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1. 发明申请

US20150044755A1 PRODUCTION OF MUCONIC ACID FROM GENETICALLY ENGINEERED MICROORGANISMS 审中-公开
标题翻译：从遗传工程微生物生产肌酸
公开(公告)号：US20150044755A1
公开(公告)日：2015-02-12
申请号：US14375071
申请日：2013-01-29
申请人： MYRIANT CORPORATION
发明人： R. Rogers Yocum , Wei Gong , Sudhanshu Dole , Ryan Sillers , Meghal Gandhi , Janice G. Pero
IPC分类号： C12N1/20
摘要： This present invention is in the field of producing renewable chemical feedstocks using biocatalysts that have been genetically engineered to increase their ability to convert renewable carbon resources into useful compounds. More specifically, the present invention provides a process for producing muconic acid form renewable carbon resources using a genetically modified organism.
摘要翻译：本发明在使用生物催化剂生产可再生化学原料的领域中进行了遗传工程，以增加其将可再生碳资源转化为有用化合物的能力。更具体地，本发明提供了使用遗传修饰的生物体生产形成可再生碳资源的粘康酸的方法。

2. 发明申请

US20120225461A1 ORGANIC ACID PRODUCTION IN MICROORGANISMS BY COMBINED REDUCTIVE AND OXIDATIVE TRICABOXYLIC ACID CYLCE PATHWAYS 有权
标题翻译：通过组合还原和氧化三羧酸的循环途径在微生物中有机酸生产
公开(公告)号：US20120225461A1
公开(公告)日：2012-09-06
申请号：US13508095
申请日：2010-11-18
申请人： Sudhanshu Dole , R. Rogers Yocum
发明人： Sudhanshu Dole , R. Rogers Yocum
IPC分类号： C12P7/46 , C12N1/21
CPC分类号： C12N15/52 , C12N9/1025 , C12N9/1205 , C12N9/88 , C12P7/46
摘要： This invention relates to succinic acid production from renewable feedstock using microbial biocatalysts genetically modified to produce succinic acid in commercially significant quantities. More specifically, this invention relates to the genetic manipulations in the pathway of carbon from renewable feedstock to succinic acid.
摘要翻译：本发明涉及使用经遗传修饰以生产商业上显着量的琥珀酸的微生物生物催化剂从可再生原料生产琥珀酸。更具体地，本发明涉及从可再生原料到琥珀酸的碳通路中的遗传操作。

3. 发明申请

US20160160245A1 METHOD OF PRODUCING SUCCINIC ACID AND OTHER CHEMICLAS USING FACILITATED DIFFUSION FOR SUGAR IMPORT 审中-公开
标题翻译：生产磺酸和其他化学品的方法使用辅助扩散进行糖进口
公开(公告)号：US20160160245A1
公开(公告)日：2016-06-09
申请号：US14906501
申请日：2014-07-22
申请人： MYRIANT CORPORATION
发明人： R. Rogers Yocum , Andrew Christopher Collard , Theron Hermann , Xiaohui Yu , Wei Gong
IPC分类号： C12P7/46 , C07K14/195
CPC分类号： C12P7/46 , C07K14/195 , C12N1/36 , C12N15/01 , C12P7/44
摘要： This invention relates to the production of succinic acid and other chemicals derived from phosphoenolpyruvate (PEP) by fermentation with a microorganism in which the fermentation medium contains one or more sugars, and in which one or more of the sugars is imported into the cell by facilitated diffusion. As a specific example, succinic acid is produced from a glucose-containing renewable feedstock through fermentation using a biocatalyst. Examples of such a biocatalyst include microorganisms that have been enhanced in their ability to utilize glucose as a carbon and energy source. The biocatalysts of the present invention are derived from the genetic manipulation of parental strains that were originally constructed with the goal to produce one or more chemicals (for example succinic acid and/or a salt of succinic acid) at a commercial scale using feedstocks that include, for example, glucose, fructose, or sucrose. The genetic manipulations of the present invention involve the introduction of exogenous genes involved in the transport and metabolism of glucose or fructose into the parental strains. The genes involved in the transport and metabolism of glucose or fructose can also be introduced into a microorganism prior to developing the organism to produce a particular chemical. The genes involved in the transport and metabolism of sucrose can also be used to augment or improve the efficiency of sugar transport and metabolism by strains already known to have some ability for glucose utilization in biological fermentations.
摘要翻译：本发明涉及通过用发酵培养基含有一种或多种糖的微生物进行发酵而生产琥珀酸和其他衍生自磷酸烯醇丙酮酸（PEP）的化学品，其中一种或多种糖通过促进扩散。作为具体实例，使用生物催化剂通过发酵从含葡萄糖的可再生原料生产琥珀酸。这种生物催化剂的实例包括增强其利用葡萄糖作为碳和能源的能力的微生物。本发明的生物催化剂来源于原始构建的亲本菌株的遗传操作，目的是以商业规模生产一种或多种化学品（例如琥珀酸和/或琥珀酸盐），其使用原料包括，例如葡萄糖，果糖或蔗糖。本发明的遗传操作涉及将参与葡萄糖或果糖的转运和代谢的外源基因引入亲本菌株。参与葡萄糖或果糖的运输和代谢的基因也可以在生物体发育生成特定化学物质之前引入微生物。参与蔗糖运输和代谢的基因也可用于增加或提高已知在生物发酵中具有一定葡萄糖利用能力的菌株的糖转运和代谢的效率。

4. 发明申请

US20150240270A1 PRODUCTION OF ORGANIC ACIDS BY FERMENTATION AT LOW PH 审中-公开
标题翻译：通过低PH发酵生产有机酸
公开(公告)号：US20150240270A1
公开(公告)日：2015-08-27
申请号：US14428202
申请日：2013-09-13
申请人： MYRIANT CORPORATION
发明人： R. Rogers Yocum , Sudhanshu Dole , Janice G. Pero
IPC分类号： C12P7/46 , C12P7/56
CPC分类号： C12P7/46 , C12N1/14 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/1025 , C12N9/12 , C12N9/88 , C12N9/93 , C12N15/52 , C12N15/81 , C12P7/56
摘要： This invention relates to the biosynthesis of organic acids in genetically modified microorganisms. More specifically, this invention provides genetically modified microorganisms that are particularly tolerant to organic acids at low pH and are capable of producing organic acids by fermentation at low pH.
摘要翻译：本发明涉及转基因微生物中有机酸的生物合成。更具体地，本发明提供了在低pH下特别耐受有机酸的遗传修饰的微生物，并且能够通过在低pH下发酵来产生有机酸。

5. 发明授权

US09845513B2 Method of producing succinic acid and other chemicals using sucrose-containing feedstock 有权
公开(公告)号：US09845513B2
公开(公告)日：2017-12-19
申请号：US13993150
申请日：2011-12-13
申请人： Sudhandshu Dole , R. Rogers Yocum , Theron Hermann , Xiaohui Yu
发明人： Sudhandshu Dole , R. Rogers Yocum , Theron Hermann , Xiaohui Yu
IPC分类号： C12P7/46 , C12R1/01 , C12N9/10 , C12N9/16 , C12P7/18 , C12P7/42
CPC分类号： C12R1/01 , C12N9/1051 , C12N9/16 , C12P7/18 , C12P7/42 , C12P7/46 , C12Y301/03024
摘要： This invention relates to the production of chemicals by fermentation with a microorganism in which the fermentation medium contains the sugar sucrose. As a specific example, succinic acid is produced from a sucrose-containing renewable feedstock through fermentation using a biocatalyst. Examples of such a biocatalyst include microorganisms that have been enhanced in their ability to utilize sucrose as a carbon and energy source. The biocatalysts of the present invention are derived from the genetic manipulation of parental strains that were originally constructed with the goal to produce one or more chemicals (for example succinic acid and/or a salt of succinic acid) at a commercial scale using feedstocks other than sucrose. The genetic manipulations of the present invention involve the introduction of exogenous genes involved in the transport and metabolism of sucrose into the parental strains. The genes involved in the transport and metabolism of sucrose can also be introduced into a microorganism prior to developing the organism to produce a particular chemical. The genes involved in the transport and metabolism of sucrose can also be used to augment or improve the sucrose transport and metabolism by strains already known to have some ability for sucrose utilization in biological fermentation.

6. 发明申请

US20160207865A1 PROCESS FOR MANUFACTURING ACRYLIC ACID, ACRYLONITRILE AND 1,4-BUTANEDIOL FROM 1,3-PROPANEDIOL 审中-公开
标题翻译： 1,3-丙二醇制备丙烯酸，丙烯腈和1,4-丁二醇的方法
公开(公告)号：US20160207865A1
公开(公告)日：2016-07-21
申请号：US14915554
申请日：2014-09-03
申请人： MYRIANT CORPORATION
发明人： Vijay GNANDESIKAN , Ramnik SINGH , Rajesh DASARI , Montgomery ALGER
IPC分类号： C07C51/27 , C07C29/44 , C07C253/26 , C07C209/16 , C07C51/285 , C07C29/60
CPC分类号： C07C51/27 , C07C29/44 , C07C29/60 , C07C51/16 , C07C51/285 , C07C209/16 , C07C253/26 , C07C33/03 , C07C255/08 , C07C211/21 , C07C57/04
摘要： The present invention is in the field of producing bio-based commodity organic chemicals such as bio-acrylic acid, bio-acrylonitrile, and bio-1,4-butanediol using renewable carbon sources as feedstock. In the first stage of the present invention, bio-1,3-propanediol is derived from renewable carbon sources through microbial fermentation. In the second stage of the present invention, bio-1,3-propanediol is converted into bio-acrylic acid or bio-acrylonitrile or bio-1,4-butanediol.
摘要翻译：本发明涉及使用可再生碳源作为原料生产生物基商品有机化学品如生物丙烯酸，生物丙烯腈和生物1,4-丁二醇的领域。在本发明的第一阶段，生物-1,3-丙二醇通过微生物发酵得自可再生碳源。在本发明的第二阶段中，将生物-1,3-丙二醇转化为生物丙烯酸或生物丙烯腈或生物-1,4-丁二醇。

7. 发明申请

US20160083753A1 METABOLIC EVOLUTION OF ESCHERICHIA COLI STRAINS THAT PRODUCE ORGANIC ACIDS 审中-公开
标题翻译：生产有机酸的食品菌株的代谢演化
公开(公告)号：US20160083753A1
公开(公告)日：2016-03-24
申请号：US14491073
申请日：2014-09-19
申请人： MYRIANT CORPORATION
发明人： Tammy Grabar , Wei Gong , R. Rogers Yocum
IPC分类号： C12P7/46 , C12N9/88 , C12N9/00
CPC分类号： C12P7/46 , C12N9/88 , C12N9/93 , C12P2203/00 , C12Y207/03009 , C12Y401/01031 , C12Y401/01032 , C12Y604/01001
摘要： This invention relates to the metabolic evolution of a microbial organism previously optimized for producing an organic acid in commercially significant quantities under fermentative conditions using a hexose sugar as sole source of carbon in a minimal mineral medium. As a result of this metabolic evolution, the microbial organism acquires the ability to use pentose sugars derived from cellulosic materials for its growth while retaining the original growth kinetics, the rate of organic acid production and the ability to use hexose sugars as a source of carbon. This invention also discloses the genetic change in the microorganism that confers the ability to use both the hexose and pentose sugars simultaneously in the production of commercially significant quantities of organic acids.
摘要翻译：本发明涉及先前优化用于在发酵条件下以商业上显着的量生产有机酸的微生物生物的代谢进化，其中使用己糖作为最小矿物培养基中的唯一碳源。作为这种代谢进化的结果，微生物生物体获得使用来自纤维素材料的戊糖的生长能力，同时保持原始生长动力学，有机酸生产速率和使用己糖作为碳源的能力。本发明还公开了赋予在生产商业上大量有机酸中同时使用己糖和戊糖的能力的微生物中的遗传变化。

8. 发明授权

US08871489B2 Metabolic evolution of Escherichia coli strains that produce organic acids 有权
标题翻译：产生有机酸的大肠杆菌菌株的代谢进化
公开(公告)号：US08871489B2
公开(公告)日：2014-10-28
申请号：US13394176
申请日：2010-11-17
申请人： Tammy Grabar , Wei Gong , R. Rogers Yocum
发明人： Tammy Grabar , Wei Gong , R. Rogers Yocum
IPC分类号： C12N1/20 , C12N1/00 , C12N15/74 , C07H21/04 , C07K14/245 , C12P7/46 , C12P7/54 , C12P7/40
CPC分类号： C07K14/245 , C12P7/40 , C12P7/46 , C12P7/54
摘要： This invention relates to the metabolic evolution of a microbial organism previously optimized for producing an organic acid in commercially significant quantities under fermentative conditions using a hexose sugar as sole source of carbon in a minimal mineral medium. As a result of this metabolic evolution, the microbial organism acquires the ability to use pentose sugars derived from cellulosic materials for its growth while retaining the original growth kinetics, the rate of organic acid production and the ability to use hexose sugars as a source of carbon. This invention also discloses the genetic change in the microorganism that confers the ability to use both the hexose and pentose sugars simultaneously in the production of commercially significant quantities of organic acids.
摘要翻译：本发明涉及先前优化用于在发酵条件下以商业上显着的量生产有机酸的微生物生物的代谢进化，其中使用己糖作为最小矿物培养基中的唯一碳源。作为这种代谢进化的结果，微生物生物体获得使用来自纤维素材料的戊糖的生长能力，同时保持原始生长动力学，有机酸生产速率和使用己糖作为碳源的能力。本发明还公开了赋予在生产商业上大量有机酸中同时使用己糖和戊糖的能力的微生物中的遗传变化。

9. 发明申请

US20130130339A1 FERMENTATION PROCESS FOR THE PRODUCTION OF ORGANIC ACIDS 审中-公开
标题翻译：用于生产有机酸的发酵方法
公开(公告)号：US20130130339A1
公开(公告)日：2013-05-23
申请号：US13812886
申请日：2011-07-30
申请人： Theron Hermann , James Reinhardt , Xiaohui Yu , Russell Udani , Lauren Staples
发明人： Theron Hermann , James Reinhardt , Xiaohui Yu , Russell Udani , Lauren Staples
IPC分类号： C12P7/46
CPC分类号： C12P7/46
摘要： This invention relates to improvements in the fermentation process used in the production of organic acids from biological feedstock using bacterial catalysts. The improvements in the fermentation process involve providing a fermentation medium comprising an appropriate form of inorganic carbon, an appropriate amount of aeration and a biocatalyst with an enhanced ability to uptake and assimilate the inorganic carbon into the organic acids. This invention also provides, as a part of an integrated fermentation facility, a novel process for producing a solid source of inorganic carbon by sequestering carbon released from the fermentation in an alkali solution.
摘要翻译：本发明涉及使用细菌催化剂从生物原料生产有机酸的发酵方法的改进。发酵过程的改进包括提供包含适当形式的无机碳，适量曝气和生物催化剂的发酵培养基，其具有增强吸收和吸收无机碳进入有机酸的能力。作为一体化发酵设备的一部分，本发明还提供了一种通过在碱溶液中从发酵中释放的碳进行螯合来生产无机碳固体源的新方法。

10. 发明授权

US10035749B2 Process for manufacturing acrylic acid, acrylonitrile and 1,4-butanediol from 1,3-propanediol 有权
公开(公告)号：US10035749B2
公开(公告)日：2018-07-31
申请号：US14915554
申请日：2014-09-03
申请人： MYRIANT CORPORATION
发明人： Vijay Gnanadesikan , Ramnik Singh , Rajesh Dasari , Montgomery Alger
IPC分类号： C07C51/27 , C07C29/60 , C07C51/285 , C07C209/16 , C07C253/26 , C07C29/44 , C07C51/16
CPC分类号： C07C51/27 , C07C29/44 , C07C29/60 , C07C51/16 , C07C51/285 , C07C209/16 , C07C253/26 , C07C33/03 , C07C255/08 , C07C211/21 , C07C57/04
摘要： The present invention is in the field of producing bio-based commodity organic chemicals such as bio-acrylic acid, bio-acrylonitrile, and bio-1,4-butanediol using renewable carbon sources as feedstock. In the first stage of the present invention, bio-1,3-propanediol is derived from renewable carbon sources through microbial fermentation. In the second stage of the present invention, bio-1,3-propanediol is converted into bio-acrylic acid or bio-acrylonitrile or bio-1,4-butanediol.

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