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1. 发明授权

US08058247B2 Antibacterial agent and therapeutic agent for johne's disease containing the same 有权
标题翻译：抗菌剂和治疗剂含有相同的约翰氏病
公开(公告)号：US08058247B2
公开(公告)日：2011-11-15
申请号：US12378172
申请日：2009-02-11
申请人： Yoshiaki Takahashi , Masayuki Igarashi
发明人： Yoshiaki Takahashi , Masayuki Igarashi
IPC分类号： A61K31/7016 , A61K31/7052 , C07G11/00 , C07H15/26
CPC分类号： A61K31/7072 , A01N43/62
摘要： An antibacterial agent having high antibacterial activity against Mycobacterium avium subsp. paratuberculosis is provided. Specifically, the antibacterial agent of the present invention having high antibacterial activity against Mycobacterium avium subsp. paratuberculosis is a caprazamycin derivative represented, for example, by the following general formula (II): wherein Me is a methyl group; and R1 is a straight or substantially straight chain alkyl group having 5 to 21 carbon atoms, a straight or substantially straight chain alkenyl group having 5 to 21 carbon atoms, a cycloalkyl group having 5 to 12 carbon atoms, or a phenyl group substituted at the para-position with a straight chain alkyl group having 1 to 14 carbon atoms, a straight chain alkoxy group having 1 to 9 carbon atoms or a cycloalkyl group having 5 to 12 carbon atoms.
摘要翻译：对鸟分枝杆菌亚种具有高抗菌活性的抗菌剂提供副结核病。具体地说，本发明的抗菌剂对鸟分枝杆菌属副结核病是由例如由以下通式（II）表示的卡拉霉素衍生物：其中Me是甲基; R1为碳原子数5〜21的直链或直链状的直链状的碳原子数为5〜21的直链或直链的烯基，碳原子数为5〜12的环烷基，具有1至14个碳原子的直链烷基的对位位置，具有1至9个碳原子的直链烷氧基或具有5至12个碳原子的环烷基。

2. 发明申请

US20110052779A1 ACIDIC SOLUBLE PROTEIN-CONTAINING BEVERAGE COMPOSITION AND METHOD FOR PRODUCING SAME 审中-公开
标题翻译：含酸可溶性蛋白质的饮料组合物及其生产方法
公开(公告)号：US20110052779A1
公开(公告)日：2011-03-03
申请号：US12848749
申请日：2010-08-02
申请人： Toshiaki Hirata , Nobutaka Yahiro , Takuya Kodama , Takayasu Fukuyama
发明人： Toshiaki Hirata , Nobutaka Yahiro , Takuya Kodama , Takayasu Fukuyama
IPC分类号： A23L2/66
CPC分类号： A23L2/38 , A23L2/52 , A23L2/66 , A23L33/185
摘要： The present invention provides a composition for beverage use comprising an acidic soluble protein, and one or two or more powdery or granular salts selected from the group consisting of alkali metal salts of organic acids and water-soluble basic salts, wherein at least the acidic soluble protein is granulated. Furthermore, the present invention provides a process for producing a composition for beverage use containing an acidic soluble protein, comprising: adding to the acidic soluble protein one or two or more powdery or granular salts selected from alkali metal salts of organic acids and water-soluble basic salts in a proportion of 0.01 to 10 parts by weight with respect to 100 parts by weight of the acidic soluble protein, and subjecting at least the acidic soluble protein to granulation. In the composition for beverage use, the formation of undissolved lumps when the composition is dissolved in water is suppressed.
摘要翻译：本发明提供了一种饮料用组合物，其包含酸性可溶性蛋白质和一种或两种以上选自有机酸碱金属盐和水溶性碱性盐的粉末状或颗粒状盐，其中至少酸性可溶性蛋白质蛋白质造粒。此外，本发明提供一种含有酸性可溶性蛋白质的饮料用组合物的制造方法，其特征在于，在酸性溶解性蛋白质中添加一种或两种以上选自有机酸的碱金属盐和水溶性的粉状或粒状盐相对于100重量份的酸性可溶性蛋白质，碱性盐的比例为0.01〜10重量份，至少使酸性可溶性蛋白质造粒。在用于饮料的组合物中，抑制组合物溶于水时形成未溶解的块状物。

3. 发明授权

US07893254B2 Process for production of 3-alkenylcephem compounds 有权
标题翻译： 3-链烯基化合物的制备方法
公开(公告)号：US07893254B2
公开(公告)日：2011-02-22
申请号：US11628248
申请日：2005-06-03
申请人： Yoichi Nishioka , Masahiro Ito , Yutaka Kameyama
发明人： Yoichi Nishioka , Masahiro Ito , Yutaka Kameyama
IPC分类号： C07D501/24 , C07D501/12
CPC分类号： C07D501/00
摘要： A process for preparing 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) and an alkali metal salt thereof, said acid and said salt being improved in the content of 7-amino-3-[(Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (2) or an alkali metal salt thereof, the process being characterized in that an aqueous solution of an alkali metal salt of 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) is treated with a high porous polymer and/or active carbon as added thereto.
摘要翻译：制备式（1）的7-氨基-3 - [（E / Z）-2-（4-甲基噻唑-5-基）乙烯基] -3-头孢烯-4-羧酸和碱金属盐所述酸和所述盐的结构改善了式（7）的7-氨基-3 - [（Z）-2-（4-甲基噻唑-5-基）乙烯基] -3-头孢烯-4-羧酸的含量 2）或其碱金属盐，该方法的特征在于将7-氨基-3 - [（E / Z）-2-（4-甲基噻唑-5-基）乙烯基] 式（1）的3-头孢烯-4-羧酸用加入其中的高多孔聚合物和/或活性炭进行处理。

4. 发明授权

US07795001B2 Midecamycin biosynthesis genes 有权
标题翻译：麦迪霉素生物合成基因
公开(公告)号：US07795001B2
公开(公告)日：2010-09-14
申请号：US11330363
申请日：2006-01-12
申请人： Naoki Midoh , Shigeru Hoshiko , Takeshi Murakami
发明人： Naoki Midoh , Shigeru Hoshiko , Takeshi Murakami
IPC分类号： C12N1/21 , C12N15/00 , C07H21/04
CPC分类号： C12N15/52 , C12P19/62
摘要： The present invention provides an isolated polypeptide comprising a nucleotide sequence encoding a protein which is involved in midecamycin biosynthesis, wherein the protein contains an amino acid sequence selected from SEQ ID NOs: 2 to 10, 13, 14, 16, 19, 20, 22 to 26, and 28 to 38 or a modified amino acid sequence of the amino acid sequence having one or more amino acid modifications without affecting activity of the protein.
摘要翻译：本发明提供了一种分离的多肽，其包含编码参与麦迪霉素生物合成的蛋白质的核苷酸序列，其中所述蛋白质含有选自SEQ ID NO：2至10,13,14,16,19,20,22的氨基酸序列至26和28至38或具有一个或多个氨基酸修饰的氨基酸序列的修饰的氨基酸序列，而不影响蛋白质的活性。

5. 发明授权

US07776579B2 Method of degrading hardly degradable protein 有权
标题翻译：降解难降解蛋白质的方法
公开(公告)号：US07776579B2
公开(公告)日：2010-08-17
申请号：US10532605
申请日：2003-10-24
申请人： Takehiro Miwa , Koji Nishizawa , Yoshie Hayashi , Manabu Watanabe , Yuichi Murayama , Miyako Yoshioka , Katsuhiro Miura
发明人： Takehiro Miwa , Koji Nishizawa , Yoshie Hayashi , Manabu Watanabe , Yuichi Murayama , Miyako Yoshioka , Katsuhiro Miura
IPC分类号： C12N9/56
CPC分类号： C12N9/54 , A23B4/22 , A61K38/00 , C12P21/06
摘要： Disclosed is an agent for digesting a protein highly resistant to denaturation and degradation, comprising as an active ingredient an enzyme exhibiting an activity of digesting a protein highly resistant to denaturation and degradation and having the following properties: (a) activity and substrate specificity: hydrolyzing a peptide bond of a protein highly resistant to denaturation and degradation; (b) molecular weight: 31,000 (determined by SDS-polyacrylamide gel electrophoresis using a homogeneous gel having a gel concentration of 12%); (c) isoelectric point: pI 9.3 (determined by polyacrylamide gel isoelectric focusing electrophoresis); (d) optimum pH: pH 9.0 to 10.0; and (e) optimum temperature for activity: 60 to 70° C.
摘要翻译：公开了一种用于消化高度抗变性和降解的蛋白质的试剂，其包含作为活性成分的酶，其具有消化高度耐变性和降解的蛋白质的活性，并具有以下性质：（a）活性和底物特异性：水解高度耐变性和降解的蛋白质的肽键; （b）分子量：31,000（使用凝胶浓度为12％的均相凝胶的SDS-聚丙烯酰胺凝胶电泳测定）; （c）等电点：pI 9.3（通过聚丙烯酰胺凝胶等电聚焦电泳测定）; （d）最适pH：pH 9.0〜10.0; 和（e）活性的最适温度：60-70℃

6. 发明授权

US07772426B2 Method for producing L-2-amino-4-(hydroxymethylphosphinyl)-butanoic acid 有权
标题翻译：制备L-2-氨基-4-（羟甲基氧膦基） - 丁酸的方法
公开(公告)号：US07772426B2
公开(公告)日：2010-08-10
申请号：US11909839
申请日：2006-03-28
申请人： Nobuto Minowa , Nozomu Nakanishi , Masaaki Mitomi
发明人： Nobuto Minowa , Nozomu Nakanishi , Masaaki Mitomi
IPC分类号： C07C227/32
CPC分类号： C07B53/00 , C07F9/301 , C07F9/65683
摘要： Disclosed is a method for efficiently and highly selectively producing L-2-amino-4-(hydroxymethylphosphinyl)-butanoic acid, which is useful as a herbicide, through a catalytic asymmetric synthesis reaction. Specifically disclosed is a method for producing L-2-amino-4-(hydroxymethylphosphinyl)-butanoic acid which is characterized in that a dehydroamino acid is subjected to an asymmetric hydrogenation by using a rhodium catalyst represented by the formula (2) below and having an optically active cyclic phosphine ligand, and then the resulting product is subjected to hydrolysis: [Rh(R4)(L)]X (2) [where R4 represents 1,5-cyclooctadien or norbornadien; L represents a substance represented by the following formula (6): (wherein R5 and R8 respectively represent a C1-4 alkyl group; R6 and R7 respectively represent hydrogen atom or hydroxyl group; and Y represents a group selected from groups represented by the following formula (7): (where Me represents methyl group)).].
摘要翻译：公开了通过催化不对称合成反应有效和高选择性地生产可用作除草剂的L-2-氨基-4-（羟甲基氧膦基） - 丁酸的方法。具体公开了一种生产L-2-氨基-4-（羟甲基氧膦基） - 丁酸的方法，其特征在于，使用下式（2）表示的铑催化剂对脱氢氨基酸进行不对称氢化，光学活性环膦配体，然后使所得产物水解：[Rh（R 4）（L）] X（2）[其中R 4表示1,5-环辛二烯或降冰片素; L表示由下式（6）表示的物质：（其中，R 5和R 8分别表示C 1-4烷基; R 6和R 7分别表示氢原子或羟基，Y表示选自下述式（7）：（Me表示甲基））。

7. 发明申请

US20100093871A1 AGENT FOR PREVENTION OR TREATMENT OF IRON OVERLOAD DISORDERS 审中-公开
标题翻译：防止或治疗铁过度病症的代理人
公开(公告)号：US20100093871A1
公开(公告)日：2010-04-15
申请号：US12532361
申请日：2008-03-19
申请人： Hideaki Kagehara , Shoji Nishiyama
发明人： Hideaki Kagehara , Shoji Nishiyama
IPC分类号： A61K31/075 , C07C43/18 , A61P7/00
CPC分类号： C07J53/00 , A61K31/56
摘要： Disclosed is an agent for prevention or treatment of iron overload disorders, comprising 22β-methoxyolean-12-ene-3β,24(4β)-diol or a pharmacologically acceptable salt thereof.
摘要翻译：公开了用于预防或治疗铁超负荷障碍的药物，其包含22-二甲氧基安非炔-12-烯-3和b，24（4'-二） - 二醇或其药理学上可接受的盐。

8. 发明授权

US07687490B2 2-thioethenyl substituted carbapenem derivatives 失效
标题翻译： 2-硫代乙烯基取代的碳青霉烯衍生物
公开(公告)号：US07687490B2
公开(公告)日：2010-03-30
申请号：US11401892
申请日：2006-04-12
申请人： Takahisa Maruyama , Yuko Kano , Takashi Ando , Takehiko Sawabe , Nobuyoshi Baba , Hiromi Takata , Hisashi Suzuki , Kazuhiro Aihara , Toshiki Fujita
发明人： Takahisa Maruyama , Yuko Kano , Takashi Ando , Takehiko Sawabe , Nobuyoshi Baba , Hiromi Takata , Hisashi Suzuki , Kazuhiro Aihara , Toshiki Fujita
IPC分类号： C07D477/20 , A61K31/426 , A61K31/454 , A61P31/04 , C07D277/56 , C07D277/26 , C07D277/30 , C07D277/40 , C07D417/06
CPC分类号： C07D487/04
摘要： An objective of the present invention is to provide compounds that are effective against various resistant bacteria which cause current clinical problems, for example, pneumococci including penicillin resistant Streptococcus pneumoneae (PRSP), Haemophilus influenzae including bata-lactamase-nonproducing ampicillin-resistant Haemophilus influenzae (BLNAR), and Moraxella (Branhamella) catarrhalis.The present invention provides 2-ethenylthio-based carbapenem derivatives represented by the formula (I) or pharmaceutically acceptable salts thereof that are effective, for example, against pneumococci including penicillin resistant Streptococcus pneumoneae (PRSP), Haemophilus influenzae including beta-lactamase-nonproducing ampicillin-resistant Haemophilus influenzae (BLNAR), and Moraxella (Branhamella) catarrhalis:
摘要翻译：本发明的目的是提供对于引起当前临床问题的各种耐药性细菌有效的化合物，例如包括耐青霉素的肺炎链球菌（PRSP），流感嗜血杆菌（Haemophilus influenzae），包括不含巴生酵母的氨苄青霉素抗性流感嗜血杆菌 BLNAR）和莫拉氏菌（Branhamella）卡他氏菌。本发明提供了由式（I）表示的2-乙烯基硫代碳青霉烯衍生物或其药学上可接受的盐，其可有效地例如针对包括耐青霉素的肺炎链球菌（PRSP）在内的肺炎球菌，流感嗜血杆菌，包括β-内酰胺酶非生产氨苄青霉素耐药性流感嗜血杆菌（BLNAR）和莫拉氏菌（Branhamella）卡他性：

9. 发明申请

US20090270647A1 METHOD FOR PRODUCING ALPHA - AMINO ACID INCLUDING PHOSPHORUS AND PRODUCTION INTERMEDIATES THEREOF 有权
标题翻译：生产含氨基酸的氨基酸及其生产中间体的方法
公开(公告)号：US20090270647A1
公开(公告)日：2009-10-29
申请号：US12442011
申请日：2007-09-19
申请人： Nobuto Minowa , Nozomu Nakanishi , Masaaki Mitomi
发明人： Nobuto Minowa , Nozomu Nakanishi , Masaaki Mitomi
IPC分类号： C07F9/32
CPC分类号： C07B53/00 , B01J31/0207 , B01J31/0209 , B01J31/0235 , B01J31/0237 , B01J31/0261 , B01J31/0271 , B01J2231/341 , C07F9/3211 , Y02P20/55
摘要： A method for efficiently producing L-2-amino-4-(hydroxymethylphosphinyl)-butanoic acid, useful as a herbicide, by a catalytic asymmetric synthesis reaction with a high asymmetric yield. The method includes a step in which a compound represented by the below formula (1) and a benzylamine are reacted in the presence of dehydrating agent, then the resulting mass is reacted with hydrogen cyanide in the presence of an asymmetric catalyst, followed by acid hydrolysis, further followed by elimination of a protective group. [chemical formula 1] (1) (where, R1 represents a C1-4 alkyl group.)
摘要翻译：通过具有高不对称产率的催化不对称合成反应有效生产可用作除草剂的L-2-氨基-4-（羟甲基氧膦基） - 丁酸的方法。该方法包括在脱水剂的存在下使由下式（1）表示的化合物和苄胺反应的步骤，然后将所得物质与氰化氢在不对称催化剂的存在下反应，随后进行酸水解，然后除去保护基。 [化学式1]（1）（其中，R 1表示C 1-4烷基）

10. 发明授权

US07563901B2 Intermediates of 2-substituted carbapenem derivatives and process for production thereof 失效
公开(公告)号：US07563901B2
公开(公告)日：2009-07-21
申请号：US12071120
申请日：2008-02-15
申请人： Toshiro Sasaki , Takashi Ando , Yasuo Yamamoto , Takahiro Imai , Dai Kubota , Katsuhiko Noguchi , Nobuyuki Hori , Eiki Shitara , Kunio Atsumi , Shohei Yasuda
发明人： Toshiro Sasaki , Takashi Ando , Yasuo Yamamoto , Takahiro Imai , Dai Kubota , Katsuhiko Noguchi , Nobuyuki Hori , Eiki Shitara , Kunio Atsumi , Shohei Yasuda
IPC分类号： C07D513/02 , A61K31/429
CPC分类号： C07D513/04 , C07F9/6561 , Y02P20/55
摘要： The present invention relates to compounds represented by formula (1) and a process for producing the same. The use of these compounds can realize the production of carbapenem derivatives having potent antimicrobial activity and a wide antimicrobial spectrum in a safe and cost-effective manner.

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