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1. 发明公开

US20230220016A1 EVOLUTION OF BT TOXINS 审中-公开
公开(公告)号：US20230220016A1
公开(公告)日：2023-07-13
申请号：US18050014
申请日：2022-10-26
申请人： President and Fellows of Harvard College , Monsanto Company
发明人： David R. Liu , Ahmed Hussein Badran , Victor Guzov , Tom Malvar , Prashanth Vishwanath , Jeff Nageotte , Qing Huai , Melissa Kemp
IPC分类号： C07K14/325 , A01N63/50 , C12N15/10 , C12N15/82
CPC分类号： C07K14/325 , A01N63/50 , C12N15/1058 , C12N15/8286
摘要： The disclosure provides amino acid sequence variants of Bacillus thuringiensis (Bt) toxins and methods of producing the same. Some aspects of this disclosure provide methods for generating Bt toxin variants by continuous directed evolution. Some aspects of this disclosure provide compositions and methods for pest control using the disclosed variant Bt toxins.

2. 发明申请

US20090197955A1 METHODS OF IMPROVING DHA DEPOSITION AND RELATED FUNCTION AND/OR DEVELOPMENT 审中-公开
标题翻译：改善DHA沉积和相关功能和/或开发的方法
公开(公告)号：US20090197955A1
公开(公告)日：2009-08-06
申请号：US12362133
申请日：2009-01-29
申请人： Shawna L. Lemke , Gary F. Hartnell
发明人： Shawna L. Lemke , Gary F. Hartnell
IPC分类号： A61K31/202
CPC分类号： A61K31/202 , A23L33/115 , A23L33/12 , A23V2002/00 , A23V2200/322 , A23V2200/326 , A23V2250/1882 , A23V2250/1868 , A23V2250/1874 , A23V2250/187
摘要： The present invention provides for improved deposition of DHA in human or animal tissues by incorporating healthy lipids containing stearidonic acid into humans or animal through prolonged food or feed, as well as through supplements, and therapeutics. Improved deposition of DHA through consumptions of edible compositions comprising stearidonic acid can be used to improve numerous indicators of health and development, including indicators of heart health, neurological function and development, and the Omega-3 Index in tissues.
摘要翻译：本发明通过将长时间的食物或饲料以及补充剂和治疗剂中的含有十八碳四烯酸的健康脂质并入人或动物中来提供DHA在人或动物组织中的沉积。通过消耗含有十八碳四烯酸的食用组合物可以改善DHA的沉积，可用于改善健康和发展的许多指标，包括心脏健康，神经功能和发育指标以及组织中的Omega-3指数。

3. 发明申请

US20050004230A1 Retroviral protease inhibitors 失效
标题翻译：逆转录病毒蛋白酶抑制剂
公开(公告)号：US20050004230A1
公开(公告)日：2005-01-06
申请号：US10793672
申请日：2004-03-05
申请人： John Talley , Daniel Getman , Gary DeCrescenzo , Kathryn Reed , Ko-Chung Lin , John Freskos , Michael Clare , Donald Rogier , Robert Heintz , Michael Vazquez , Richard Mueller
发明人： John Talley , Daniel Getman , Gary DeCrescenzo , Kathryn Reed , Ko-Chung Lin , John Freskos , Michael Clare , Donald Rogier , Robert Heintz , Michael Vazquez , Richard Mueller
IPC分类号： A61K31/40 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/47 , A61K31/472 , A61K38/55 , A61P31/12 , C07D207/16 , C07D211/60 , C07D217/26 , C07D241/04 , C07D401/12 , C07K5/06 , C07K14/81 , A61K31/165 , A61K31/16 , C07C233/02
CPC分类号： C07D401/12 , C07D207/16 , C07D211/60 , C07D217/26
摘要： N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译：含有羟基胺化合物的N-杂环部分作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶抑制剂。

4. 发明申请

US20010031489A1 Methods for producing poly (hydroxy) fatty acids in bacteria 有权
标题翻译：在细菌中生产聚（羟基）脂肪酸的方法
公开(公告)号：US20010031489A1
公开(公告)日：2001-10-18
申请号：US09779427
申请日：2001-02-08
申请人： Monsanto Company
发明人： Alexander Steinbuchel , Mathias Liebergesell , Henry Valentin , Andreas Pries
IPC分类号： C12P007/62
CPC分类号： C12N9/00 , C07C59/10 , C12P7/625
摘要： The present invention relates to a process for the production of poly (hydroxy fatty acids) as well as recombinant bacterial strains for carrying out the process. In addition, new poly(hydroxy fatty acids) and new substrates for the production of conventional and new poly(hydroxy fatty acids) are described. Moreover, the invention also relates to a DNA fragment, which codes for a PhaE and a PhaC component of the poly(hydroxy fatty acid) synthase from Thiocapsa pfennigii, as well as the corresponding poly (hydroxy fatty acid) synthase protein.
摘要翻译：本发明涉及一种生产聚（羟基脂肪酸）的方法以及用于进行该方法的重组细菌菌株。此外，还描述了用于生产常规和新的聚（羟基脂肪酸）的新的聚（羟基脂肪酸）和新的底物。此外，本发明还涉及一种DNA片段，其编码来自Thiocapsa pfennigii的聚（羟基脂肪酸）合酶的PhaE和PhaC组分以及相应的聚（羟基脂肪酸）合酶蛋白。

5. 发明授权

US06156852A Hydroxy-terminated polyhydroxyalkanoates 失效
标题翻译：羟基封端的聚羟基链烷酸酯
公开(公告)号：US06156852A
公开(公告)日：2000-12-05
申请号：US96797
申请日：1998-06-12
申请人： Jawed Asrar , Devang T. Shah , Minhtien Tran
发明人： Jawed Asrar , Devang T. Shah , Minhtien Tran
IPC分类号： C08G18/42 , C08G63/06 , C08G63/91 , C08G81/00 , C08L71/02 , C12P7/62 , C08F20/00
CPC分类号： C08G18/4266 , C08G18/4286 , C08G63/06 , C08G63/912 , C08G81/00 , C08L71/02 , C12P7/625 , C08G2230/00
摘要： Hydroxyterminated PHA is produced by cultivating a PHA-producing microorganism in the presence of an aliphatic diol or an aliphatic polyol. High molecular weight hydroxy-terminated PHA is obtainable by the disclosed process, and is useful in the production of graft, block and random polymers and copolymers with other monomers, oligomers and polymers containing appropriate functionality and end group compatibility. The hydroxyterminated PHAs of the invention display improved thermal stability compared with PHAs not modified to contain increased end-group hydroxyl content. In addition, a branched PHA structure is provided by melt processing polyol terminated PHA.
摘要翻译：在脂肪族二醇或脂肪族多元醇的存在下，通过培养产生PHA的微生物来产生氢离子化的PHA。高分子量羟基封端的PHA可以通过公开的方法获得，并且可用于生产与其它单体，低聚物和包含适当功能和端基相容性的聚合物的接枝，嵌段和无规聚合物和共聚物。与未被修饰以含有增加的端基羟基含量的PHAs相比，本发明的羟基封端的PHA显示出改进的热稳定性。此外，通过熔融加工多元醇封端的PHA提供分支的PHA结构。

6. 发明授权

US6140511A Fungicidal compositions and methods of making thereof 有权
标题翻译：杀真菌组合物及其制备方法
公开(公告)号：US6140511A
公开(公告)日：2000-10-31
申请号：US326225
申请日：1999-06-04
申请人： Wendell G. Phillips , Michael K. Mao , Chun Ma , Thomas L. Fevig
发明人： Wendell G. Phillips , Michael K. Mao , Chun Ma , Thomas L. Fevig
IPC分类号： A01N43/10 , A01N55/00 , A01N55/10 , A01P3/00 , C07D333/38 , C07F7/08 , C07D333/30
CPC分类号： C07F7/083 , C07D333/38 , C07F7/0814
摘要： The fungicidal compound 4,5-dimethyl-N-2-propenyl-2-(trimethylsilyl)-3-thiophenecarboxamide (Formula (I) shown superior and unexpected control of the growth of the soil-borne fungus Gaeumannomyces graminis (Gg). The present invention provides a novel compound for synthesizing the compound of Formula (I) which uses the compound 4-hydroxy-4,5-dimethyl-2-trimethylsilanyl-dihydrothiophene-3-carboxylic acid allylamide (Formula (II)) as well as novel compounds of synthesizing the allylamide. In addition, Formula (II) itself has unexpectedly been found to provide control of Gg. Therefore, the compounds having Formula (III): ##STR1## or an agronomic salts and compositions thereof are expected to provide such control as well; wherein:Q is --NH, S, or O;W is O, or S;X is --OH, --OAc, --OR, where R is lower alkyl;Y is S, O, or --NH;Z is --Si(R).sub.3, --C(R).sub.3, where R is lower alkyl;R.sub.1 is a lower alkyl, allyl, or propargyl;R.sub.2 is a lower alkyl or aryl; andR.sub.3 and R.sub.4 are independently chosen from hydrogen, a lower alkyl and aryl;optionally, R.sub.2 and R.sub.3 together form a 5- or 6-membered ring.
摘要翻译：杀真菌化合物4,5-二甲基-N-2-丙烯基-2-（三甲基甲硅烷基）-3-噻吩甲酰胺（式（I））显示出对土壤真菌Gaeumannomyces graminis（Gg）的生长的优异和意想不到的控制。本发明提供用于合成使用化合物4-羟基-4,5-二甲基-2-三甲基硅烷基 - 二氢噻吩-3-甲酸烯丙基酰胺（式（II））的式（I）化合物的新化合物以及新颖的此外，意外地发现式（II）本身提供了对Gg的控制。因此，具有式（III）的化合物或其农艺盐及其组合物也预期也提供这样的控制; 其中：Q是-NH，S或O; W是O或S; X是-OH，-OAc，-OR，其中R是低级烷基; Y是S，O或-NH; Z是-Si （R）3，-C（R）3，其中R是低级烷基; R 1是低级烷基，烯丙基或炔丙基; R 2是低级烷基或芳基; R 3和R 4独立地选自氢，低烷基和芳基; 任选地，R 2和R 3一起形成5-或6-元环。

7. 发明授权

US6130351A Continuous process for the preparation of N-(phosphonomethyl) iminodiacetic acid 有权
标题翻译：连续制备N-（膦酰基甲基）亚氨基二乙酸的方法
公开(公告)号：US6130351A
公开(公告)日：2000-10-10
申请号：US373106
申请日：1999-08-12
申请人： Michael K. Stern , Todd J. Johnson , Amy L. Jorgenson , Michael D. Rogers , Thaddeus S. Franczyk, II
发明人： Michael K. Stern , Todd J. Johnson , Amy L. Jorgenson , Michael D. Rogers , Thaddeus S. Franczyk, II
IPC分类号： B01J20/26 , B01J20/34 , B01J31/20 , B01J31/40 , B01J38/00 , C07B61/00 , C07C233/47 , C07D241/08 , C07F9/38
CPC分类号： C07D241/08 , C07C233/47 , C07F9/3808
摘要： A process for the production of N-(phosphonomethyl)iminodiacetic acid. N-(acetyl)iminodiacetic acid is formed in a amidocarboxymethylation reactor system, into which a source of each of the following is continuously fed: (1) acetamide or an acetamide derivative, (2) formaldehyde or a formaldehyde generator or derivative, (3) a carbonylation catalyst, (4) carbon monoxide, and optionally (5) hydrogen. In turn, an amidocarboxymethylation reaction product stream, which contains N-(acetyl)iminodiacetic acid and the carbonylation catalyst, is withdrawn from the amidocarboxymethylation reactor system. The carbonylation catalyst is separated from the amidocarboxymethylation reaction product stream to recover the carbonylation catalyst and form a catalyst depleted product stream which contains N-(acetyl)iminodiacetic acid. The separated carbonylation catalyst is returned to the amidocarboxymethylation reactor system, and the N-(acetyl)iminodiacetic acid in the catalyst depleted product stream is either: (1) reacted with a source of phosphorous and a source of formaldehyde in the presence of an acid to form a phosphonomethylation reaction product stream containing N-(phosphonomethyl)iminodiacetic acid and acetic acid; or (2) deacylated and cyclized to form a 2,5-diketopiperazine, and then reacted with a source of phosphorous and a source of formaldehyde in the presence of an acid to form a phosphonomethylation reaction product stream containing N-(phosphonomethyl)iminodiacetic acid and acetic acid. Either way, the N-(phosphonomethyl)iminodiacetic acid is precipitated from the phosphonomethylation reaction product stream in the presence of acetic acid, and the precipitate is recovered to form a filtrate stream.
摘要翻译：一种生产N-（膦酰基甲基）亚氨基二乙酸的方法。在酰胺羧甲基化反应器系统中形成N-（乙酰基）亚氨基二乙酸，其中连续供给以下各项的源：（1）乙酰胺或乙酰胺衍生物，（2）甲醛或甲醛发生剂或衍生物，（3 ）羰基化催化剂，（4）一氧化碳和任选的（5）氢。反过来，含有N-（乙酰基）亚氨基二乙酸和羰基化催化剂的酰胺甲基甲基化反应产物流从酰胺羧甲基化反应器系统中排出。从酰胺羧甲基化反应产物流中分离羰基化催化剂以回收羰基化催化剂并形成含有N-（乙酰基）亚氨基二乙酸的催化剂贫化产物流。将分离的羰基化催化剂返回到酰胺羧甲基化反应器系统中，催化剂贫化产物流中的N-（乙酰基）亚氨基二乙酸是：（1）在酸存在下与磷源和甲醛源反应以形成含有N-（膦酰基甲基）亚氨基二乙酸和乙酸的膦酰基甲基化反应产物流; 或（2）脱酰基并环化形成2,5-二酮哌嗪，然后在酸存在下与磷源和甲醛源反应，形成含有N-（膦酰基甲基）亚氨基二乙酸的膦酰基甲基化反应产物流和乙酸。无论哪种方式，在乙酸存在下，从膦酰基甲基化反应产物流中沉淀N-（膦酰基甲基）亚氨基二乙酸，并回收沉淀物以形成滤液流。

8. 发明授权

US06130333A Bicyclic imidazolyl derivatives as phosphodiesterase inhibitors, pharmaceutical compositions and method of use 失效
标题翻译：作为磷酸二酯酶抑制剂的双环咪唑基衍生物，药物组合物和使用方法
公开(公告)号：US06130333A
公开(公告)日：2000-10-10
申请号：US200863
申请日：1998-11-27
申请人： Horng-Chih Huang , Timothy S. Chamberlain , Steven Lynn Settle , William Dean Joy , Ned R. Siegel , Leslie D. Bell
发明人： Horng-Chih Huang , Timothy S. Chamberlain , Steven Lynn Settle , William Dean Joy , Ned R. Siegel , Leslie D. Bell
IPC分类号： A61K31/4184 , C07D405/04 , C07D405/14 , C07D471/04 , C07D235/04 , A61K31/443 , C07D401/06 , C07D471/02 , A61K81/437 , A61N27/06
CPC分类号： C07D405/04 , A61K31/4184 , C07D405/14 , C07D471/04
摘要： The present invention provides for compounds having the following Formulae I-III, ##STR1## and ##STR2## The compounds of the present invention are useful in the treatment of a variety of disease such as glaucoma, sexual dysfunction, asthma and cardiovascular disorders such as stable-, unstable- and variant-angina, hypertension, pulmonary hypertension, congestive heart failure, atherosclerosis, and thrombosis.
摘要翻译：本发明提供具有以下式I-III的化合物，本发明化合物可用于治疗各种疾病，如青光眼，性功能障碍，哮喘和心血管疾病如稳定，不稳定和变异型心绞痛，高血压，肺动脉高压，充血性心力衰竭，动脉粥样硬化和血栓形成。

9. 发明授权

US6121199A Herbicidal compositions of polyoxyalkylene alkylamine surfactants having reduced eye irritation 有权
标题翻译：具有减轻眼睛刺激性的聚氧化烯烷基胺表面活性剂的除草组合物
公开(公告)号：US6121199A
公开(公告)日：2000-09-19
申请号：US320356
申请日：1999-05-26
申请人： Paul D. Berger , Antonio M. Jimenez
发明人： Paul D. Berger , Antonio M. Jimenez
IPC分类号： A01N25/30 , A01N25/32 , A01N57/20 , B01F17/00 , A01N57/02
CPC分类号： B01F17/0085 , A01N25/30 , A01N25/32 , A01N57/20 , B01F17/005 , Y10S516/05 , Y10S516/07 , Y10S516/916
摘要： There are provided compositions of certain polyoxyalkylene alkylamine surfactants having eye irritation reduced by the addition of an effective amount of a sulfated polyoxyalkylene alkylphenol alcohol sulfate, polyoxyalkylene alcohol sulfate, mono- or dialcohol phosphate mono- or di-(polyoxyalkylene alcohol) phosphate, polyoxyalkylene alkylphenol carboxylate or polyoxyalkylene alcohol carboxylate surfactant. Also provided are pesticidal, particularly herbicidal, compositions comprising polyoxyalkylene alkylamine surfactants having eye irritation reduced by addition of these eye irritation reducing compounds.
摘要翻译：提供了通过添加有效量的硫酸化聚氧化烯烷基酚醇硫酸盐，聚氧化烯醇硫酸酯，磷酸单或二醇（聚氧化烯醇）磷酸酯，聚氧化烯烷基苯酚的聚氧亚烷基烷基酚羧酸盐或聚氧化烯醇羧酸盐表面活性剂。还提供了包含通过加入这些眼睛刺激性还原化合物减少眼刺激性的聚氧化烯烷基胺表面活性剂的杀虫剂，特别是除草剂的组合物。

10. 发明授权

US06111006A Process for preparing films and coatings 失效
标题翻译：制备薄膜和涂料的方法
公开(公告)号：US06111006A
公开(公告)日：2000-08-29
申请号：US663088
申请日：1997-07-07
申请人： Simon Dominic Waddington
发明人： Simon Dominic Waddington
IPC分类号： C08L67/04 , C09D167/04 , C08K3/38
CPC分类号： C09D167/04 , C08L67/04
摘要： Extrusion films and coatings are prepared by applying a polyhydroxyalkanoate (PHA) to a surface which is in the range from 20.degree. C. above to 20.degree. C. below the optimum crystallisation temperature of the PHA. A PHA of high melt flow index is preferred.
摘要翻译： PCT No.PCT / GB94 / 02761 Sec。 371日期1997年7月7日 102（e）日期1997年7月7日PCT 1994年12月19日PCT PCT。第WO95 / 17454号公报日期1995年6月29日通过将聚羟基链烷酸酯（PHA）应用于低于PHA的最佳结晶温度的20℃以上20℃以上的表面来制备渗出膜和涂层。高熔体流动指数的PHA是优选的。

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