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1. 发明授权

US07276474B2 Methods of making and using surfactant polymers 有权
标题翻译：制造和使用表面活性剂聚合物的方法
公开(公告)号：US07276474B2
公开(公告)日：2007-10-02
申请号：US10823218
申请日：2004-04-13
申请人： Roger E. Marchant , Tianhong Zhang , Yongxing Qiu , Mark A. Ruegsegger
发明人： Roger E. Marchant , Tianhong Zhang , Yongxing Qiu , Mark A. Ruegsegger
IPC分类号： A61K38/16
CPC分类号： C07K7/06 , A61L27/34 , A61L31/10 , A61L33/0017 , A61L33/08 , A61L33/128 , C07K5/0817 , C07K5/1019 , C08B37/0021 , C08F8/00 , C08F26/02 , C08F16/06
摘要： Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to said backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. The hydrophobic side chains comprise an alkyl group comprising from 2 to 18 methylene groups. The alkyl groups are linked to the polymeric backbone through ester linkages, secondary amine linkages, or, preferably, amide linkages. The hydrophilic side chain is selected from the group consisting of: a neutral oligosaccharide, which, preferably, has weight average molecular weight of less than 7000; a charged oligosaccharide, preferably a negatively charged oligosaccharide having a weight average molecular weight of less than 10,000; an oligopeptide of from about 3 to about 30 amino acid residues, said oligopeptide having an amino acid sequence which interacts with protein receptors on the surface of cells; and combinations thereof. Methods of making the surfactant polymers and using the surfactant polymers to alter the surface properties of a biomaterial are also provided.
摘要翻译：提供了梳状，用于改变生物材料表面性质的表面活性剂聚合物。这种表面活性剂聚合物包括具有用于与侧链偶联的官能团的重复单体单元的聚合物主链，经由官能团连接到所述主链的多个疏水侧链，以及通过官能团连接至所述骨架的多个亲水侧链。疏水侧链包括含有2至18个亚甲基的烷基。烷基通过酯键，仲胺键或优选酰胺键与聚合物主链相连。亲水侧链选自：中性寡糖，其优选具有小于7000的重均分子量; 带电荷的寡糖，优选具有小于10,000的重均分子量的带负电荷的寡糖; 所述寡肽具有约3至约30个氨基酸残基的寡肽，所述寡肽具有与细胞表面上的蛋白受体相互作用的氨基酸序列; 及其组合。还提供了使表面活性剂聚合物和使用表面活性剂聚合物改变生物材料的表面性质的方法。

2. 发明授权

US08163302B2 Methods of making and using surfactant polymers 有权
标题翻译：制造和使用表面活性剂聚合物的方法
公开(公告)号：US08163302B2
公开(公告)日：2012-04-24
申请号：US12062768
申请日：2008-04-04
申请人： Roger E. Marchant , Tianhong Zhang , Yongxing Qiu , Mark A. Ruegsegger
发明人： Roger E. Marchant , Tianhong Zhang , Yongxing Qiu , Mark A. Ruegsegger
IPC分类号： A61F2/08
CPC分类号： A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0017 , A61L33/08 , A61L33/128 , C08B37/0021 , C08B37/0078 , C08F8/00 , C08L101/00 , C08F26/02 , C08F16/06
摘要： Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to the backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. Medical devices coated with the surfactant polymers are also provided. The surfactant polymers may be used to decrease the thrombogenic properties, encapsulation, and bacterial colonization of medical devices.
摘要翻译：提供了梳状，用于改变生物材料表面性质的表面活性剂聚合物。这种表面活性剂聚合物包含具有用于与侧链偶联的官能团的重复单体单元的聚合物主链，经由官能团与主链连接的多个疏水侧链，以及通过官能团连接至所述骨架的多个亲水侧链。还提供了涂有表面活性剂聚合物的医疗装置。表面活性剂聚合物可用于降低医疗装置的血栓形成性质，包封和细菌定植。

3. 发明申请

US20120245288A1 METHODS OF MAKING AND USING SURFACTANT POLYMERS 有权
标题翻译：制造和使用表面活性剂聚合物的方法
公开(公告)号：US20120245288A1
公开(公告)日：2012-09-27
申请号：US13422150
申请日：2012-03-16
申请人： Jan J. LEWANDOWSKI , Yubiao LIU
发明人： Jan J. LEWANDOWSKI , Yubiao LIU
IPC分类号： C08F8/00 , C08F26/02 , C08F8/30
CPC分类号： A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0017 , A61L33/08 , A61L33/128 , C08B37/0021 , C08B37/0078 , C08F8/00 , C08L101/00 , C08F26/02 , C08F16/06
摘要： Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to the backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. Medical devices coated with the surfactant polymers are also provided. The surfactant polymers may be used to decrease the thrombogenic properties, encapsulation, and bacterial colonization of medical devices.
摘要翻译：提供了梳状，用于改变生物材料表面性质的表面活性剂聚合物。这种表面活性剂聚合物包含具有用于与侧链偶联的官能团的重复单体单元的聚合物主链，经由官能团与主链连接的多个疏水侧链，以及通过官能团连接至所述骨架的多个亲水侧链。还提供了涂有表面活性剂聚合物的医疗装置。表面活性剂聚合物可用于降低医疗装置的血栓形成性质，包封和细菌定植。

4. 发明授权

US09125969B2 Methods of making and using surfactant polymers 有权
标题翻译：制造和使用表面活性剂聚合物的方法
公开(公告)号：US09125969B2
公开(公告)日：2015-09-08
申请号：US13422150
申请日：2012-03-16
申请人： Jan J. Lewandowski , Yubiao Liu , Roger Marchant , Tianhong Zhang , Yongxing Qiu , Mark A. Ruegsegger
发明人： Jan J. Lewandowski , Yubiao Liu , Roger Marchant , Tianhong Zhang , Yongxing Qiu , Mark A. Ruegsegger
IPC分类号： A61L27/34 , A61L29/08 , A61L31/10 , A61L33/00 , A61L33/08 , A61L33/12 , C08B37/02 , C08B37/00 , C08F8/00
CPC分类号： A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0017 , A61L33/08 , A61L33/128 , C08B37/0021 , C08B37/0078 , C08F8/00 , C08L101/00 , C08F26/02 , C08F16/06
摘要： Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to the backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. Medical devices coated with the surfactant polymers are also provided. The surfactant polymers may be used to decrease the thrombogenic properties, encapsulation, and bacterial colonization of medical devices.
摘要翻译：提供了梳状，用于改变生物材料表面性质的表面活性剂聚合物。这种表面活性剂聚合物包含具有用于与侧链偶联的官能团的重复单体单元的聚合物主链，经由官能团与主链连接的多个疏水侧链，以及通过官能团连接至所述骨架的多个亲水侧链。还提供了涂有表面活性剂聚合物的医疗装置。表面活性剂聚合物可用于降低医疗装置的血栓形成性质，包封和细菌定植。

5. 发明申请

US20080262614A1 METHODS OF MAKING AND USING SURFACTANT POLYMERS 有权
标题翻译：制造和使用表面活性剂聚合物的方法
公开(公告)号：US20080262614A1
公开(公告)日：2008-10-23
申请号：US12062768
申请日：2008-04-04
申请人： Roger E. MARCHANT , Jan J. LEWANDOWSKI , Yubiao LIU
发明人： Roger E. MARCHANT , Jan J. LEWANDOWSKI , Yubiao LIU
IPC分类号： A61F2/08 , A61F2/00 , C08F16/06 , C08F12/28 , C08G69/00
CPC分类号： A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0017 , A61L33/08 , A61L33/128 , C08B37/0021 , C08B37/0078 , C08F8/00 , C08L101/00 , C08F26/02 , C08F16/06
摘要： Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to the backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. Medical devices coated with the surfactant polymers are also provided. The surfactant polymers may be used to decrease the thrombogenic properties, encapsulation, and bacterial colonization of medical devices.
摘要翻译：提供了梳状，用于改变生物材料表面性质的表面活性剂聚合物。这种表面活性剂聚合物包含具有用于与侧链偶联的官能团的重复单体单元的聚合物主链，经由官能团与主链连接的多个疏水侧链，以及通过官能团连接至所述骨架的多个亲水侧链。还提供了涂有表面活性剂聚合物的医疗装置。表面活性剂聚合物可用于降低医疗装置的血栓形成性质，包封和细菌定植。

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