专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09228180B2 Polypeptide variants of sleeping beauty transposase 有权
标题翻译：睡眠美容转座酶的多肽变体
公开(公告)号：US09228180B2
公开(公告)日：2016-01-05
申请号：US12667527
申请日：2008-06-30
申请人： Zsuzsanna Izsvak , Zoltan Ivics , Lajos Mates , Namitha Manoj , Carmen-Anisia Judis , Andrea Katzer
发明人： Zsuzsanna Izsvak , Zoltan Ivics , Lajos Mates , Namitha Manoj , Carmen-Anisia Judis , Andrea Katzer
IPC分类号： A61K38/00 , C12N9/22 , C12N15/90 , A61K48/00
CPC分类号： C12N9/1241 , A61K38/45 , A61K48/00 , A61K48/0066 , C12N9/22 , C12N15/90 , C12N2800/90 , C12Y207/07
摘要： The present invention refers to hyperactive variants of a transposase of the transposon system Sleeping Beauty (SB). The invention further refers to corresponding nucleic acids producing these variants, to a gene transfer system for stably introducing nucleic acid(s) into the DNA of a cell by using these hyperactive variants of a transposase of the transposon system Sleeping Beauty (SB) and to transposons used in the inventive gene transfer system, comprising a nucleic acid sequence with flanking repeats (IRs and/or RSDs). Furthermore, applications of these transposase variants, the transpsoson, or the gene transfer system are also disclosed such as gene therapy, insertional mutagenesis, gene discovery (including genome mapping), mobilization of genes, library screening, or functional analysis of genomes in vivo and in vitro. Finally, pharmaceutical compositions and kits are also encompassed.
摘要翻译：本发明涉及转座子系统睡美人（SB）的转座酶的多活性变体。本发明还涉及产生这些变体的相应核酸，通过使用转座子系统睡美人（SB）的转座酶的这些多活性变体将稳定地将核酸稳定地导入细胞的DNA的基因转移系统，以及用于本发明基因转移系统的转座子，其包含具有侧翼重复序列（IRs和/或RSD）的核酸序列。此外，还公开了这些转座酶变体，体管群或基因转移系统的应用，例如基因治疗，插入诱变，基因发现（包括基因组测绘），基因的移动，文库筛选或体内基因组的功能分析，以及体外。最后，还包括药物组合物和试剂盒。

2. 发明申请

US20120277282A1 POLYNUCLEOTIDES FOR USE IN MEDICINE 有权
标题翻译：用于医学的多核苷酸
公开(公告)号：US20120277282A1
公开(公告)日：2012-11-01
申请号：US13380147
申请日：2010-06-22
申请人： Michael Gotthardt , Norbert Hübner , Marion Lewis Greaser , Wei Guo
发明人： Michael Gotthardt , Norbert Hübner , Marion Lewis Greaser , Wei Guo
IPC分类号： A61K31/7105 , A61P9/00 , A61K31/713 , C07K14/00 , C12Q1/68 , C07H21/02
CPC分类号： C12Q1/6853 , C12Q1/6883 , C12Q2535/125 , C12Q2535/131
摘要： The invention refers to polynucleotides selected from the group consisting of a) polynucleotides encoding for the polypeptide RBM20 comprising a P638L mutation for a human polypeptide RBM20, or a P641L mutation for a rat polypeptide RBM20, b) polynucleotides with a reverse complementary sequence of the polynucleotide of a) above, and c) polynucleotides with an identity at least 50% to a polynucleotide of a) or b) above
摘要翻译：本发明涉及选自以下的多核苷酸：a）编码多肽RBM20的多核苷酸，其包含人多肽RBM20的P638L突变，或大鼠多肽RBM20的P641L突变，b）具有多核苷酸的反向互补序列的多核苷酸 a）和c）与上述a）或b）的多核苷酸具有至少50％同一性的多核苷酸

3. 发明申请

US20110117072A1 HYPERACTIVE VARIANTS OF THE TRANSPOSASE PROTEIN OF THE TRANSPOSON SYSTEM SLEEPING BEAUTY 有权
标题翻译：运输系统睡眠美容的转运蛋白的高血压变异
公开(公告)号：US20110117072A1
公开(公告)日：2011-05-19
申请号：US12667527
申请日：2008-06-30
申请人： Zsuzsanna Izsvak , Zoltan Ivics , Lajos Mates , Namitha Manoj , Carmen-Anisia Judis , Andrea Katzer
发明人： Zsuzsanna Izsvak , Zoltan Ivics , Lajos Mates , Namitha Manoj , Carmen-Anisia Judis , Andrea Katzer
IPC分类号： A61K48/00 , C12N9/12 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/63 , C12N5/10 , A61P37/04
CPC分类号： C12N9/1241 , A61K38/45 , A61K48/00 , A61K48/0066 , C12N9/22 , C12N15/90 , C12N2800/90 , C12Y207/07
摘要： The present invention refers to hyperactive variants of a transposase of the transposon system Sleeping Beauty (SB). The invention further refers to corresponding nucleic acids producing these variants, to a gene transfer system for stably introducing nucleic acid(s) into the DNA of a cell by using these hyperactive variants of a transposase of the transposon system Sleeping Beauty (SB) and to transposons used in the inventive gene transfer system, comprising a nucleic acid sequence with flanking repeats (IRs and/or RSDs). Furthermore, applications of these transposase variants, the transpsoson, or the gene transfer system are also disclosed such as gene therapy, insertional mutagenesis, gene discovery (including genome mapping), mobilization of genes, library screening, or functional analysis of genomes in vivo and in vitro. Finally, pharmaceutical compositions and kits are also encompassed.
摘要翻译：本发明涉及转座子系统睡美人（SB）的转座酶的多活性变体。本发明还涉及产生这些变体的相应核酸，通过使用转座子系统睡美人（SB）的转座酶的这些多活性变体将稳定地将核酸稳定地导入细胞的DNA的基因转移系统，以及用于本发明基因转移系统的转座子，其包含具有侧翼重复序列（IRs和/或RSD）的核酸序列。此外，还公开了这些转座酶变体，体管群或基因转移系统的应用，例如基因治疗，插入诱变，基因发现（包括基因组测绘），基因的移动，文库筛选或体内基因组的功能分析，以及体外。最后，还包括药物组合物和试剂盒。

4. 发明申请

US20040101888A1 Vector system used in screening active substances 审中-公开
标题翻译：用于筛选活性物质的载体系统
公开(公告)号：US20040101888A1
公开(公告)日：2004-05-27
申请号：US10631636
申请日：2003-07-31
申请人： Max-Delbruck-Centrum Fur Molekulare Medizin
发明人： Cornelis Calkhoven , Achim Leutz
IPC分类号： C12Q001/68 , C12N015/00
CPC分类号： C12Q1/6897 , C12N15/67
摘要： The invention relates to a vector system for use in screening active substances that influence translation in the cell. The inventive system is suitable for use in the pharmaceutical industry, in medicine and in molecular biology. The vector system consists of control elements of translation that substantially lie 5null from the detection cassette, but optionally also 3null from or within the detection cassette, a detection cassette that encodes two or more protein reporter constructs in different reading frames, said reporter constructs containing signal sequences for the release from the cell and various antigenic sites allowing immobilization and differential detection of reporter proteins.
摘要翻译：本发明涉及用于筛选影响细胞中的翻译的活性物质的载体系统。本发明的系统适用于制药工业，医药和分子生物学。载体系统由翻译的控制元件组成，其基本上位于检测盒5'处，但也可选地包含在检测盒内或检测盒内的3'，检测盒，其编码不同阅读框中的两个或多个蛋白质报道构建体，所述报道构建体含有从细胞释放的信号序列和各种抗原位点，允许报告蛋白的固定化和差异检测。

5. 发明授权

US6090955A Liposome-encapsulated taxol, its preparation and its use 失效
标题翻译：脂质体包裹的紫杉醇，其制备及其用途
公开(公告)号：US6090955A
公开(公告)日：2000-07-18
申请号：US793238
申请日：1997-06-19
申请人： Regine Reszka , Martin Brandl , Iduna Fichtner , Gernot Warnke
发明人： Regine Reszka , Martin Brandl , Iduna Fichtner , Gernot Warnke
IPC分类号： A61K9/00 , A61K9/127 , A61K31/335 , A61K31/337 , A61K31/555 , C07D493/00
CPC分类号： A61K9/0078 , A61K31/337 , A61K31/555 , A61K9/1277
摘要： The aim of the invention is to produce liposome-encapsulated taxol with a high taxol concentration and high stability and hence a high therapeutic effect. The invention involves the development of specific forms of taxol encapsulation and the use of these, optionally in combination with other substances, in the treatment of various types of tumor. The liposome-encapsulated taxol is characterized in that it is prepared by high-pressure homogenization or by aerosol formulation.
摘要翻译： PCT No.PCT / DE95 / 01163 Sec。 371日期：1997年6月19日 102（e）日期1997年6月19日PCT 1995年8月18日PCT PCT。公开号WO96 / 05821 日期1996年2月29日本发明的目的是制备具有高紫杉醇浓度和高稳定性的脂质体包裹的紫杉醇，因此具有高治疗效果。本发明涉及特定形式的紫杉醇包封的开发，以及它们的使用，任选地与其他物质组合用于治疗各种类型的肿瘤。脂质体包裹的紫杉醇的特征在于其通过高压均化或通过气溶胶制剂制备。

6. 发明授权

US09213028B2 Method and kit for rapid isolation of human Foxp3+ Treg cells 有权
标题翻译：用于快速分离人Foxp3 + Treg细胞的方法和试剂盒
公开(公告)号：US09213028B2
公开(公告)日：2015-12-15
申请号：US14089179
申请日：2013-11-25
申请人： Max-Delbruck-Centrum fur Molekulare Medizin (MDC)
发明人： Olaf Roetzschke , Kirsten Falk , Markus Kleinewietfeld
IPC分类号： C12N5/071 , G01N33/535 , G01N33/569 , C12N5/0783 , A61K35/12
CPC分类号： G01N33/56972 , A61K2035/122 , C12N5/0636
摘要： The present invention relates to methods for isolating human forkhead box P3 (Foxp3+) CD4+ regulatory T cells (herein referred to a Foxp3+ Treg cells) from a sample containing (i) peripheral blood mononuclear cells (PBMCs), (ii) a lymphocyte containing fluid, or (iii) a lymphocyte containing tissue, a kit for isolating human Foxp3+ Treg cells, and the use of anti-CD49d antibody for the isolation of human Foxp3+ Treg cells.
摘要翻译：本发明涉及从含有（i）外周血单核细胞（PBMC）的样品中分离人类叉头盒P3（Foxp3 +）CD4 +调节性T细胞（本文称为Foxp3 + Treg细胞）的方法，（ii）含淋巴细胞的流体，或（iii）含淋巴细胞的组织，用于分离人Foxp3 + Treg细胞的试剂盒，以及使用抗CD49d抗体分离人Foxp3 + Treg细胞。

7. 发明授权

US07868185B2 Shp-2 inhibitors and pharmaceutical compositions comprising them 有权
标题翻译： Shp-2抑制剂和包含它们的药物组合物
公开(公告)号：US07868185B2
公开(公告)日：2011-01-11
申请号：US11916111
申请日：2006-06-01
申请人： Klaus Hellmuth , Walter Birchmeier , Joerg Rademann , Stefanie Grosskopf
发明人： Klaus Hellmuth , Walter Birchmeier , Joerg Rademann , Stefanie Grosskopf
IPC分类号： C07D231/08 , A01N43/56
CPC分类号： A61K31/4152 , A61K31/427 , C07D231/48 , C07D417/04
摘要： The present invention relates to small molecule protein tyrosine phosphatase inhibitors, especially Shp-2 inhibitors, of formula (I) and/or (II), and to pharmaceutical compositions comprising them. The invention is also directed to the use of said compounds for the treatment of phosphatase-mediated diseases, especially cancer and metastasis. The invention further concerns a method for treating a proliferative disease, a genetic disorder, an autoimmune disease, an angiogenic disorder or cancer in a patient in need of such treatment, comprising administering to said patient a therapeutically effective amount of at least one compound of formula (I) and/or (II).
摘要翻译：本发明涉及式（I）和/或（II）的小分子蛋白酪氨酸磷酸酶抑制剂，特别是Shp-2抑制剂，以及包含它们的药物组合物。本发明还涉及所述化合物用于治疗磷酸酶介导的疾病，特别是癌症和转移的用途。本发明还涉及在需要这种治疗的患者中治疗增殖性疾病，遗传疾病，自身免疫疾病，血管生成病症或癌症的方法，包括向所述患者施用治疗有效量的至少一种式（I）和/或（II）。

8. 发明申请

US20100104556A1 EPITOPE-TAG FOR SURFACE-EXPRESSED PROTEINS AND USES THEREOF 有权
标题翻译：用于表面表达蛋白的表皮标记及其用途
公开(公告)号：US20100104556A1
公开(公告)日：2010-04-29
申请号：US12373362
申请日：2007-06-22
申请人： Thomas Blankenstein , Wolfgang Uckert , Elisa Kieback , Jehad Charo
发明人： Thomas Blankenstein , Wolfgang Uckert , Elisa Kieback , Jehad Charo
IPC分类号： A61K39/395 , C07K16/00 , C07H21/00 , C12N15/74 , C12N5/0783 , C12P21/00 , A61K45/00 , A61P35/00
CPC分类号： C07K14/7051 , A61K38/00 , A61K38/177 , A61K48/00 , A61K2035/124 , A61K2039/5158 , C07K2319/20 , C07K2319/21 , C07K2319/23 , C07K2319/40 , C07K2319/41 , C07K2319/43 , C12N15/62 , C12N15/79
摘要： The present invention relates to a method for selecting a host cell population expressing a functional fusion protein comprising at least one epitope-providing amino acid sequence (epitope-tag) and the amino acid sequence of a protein that is expressed on the surface of said host cell. Preferably, the amino acid sequence comprises an alpha or beta chain of a T-cell receptor. The present invention further relates to uses of said functional T-cell receptor (TCR) alpha or beta chain fusion protein in medicine, in particular in adoptive transfer.
摘要翻译：本发明涉及一种选择表达功能性融合蛋白的宿主细胞群的方法，所述功能性融合蛋白包含至少一个提供表位的氨基酸序列（表位标签）和在所述宿主的表面上表达的蛋白质的氨基酸序列细胞。优选地，氨基酸序列包含T细胞受体的α或β链。本发明还涉及所述功能性T细胞受体（TCR）α或β链融合蛋白在药物中的用途，特别是在过继转移中。

9. 发明申请

US20090197851A1 THERAPY AND USE OF COMPOUNDS IN THERAPY 审中-公开
标题翻译：治疗方法和化疗方法的使用
公开(公告)号：US20090197851A1
公开(公告)日：2009-08-06
申请号：US12187169
申请日：2008-08-06
申请人： Stefan Anker , Andrew Coats , Hans-Dieter Volk , Mathias Rauchhaus , Ralf Reiner Schumann
发明人： Stefan Anker , Andrew Coats , Hans-Dieter Volk , Mathias Rauchhaus , Ralf Reiner Schumann
IPC分类号： A61K31/575 , A61P9/00
CPC分类号： A61K31/575
摘要： A method of treating, preventing or ameliorating chronic heart failure or acute heart failure in a patient the method comprising administering to the patient an effective amount of: a compound that is able to bind to an endotoxin (lipopolysaccharide; LPS) molecule, for example LPS binding protein, BPI, lipoproteins, bile acids or an antibody capable of binding LPS, a compound that is able to bind to an endotoxin (lipopolysaccharide; LPS) molecule or bacterium in the gut, for example charcoal, a bile acid or Fuller's earth, an antibacterial agent that is substantially active in the gut, an agent that is able to inhibit the response by a cell to endotoxin (lipopolysaccharide; LPS), an agent that may form a barrier or that otherwise impedes translocation of bacteria or endotoxin (LPS) from the gut into the patient's circulation. A method of treating, preventing or ameliorating endotoxin-mediated immune activation in acute or chronic heart failure in a patient the method comprising administering to the patient an effective amount of: a compound that is able to bind to an endotoxin (lipopolysaccharide; LPS) molecule, for example LPS binding protein, BPI, lipoproteins, bile acids or an antibody capable of binding LPS, a compound that is able to bind to an endotoxin (lipopolysaccharide; LPS) molecule or bacterium in the gut, for example charcoal, a bile acid or Fuller's earth, an antibacterial agent that is substantially active in the gut, an agent that is able to inhibit the response by a cell to endotoxin (lipopolysaccharide; LPS), an agent that may form a barrier or that otherwise impedes translocation of bacteria or endotoxin (LPS) from the gut into the patient's circulation.
摘要翻译：一种治疗，预防或改善患者的慢性心力衰竭或急性心力衰竭的方法，该方法包括向患者施用有效量的：能够结合内毒素（脂多糖; LPS）分子的化合物，例如LPS 结合蛋白质，BPI，脂蛋白，胆汁酸或能够结合LPS的抗体，能够结合肠中的内毒素（脂多糖; LPS）分子或细菌的化合物，例如活性炭，胆汁酸或富勒氏土，在肠道中基本上具有活性的抗菌剂，能够抑制细胞对内毒素（脂多糖; LPS）的反应的试剂，可能形成屏障或另外阻碍细菌或内毒素（LPS）易位的药剂，从肠道到患者的流通。一种在患者急性或慢性心力衰竭中治疗，预防或改善内毒素介导的免疫激活的方法，该方法包括向患者施用有效量的：能够结合内毒素（脂多糖; LPS）分子的化合物，例如LPS结合蛋白，BPI，脂蛋白，胆汁酸或能够结合LPS的抗体，能够结合肠中的内毒素（脂多糖; LPS）分子或细菌的化合物，例如活性炭，胆汁酸或富勒的地球，在肠中基本上具有活性的抗菌剂，能够抑制细胞对内毒素（脂多糖; LPS）的反应的试剂，可能形成屏障或以其它方式阻碍细菌易位的药剂或内毒素（LPS）从肠道进入患者的循环。

10. 发明申请

US20080008687A1 Transposon-Based Targeting System 审中-公开
标题翻译：基于转座子的目标系统
公开(公告)号：US20080008687A1
公开(公告)日：2008-01-10
申请号：US10544976
申请日：2004-02-10
申请人： Zoltan Ivics , Zsuzsanna Izsvak
发明人： Zoltan Ivics , Zsuzsanna Izsvak
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , A61P43/00 , C12N5/06 , C12Q1/68
CPC分类号： C12N15/90
摘要： The present invention relates to a targeting system comprising, preferably as distinct components, (a) a transposon which is devoid of a polynucleotide encoding a functional transposase comprising a polynucleotide of interest; and (b) a fusion protein comprising (ba) a transposase or a fragment or derivative thereof having transposase function; and (bb) a DNA targeting domain; or (bc) a (poly)peptide binding domain that binds to a cellular or engineered (poly)peptide comprising a DNA targeting domain; or (bd) a (poly)peptide comprising the DNA targeting domain of (bb) or the (poly)peptide binding domain of (bc), wherein the transposase or a fragment or derivative thereof having transposase function of (a) is joined by a linker to the domain of (bb) or to the domain of (bc) or to the (poly)peptide of (bd); or (c) a polynucleotide encoding the fusion protein of (b).
摘要翻译：本发明涉及一种靶向系统，其优选包含不同组分，（a）转座子，其不含编码包含感兴趣多核苷酸的功能转座酶的多核苷酸; 和（b）包含（ba）具有转座酶功能的转座酶或其片段或衍生物的融合蛋白; 和（bb）DNA靶向结构域; 或（bc）结合包含DNA靶向结构域的细胞或工程化（多）肽的（多）肽结合结构域; 或（bd）包含（bb）的DNA靶向结构域或（bc）的（多）肽结合结构域的（多）肽，其中具有（a）的转座酶功能的转座酶或其片段或衍生物通过（bb）或（bc）结构域的接头或（bd）的（多）肽的接头; 或（c）编码（b）的融合蛋白的多核苷酸。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式