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1. 发明授权

US06278017B1 Continuous process for the preparation of N-(phosphonomethyl)iminodiacetic acid 有权
标题翻译：连续制备N-（膦酰基甲基）亚氨基二乙酸的方法
公开(公告)号：US06278017B1
公开(公告)日：2001-08-21
申请号：US09612705
申请日：2000-07-10
申请人： Michael K. Stern , Todd J. Johnson , Amy L. Jorgenson , Michael D. Rogers , Thaddeus S. Franczyk, II
发明人： Michael K. Stern , Todd J. Johnson , Amy L. Jorgenson , Michael D. Rogers , Thaddeus S. Franczyk, II
IPC分类号： C07F938
CPC分类号： C07D241/08 , C07C233/47 , C07F9/3808
摘要： A process for the continuous production of N-(phosphonomethyl)glycine is provided. In the process, N-(acetyl)iminodiacetic acid is formed in an amidocarboxymethylation reactor system. The N-(acetyl)iminodiacetic acid product stream is either: (1) reacted with a source of phosphorous and a source of formaldehyde in the presence of an acid to form a phosphonomethylation reaction product stream containing N-(phosphonomethyl)iminodiacetic acid and acetic acid; or (2) deacylated and cyclized to form a 2,5-diketopiperazine, and then reacted with a source of phosphorous and a source of formaldehyde in the presence of an acid to form a phosphonomethylation reaction product stream containing N-(phosphonomethyl)iminodiacetic acid and acetic acid. In either case, the N-(phosphonomethyl)iminodiacetic acid product is recovered and converted to N-(phosphonomethyl)glycine.
摘要翻译：提供了连续生产N-（膦酰基甲基）甘氨酸的方法。在此过程中，N-（乙酰基）亚氨基二乙酸在酰胺羧甲基化反应器体系中形成。 N-（乙酰基）亚氨基二乙酸产物流是：（1）在酸存在下与磷源和甲醛源反应，形成含有N-（膦酰基甲基）亚氨基二乙酸和乙酸的膦酰基甲基化反应产物流酸; 或（2）脱酰基并环化形成2,5-二酮哌嗪，然后在酸存在下与磷源和甲醛源反应，形成含有N-（膦酰基甲基）亚氨基二乙酸的膦酰基甲基化反应产物流和乙酸。在任一种情况下，N-（膦酰基甲基）亚氨基二乙酸产物被回收并转化成N-（膦酰基甲基）甘氨酸。

2. 发明申请

US20090259068A1 REACTION SYSTEMS FOR MAKING N-(PHOSPHONOMETHYL) GLYCINE COMPOUNDS 审中-公开
标题翻译：制备N-（膦酰基）乙酰化合物的反应体系
公开(公告)号：US20090259068A1
公开(公告)日：2009-10-15
申请号：US12365507
申请日：2009-02-04
申请人： Eric Haupfear , Jerald D. Heise , Amy L. Jorgenson , Michael Rogers , Henry Chien , Eduardo Casanova , William Hooper , William Scholle , Juan Arhancet , Mark A. Leiber , Kent Wittler , Karen A. Wittler
发明人： Eric Haupfear , Jerald D. Heise , Amy L. Jorgenson , Michael Rogers , Henry Chien , Eduardo Casanova , William Hooper , William Scholle , Juan Arhancet , Mark A. Leiber , Kent Wittler , Karen A. Wittler
IPC分类号： C07F9/38 , B01D1/00 , B01D9/00
CPC分类号： C07F9/3813 , Y02P20/582
摘要： This invention generally relates to liquid phase oxidation processes for making N-(phosphonomethyl)glycine (also known in the agricultural chemical industry as glyphosate) and related compounds. This invention, for example, particularly relates to processes wherein an N-(phosphonomethyl)iminodiacetic acid (NPMIDA) substrate (i.e., N-(phosphonomethyl)iminodiacetic acid, a salt of N-(phosphonomethyl)iminodiacetic acid, or an ester of N-(phosphonomethyl)iminodiacetic acid) is continuously oxidized to form an N-(phosphonomethyl)glycine product (i.e., N-(phosphonomethyl)glycine, a salt of N-(phosphonomethyl)glycine, or an ester of N-(phosphonomethyl)glycine). This invention also, for example, particularly relates to processes wherein an N-(phosphonomethyl)iminodiacetic acid substrate is oxidized to form an N-(phosphonomethyl)glycine product, which, in turn, is crystallized (at least in part) in an adiabatic crystallizer.
摘要翻译：本发明一般涉及制备N-（膦酰基甲基）甘氨酸（农业化学工业中也称为草甘膦）和相关化合物的液相氧化方法。本发明特别涉及N-（膦酰基甲基）亚氨基二乙酸（NPMIDA）底物（即N-（膦酰基甲基）亚氨基二乙酸，N-（膦酰基甲基）亚氨基二乙酸的盐或N - （膦酰基甲基）亚氨基二乙酸）连续氧化形成N-（膦酰基甲基）甘氨酸产物（即N-（膦酰基甲基）甘氨酸，N-（膦酰基甲基）甘氨酸的盐或N-（膦酰基甲基）甘氨酸的酯）。本发明还特别涉及其中N-（膦酰基甲基）亚氨基二乙酸底物被氧化以形成N-（膦酰基甲基）甘氨酸产物的方法，其反过来在绝热中结晶（至少部分地）结晶器。

3. 发明授权

US07015351B2 Reaction systems for making N-(phosphonomethyl) glycine compounds 有权
公开(公告)号：US07015351B2
公开(公告)日：2006-03-21
申请号：US09863885
申请日：2001-05-22
申请人： Eric Haupfear , Jerald D. Heise , Amy L. Jorgenson , Michael Rogers , Henry Chien , Eduardo Casanova , William Hooper , William Scholle , Juan Arhancet , Mark A. Leiber , Karen A. Wittler, legal representative
发明人： Kent Wittler, deceased
IPC分类号： C07F9/28
CPC分类号： C07F9/3813 , Y02P20/582
摘要： This invention generally relates to liquid phase oxidation processes for making N-(phosphonomethyl)glycine (also known in the agricultural chemical industry as glyphosate) and related compounds. This invention, for example, particularly relates to processes wherein an N-(phosphonomethyl)iminodiacetic acid (NPMIDA) substrate (i.e., N-(phosphonomethyl)iminodiacetic acid, a salt of N-(phosphonomethyl)iminodiacetic acid, or an ester of N-(phosphonomethyl)iminodiacetic acid) is continuously oxidized to form an N-(phosphonomethyl)glycine product (i.e., N-(phosphonomethyl)glycine, a salt of N-(phosphonomethyl)glycine, or an ester of N-(phosphonomethyl)glycine). This invention also, for example, particularly relates to processes wherein an N-(phosphonomethyl)iminodiacetic acid substrate is oxidized to form an N-(phosphonomethyl)glycine product, which, in turn, is crystallized (at least in part) in an adiabatic crystallizer.

4. 发明授权

US6130351A Continuous process for the preparation of N-(phosphonomethyl) iminodiacetic acid 有权
标题翻译：连续制备N-（膦酰基甲基）亚氨基二乙酸的方法
公开(公告)号：US6130351A
公开(公告)日：2000-10-10
申请号：US373106
申请日：1999-08-12
申请人： Michael K. Stern , Todd J. Johnson , Amy L. Jorgenson , Michael D. Rogers , Thaddeus S. Franczyk, II
发明人： Michael K. Stern , Todd J. Johnson , Amy L. Jorgenson , Michael D. Rogers , Thaddeus S. Franczyk, II
IPC分类号： B01J20/26 , B01J20/34 , B01J31/20 , B01J31/40 , B01J38/00 , C07B61/00 , C07C233/47 , C07D241/08 , C07F9/38
CPC分类号： C07D241/08 , C07C233/47 , C07F9/3808
摘要： A process for the production of N-(phosphonomethyl)iminodiacetic acid. N-(acetyl)iminodiacetic acid is formed in a amidocarboxymethylation reactor system, into which a source of each of the following is continuously fed: (1) acetamide or an acetamide derivative, (2) formaldehyde or a formaldehyde generator or derivative, (3) a carbonylation catalyst, (4) carbon monoxide, and optionally (5) hydrogen. In turn, an amidocarboxymethylation reaction product stream, which contains N-(acetyl)iminodiacetic acid and the carbonylation catalyst, is withdrawn from the amidocarboxymethylation reactor system. The carbonylation catalyst is separated from the amidocarboxymethylation reaction product stream to recover the carbonylation catalyst and form a catalyst depleted product stream which contains N-(acetyl)iminodiacetic acid. The separated carbonylation catalyst is returned to the amidocarboxymethylation reactor system, and the N-(acetyl)iminodiacetic acid in the catalyst depleted product stream is either: (1) reacted with a source of phosphorous and a source of formaldehyde in the presence of an acid to form a phosphonomethylation reaction product stream containing N-(phosphonomethyl)iminodiacetic acid and acetic acid; or (2) deacylated and cyclized to form a 2,5-diketopiperazine, and then reacted with a source of phosphorous and a source of formaldehyde in the presence of an acid to form a phosphonomethylation reaction product stream containing N-(phosphonomethyl)iminodiacetic acid and acetic acid. Either way, the N-(phosphonomethyl)iminodiacetic acid is precipitated from the phosphonomethylation reaction product stream in the presence of acetic acid, and the precipitate is recovered to form a filtrate stream.
摘要翻译：一种生产N-（膦酰基甲基）亚氨基二乙酸的方法。在酰胺羧甲基化反应器系统中形成N-（乙酰基）亚氨基二乙酸，其中连续供给以下各项的源：（1）乙酰胺或乙酰胺衍生物，（2）甲醛或甲醛发生剂或衍生物，（3 ）羰基化催化剂，（4）一氧化碳和任选的（5）氢。反过来，含有N-（乙酰基）亚氨基二乙酸和羰基化催化剂的酰胺甲基甲基化反应产物流从酰胺羧甲基化反应器系统中排出。从酰胺羧甲基化反应产物流中分离羰基化催化剂以回收羰基化催化剂并形成含有N-（乙酰基）亚氨基二乙酸的催化剂贫化产物流。将分离的羰基化催化剂返回到酰胺羧甲基化反应器系统中，催化剂贫化产物流中的N-（乙酰基）亚氨基二乙酸是：（1）在酸存在下与磷源和甲醛源反应以形成含有N-（膦酰基甲基）亚氨基二乙酸和乙酸的膦酰基甲基化反应产物流; 或（2）脱酰基并环化形成2,5-二酮哌嗪，然后在酸存在下与磷源和甲醛源反应，形成含有N-（膦酰基甲基）亚氨基二乙酸的膦酰基甲基化反应产物流和乙酸。无论哪种方式，在乙酸存在下，从膦酰基甲基化反应产物流中沉淀N-（膦酰基甲基）亚氨基二乙酸，并回收沉淀物以形成滤液流。

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