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1. 发明授权

US08079998B2 Methods and devices for the delivery of therapeutic gases including nitric oxide 有权
标题翻译：用于输送包括一氧化氮在内的治疗气体的方法和装置
公开(公告)号：US08079998B2
公开(公告)日：2011-12-20
申请号：US11713344
申请日：2007-03-02
申请人： Douglas R. Hole , Curtis Figley , Robert E. Lee , Michael Hudec , Robert Rolfson
发明人： Douglas R. Hole , Curtis Figley , Robert E. Lee , Michael Hudec , Robert Rolfson
IPC分类号： A61M31/00
CPC分类号： A61K33/00 , A61F13/0216 , A61F13/0226 , A61F13/8405 , A61F2013/00646 , A61F2013/0091 , A61J3/08 , A61K9/7007 , A61L2/0094 , A61L15/44 , A61L2300/114 , A61L2300/60 , A61M16/1055 , A61M16/106 , A61M16/12 , A61M16/208 , A61M2202/0275
摘要： Gas packages for the delivery of therapeutic gases, and in particular gaseous nitric oxide (gNO) are provided herein. The gas packages comprise one or more of a gas reservoir, interface layer, sealing layer, and holding container. The interface layer regulates discharge of the therapeutic gas from the gas reservoir to the external environment. The sealing layer and/or holding container prevent evolution of the gas until the sealing layer is compromised or the holding container is opened. The gas packages and methods for using them are useful for the treatment, alleviation, and prevention of various disease and non-disease, medical and non-medical, conditions in humans and animals.
摘要翻译：用于递送治疗气体的气体包装，特别是气态一氧化氮（gNO）。气体包装包括气体储存器，界面层，密封层和保持容器中的一个或多个。界面层调节治疗气体从气体储存器到外部环境的排放。密封层和/或保持容器防止气体的逸出，直到密封层受损或保持容器打开。气体包装和使用它们的方法可用于治疗，缓解和预防人类和动物中的各种疾病和非疾病，医学和非医学的条件。

2. 发明申请

US20110226241A1 INTERMITTENT DOSING OF NITRIC OXIDE GAS 审中-公开
标题翻译：硝酸氧化物的间歇剂量
公开(公告)号：US20110226241A1
公开(公告)日：2011-09-22
申请号：US13007273
申请日：2011-01-14
申请人： Alex STENZLER , Chris Miller , Bevin B. McMullin
发明人： Alex STENZLER , Chris Miller , Bevin B. McMullin
IPC分类号： A61M16/12 , A61M37/00
CPC分类号： A61M16/122 , A61H33/14 , A61K33/00 , A61M16/0003 , A61M16/024 , A61M16/04 , A61M16/0666 , A61M16/0833 , A61M16/12 , A61M16/201 , A61M16/202 , A61M16/204 , A61M2016/003 , A61M2016/102 , A61M2202/0275 , A61M2205/3327 , A61M2205/3334
摘要： A method and corresponding device are described for combating microbes and infections by delivering intermittent high doses of nitric oxide to a mammal for a period of time and which cycles between high and low concentration of nitric oxide gas. The high concentration of nitric oxide is preferably delivered intermittently for brief periods of time that are interspersed with periods of time with either no nitric oxide delivery or lower concentrations of nitric oxide. The method is advantageous because at higher concentration, nitric oxide gas overwhelms the defense mechanism of pathogens that use the mammalian body to replenish their thiol defense system. A lower dose or concentration of nitric oxide gas delivered in between the bursts of high concentration nitric oxide maintains nitrosative stress pressure on the pathogens and also reduces the risk of toxicity of nitric oxide gas.
摘要翻译：描述了一种方法和相应的装置，用于通过向哺乳动物递送间歇性高剂量的一氧化氮一段时间并在高浓度和低浓度的一氧化氮气体之间循环来对抗微生物和感染。高浓度的一氧化氮优选间歇地递送短暂的时间段，其间隔着不含一氧化氮递送或较低浓度的一氧化氮的时间段。该方法是有利的，因为在较高的浓度下，一氧化氮气体压倒了使用哺乳动物身体补充其硫醇防御系统的病原体的防御机制。在高浓度一氧化氮脉冲之间输送的一氧化氮气体的较低剂量或浓度保持对病原体的亚硝化应激压力，并降低一氧化氮气体毒性的风险。

3. 发明授权

US07520866B2 Device and method for treatment of wounds with nitric oxide 有权
标题翻译：用一氧化氮治疗伤口的装置和方法
公开(公告)号：US07520866B2
公开(公告)日：2009-04-21
申请号：US11487600
申请日：2006-07-13
申请人： Alex Stenzler , Chris C Miller
发明人： Alex Stenzler , Chris C Miller
IPC分类号： A61M37/00 , A61M1/00 , A01N59/02
CPC分类号： A61M35/00 , A61B90/40 , A61H33/14 , A61K33/00 , A61L2/0094 , A61L15/18 , A61L15/44 , A61L2300/114 , A61L2300/602 , A61M1/0031 , A61M1/0088 , A61M13/003 , A61M13/006 , A61M2202/0275 , A61M2205/3334 , A61K2300/00
摘要： Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing of the wound and in preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used, for example, to reduce the microbial infection and burden on these wounds, manage exudate secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from about 160 to 400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide preferably ranging from about 5-20 ppm may to provided to restore the balance of nitric oxide and induce collagen expression to aid in the closure of the wound.
摘要翻译：一氧化氮气体局部暴露于伤口如慢性非愈合伤口可能有益于促进伤口愈合和制备伤口床进一步治疗和恢复。例如，可以使用一氧化氮气体来减少这些伤口的微生物感染和负担，通过减少炎症，上调内源性胶原酶的表达来局部清创伤口并调节胶原的形成来控制渗出物分泌。可以使用约160至400ppm范围内的高浓度一氧化氮，而不会在伤口部位周围的健康细胞中引起毒性。此外，在第一次治疗期间暴露于高浓度可减少伤口部位的微生物负担和炎症，并增加胶原酶表达以清除伤口部位的坏死组织。在具有高浓度一氧化氮的第一次治疗期后，可提供较低浓度的一氧化氮优选约5-20ppm的第二治疗期以恢复一氧化氮的平衡并诱导胶原表达以帮助闭合的伤口。

4. 发明授权

US07122018B2 Device and method for treatment of wounds with nitric oxide 有权
标题翻译：用一氧化氮治疗伤口的装置和方法
公开(公告)号：US07122018B2
公开(公告)日：2006-10-17
申请号：US11021109
申请日：2004-12-23
申请人： Alex Stenzler , Chris C Miller
发明人： Alex Stenzler , Chris C Miller
IPC分类号： A61M37/00 , A61M1/00 , A01N59/02
CPC分类号： A61M35/00 , A61B90/40 , A61H33/14 , A61K33/00 , A61L2/0094 , A61L15/18 , A61L15/44 , A61L2300/114 , A61L2300/602 , A61M1/0031 , A61M1/0088 , A61M13/003 , A61M13/006 , A61M2202/0275 , A61M2205/3334 , A61K2300/00
摘要： Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing and preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used to reduce the microbial infection, manage exudates secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from 160–400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation, and increases collagenase expression to debride necrotic tissue at the wound site. After a first treatment period, a second treatment period at a lower concentration of nitric oxide, preferably ranging from 5–20 ppm may be used to restore the balance of nitric oxide and induce collagen expression aiding in the wound closure.
摘要翻译：一氧化氮气体局部暴露于伤口如慢性非愈合伤口可能有益于促进愈合和制备伤口床进一步治疗和恢复。可以使用一氧化氮气体来减少微生物感染，通过减少炎症，上调内源性胶原酶的表达来局部清创伤口，调节胶原蛋白的形成来控制渗出物的分泌。可以使用160-400ppm范围内的高浓度一氧化氮，而不会在伤口部位周围的健康细胞中引起毒性。在第一次治疗期间暴露于高浓度会降低微生物负担和炎症，并增加胶原酶表达以清除伤口部位的坏死组织。在第一次治疗期后，可以使用较低浓度的一氧化氮，优选5-20ppm的第二治疗期，以恢复一氧化氮的平衡并诱导帮助伤口闭合的胶原表达。

5. 发明申请

US20120118287A1 METHODS AND DEVICES FOR THE DELIVERY OF THERAPEUTIC GASES INCLUDING NITRIC OXIDE 审中-公开
标题翻译：用于输送含氮氧化物的治疗气体的方法和装置
公开(公告)号：US20120118287A1
公开(公告)日：2012-05-17
申请号：US13289956
申请日：2011-11-04
申请人： Douglas R. Hole , Curtis Figley , Robert E. Lee , Michael Hudec , Robert Rolfson
发明人： Douglas R. Hole , Curtis Figley , Robert E. Lee , Michael Hudec , Robert Rolfson
IPC分类号： A61M37/00 , A61M16/12
CPC分类号： A61K33/00 , A61F13/0216 , A61F13/0226 , A61F13/8405 , A61F2013/00646 , A61F2013/0091 , A61J3/08 , A61K9/7007 , A61L2/0094 , A61L15/44 , A61L2300/114 , A61L2300/60 , A61M16/1055 , A61M16/106 , A61M16/12 , A61M16/208 , A61M2202/0275
摘要： Gas packages for the delivery of therapeutic gases, and in particular gaseous nitric oxide (gNO) are provided herein. The gas packages comprise one or more of a gas reservoir, interface layer, sealing layer, and holding container. The interface layer regulates discharge of the therapeutic gas from the gas reservoir to the external environment. The sealing layer and/or holding container prevent evolution of the gas until the sealing layer is compromised or the holding container is opened. The gas packages and methods for using them are useful for the treatment, alleviation, and prevention of various disease and non-disease, medical and non-medical, conditions in humans and animals,
摘要翻译：用于递送治疗气体的气体包装，特别是气态一氧化氮（gNO）。气体包装包括气体储存器，界面层，密封层和保持容器中的一个或多个。界面层调节治疗气体从气体储存器到外部环境的排放。密封层和/或保持容器防止气体的逸出，直到密封层受损或保持容器打开。气体包装和使用它们的方法可用于治疗，减轻和预防人类和动物中的各种疾病和非疾病，医学和非医学的条件，

6. 发明授权

US07955294B2 Intermittent dosing of nitric oxide gas 有权
标题翻译：间歇给药一氧化氮气体
公开(公告)号：US07955294B2
公开(公告)日：2011-06-07
申请号：US11598221
申请日：2006-11-10
申请人： Alex Stenzler , Christopher C. Miller , Bevin B. McMullin
发明人： Alex Stenzler , Christopher C. Miller , Bevin B. McMullin
IPC分类号： A61M35/00 , A61M16/10
CPC分类号： A61M16/122 , A61H33/14 , A61K33/00 , A61M16/0003 , A61M16/0051 , A61M16/024 , A61M16/04 , A61M16/0666 , A61M16/0833 , A61M16/12 , A61M16/201 , A61M16/202 , A61M16/204 , A61M2016/003 , A61M2016/102 , A61M2202/0275 , A61M2205/3327 , A61M2205/3334
摘要： A method and corresponding device are described for combating microbes and infections by delivering intermittent high doses of nitric oxide to a mammal for a period of time and which cycles between high and low concentration of nitric oxide gas. The high concentration of nitric oxide is preferably delivered intermittently for brief periods of time that are interspersed with periods of time with either no nitric oxide delivery or lower concentrations of nitric oxide. The method is advantageous because at higher concentration, nitric oxide gas overwhelms the defense mechanism of pathogens that use the mammalian body to replenish their thiol defense system. A lower dose or concentration of nitric oxide gas delivered in between the bursts of high concentration nitric oxide maintains nitrosative stress pressure on the pathogens and also reduces the risk of toxicity of nitric oxide gas.
摘要翻译：描述了一种方法和相应的装置，用于通过向哺乳动物递送间歇性高剂量的一氧化氮一段时间并在高浓度和低浓度的一氧化氮气体之间循环来对抗微生物和感染。高浓度的一氧化氮优选间歇地递送短暂的时间段，其间隔着不含一氧化氮递送或较低浓度的一氧化氮的时间段。该方法是有利的，因为在较高的浓度下，一氧化氮气体压倒了使用哺乳动物身体补充其硫醇防御系统的病原体的防御机制。在高浓度一氧化氮脉冲之间输送的一氧化氮气体的较低剂量或浓度保持对病原体的亚硝化应激压力，并降低一氧化氮气体毒性的风险。

7. 发明授权

US07335181B2 Nitric oxide decontamination of the upper respiratory tract 有权
公开(公告)号：US07335181B2
公开(公告)日：2008-02-26
申请号：US11107618
申请日：2005-04-14
申请人： Christopher Miller , Alex Stenzler
发明人： Christopher Miller , Alex Stenzler
IPC分类号： A61M37/00 , A61M15/00 , A61M15/08
CPC分类号： A61M15/08 , A61M15/0091 , A61M15/0098 , A61M16/0084 , A61M16/0666 , A61M16/0672 , A61M16/0866 , A61M16/10 , A61M16/1055 , A61M16/1065 , A61M16/107 , A61M16/201 , A61M16/208 , A61M2016/0027 , A61M2202/0275 , A61M2202/20 , A61M2230/43
摘要： A method of topically treating the respiratory tract of a mammal with nitric oxide exposure includes the steps of providing a source of nitric oxide containing gas and delivering the nitric oxide containing gas nasally to the upper respiratory tract of the mammal. Also provided are several designs for a nasal delivery device for the controlled nasal deliver the nitric oxide containing gas.

8. 发明申请

US20040163647A1 System and elements for managing therapeutic gas administration to a spontaneously breathing non-ventilated patient 失效
标题翻译：用于管理治疗气体给自发呼吸的非通气患者的系统和元件
公开(公告)号：US20040163647A1
公开(公告)日：2004-08-26
申请号：US10691649
申请日：2003-10-24
申请人： Pulmonox Technologies Corporation
发明人： Curtis B. Figley , Darin W. Hunt , Christopher C. Miller
IPC分类号： A61M016/00 , A62B007/00
CPC分类号： A61M16/0816 , A61M16/0051 , A61M16/024 , A61M16/0677 , A61M16/203 , A61M16/208 , A61M16/209 , A61M2016/0027 , A61M2016/0039 , A61M2016/0042 , A61M2202/0275 , A61M2205/6018 , A61M2205/6027 , A61M2205/8206 , A61M2205/8237 , Y10T137/7808
摘要： A system controls and manages administration of a therapeutic gas, such as NO, O2, or the like, to a spontaneously breathing, non-ventilated patient such that concentrated NO is as low as reasonably possible while delivering the desired amount of NO to the distal portions of the lungs. The system includes an entrainment cell that provides remote, turbulent mixing with low temporal latency and can be used with a nasal cannula or a mask. The entrainment cell uses room air to dilute the therapeutic gas; however, supplementary gases can also be used. A baffle can be included to promote mixing and a flow sensor can also be used if desired. Multiple ports can be included in the entrainment cell. An equalizing valve is also disclosed.
摘要翻译：系统控制和管理诸如NO，O 2等的治疗气体的给药给自发呼吸的非通气患者，使得浓缩的NO尽可能低，同时将期望量的NO递送到远端部分肺部。该系统包括夹带细胞，其提供具有低时间潜伏期的远程湍流混合，并且可以与鼻插管或面罩一起使用。夹带细胞使用室内空气稀释治疗气体; 然而，也可以使用补充气体。可以包括挡板以促进混合，并且如果需要也可以使用流量传感器。夹带单元中可以包含多个端口。还公开了一种均衡阀。

9. 发明授权

US09095534B2 Intermittent dosing of nitric oxide gas 有权
标题翻译：间歇给药一氧化氮气体
公开(公告)号：US09095534B2
公开(公告)日：2015-08-04
申请号：US13369205
申请日：2012-02-08
申请人： Alex Stenzler , Chris Miller , Bevin B. McMullin
发明人： Alex Stenzler , Chris Miller , Bevin B. McMullin
IPC分类号： A61M16/18 , A61K33/00 , A61M16/00 , A61M16/12 , A61M16/20 , A61H33/14 , A61M16/10
CPC分类号： A61M16/122 , A61H33/14 , A61K33/00 , A61M16/0003 , A61M16/0051 , A61M16/024 , A61M16/04 , A61M16/0666 , A61M16/0833 , A61M16/12 , A61M16/201 , A61M16/202 , A61M16/204 , A61M2016/003 , A61M2016/102 , A61M2202/0275 , A61M2205/3327 , A61M2205/3334
摘要： A method and corresponding device are described for combating microbes and infections by delivering intermittent high doses of nitric oxide to a mammal for a period of time and which cycles between high and low concentration of nitric oxide gas. The high concentration of nitric oxide is preferably delivered intermittently for brief periods of time that are interspersed with periods of time with either no nitric oxide delivery or lower concentrations of nitric oxide. The method is advantageous because at higher concentration, nitric oxide gas overwhelms the defense mechanism of pathogens that use the mammalian body to replenish their thiol defense system. A lower dose or concentration of nitric oxide gas delivered in between the bursts of high concentration nitric oxide maintains nitrosative stress pressure on the pathogens and also reduces the risk of toxicity of nitric oxide gas.
摘要翻译：描述了一种方法和相应的装置，用于通过向哺乳动物递送间歇性高剂量的一氧化氮一段时间并在高浓度和低浓度的一氧化氮气体之间循环来对抗微生物和感染。高浓度的一氧化氮优选间歇地递送短暂的时间段，其间隔着不含一氧化氮递送或较低浓度的一氧化氮的时间段。该方法是有利的，因为在较高的浓度下，一氧化氮气体压倒了使用哺乳动物身体补充其硫醇防御系统的病原体的防御机制。在高浓度一氧化氮脉冲之间输送的一氧化氮气体的较低剂量或浓度保持对病原体的亚硝化应激压力，并降低一氧化氮气体毒性的风险。

10. 发明申请

US20120199123A1 INTERMITTENT DOSING OF NITRIC OXIDE GAS 有权
标题翻译：硝酸氧化物的间歇剂量
公开(公告)号：US20120199123A1
公开(公告)日：2012-08-09
申请号：US13369205
申请日：2012-02-08
申请人： Alex STENZLER , Chris MILLER , Bevin B. MCMULLIN
发明人： Alex STENZLER , Chris MILLER , Bevin B. MCMULLIN
IPC分类号： A61M16/12
CPC分类号： A61M16/122 , A61H33/14 , A61K33/00 , A61M16/0003 , A61M16/0051 , A61M16/024 , A61M16/04 , A61M16/0666 , A61M16/0833 , A61M16/12 , A61M16/201 , A61M16/202 , A61M16/204 , A61M2016/003 , A61M2016/102 , A61M2202/0275 , A61M2205/3327 , A61M2205/3334
摘要： A method and corresponding device are described for combating microbes and infections by delivering intermittent high doses of nitric oxide to a mammal for a period of time and which cycles between high and low concentration of nitric oxide gas. The high concentration of nitric oxide is preferably delivered intermittently for brief periods of time that are interspersed with periods of time with either no nitric oxide delivery or lower concentrations of nitric oxide. The method is advantageous because at higher concentration, nitric oxide gas overwhelms the defense mechanism of pathogens that use the mammalian body to replenish their thiol defense system. A lower dose or concentration of nitric oxide gas delivered in between the bursts of high concentration nitric oxide maintains nitrosative stress pressure on the pathogens and also reduces the risk of toxicity of nitric oxide gas.
摘要翻译：描述了一种方法和相应的装置，用于通过向哺乳动物递送间歇性高剂量的一氧化氮一段时间并在高浓度和低浓度的一氧化氮气体之间循环来对抗微生物和感染。高浓度的一氧化氮优选间歇地递送短暂的时间段，其间隔着不含一氧化氮递送或较低浓度的一氧化氮的时间段。该方法是有利的，因为在较高的浓度下，一氧化氮气体压倒了使用哺乳动物身体补充其硫醇防御系统的病原体的防御机制。在高浓度一氧化氮脉冲之间输送的一氧化氮气体的较低剂量或浓度保持对病原体的亚硝化应激压力，并降低一氧化氮气体毒性的风险。

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