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1. 发明授权

US10600529B2 Method of manufacturing a radiation source 有权
公开(公告)号：US10600529B2
公开(公告)日：2020-03-24
申请号：US15532089
申请日：2015-12-04
申请人： General Electric Company , Medi-Physics Inc.
发明人： Matthew David Butts , Charles E. Shanks
IPC分类号： G21G4/06 , G21G4/08 , G21G1/00 , G21G1/02 , G21G1/06 , B29C39/00 , B29K63/00 , B29K505/08
摘要： An equatorial anthropic radiation source and a method of making an equatorial anthropic radiation source are described. The radiation source is useful in diagnostic imaging applications in healthcare or other industries (e.g. computerized three-dimensional segmental imaging; Crompton scattering imaging techniques; radiation detector check and calibration, in particular CdZnTe detectors commonly used in medical imaging).

2. 发明授权

US10596533B2 Impeller bottle with an elongated evacuation tube 有权
公开(公告)号：US10596533B2
公开(公告)日：2020-03-24
申请号：US15107340
申请日：2014-12-22
申请人： Medi-Physics, Inc.
发明人： Kevin M. Helle , Robert F. Chisholm , Jay Christopher Reed , Michael T. Schneider
IPC分类号： B01F13/08 , B01F15/02
摘要： A mixing device including a container defining a container cavity, the container including a bottom wall supporting a hollow shaft, the shaft supporting an impeller thereon such that the impeller is free to rotate about the shaft, the impeller including a central passageway therethrough for receiving the shaft, the container further including an elongated evacuation tube having a first end positioned within the passageway of the shaft and an opposed second end extending to a port of the container. Methods of using the mixing device to provide improved cell culture.

3. 发明授权

US09775638B2 Braced brachytherapy needle 有权
公开(公告)号：US09775638B2
公开(公告)日：2017-10-03
申请号：US13515375
申请日：2010-12-22
申请人： Robert F. Chisholm , Jay Reed , Kevin Helle
发明人： Robert F. Chisholm , Jay Reed , Kevin Helle
IPC分类号： A61N5/10 , A61B17/34
CPC分类号： A61B17/3403 , A61B2017/3405 , A61N5/1027 , A61N2005/1012
摘要： Braces to reduce bending of a brachytherapy needle during insertion into a patient, as well as methods of using the needle braces and kits useful therefor.

4. 发明授权

US08007427B2 Products and methods for brachytherapy 有权
标题翻译：近距离放射疗法的产品和方法
公开(公告)号：US08007427B2
公开(公告)日：2011-08-30
申请号：US11959687
申请日：2007-12-19
申请人： Jay Reed , Mike Rapach , Kevin Helle , Juliano Oei
发明人： Jay Reed , Mike Rapach , Kevin Helle , Juliano Oei
IPC分类号： A61M36/00
CPC分类号： A61N5/1027 , A61N2005/1023
摘要： A radioactive member for use in brachytherapy comprising a hollow elongate bioabsorbable suture member with radioactive seeds and spacer members without different coloration and diameter from the radioactive seeds alternately disposed therein, and methods for the manufacture and the use thereof. The radioactive members may be used in the treatment of, for example, prostate cancer.
摘要翻译：一种用于近距离放射治疗的放射性构件，包括具有放射性种子的空心细长生物可吸收缝合构件和与其交替设置的放射性种子没有不同着色和直径的间隔构件及其制造和使用方法。放射性成分可用于治疗例如前列腺癌。

5. 发明申请

US20110104067A1 METHODS FOR IN VIVO EVALUATION OF PULMONARY PHYSIOLOGY AND/OR FUNCTION USING NMR SIGNALS OF POLARIZED 129XE 审中-公开
标题翻译：使用极化129XE的NMR信号进行血管生成和/或功能的血管生成评估方法
公开(公告)号：US20110104067A1
公开(公告)日：2011-05-05
申请号：US12987313
申请日：2011-01-10
申请人： Bastiaan Driehuys , Margaret Hall , Claudio Marelli , Sven Mansson , Jan Wolber
发明人： Bastiaan Driehuys , Margaret Hall , Claudio Marelli , Sven Mansson , Jan Wolber
IPC分类号： A61B5/055
CPC分类号： A61K49/06 , A61B5/02755 , A61B5/055 , A61B5/0813 , A61B5/411 , A61B5/413 , G01N24/08 , G01R33/46 , G01R33/485 , G01R33/5601 , G01R33/563 , G01R33/56308
摘要： In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129Xe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane or tissue; (b) the operational condition or function of a body system or portion thereof (when at rest or under stimulation); and/or (c) the efficacy of a therapeutic treatment used to treat a diagnosed disorder, disease, or condition. Thus, the present invention provides methods for screening and/or diagnosing a respiratory, cardiopulmonary disorder or disease such as chronic heart failure, and/or methods for monitoring the efficacy of therapeutics administered to subject to treat the disorder or disease.
摘要翻译：在某些实施方案中，本发明的方法获得在所选结构，环境或系统中的极化129Xe的NMR光谱信号的动态数据集。信号数据可用于评估：（a）膜或组织的生理学; （b）身体系统或其部分的运行状况或功能（休息时或刺激时）; 和/或（c）用于治疗诊断的病症，疾病或病症的治疗性治疗的功效。因此，本发明提供了用于筛选和/或诊断呼吸，心肺病或疾病如慢性心力衰竭的方法和/或用于监测施用于受治疗疾病或疾病的治疗剂的功效的方法。

6. 发明授权

US07287390B2 Optical pumping modules, polarized gas blending and dispensing systems, and automated polarized gas distribution systems and related devices and methods 有权
标题翻译：光泵模块，极化气体混合和分配系统以及自动化极化气体分配系统及相关装置和方法
公开(公告)号：US07287390B2
公开(公告)日：2007-10-30
申请号：US10277909
申请日：2002-10-22
申请人： Kenneth Bolam
发明人： Kenneth Bolam
IPC分类号： B01D8/00 , F25B21/00 , F25B49/00 , G01N1/00 , G01N24/00
CPC分类号： G01R33/282 , A61K49/1815 , Y10T436/10 , Y10T436/24 , Y10T436/25 , Y10T436/25875
摘要： Hyperpolarizers for producing polarized noble gases can include: (a) a control module configured to direct the operation of a hyperpolarizer to produce polarized noble gas via spin-exchange interactions between a noble gas and an alkali metal; (b) at least one optical pumping module including an optical pumping cell operably associated with the control module; (c) a dispensing system operably associated with the control module and the optical pumping module to dispense meted volumes of polarized gas from the hyperpolarizer; and (d) a fluid distribution system operably associated with the control module, the optical pumping module, and the dispensing system, such that, in response to commands transmitted from the control module, the fluid distribution system operates to automatically direct purge gas into and out of a gas travel path that extends from the control module to the optical pumping cell prior to commencing the spin-exchange interactions in the optical pumping cell, then to receive unpolarized gas and direct it to travel in the gas travel path to the optical pumping cell, and, following the spin-exchange interactions, to automatically direct polarized gas from the optical pumping cell into a polarized gas exit travel path to the dispensing system. Related methods and computer program products as well as particular embodiments of optical pumping modules, thermal oven assemblies, and manifold blocks are also described.
摘要翻译：用于生产极化惰性气体的超极化剂可以包括：（a）控制模块，其配置为引导超极化器的操作，以通过惰性气体和碱金属之间的自旋交换相互作用产生极性惰性气体; （b）至少一个光泵送模块，其包括与所述控制模块可操作地相关联的光泵浦单元; （c）与所述控制模块和所述光泵送模块可操作地相关联的分配系统，以从所述超极化器分配经测量的极化气体体积; 以及（d）与所述控制模块，所述光泵送模块和所述分配系统可操作地相关联的流体分配系统，使得响应于从所述控制模块传送的命令，所述流体分配系统操作以自动地将吹扫气体引导进入和在开始光泵浦单元之间的自旋交换相互作用之前从控制模块延伸到光泵浦单元的气体行进路径中，然后接收非偏振气体并引导其在气体行进路径中行进到光泵浦并且在自旋交换相互作用之后，自动地将来自光学泵浦单元的极化气体引导到分配系统的极化气体出口行进路径中。还描述了相关方法和计算机程序产品以及光泵模块，热烘箱组件和歧管块的特定实施例。

7. 发明授权

US5026913A Hydrocarbylphenyl diaminodithiol derivatives 失效
标题翻译：烃基苯基二氨基二硫醇衍生物
公开(公告)号：US5026913A
公开(公告)日：1991-06-25
申请号：US576163
申请日：1990-08-30
申请人： William J. McBride , Ronald M. Baldwin , Janice M. Kerr , Lisa M. Schultze , Nilda Salazar
发明人： William J. McBride , Ronald M. Baldwin , Janice M. Kerr , Lisa M. Schultze , Nilda Salazar
IPC分类号： A61K51/04 , C07C323/25 , C07C323/60 , C07D285/00 , C07F13/00
CPC分类号： C07F13/005 , A61K51/0478 , C07C323/25 , C07C323/60 , C07D285/00
摘要： An agent for imaging organs using a radioactive complex of a radioactive metal with a benzene ring having two 2-mercapto-2-methylpropylamino substitutents where one of these mercapto substituents is substituted with a hydrocarbyl group.
摘要翻译：使用放射性金属的放射性配合物与具有两个2-巯基-2-甲基丙基氨基取代基的苯环成像器官的成像器官，其中这些巯基取代基之一被烃基取代。

8. 发明授权

US4434151A Bifunctional chelating agents 失效
标题翻译：双功能螯合剂
公开(公告)号：US4434151A
公开(公告)日：1984-02-28
申请号：US439960
申请日：1982-11-08
申请人： Edmund F. Byrne , Glen L. Tolman
发明人： Edmund F. Byrne , Glen L. Tolman
IPC分类号： C07D333/36 , A61K51/00 , A61K51/04 , C07C67/00 , C07C313/00 , C07C323/60 , C07F13/00 , C07K1/113 , C07K5/02 , C07K5/06 , C09K3/00 , A61K43/00 , A61K49/00
CPC分类号： C07K5/06026 , A61K51/0478 , A61K2123/00 , Y02P20/55
摘要： Novel homocysteine thiolactone bifunctional chelating agents useful for chelating radionuclides to produce a radiodiagnostic agent for use in in vivo imaging and a method for producing this chelating agent.
摘要翻译：可用于螯合放射性核素以产生用于体内成像的放射性诊断剂的新型同型半胱氨酸硫内酯双功能螯合剂及其生产该螯合剂的方法。

9. 发明授权

US4176173A Radiographic compositions 失效
标题翻译：射线成像
公开(公告)号：US4176173A
公开(公告)日：1979-11-27
申请号：US816618
申请日：1977-07-18
申请人： Harry S. Winchell , Tz-Hong Lin , Charles A. Panneciere
发明人： Harry S. Winchell , Tz-Hong Lin , Charles A. Panneciere
IPC分类号： A61K49/04 , C07C59/10 , C07C59/105 , C07C59/255 , C07C59/265 , C07D307/62 , C07F7/00 , C07F9/00 , C07F9/02 , C07F9/38 , C07F9/40 , A61K29/02
CPC分类号： C07F9/02 , A61K49/04 , C07C59/10 , C07C59/105 , C07C59/255 , C07C59/265 , C07D307/62
摘要： Radiographic contrast media preparations suitable for use with high-energy x-ray sources and useful for intestinal tract studies and, in particular, computerized tomography are disclosed. The disclosed preparations comprise aqueous solutions of stable, non-toxic complexes of hafnium and tantalum with certain organic acids.
摘要翻译：公开了适用于高能x射线源并且可用于肠道研究，特别是计算机断层扫描的射线照相造影剂制剂。所公开的制剂包括铪和钽与某些有机酸的稳定的无毒络合物的水溶液。

10. 发明授权

US3968221A 99M-Technetium labeled tin colloid radiopharmaceuticals 失效
标题翻译： 99M-锝标记锡胶体放射性药物
公开(公告)号：US3968221A
公开(公告)日：1976-07-06
申请号：US477864
申请日：1974-06-10
申请人： Harry S. Winchell , Morton Barak , Parmer Van Fleet, III
发明人： Harry S. Winchell , Morton Barak , Parmer Van Fleet, III
IPC分类号： A61K51/12 , A61K43/00 , B65D25/08
CPC分类号： A61K51/1217 , A61K2123/00
摘要： An improved 99m-technetium labeled tin(II) colloid, size-stabilized for reticuloendothelial organ imaging without the use of macromolecular stabilizers and a packaged tin base reagent and an improved method for making it are disclosed.
摘要翻译：公开了改进的99m-锝标记的锡（II）胶体，尺寸稳定的网状内皮成像，而不使用大分子稳定剂和包装的锡基试剂，以及改进的制备方法。

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