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1. 发明申请

US20100227363A1 ALG3 MUTANT 审中-公开
标题翻译： ALG3突击队
公开(公告)号：US20100227363A1
公开(公告)日：2010-09-09
申请号：US12601350
申请日：2008-05-23
申请人： Hendrik Jan Bosch , Alexander Ronald van der Krol , Maurice Gerard Leon Henquet , Dionisius Elisabeth Antonius Florack
发明人： Hendrik Jan Bosch , Alexander Ronald van der Krol , Maurice Gerard Leon Henquet , Dionisius Elisabeth Antonius Florack
IPC分类号： A01H1/06 , C12N15/82 , C07H21/04 , C12N5/10 , A01H5/00 , C12P21/00
CPC分类号： C12N15/8257 , C07K14/59 , C12N9/1051 , C12N15/8218 , C12N15/8245 , C12P21/005
摘要： The present invention relates to a method to produce proteins reduced in high mannose type glycans in a plant or plant cell by partially inhibiting the expression of the Alg3 gene in said plant or plant cell. Said partial inhibition can be provided for by inserting the Alg3 mutant gene from Arabidopsis as derived from the plant line Salk_040296c or by partially inhibiting the endogenous Alg3 gene by providing the plant or plant cell either with an antisense expression, a sense co-suppressing or with an RNA inhibition genetic construct. Optionally also tissue-specific expression of said inhibiting constructs can yield partial inhibition in a plant.
摘要翻译：本发明涉及在植物或植物细胞中通过部分抑制Alg3基因在所述植物或植物细胞中的表达来产生在高甘露糖型聚糖中还原的蛋白质的方法。所述部分抑制可以通过从植物系Salk_040296c引入来自拟南芥的Alg3突变体基因或通过将植物或植物细胞提供反义表达，感觉共抑制或与 RNA抑制遗传构建体。任选地，所述抑制构建体的组织特异性表达可以在植物中产生部分抑制。

2. 发明申请

US20080286297A1 Chimeric Carrier Molecules for the Production of Mucosal Vaccines 审中-公开
标题翻译：用于生产粘膜疫苗的嵌合载体分子
公开(公告)号：US20080286297A1
公开(公告)日：2008-11-20
申请号：US10574888
申请日：2004-10-08
申请人： Dionisius Elisabeth Antonius Florack , Hendrik Jan Bosch
发明人： Dionisius Elisabeth Antonius Florack , Hendrik Jan Bosch
IPC分类号： A61K39/00 , C07K14/195 , C12P21/06 , A61K36/00 , C12N5/10
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/541 , A61K2039/55544 , C07K14/245 , C07K14/28 , C07K2319/00 , C12N15/8258 , C12N2770/24022
摘要： The invention relates to a protein complex for the delivery of an antigen to and across mucosal surfaces and the production of said complex in a host cell, such as a plant. Provided is a protein complex comprising at least two, preferably identical, subunits wherein at least one subunit is unaltered and at least one subunit is fused to a first molecule of interest and wherein the protein complex is able to interact with a cell surface receptor via said subunits. Also provided is a method for producing a protein complex according to the invention, comprising a) providing a host cell with a nucleotide sequence encoding an unaltered subunit and a nucleotide sequence encoding a molecule of interest, wherein at least one molecule of interest is fused to a subunit; b) culturing said host cell thereby allowing expression of said nucleotide sequences and allowing for assembly of the protein complex; c) isolating the complex; d) determining the binding of the complex to a cell surface receptor or to a molecule which mimics a cell surface receptor
摘要翻译：本发明涉及用于将抗原递送至粘膜表面并跨过粘膜表面并在宿主细胞如植物中产生所述复合物的蛋白质复合物。提供了包含至少两个，优选相同的亚基的蛋白质复合物，其中至少一个亚基是未改变的，并且至少一个亚基与第一目的分子融合，并且其中所述蛋白质复合物能够通过所述蛋白质复合体与细胞表面受体相互作用亚单位。还提供了一种用于生产根据本发明的蛋白质复合物的方法，包括：a）向宿主细胞提供编码未改变亚基的核苷酸序列和编码目的分子的核苷酸序列，其中至少一个目的分子融合到一个亚单位 b）培养所述宿主细胞，从而允许表达所述核苷酸序列并允许蛋白质复合物的装配; c）分离复合物; d）确定复合物与细胞表面受体或模拟细胞表面受体的分子的结合

3. 发明申请

US20120210466A9 MAMMALIAN-TYPE GLYCOSYLATION IN PLANTS BY EXPRESSION OF NON-MAMMALIAN GLYCOSYLTRANSFERASES 有权
标题翻译：通过表达非马氏甘露糖衍生物的植物中的MAMMALIAN-TYPE GLYCOSYLATION
公开(公告)号：US20120210466A9
公开(公告)日：2012-08-16
申请号：US12596063
申请日：2008-04-17
申请人： Gerard Johan Adolph Rouwendal , Dionisius Elisabeth Antonius Florack , Hendrik Jan Bosch
发明人： Gerard Johan Adolph Rouwendal , Dionisius Elisabeth Antonius Florack , Hendrik Jan Bosch
IPC分类号： C12N15/82 , A01H5/10 , C07H21/00 , A01H5/06 , C12N5/10 , C12P21/00 , A01H5/00 , A01H5/12
CPC分类号： C12N15/8257 , C07K2319/00 , C12N9/1051 , C12N15/8245 , C12N15/8246 , C12P21/005
摘要： The present invention relates to non-mammalian β-1,4-galactosyltransferases that can be used in their wild-type or in modified forms. The invention further relates to transformed plants and plant cells expressing non-mammalian β-1,4-galacto-syltransferase and methods to produce glycoproteins with altered and preferably mammalian-type glycosylation. The invention additionally provides nucleic acid molecules and expression vectors of non-mammalian β-1,4-galactosyltransferases.
摘要翻译：本发明涉及可以以其野生型或修饰形式使用的非哺乳动物和β-蔗糖-1,4-半乳糖基转移酶。本发明还涉及表达非哺乳动物和-1,4-半乳糖基转移酶的转化植物和植物细胞以及产生具有改变且优选哺乳动物型糖基化的糖蛋白的方法。本发明另外提供了非哺乳动物和-1,4'-半乳糖基转移酶的核酸分子和表达载体。

4. 发明授权

US07214507B2 Plant enzymes for bioconversion 失效
标题翻译：用于生物转化的植物酶
公开(公告)号：US07214507B2
公开(公告)日：2007-05-08
申请号：US10489762
申请日：2002-09-17
申请人： Hendrik Jan Bouwmeester , Jan-Willem de Kraker , Marloes Schurink , Raoul John Bino , Aede de Groot , Maurice Charles R. Franssen
发明人： Hendrik Jan Bouwmeester , Jan-Willem de Kraker , Marloes Schurink , Raoul John Bino , Aede de Groot , Maurice Charles R. Franssen
IPC分类号： C12P1/00 , A61K36/28
CPC分类号： C12N9/0077 , C12N9/00 , C12N9/78 , C12N9/88 , C12N15/8243 , C12P7/26 , C12P7/40 , C12P17/04
摘要： The invention provides a method for converting sesquiterpene. The method includes reacting a sesquiterpene substract with a sesquiterpene converting enzyme. The enzyme is from a species or organism containing sesquiterpenes. The sesquiterpene substrate is not naturally present in the species or organism.
摘要翻译：本发明提供了一种转化倍半萜烯的方法。该方法包括使倍半萜烯与倍半萜烯转化酶反应。该酶来自含有倍半萜烯的物种或生物体。倍半萜烯底物不是天然存在于物种或生物中。

5. 发明申请

US20060102851A1 Method and a device for making images of the quantum efficiency of the photosynthetic system with the purpose of determining the quality of plant material and a method and a device for measuring, classifying and sorting plant material 失效
标题翻译：用于确定植物材料质量的光合系统的量子效率的图像的方法和装置以及用于测量，分类和分选植物材料的方法和装置
公开(公告)号：US20060102851A1
公开(公告)日：2006-05-18
申请号：US10533447
申请日：2003-10-31
申请人： Hendrik Jalink , Rob Van Der Schoor , Adrianus Henricus Schapendonk
发明人： Hendrik Jalink , Rob Van Der Schoor , Adrianus Henricus Schapendonk
IPC分类号： G01N21/64
CPC分类号： B07C5/342 , G01N21/6408 , G01N21/6456 , G01N2021/635
摘要： The present invention relates to a method for determining the quality of plant material by making chlorophyll fluorescence images of said material by scanning the material with a beam of electromagnetic radiation so that the chlorophyll present is excitated, and measuring the chlorophyll fluorescence with an imaging detector. From the fluorescence images obtained with a fast and a slow scan, the image of the quantum efficiency of the photosynthetic system of the plant material is calculated. The invention further relates to a device for measuring the chlorophyll fluorescence images and to a method and devices for sorting and classifying plant material.
摘要翻译：本发明涉及一种用于通过用电磁辐射束扫描材料以使得存在的叶绿素被激发并用成像检测器测量叶绿素荧光来确定所述材料的叶绿素荧光图像来确定植物材料质量的方法。从快速扫描和慢扫描获得的荧光图像中，计算植物材料光合系统的量子效率的图像。本发明还涉及用于测量叶绿素荧光图像的装置以及用于对植物材料进行分类和分类的方法和装置。

6. 发明授权

US07897842B2 GnTIII expression in plants 有权
标题翻译：植物中GnTIII表达
公开(公告)号：US07897842B2
公开(公告)日：2011-03-01
申请号：US10508166
申请日：2003-03-18
申请人： Hendrikus Antonius Cornelis Bakker , Dionisius Elisabeth Antonius Florack , Hendrik Jan Bosch
发明人： Hendrikus Antonius Cornelis Bakker , Dionisius Elisabeth Antonius Florack , Hendrik Jan Bosch
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N15/8243 , C12N9/1051 , C12N15/8257 , C12P21/02
摘要： The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these glycoproteins. The invention provides a plant comprising a functional mammalian enzyme providing mammalian GnTIII that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.
摘要翻译：本发明涉及用作生产重组生物药物蛋白质或包含这些糖蛋白的药物组合物的成本效益和污染安全的工厂的转基因植物中的糖蛋白加工领域。本发明提供了一种植物，其包含提供通常不存在于植物中的哺乳动物GnTIII的功能哺乳动物酶，所述植物另外包含至少一种通常不存在于植物中的哺乳动物蛋白质或其功能片段。

7. 发明申请

US20100122365A1 OPTIMIZING GLYCAN PROCESSING IN PLANTS 有权
标题翻译：优化植物中的甘蔗加工
公开(公告)号：US20100122365A1
公开(公告)日：2010-05-13
申请号：US12553043
申请日：2009-09-02
申请人： Hendrikus Antonius Cornelis Bakker , Hendrik Jan Bosch , Dionisius Elisabeth Antonius Florack , Gerard Johan Adolph Rouwendal
发明人： Hendrikus Antonius Cornelis Bakker , Hendrik Jan Bosch , Dionisius Elisabeth Antonius Florack , Gerard Johan Adolph Rouwendal
IPC分类号： A01H1/00 , C07H21/04 , C12N15/63 , C12N5/10 , C12N9/10 , A01H5/00 , C12P21/06
CPC分类号： C12N9/1051 , C07K2317/13 , C07K2317/41 , C07K2319/02 , C12N15/8257 , C12N15/8258
摘要： The invention is directed to methods for optimizing glycan processing in organisms (and in particular, plants) so that a glycoprotein having complex type bi-antennary glycans and thus containing galactose residues on both arms and which are devoid of (or reduce in) xylose and fucose can be obtained. The invention is further directed to said glycoprotein obtained and host system comprising said protein.
摘要翻译：本发明涉及用于优化生物（特别是植物）中的聚糖加工的方法，使得具有复合型双触角聚糖并因此在两臂上含有半乳糖残基并且没有（或减少）木糖的糖蛋白和岩藻糖可以得到。本发明还涉及所获得的所述糖蛋白和包含所述蛋白质的宿主系统。

8. 发明申请

US20090178158A1 RESISTANCE AGAINST PARASITIC WEEDS 审中-公开
标题翻译：抗性对抗性
公开(公告)号：US20090178158A1
公开(公告)日：2009-07-09
申请号：US11908904
申请日：2006-03-20
申请人： Hendrik Jan Bouwmeester , Radoslava Matusova , Zhongkui Sun , Michael Beale , Kumkum Rani
发明人： Hendrik Jan Bouwmeester , Radoslava Matusova , Zhongkui Sun , Michael Beale , Kumkum Rani
IPC分类号： C12N15/82 , A01H5/00 , C12Q1/68 , A01N43/40 , A01N43/58 , A01P13/02
CPC分类号： C12N15/8279 , A01H17/00
摘要： The seeds of parasitic plants of the genera Striga and Orobanche will only germinate after induction by a chemical signal exuded from the roots of their host. Many of these compounds have been isolated and identified from a number of different plant species and are collectively called the strigolactones. Here we show that the strigolactone germination stimulants are derived from the carotenoid pathway. This finding is used to create crop species that do not induce germination of parasitic plant seeds anymore and therefore are resistant to parasitic plants. Also provided is a method to use chemicals and mycorrhizae to inhibit germination stimulant production to control parasitic plants. Also provided are strigolactone overproducing trap and catch crops.
摘要翻译： Striga和Orobanche属的寄生植物的种子将在诱导后通过从其宿主的根源渗出的化学信号发芽。许多这些化合物已经从许多不同的植物物种分离和鉴定，并且统称为晶体内酯。在这里我们显示，晶体内酯萌发兴奋剂来自类胡萝卜素途径。这一发现用于产生不再引起寄生植物种子萌发的作物物种，因此对寄生植物具有抗性。还提供了使用化学品和菌根抑制发芽刺激物产生以控制寄生植物的方法。还提供了过氧化str内酯捕获和捕获作物。

9. 发明申请

US20080171104A1 Health Promoting Dairy and Food Products Containing Mushroom Glucan Produced Through Fermentation of Grifola Frondosa 审中-公开
标题翻译：健康促进含有通过发酵的三叶草生产的蘑菇葡聚糖的乳制品和食品
公开(公告)号：US20080171104A1
公开(公告)日：2008-07-17
申请号：US11910814
申请日：2006-04-07
申请人： Yang Zhu , Antonius Silvester Maria Sonnenberg , Eibertus Nicolaas Van Loo
发明人： Yang Zhu , Antonius Silvester Maria Sonnenberg , Eibertus Nicolaas Van Loo
IPC分类号： A23L1/28 , A23C15/00 , A23C19/00 , A23C9/00 , A23C9/123 , A23C23/00 , A23G9/04 , C12N1/14
CPC分类号： A23D9/00 , A23C9/1307 , A23C19/06 , A23D7/001 , A23L5/00 , A23L29/269 , A23L31/00 , A23V2002/00 , A23V2250/208 , A23V2200/30 , A23V2200/328
摘要： The present invention deals with the production of food products with a health promoting effect, namely immune modulation in general, and lowering and/or stabilizing blood sugar levels. The food products concerned comprise polysaccharides from edible or medicinal mushrooms. These are produced through fermentation instead of conventional cultivation of mushrooms. Fermentation process is preferably done in submerged cultures, especially fed-batch or step-up cultures.
摘要翻译：本发明涉及具有健康促进作用的食品的生产，即一般的免疫调节，以及降低和/或稳定血糖水平。涉及的食品包括可食用或药用蘑菇的多糖。这些是通过发酵而不是常规栽培蘑菇来生产的。发酵方法优选在浸没培养物，特别是补料分批或升高培养物中进行。

10. 发明申请

US20070300327A1 Plant enzymes for bioconversion 审中-公开
公开(公告)号：US20070300327A1
公开(公告)日：2007-12-27
申请号：US11796503
申请日：2007-04-27
申请人： Hendrik Bouwmeester , Jan-Willem de Kraker , Marloes Schurink , Raoul Bino , Aede de Groot , Maurice Franssen
发明人： Hendrik Bouwmeester , Jan-Willem de Kraker , Marloes Schurink , Raoul Bino , Aede de Groot , Maurice Franssen
IPC分类号： C12N15/82 , A01H5/00 , C12N9/88
CPC分类号： C12N9/0077 , C12N9/00 , C12N9/78 , C12N9/88 , C12N15/8243 , C12P7/26 , C12P7/40 , C12P17/04
摘要： The invention provides a method for converting sesquiterpene. The method includes reacting a sesquiterpene substract with a sesquiterpene converting enzyme. The enzyme is from a species or organism containing sesquiterpenes. The sesquiterpene substrate is not naturally present in the species or organism.

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