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    • 5. 发明申请
    • PHOTOLABILE DINITROINDOLINYL BASED COMPOUNDS
    • 可溶性丁基酚基酚化合物
    • US20100096252A1
    • 2010-04-22
    • US12520924
    • 2008-01-29
    • Graham Ellis-Davies
    • Graham Ellis-Davies
    • C07D209/18B01J19/12
    • C07F9/5728C07D209/08
    • The present invention relates to photolabile or photoreleasable compounds including a caging moiety linked to an effector moiety, wherein the compounds are capable of releasing the effector moiety on irradiation, typically by flash irradiation with light. These compounds are particularly suitable for focal 2-photon uncaging The photoreleasable compounds can be used to deliver effector moieties such as carboxylic acids, preferably, neuroactive amino acids to sites where their activity is required. In preferred embodiments of the invention, the caging moiety is based on 4-carboxymethoxy-5,7-dinitroinlinyl and derivatives thereof.
    • 本发明涉及光不稳定或光可释放化合物,其包括与效应子部分连接的笼蔽部分,其中所述化合物通常通过在光照射下通过照射而释放效应部分。 这些化合物特别适用于焦点2光子褪色。可光致发光的化合物可用于将效应部分如羧酸,优选神经活性氨基酸递送至需要其活性的位点。 在本发明的优选实施方案中,笼状部分基于4-羧基甲氧基-5,7-二硝基苯乙烯基及其衍生物。