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1. 发明申请

US20230109998A1 MALARIA TRANSMISSION-BLOCKING VACCINES 有权
公开(公告)号：US20230109998A1
公开(公告)日：2023-04-13
申请号：US17913699
申请日：2020-11-06
申请人： PATH , National University Corporation Ehime University , Sumitomo Pharma Co., Ltd.
发明人： C. Richter King , Yimin Wu , Jordan Lee Plieskatt , Shwu-Maan Lee , Chia-Kuel Wu , Takafumi Tsuboi , Akihisa Fukushima
IPC分类号： A61K39/39 , A61K39/015 , A61K31/505 , A61P33/06
摘要： Malaria transmission-blocking vaccines with good preservation stability and immunostimulatory action are provided. According the present invention, combination use of a pharmaceutical composition comprising (4E,8E,12E,16E,20E)-N-{2-[{4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]benzyl}(methyl)amino]ethyl}-4,8,12,17,21,25-hexamethylhexacosa-4,8,12,16,20,24-hexaeneamide, or a pharmaceutically acceptable salt thereof, as a vaccine adjuvant with enhanced specific immune response against antigens and good preservation stability and a malaria vaccine with non-glycosylation, homogeneity, and biological activity allow for the provision of malaria transmission-blocking vaccines with good preservation stability and immunostimulatory action.

2. 发明申请

US20220396638A1 SULFONATED PULP FIBERS, DERIVATIVE PULP, SULFONATED FINE CELLULOSE FIBERS, METHOD FOR PRODUCING SULFONATED FINE CELLULOSE FIBERS, AND METHOD FOR PRODUCING SULFONATED PULP FIBERS 有权
公开(公告)号：US20220396638A1
公开(公告)日：2022-12-15
申请号：US17850514
申请日：2022-06-27
申请人： MARUSUMI PAPER CO., LTD. , NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY
发明人： Shou HIASA , Hiromi UCHIMURA , Tomoki YABUTANI
IPC分类号： C08B5/14 , D21H11/20
摘要： [Object] An object is to provide a sulfonated fine cellulose fiber having excellent transparency a sulfonated pulp fiber suitable for the sulfonated fine cellulose fiber, a method for producing these fibers, and a derivative pulp containing the sulfonated pulp fiber.
[Means for achieving the object] The sulfonated pulp fiber of the present invention is a pulp fiber comprising a plurality of cellulose fibers, wherein a part of hydroxyl groups of the cellulose fibers of the pulp fiber is substituted with sulfo groups, an introduction amount of sulfur attributable to the sulfo groups is adjusted to be higher than 0.42 mmol/g while maintaining a fiber shape, and a water retention value of the pulp fiber is adjusted to 150% or more. Since the sulfonated pulp fiber has a predetermined water retaining property or more while maintaining the fiber shape, the degree of flexibility in handling can be improved.

3. 发明授权

US11273212B2 Malaria vaccine 有权
公开(公告)号：US11273212B2
公开(公告)日：2022-03-15
申请号：US16348803
申请日：2017-11-10
申请人： Sumitomo Dainippon Pharma Co., Ltd. , NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY
发明人： Akihisa Fukushima , Takafumi Tsuboi , Eizo Takashima , Hikaru Nagaoka
IPC分类号： A61K39/015 , A61P33/06 , A61K39/05 , A61K39/13 , C07K14/445 , C07K16/20 , C12N15/10
摘要： The present invention relates to a polypeptide consisting of an amino acid sequence selected from: (a) the amino acid sequence of SEQ ID NO: 4 or SEQ ID NO: 8, (b) an amino acid sequence that differs from the amino acid sequence of SEQ ID NO: 4 or SEQ ID NO: 8 by substitution, deletion, addition, or insertion of 1 to 10, preferably 1-5, more preferably 1, 2 or 3 amino acids, and (c) an amino acid sequence that has at least 95%, preferably 97%, more preferably 99% sequence identity with the amino acid sequence of SEQ ID NO: 4 or SEQ ID NO: 8, and a malaria vaccine comprising the polypeptide, for example.

4. 发明申请

US20210196220A1 COMPUTER PROGRAM, IMAGE PROCESSING DEVICE, AND IMAGE PROCESSING METHOD 有权
公开(公告)号：US20210196220A1
公开(公告)日：2021-07-01
申请号：US17058694
申请日：2019-05-28
申请人： NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY
发明人： Teruhito KIDO
IPC分类号： A61B6/00 , G06T11/00 , A61B6/03
摘要： An object of the present invention is to provide an analysis method capable of analyzing time-series images by a method simpler than ever. A computer program that is an application example of the present invention is a computer program for an image processing device including a storage unit that stores therein image data including time-series computed tomography (CT) images in a plurality of frames, of an organ of a subject captured after a contrast medium has been administered causes the image processing device to execute: a first step of determining a change-over-time of a CT value on the basis of image data including CT images in the plurality of frames; a second step of determining a predetermined slope that is a slope of the CT value with respect to a predetermined time on the basis of a change-over-time of the CT value determined in the first step; and a third step of approximating a change-over-time of the CT value with a predetermined function on the basis of the predetermined slope determined in the second step.

5. 发明申请

US20200148765A1 ANTI-CLDN-5 ANTIBODY, AND DRUG CONTAINING SAID ANTIBODY 审中-公开
公开(公告)号：US20200148765A1
公开(公告)日：2020-05-14
申请号：US16611678
申请日：2018-04-26
申请人： OSAKA UNIVERSITY , NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY , FUJIFILM Wako Pure Chemical Corporation
发明人： Masuo KONDOH , Kiyohito YAGI , Takefumi DOI , Yoshiaki OKADA , Yosuke HASHIMOTO , Tatsuya SAWASAKI , Hiroyuki TAKEDA , Kohki ENDO , Maki TAMURA
IPC分类号： C07K16/28
摘要： An object of the present invention is to provide a novel molecule which has high specificity to CLDN-5 and recognizes an extracellular domain of CLDN-5. The object is achieved by an antibody which specifically recognizes a three-dimensional structure or a primary structure of an extracellular domain of a Claudin-5 protein.

6. 发明申请

US20170113220A1 FUNCTIONAL MATERIAL, METHOD FOR PRODUCING FUNCTIONAL MATERIAL, AND FUNCTIONAL LIQUID 审中-公开
公开(公告)号：US20170113220A1
公开(公告)日：2017-04-27
申请号：US15300557
申请日：2015-03-31
申请人： NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY
发明人： Hiromi UCHIMURA
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01L3/5023 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B01L2300/161 , B01L2400/0406 , B81B7/00 , G01N2035/00237 , G01N2035/1034
摘要： Disclosed herein is a functional material having the function of detecting a predetermined substance or the like present in a sample with high accuracy even when the amount of the sample is small, and a method for producing the functional material. The functional material includes a channel part 10 that allows a liquid to pass therethrough, and the channel part 10 is made of a water-permeable material 11 containing a water-impermeable material 12. The water-impermeable material 12 is placed between pieces of the water-permeable material 11, and therefore voids 10h can be formed between the water-impermeable material 12 and the water-permeable material 11. That is, a network of the voids 10h can be formed in the channel part 10. A liquid sample supplied to the channel part 10 is allowed to move while being allowed to penetrate into the voids 10h. In addition, components other than a desired component can be separated and removed from a mixture present in the liquid sample while the liquid sample is allowed to move. Therefore, a water-absorbing function and a filtering function can be imparted to the channel part 10.

7. 发明申请

US20110229656A1 IN-LIQUID PLASMA FILM-FORMING APPARATUS, ELECTRODE FOR IN-LIQUID PLASMA, AND FILM-FORMING METHOD USING IN-LIQUID PLASMA 有权
标题翻译：液体等离子体成膜装置，液体等离子体电极和使用液体等离子体的成膜方法
公开(公告)号：US20110229656A1
公开(公告)日：2011-09-22
申请号：US12671773
申请日：2009-03-02
申请人： Kenji Shibata , Toshihisa Shimo , Kyoko Kumagai , Hidetaka Hayashi , Shinya Okuda , Shinfuku Nomura , Hiromichi Toyota
发明人： Kenji Shibata , Toshihisa Shimo , Kyoko Kumagai , Hidetaka Hayashi , Shinya Okuda , Shinfuku Nomura , Hiromichi Toyota
IPC分类号： H05H1/48
CPC分类号： C23C16/509 , C23C16/26 , C23C16/4485 , H01J37/32357
摘要： In an in-liquid plasma film-forming apparatus having: a vessel 1 being capable of accommodating a substrate “S” and a liquid “L” including raw material therein; an electrode 2 for in-liquid plasma, electrode 2 which is disposed in the vessel 1; an electric power device 3 for supplying electricity to the electrode 2 for in-liquid plasma; the electrode 2 for in-liquid plasma is equipped with: a main electrode 21 having a discharging end 22; an auxiliary electrode 26 not only facing the discharging end 22 but also being disposed between the discharging end 22 and the substrate “S” that face each other; and a plasma generating unit 29 having a space that is demarcated by a surface 22a of the discharging end 22 and a surface 26a of the auxiliary electrode 26 facing the surface 22a, and being for generating plasma by means of electricity being supplied to the main electrode 21. And, a decomposed component of the raw material is deposited onto a surface of the substrate “S” by contacting the plasma, which has generated at the plasma generating unit 29, with the substrate “S.”By means of the present construction, it becomes feasible to generate plasma in liquid without ever using a second electrode that serves as a substrate.
摘要翻译：在液体等离子体成膜装置中，具有容纳基材“S”的容器1和包含原料的液体“L” 用于液体内等离子体的电极2，设置在容器1中的电极2; 用于向用于液体内等离子体的电极2供电的电力装置3; 用于液体内等离子体的电极2装备有：具有放电端22的主电极21; 辅助电极26不仅面向放电端22，而且还设置在放电端22和彼此相对的衬底“S”之间; 以及等离子体产生单元29，其具有由排放端22的表面22a和辅助电极26的面向表面22a的表面26a划分的空间，并且用于通过向主电极供电的方式产生等离子体并且，通过使在等离子体产生单元29产生的等离子体与基板“S”接触，将原料的分解成分沉积在基板“S”的表面上。借助于本构造在不用使用作为基板的第二电极的情况下，可以在液体中产生等离子体。

8. 发明公开

US20240148241A1 ENDOSCOPE CLEANING CART 审中-公开
公开(公告)号：US20240148241A1
公开(公告)日：2024-05-09
申请号：US18549678
申请日：2022-03-04
申请人： NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY
发明人： Yoshio IKEDA , Kunihiro FUJIMOTO , Rumiko MORIWAKI
IPC分类号： A61B1/12 , A61B50/20 , A61B90/70
CPC分类号： A61B1/12 , A61B50/20 , A61B90/70 , A61B2090/701
摘要： The present invention provides a cart that can perform bedside cleaning and carry an endoscope, and carries the endoscope, and carries an endoscope including an insertion unit to be inserted into a body cavity and an operation unit for operating the insertion unit, the cart including: a placement portion on which a storage bag storing a cleaning liquid is placed; and a holding portion that holds the operation unit above the placement portion, in which the operation unit is held by the holding portion, and the insertion unit is immersed in the cleaning liquid in the storage bag.

9. 发明授权

US11517897B2 Functional material for testing liquid sample 有权
公开(公告)号：US11517897B2
公开(公告)日：2022-12-06
申请号：US16786918
申请日：2020-02-10
申请人： NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY
发明人： Hiromi Uchimura
IPC分类号： B01L3/00 , G01N35/00
摘要： A functional material for testing a liquid sample includes a based material in a sheet shape and a channel part provided on a mounting surface of the base material wherein the channel part is composed with water-permeable fibers having permeability, and water-impermeable fibers having impermeability. The water-permeable fibers and the water-impermeable fibers are arranged along the longitudinal direction of the channel part, forming voids wherein the voids are in a mesh structure in which one of the voids connects to another of the voids such that the empty spaces are linked from a base end to a tip end of the channel part. A thickness of the channel part is ranged from 20 μm mm to 5 mm, and a width of the voids is ranged from 10 μm to 200 μm, allowing the liquid sample to move from the base end to the tip end due to capillarity.

10. 发明申请

US20220290107A1 METHOD FOR PRODUCING CULTURED TISSUE, AND PREPARATION FOR EXTERNAL APPLICATION 有权
公开(公告)号：US20220290107A1
公开(公告)日：2022-09-15
申请号：US17753282
申请日：2020-08-26
申请人： National University Corporation Ehime University
发明人： Jun Muto , Koji Sayama
IPC分类号： C12N5/071 , A61K31/7016 , A61P17/02 , A61K35/12
摘要： An object of the present invention is to provide a new means for suppressing inhibition of proliferation of keratinocytes even when the keratinocytes start to come into contact with each other. The present invention solves the above problem by culturing keratinocytes in contact with a common medium with fibroblasts treated with a composition containing a specific compound.

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