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1. 发明申请

US20100168733A1 TREATMENT OF TISSUE IN SPHINCTERS, SINUSES, AND ORIFICES 失效
标题翻译：治疗组织，细胞和组织中的组织
公开(公告)号：US20100168733A1
公开(公告)日：2010-07-01
申请号：US12648249
申请日：2009-12-28
申请人： STUART D. EDWARDS , SIMON W. H. THOMAS
发明人： STUART D. EDWARDS , SIMON W. H. THOMAS
IPC分类号： A61B18/18
CPC分类号： A61N1/0514 , A61B18/18 , A61B2018/0212 , A61N1/06 , A61N1/403
摘要： The invention comprises a method and apparatus for treatment of a body part. More particularly, a method and apparatus for heat treatment of tissue using a catheter inserted into a body part is described along with means for positioning the catheter and means for positioning a set of electrodes relative to a tissue sample for treatment. Still more particularly, radio frequency energy at about 400 to 500 kilohertz is used to provide heat for the tissue treatment.
摘要翻译：本发明包括一种用于治疗身体部位的方法和装置。更具体地，描述了使用插入到身体部分中的导管来热处理组织的方法和装置，以及用于定位导管的装置和用于相对于组织样本定位一组电极的装置用于治疗。更具体地，使用约400至500千赫兹的射频能量来为组织处理提供热量。

2. 发明授权

US07022105B1 Treatment of tissue in sphincters, sinuses and orifices 失效
标题翻译：治疗括约肌，鼻窦和孔的组织
公开(公告)号：US07022105B1
公开(公告)日：2006-04-04
申请号：US09356110
申请日：1999-07-16
申请人： Stuart D. Edwards
发明人： Stuart D. Edwards
IPC分类号： A61M31/00
CPC分类号： A61N1/06 , A61N1/403
摘要： The invention provides a method and system for ablation of body structures or tissue in a sphincter, sinus or orifice such as the rectum, colon, esophagus, vagina, penis, larynx or pharynx. In one aspect of the invention, the environment surrounding the targeted ablation region can be isolated or controlled by blocking the flow of gases or liquids using an inflatable balloon positioned immediately adjacent to the tissue that is to be ablated. In a preferred embodiment, the inflatable balloon also serves to anchor the catheter in place and prevent the catheter from being expelled from the body. The inflatable balloon also insures that locally administered drug remain in the area where most needed. In a second aspect of the invention, positive pressure is used to inflate the balloon. Inflation of balloon triggers the extension of at least one curvilinear electrode into the targeted tissue. Negative pressure deflates the air sac and helps retract the curvilinear electrodes so as to allow the catheter to be removed from the body without damaging adjacent body structures. In a third aspect of the invention, the electrodes are coupled to sensors that measure properties of the target region such as temperature and impedance. Measurement of these properties permits the use of feedback technique to control delivery of the RF energy and administration of fluids for cooling and hydrating the affected tissues. In a fourth aspect of the invention, the catheter includes an optical path that can be coupled to external viewing apparatus. In this way, the position of the electrodes in the body can be determined by fluoroscopic or fiber optic techniques.
摘要翻译：本发明提供了一种用于消融括约肌，窦或孔如直肠，结肠，食管，阴道，阴茎，喉或咽部中的身体结构或组织的方法和系统。在本发明的一个方面，围绕目标消融区域的环境可以通过使用紧邻待烧伤组织定位的可充气气囊来阻止气体或液体的流动而被隔离或控制。在优选实施例中，可膨胀气囊还用于将导管锚定在适当位置并防止导管从身体排出。充气气囊还确保局部给药的药物保留在最需要的区域。在本发明的第二方面中，使用正压使气囊膨胀。球囊的充气触发了至少一个曲线电极延伸到目标组织中。负压使气囊缩小并帮助缩回曲线电极，以便允许导管从身体移除而不损坏邻近的身体结构。在本发明的第三方面中，电极耦合到测量目标区域的性质（诸如温度和阻抗）的传感器。这些性质的测量允许使用反馈技术来控制RF能量的传递和给予流体以冷却和保湿受影响的组织。在本发明的第四方面中，导管包括可以连接到外部观察装置的光路。以这种方式，电极在体内的位置可以通过荧光镜或光纤技术来确定。

3. 发明申请

US20130197505A1 TREATMENT OF TISSUE IN SPHINCTERS, SINUSES, AND ORIFICES 失效
标题翻译：治疗组织，细胞和组织中的组织
公开(公告)号：US20130197505A1
公开(公告)日：2013-08-01
申请号：US13717289
申请日：2012-12-17
申请人： NOVASYS MEDICAL, INC.
发明人： Stuart D. EDWARDS , Simon W. H. THOMAS
IPC分类号： A61B18/18
CPC分类号： A61N1/0514 , A61B18/18 , A61B2018/0212 , A61N1/06 , A61N1/403
摘要： The invention comprises a method and apparatus for treatment of a body part. More particularly, a method and apparatus for heat treatment of tissue using a catheter inserted into a body part is described along with means for positioning the catheter and means for positioning a set of electrodes relative to a tissue sample for treatment. Still more particularly, radio frequency energy at about 400 to 500 kilohertz is used to provide heat for the tissue treatment.
摘要翻译：本发明包括一种用于治疗身体部位的方法和装置。更具体地，描述了使用插入到身体部分中的导管来热处理组织的方法和装置，以及用于定位导管的装置和用于相对于组织样本定位一组电极的装置用于治疗。更具体地，使用约400至500千赫兹的射频能量来为组织处理提供热量。

4. 发明授权

US07291129B2 Apparatus and methods for treating female urinary incontinence 失效
标题翻译：女性尿失禁治疗的装置及方法
公开(公告)号：US07291129B2
公开(公告)日：2007-11-06
申请号：US10207689
申请日：2002-07-25
申请人： Hong Li , Peter S Edelstein , John T To , Simon W. H. Thomas , Benjamin T Nordell
发明人： Hong Li , Peter S Edelstein , John T To , Simon W. H. Thomas , Benjamin T Nordell
IPC分类号： A61M5/178
CPC分类号： A61B18/1477 , A61B18/1485 , A61B2018/00029 , A61B2018/00285 , A61B2018/00523 , A61B2018/00553 , A61B2018/00916 , A61B2218/007 , A61N1/06
摘要： Apparatus and methods are provided for treating female urinary incontinence by injecting a bulking agent at the interface between the mucosal and submucosal layers of the urethral wall. The remodeling device comprises an elongated shaft preferably having means for forming a localized inward protrusion of the urethral wall, and a needle, movable between retracted and deployed positions, for delivering a bulking agent into the urethral wall in the vicinity of the localized inward protrusion to thereby reduce or eliminate symptoms associated with urinary incontinence.
摘要翻译：提供了通过在尿道壁的粘膜和粘膜下层之间的界面处注射填充剂来治疗女性尿失禁的装置和方法。重塑装置包括细长轴，优选地具有用于形成尿道壁的局部向内突出的装置，以及可在缩回和展开位置之间移动的针，用于将填充剂输送到局部向内突出部附近的尿道壁中，从而减少或消除与尿失禁相关的症状。

5. 发明授权

US07722338B2 Peristaltic pump providing simplified loading and improved tubing kink resistance 有权
标题翻译：蠕动泵提供简化的负载和改善的扭结线圈阻力
公开(公告)号：US07722338B2
公开(公告)日：2010-05-25
申请号：US11056086
申请日：2005-02-10
申请人： Benjamin T. Nordell , Peter S. Edelstein , Simon W. H. Thomas
发明人： Benjamin T. Nordell , Peter S. Edelstein , Simon W. H. Thomas
IPC分类号： F04B45/06 , F04B43/12 , F04B43/08
CPC分类号： F04B43/1253
摘要： A peristaltic pump is provided that simplifies the loading of tubing and automatically self-centers the tubing relative to the pump wheel, wherein the pump includes an elongated arm having slotted pinch forks for engaging the tubing. The pinch forks are arranged substantially tangential to the pump wheel to reduce tubing kinking. The pump further includes a spring-loaded clamp that moves the elongated arm between engaged and disengaged positions, the clamp optionally including a sensor element used to detect when the pump is ready for operation.
摘要翻译：提供了一种蠕动泵，其简化了管道的装载并且自动使管道相对于泵轮自中心，其中泵包括细长的臂，其具有用于接合管道的开槽的夹紧叉。夹紧叉布置成基本上与泵轮相切，以减少油管扭结。泵还包括弹簧加载的夹具，其将细长臂移动在接合位置和脱离位置之间，夹具可选地包括用于检测泵何时准备运行的传感器元件。

6. 发明授权

US07306591B2 Apparatus and methods for treating female urinary incontinence 有权
公开(公告)号：US07306591B2
公开(公告)日：2007-12-11
申请号：US10273900
申请日：2002-10-16
申请人： Simon W. H. Thomas , Peter S. Edelstein , John T. To , Benjamin T. Nordell
发明人： Simon W. H. Thomas , Peter S. Edelstein , John T. To , Benjamin T. Nordell
IPC分类号： A61B18/18
CPC分类号： A61B18/00 , A61B17/0625 , A61B18/02 , A61B18/14 , A61B18/1477 , A61B18/1485 , A61B2017/00805 , A61B2017/00867 , A61B2018/00029 , A61B2018/00035 , A61B2018/00178 , A61B2018/00285 , A61B2018/00523 , A61B2018/00553 , A61B2018/00559 , A61B2018/00916 , A61B2018/1425 , A61B2018/143 , A61B2218/007 , A61N1/06 , A61N7/022 , C08L2201/12
摘要： Apparatus and methods are provided for treating female urinary incontinence by applying a form of energy to tissue in the vicinity of the urethra and/or bladder outlet to change tissue compliance without substantially narrowing the urethral and/or bladder outlet lumen. The apparatus comprises an elongated shaft having a means for treating urethral tissue and an expandable member deployable distal of the means for treating. The expandable member is configured to be anchored against the bladder outlet to dispose the means for treating at a desired treatment site in the urethra using only tactile feedback. The means for treating may include a needleless RF electrode, an ultrasound transducer, or a cryogenic probe configured to be advanced through a hollow needle, each of which are designed to reduce or eliminate symptoms associated with urinary incontinence.

7. 发明申请

US20070112340A1 Apparatus and methods for treating female urinary incontinence 有权
标题翻译：女性尿失禁治疗的装置及方法
公开(公告)号：US20070112340A1
公开(公告)日：2007-05-17
申请号：US11431213
申请日：2006-05-10
申请人： Simon Thomas , Peter Edelstein , John To , Benjamin Nordell , Stuart Edwards
发明人： Simon Thomas , Peter Edelstein , John To , Benjamin Nordell , Stuart Edwards
IPC分类号： A61B18/04
CPC分类号： A61B18/00 , A61B17/0625 , A61B18/02 , A61B18/14 , A61B18/1477 , A61B18/1485 , A61B2017/00805 , A61B2017/00867 , A61B2018/00029 , A61B2018/00035 , A61B2018/00178 , A61B2018/00285 , A61B2018/00523 , A61B2018/00553 , A61B2018/00559 , A61B2018/00916 , A61B2018/1425 , A61B2018/143 , A61B2218/007 , A61N1/06 , A61N7/022 , C08L2201/12
摘要： Apparatus and methods are provided for treating female urinary incontinence by applying a form of energy to tissue in the vicinity of the urethra and/or bladder outlet to change tissue compliance without substantially narrowing the urethral and/or bladder outlet lumen. The apparatus comprises an elongated shaft having a means for treating urethral tissue and an expandable member deployable distal of the means for treating. The expandable member is configured to be anchored against the bladder outlet to dispose the means for treating at a desired treatment site in the urethra using only tactile feedback. The means for treating may include a needleless RF electrode, an ultrasound transducer, or a cryogenic probe configured to be advanced through a hollow needle, each of which are designed to reduce or eliminate symptoms associated with urinary incontinence.
摘要翻译：提供了用于通过向尿道和/或膀胱出口附近的组织施加能量来改变组织依从性而不使尿道和/或膀胱出口腔基本上变窄来治疗女性尿失禁的装置和方法。该装置包括细长轴，其具有用于治疗尿道组织的装置和可展开装置的可扩展构件。可膨胀构件被构造成锚固在膀胱出口上，以仅使用触觉反馈来将用于治疗的装置设置在尿道中的期望的治疗部位。用于治疗的装置可以包括无针RF电极，超声换能器或构造成通过中空针前进的低温探针，每个都被设计为减少或消除与尿失禁相关的症状。

8. 发明申请

US20060177328A1 Peristaltic pump providing simplified loading and improved tubing kink resistance 有权
标题翻译：蠕动泵提供简化的负载和改善的扭结线圈阻力
公开(公告)号：US20060177328A1
公开(公告)日：2006-08-10
申请号：US11056086
申请日：2005-02-10
申请人： Benjamin Nordell , Peter Edelstein , Simon Thomas
发明人： Benjamin Nordell , Peter Edelstein , Simon Thomas
IPC分类号： F04B43/12
CPC分类号： F04B43/1253
摘要： A peristaltic pump is provided that simplifies the loading of tubing and automatically self-centers the tubing relative to the pump wheel, wherein the pump includes an elongated arm having slotted pinch forks for engaging the tubing. The pinch forks are arranged substantially tangential to the pump wheel to reduce tubing kinking. The pump further includes a spring-loaded clamp that moves the elongated arm between engaged and disengaged positions, the clamp optionally including a sensor element used to detect when the pump is ready for operation.
摘要翻译：提供了一种蠕动泵，其简化了管道的装载并且自动使管道相对于泵轮自中心，其中泵包括细长的臂，其具有用于接合管道的开槽的夹紧叉。夹紧叉布置成基本上与泵轮相切，以减少油管扭结。泵还包括弹簧加载的夹具，其将细长臂移动在接合位置和脱离位置之间，夹具可选地包括用于检测泵何时准备运行的传感器元件。

9. 发明授权

US08412318B2 Treatment of tissue in sphincters, sinuses, and orifices 有权
公开(公告)号：US08412318B2
公开(公告)日：2013-04-02
申请号：US11207677
申请日：2005-08-18
申请人： Stuart D. Edwards , Simon W. H. Thomas
发明人： Stuart D. Edwards , Simon W. H. Thomas
IPC分类号： A61N1/30
CPC分类号： A61N1/06 , A61N1/403
摘要： The invention comprises a method and apparatus for treatment of a body part. More particularly, a method and apparatus for heat treatment of tissue using a catheter inserted into a body part is described along with means for positioning the catheter and means for positioning a set of electrodes relative to a tissue sample for treatment. Still more particularly, radio frequency energy at about 400 to 500 kilohertz is used to provide heat for the tissue treatment.

10. 发明授权

US08353908B2 Treatment of tissue in sphincters, sinuses, and orifices 失效
标题翻译：治疗括约肌，鼻窦和孔的组织
公开(公告)号：US08353908B2
公开(公告)日：2013-01-15
申请号：US12648249
申请日：2009-12-28
申请人： Stuart D. Edwards , Simon W. H. Thomas
发明人： Stuart D. Edwards , Simon W. H. Thomas
IPC分类号： A61B18/18
CPC分类号： A61N1/0514 , A61B18/18 , A61B2018/0212 , A61N1/06 , A61N1/403
摘要： The invention comprises a method and apparatus for treatment of a body part. More particularly, a method and apparatus for heat treatment of tissue using a catheter inserted into a body part is described along with means for positioning the catheter and means for positioning a set of electrodes relative to a tissue sample for treatment. Still more particularly, radio frequency energy at about 400 to 500 kilohertz is used to provide heat for the tissue treatment.
摘要翻译：本发明包括一种用于治疗身体部位的方法和装置。更具体地，描述了使用插入到身体部分中的导管来热处理组织的方法和装置，以及用于定位导管的装置和用于相对于组织样本定位一组电极的装置用于治疗。更具体地，使用约400至500千赫兹的射频能量来为组织处理提供热量。

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