can include a sample of blood from a test subject, the blood having been oxygenated to a known oxygen content. A light-attenuating layer, with light transmissivity characteristics that are additive to those of the filter, can be provided in the light path to simulate an abnormal blood condition, such as the presence of carboxyhemoglobin, methemoglobin, or venous blood.
摘要翻译：公开了用于校准脉搏血氧计的装置和方法。将具有已知氧饱和度的血红蛋白的光学特性的标准样品置于脉搏血氧计探针的光路中。脉冲的图像由周期性地增加和减少允许到达探针的传感器的光量的滤光器产生。在一个实施例中，滤波器包括在具有电动机接口装置的数字计算机的控制下相对于彼此旋转的一对偏振滤光器。在另一个实施例中，诸如含有氧合血液的比色皿之类的光衰减介质的楔形物在光路中往复运动，楔形物的宽部分比窄部分减弱更多的光量。这样的比色皿可以包括填充开口，在宽和窄端都具有向外延伸的管。为了比较测试，比色皿可以包括来自测试对象的血液样品，血液已被氧化成已知的氧含量。可以在光路中提供具有与过滤器相反的光透射特性的光衰减层，以模拟异常血液状况，例如存在碳氧血红蛋白，高铁血红蛋白或静脉血。

4. 发明授权

US5393777A Deferration using anguibactin siderophore 失效
标题翻译：使用Anguibactin铁载体延长
公开(公告)号：US5393777A
公开(公告)日：1995-02-28
申请号：US614231
申请日：1990-11-15
申请人： Jorge H. Crosa
发明人： Jorge H. Crosa
IPC分类号： A61K31/425 , C07D417/12 , A61K31/295
CPC分类号： C07D417/12 , A61K31/425
摘要： Methods for removing ferric iron from aqueous liquids and for performing deferration therapy are disclosed, involving the use of a novel siderophore, termed anguibactin. Anguibactin is isolated from a marine pathogen, Vibrio anguillarum, containing the pMJ1 plasmid. Anguibactin inhibits iron uptake by living cells, wrests iron from vertebrate tissues, removes iron from other siderophores and ferric hydroxide, and removes ferric iron from aqueous solutions, including cell-culture media. For deferration therapy, anguibactin from which bound iron has been removed is administered by dissolving in water or other liquid aqueous pharmaceutical carrier at a dosage typical for other siderophores. Anguibactin is preferably administered intramuscularly or subcutaneously, but can be given intravenously. Oral administration is also possible, particularly if the siderophore is encapsulated in a form allowing it to pass intact through the acidic environment of the stomach but become available for absorption in the intestine. This siderophore has the advantages of low molecular weight, extremely high affinity for ferric iron, and non-use by any known human pathogen. The structure is amenable to immobilization on a solid substrate.
摘要翻译：公开了从水性液体中除去三价铁并进行延展疗法的方法，涉及使用称为Anguibactin的新型铁载体。从海洋病原体鳗弧菌（Vibrio anguillarum）中分离出一种含有pMJ1质粒的Anguibactin。 Anguibactin抑制活细胞吸收铁，从脊椎动物组织中取铁，从其他铁载体和氢氧化铁中去除铁，并从水溶液中除去三价铁，包括细胞培养基。对于延迟治疗，已经除去结合铁的角质形
成胰蛋白酶是以其它铁载体的典型剂量溶解在水或其它液体含水药物载体中来施用的。安圭霉素优选肌肉内或皮下给药，但可静脉内给予。口服给药也是可行的，特别是如果铁载体被封装成允许其穿过胃的酸性环境完整的形式，但是可以在肠中吸收。该铁载体具有低分子量，对三价铁极高的亲和力以及任何已知的人类病原体不使用的优点。该结构适于固定在固体基质上。

5. 发明授权

US5026837A DNA probe which reveals a hypervariable region on human chromosome 16 失效
标题翻译： DNA探针，显示人类16号染色体上的高变区
公开(公告)号：US5026837A
公开(公告)日：1991-06-25
申请号：US103021
申请日：1987-09-30
申请人： Michael Litt , Linda L. Bufton
发明人： Michael Litt , Linda L. Bufton
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q2600/156
摘要： A DNA probe p79-2-23 is homologous to at least a portion of a hypervariable DNA region located on chromosome 16q22.fwdarw.q24 in the human genome. The DNA region displays a restriction fragment length polymorphism when digested with certain restriction endonucleases. Unrelated individuals display unique fragment patterns on Southern blots probed with p79-2-23. The probe can be used to produce a genetic "fingerprint" for establishing human identity, determining engraftment of bone marrow transplants, determining parentage, and otherwise mapping genes.
摘要翻译： DNA探针p79-2-23与位于人类基因组中16q22-> q24染色体上的高变区DNA的至少一部分同源。当用某些限制性内切核酸酶消化时，DNA区域显示限制性片段长度多态性。不相关的个体在p79-2-23探测的Southern印迹上显示独特的片段图谱。该探针可用于产生用于建立人类身份的遗传“指纹”，确定骨髓移植的移植，确定亲本和否则绘制基因。

6. 发明授权

US07273929B2 B1k chain of laminin and methods of use 失效
标题翻译： B1K链的层粘连蛋白和使用方法
公开(公告)号：US07273929B2
公开(公告)日：2007-09-25
申请号：US10443349
申请日：2003-05-22
申请人： Robert E. Burgeson , David Wolfe Wagman
发明人： Robert E. Burgeson , David Wolfe Wagman
IPC分类号： C12N15/12 , C07K14/78
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C07K14/78
摘要： Recombinant laminin B1k and fragments thereof.
摘要翻译：重组层粘连蛋白B1k及其片段。

7. 发明授权

US5352668A Product and method for improving keratinocyte adhesion to the dermis 失效
标题翻译：改善角质形成细胞对真皮粘附的产物和方法
公开(公告)号：US5352668A
公开(公告)日：1994-10-04
申请号：US936850
申请日：1992-08-28
申请人： Robnert E. Burgeson , Gregory P. Lunstrum , Patricia Rousselle , Douglas R. Keene , M. Peter Marinkovich
发明人： Robnert E. Burgeson , Gregory P. Lunstrum , Patricia Rousselle , Douglas R. Keene , M. Peter Marinkovich
IPC分类号： A61K38/17 , A61K35/12 , A61K35/36 , A61K38/39 , A61L27/22 , A61L27/60 , A61P17/00 , C07K1/22 , C07K14/47 , C07K14/78 , C07K16/00 , C07K16/18 , C12N5/00 , C12N5/071 , A61F2/10 , A61K37/12 , C07K15/06 , C07K15/20
CPC分类号： C12N5/0629 , A61K35/36 , A61K38/39 , A61L27/227 , A61L27/60 , C07K14/47 , C07K14/78 , C07K16/18 , C12N5/0068 , A61K35/12 , C12N2501/58 , C12N2533/50 , C12N2533/52 , Y10S530/842 , Y10S530/851 , Y10S623/915
摘要： A purified protein kalinin is disclosed that provides adhesion between epidermal keratinocytes and the underlying dermis. Purified kalinin localizes to the anchoring filaments of basement membranes or human subepithelial skin, trachea, esophagus, cornea and amnion when such areas are probed with BM165 monoclonal antibody after localization. The protein has a molecular weight of approximately 400-460 kDa and exists in a cell-associated form (about 460 kDa) and two medium-associated forms (about 440 and 400 kDa, respectively). The cell-associated form comprises a 200-, a 155- and a 140-kDa subunit, all normally held together by disulflde bonds. The cell-associated form is subjected to extracellular processing to produce the two medium-associated forms, wherein, in the 440-kDa form, the 200-kDa subunit has been processed to a 165-kDa subunit and, in the 400-kDa form, the 155-kDa subunit has been processed to a 105-KDa subunit. The BM165 epitope is located on the 165-kDa subunit. Kalinin has a rotary-shadow image revealing an asymmetric rod 107-nm long having two globules at a first end and a single globule at an opposing end. A method is also disclosed for improving adhesion of transplanted keratinocytes to an underlying substrate, such as the human dermis, by optimizing production of kalinin from cultured keratinocytes, or by providing an exogenous source of kalinin between the keratinocytes and substrate.
摘要翻译：公开了提供表皮角化细胞和潜在真皮之间的粘附的纯化的蛋白质卡林林。纯化的卡林林定位于基底膜或人类上皮皮肤，气管，食道，角膜和羊膜的锚定细丝上，当这些区域在定位后用BM165单克隆抗体探测时。该蛋白质具有约400-460kDa的分子量，并以细胞相关形式（约460kDa）和两种培养基相关形式（分别为约440和400kDa）存在。细胞相关形式包括通常由二硫键连接在一起的200个，一个155和一个140kDa的亚基。将细胞相关形式进行细胞外加工以产生两种中等相关形式，其中在440-kDa形式中，200kDa亚基已经被加工成165-kDa亚基，并且以400-kDa形式，155-kDa亚基已被处理成105-KDa亚基。 BM165表位位于165-kDa亚基上。加里宁具有旋转阴影图像，其显示107nm长的不对称杆，在第一端具有两个球，在相对端具有单个球。还公开了通过优化来自培养的角质形成细胞的生产kalinin或通过在角质形成细胞和底物之间提供外源的卡林林来改善移植的角质形成细胞与底物（例如人真皮）的粘附的方法。

8. 发明授权

US5124146A Differential delivery of therapeutic agents across the blood brain barrier 失效
标题翻译：治疗药物通过血液脑膜进行差异分娩
公开(公告)号：US5124146A
公开(公告)日：1992-06-23
申请号：US644331
申请日：1991-01-22
申请人： Edward A. Neuwelt
发明人： Edward A. Neuwelt
IPC分类号： A61K45/06 , A61K31/70 , A61K38/00 , A61K39/395 , A61K47/48 , A61P9/00 , A61P35/00 , C07K16/44
CPC分类号： B82Y5/00 , A61K39/395 , A61K47/48738 , C07K16/44 , A61K38/00 , Y10S514/922
摘要： A method for the delivery of therapeutic agents across the blood brain barrier is disclosed which utilizes drug neutralization technology, and the selective permeability oThis invention was made with support by the Preuss Foundation and with Government support by the Veterans Administration and under Grant No. 31770 awarded by the National Institutes of Health. The Government has certain rights in this invention.
摘要翻译：公开了通过血脑屏障递送治疗剂的方法，其利用药物中和技术和血脑屏障（BBB）的选择性渗透性。在脑损伤形成期间和之后，BBB变得越来越透明。为了治疗这些病症，施用治疗有效量的所选择的药物，其具有允许药物通过经修饰的BBB的分子量和其它特征。然后，给予药物特异性的中和材料。中和材料具有高分子量和/或一些阻止其通过改性BBB的其它特征。中和物质与BBB外循环的过量药物结合或反应，以防止药物毒性问题的出现。

9. 发明授权

US5324636A Radiorespirometer and method of use 失效
标题翻译：无线电测量仪和使用方法
公开(公告)号：US5324636A
公开(公告)日：1994-06-28
申请号：US31032
申请日：1993-03-11
申请人： Dagmar Bartos , Donald D. Trunkey , Angelo A. Vlessis
发明人： Dagmar Bartos , Donald D. Trunkey , Angelo A. Vlessis
IPC分类号： C12M1/34 , C12Q1/16
CPC分类号： C12M23/38 , C12M23/10 , C12M41/34 , C12Q1/16 , Y10S435/807
摘要： A simple device functioning as a radiorespirometer is a petri dish with a modified cover for quantitating an amount of CO.sub.2 evolved by living cultured cells. The device is a plastic culture dish having a culture surface circumscribed by a continuous sidewall. A removable flat plastic cover has a flat inside face and an annular collar around the face that fits against a sidewall. The collar is maintained in substantially gas-tight relationship against the sidewall by an elastic band or tightly mating surfaces. An opening through the cover is sealed by a gas-impervious material, such as a plastic film, that can be penetrated by a needle to introduce acid into the dish for terminating culture growth and lysing the cells. A collector tube is removably secured to the inside face of the cover and contains a CO.sub.2 trapping material, such as hyamine (methylbenzethonium hydroxide). The culture medium is provided with a cell substrate that contains radioactive carbon, and radioactive CO.sub.2 produced by the cells is then collected by the hyamine in the tube. The cover is afterwards removed from the dish, and the tube is detached from the cover and placed in a liquid scintillator to quantitate the amount of radioactive CO.sub.2 contained in the liquid.
摘要翻译：用作放射测光仪的简单装置是具有修改的盖子的培养皿，用于定量由活的培养细胞产生的CO 2量。该装置是具有由连续侧壁限定的培养物表面的塑料培养皿。一个可移动的扁平塑料盖具有一个平坦的内表面和一个围绕着侧壁配合的环形环圈。轴环通过弹性带或紧密配合的表面保持与侧壁基本上气密的关系。通过盖的开口由不透气材料（例如塑料膜）密封，其可以被针刺入以将酸引入培养皿中以终止培养生长和裂解细胞。收集器管可移除地固定到盖的内表面并且包含二氧化碳捕集材料，例如苯胺（甲基苄基氢氧化铵）。提供培养基含有放射性碳的细胞基质，然后通过管中的香胺收集由细胞产生的放射性CO 2。之后将该盖从盘中取出，将管与盖分离并置于液体闪烁体中以定量液体中所含的放射性CO 2的量。

10. 发明授权

US5044367A Method and apparatus for switching cardiac stimulation signals 失效
标题翻译：用于切换心脏刺激信号的方法和装置
公开(公告)号：US5044367A
公开(公告)日：1991-09-03
申请号：US371495
申请日：1989-06-26
申请人： William P. Endres , Betty Stephens
发明人： William P. Endres , Betty Stephens
IPC分类号： A61N1/37
CPC分类号： A61N1/37
摘要： Cardiac stimulation signals are routed through a switching network to select only one cardiac stimulation signal as an output signal. The selected output signal may be routed to one of two patient electrode pairs for application to specific stimulation sites on the heart.
摘要翻译：心脏刺激信号通过交换网络路由，仅选择一个心脏刺激信号作为输出信号。选择的输出信号可以被路由到两个患者电极对中的一个，以应用于心脏上的特定刺激部位。

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