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1. 发明授权

US09845513B2 Method of producing succinic acid and other chemicals using sucrose-containing feedstock 有权
公开(公告)号：US09845513B2
公开(公告)日：2017-12-19
申请号：US13993150
申请日：2011-12-13
申请人： Sudhandshu Dole , R. Rogers Yocum , Theron Hermann , Xiaohui Yu
发明人： Sudhandshu Dole , R. Rogers Yocum , Theron Hermann , Xiaohui Yu
IPC分类号： C12P7/46 , C12R1/01 , C12N9/10 , C12N9/16 , C12P7/18 , C12P7/42
CPC分类号： C12R1/01 , C12N9/1051 , C12N9/16 , C12P7/18 , C12P7/42 , C12P7/46 , C12Y301/03024
摘要： This invention relates to the production of chemicals by fermentation with a microorganism in which the fermentation medium contains the sugar sucrose. As a specific example, succinic acid is produced from a sucrose-containing renewable feedstock through fermentation using a biocatalyst. Examples of such a biocatalyst include microorganisms that have been enhanced in their ability to utilize sucrose as a carbon and energy source. The biocatalysts of the present invention are derived from the genetic manipulation of parental strains that were originally constructed with the goal to produce one or more chemicals (for example succinic acid and/or a salt of succinic acid) at a commercial scale using feedstocks other than sucrose. The genetic manipulations of the present invention involve the introduction of exogenous genes involved in the transport and metabolism of sucrose into the parental strains. The genes involved in the transport and metabolism of sucrose can also be introduced into a microorganism prior to developing the organism to produce a particular chemical. The genes involved in the transport and metabolism of sucrose can also be used to augment or improve the sucrose transport and metabolism by strains already known to have some ability for sucrose utilization in biological fermentation.

2. 发明申请

US20130337519A1 METHOD OF PRODUCING SUCCINIC ACID AND OTHER CHEMICALS USING SUCROSE-CONTAINING FEEDSTOCK 有权
标题翻译：使用含蔗糖的饲料生产农药和其他化学品的方法
公开(公告)号：US20130337519A1
公开(公告)日：2013-12-19
申请号：US13993150
申请日：2011-12-13
申请人： Sudhandshu Dole , R. Rogers Yocum , Theron Hermann , Xiaohui Yu
发明人： Sudhandshu Dole , R. Rogers Yocum , Theron Hermann , Xiaohui Yu
IPC分类号： C12P7/46 , C12R1/01
CPC分类号： C12R1/01 , C12N9/1051 , C12N9/16 , C12P7/18 , C12P7/42 , C12P7/46 , C12Y301/03024
摘要： This invention relates to the production of chemicals by fermentation with a microorganism in which the fermentation medium contains the sugar sucrose. As a specific example, succinic acid is produced from a sucrose-containing renewable feedstock through fermentation using a biocatalyst. Examples of such a biocatalyst include microorganisms that have been enhanced in their ability to utilize sucrose as a carbon and energy source. The biocatalysts of the present invention are derived from the genetic manipulation of parental strains that were originally constructed with the goal to produce one or more chemicals (for example succinic acid and/or a salt of succinic acid) at a commercial scale using feedstocks other than sucrose. The genetic manipulations of the present invention involve the introduction of exogenous genes involved in the transport and metabolism of sucrose into the parental strains. The genes involved in the transport and metabolism of sucrose can also be introduced into a microorganism prior to developing the organism to produce a particular chemical. The genes involved in the transport and metabolism of sucrose can also be used to augment or improve the sucrose transport and metabolism by strains already known to have some ability for sucrose utilization in biological fermentation.
摘要翻译：本发明涉及通过用发酵培养基含有蔗糖的微生物进行发酵来生产化学品。作为具体实例，使用生物催化剂通过发酵从含蔗糖的可再生原料生产琥珀酸。这种生物催化剂的实例包括增强其利用蔗糖作为碳和能源的能力的微生物。本发明的生物催化剂来源于最初以以商业规模生产一种或多种化学物（例如琥珀酸和/或琥珀酸盐）的目的而构建的亲本菌株的遗传操作，其使用除了蔗糖。本发明的遗传操作涉及将参与蔗糖转运和代谢的外源基因导入亲本菌株。参与蔗糖运输和代谢的基因也可以在开发生物体之前被引入微生物以产生特定的化学物质。参与蔗糖运输和代谢的基因也可用于增加或改善已知在生物发酵中具有蔗糖利用能力的菌株的蔗糖转运和代谢。

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