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1. 发明申请

US20120130470A1 STENT WITH PROTECTED BARBS 有权
标题翻译：有保护的酒吧
公开(公告)号：US20120130470A1
公开(公告)日：2012-05-24
申请号：US13266228
申请日：2010-04-27
申请人： Carl Agnew , Jason Bowe , Kurt Dierking , Jarin Kratzberg , Alan Leewood , David Orr
发明人： Carl Agnew , Jason Bowe , Kurt Dierking , Jarin Kratzberg , Alan Leewood , David Orr
IPC分类号： A61F2/84 , A61F2/82
CPC分类号： A61F2/86 , A61F2/848 , A61F2/95 , A61F2002/8483 , A61F2210/0004 , A61F2220/0016 , A61F2250/0071
摘要： An endoluminal prosthesis is described and comprises a stent (40), At least one barb (42) secured to the stent, and a degradable barb guard (52) covering at least a portion of the barb and protecting the distal tip when the stent is in a compressed configuration. The barb guard (52) comprises a degradable structure that degrades to expose the distal tip of the barb when the stent is placed in a vessel. An endoluminal prosthesis deployment system comprising a sheath having a lumen and a prostesis within the sheath lumen is also described
摘要翻译：描述了腔内假体并且包括支架（40），固定到支架的至少一个倒钩（42）和覆盖至少一部分倒钩的可降解的倒钩保护件（52），并且当支架是在压缩配置。所述倒钩保护件（52）包括可降解结构，当所述支架放置在容器中时，所述可降解结构劣化以暴露所述倒钩的远端。还描述了包括在鞘腔内具有内腔和假体的鞘的腔内假体展开系统

2. 发明申请

US20110313512A1 Side Branch Stent Graft 有权
标题翻译：侧分支支架移植
公开(公告)号：US20110313512A1
公开(公告)日：2011-12-22
申请号：US12912175
申请日：2010-10-26
申请人： David Ernest Hartley , Werner Dieter Ducke , Chantelle King , Blayne A. Roeder
发明人： David Ernest Hartley , Werner Dieter Ducke , Chantelle King , Blayne A. Roeder
IPC分类号： A61F2/82
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/061 , A61F2220/0075
摘要： A stent graft has a tubular side arm which can be angled proximally and distally and from side to side. The wall of the stent graft in the vicinity of the side arm has a loose fold of the graft material and the side arm is fastened to the loose fold of graft material. The tubular side arm has an inner end and an outer end and is fastened into the loose fold of graft material by a circumferential fastening around the tubular side arm between the inner end and the outer end so that the tubular side arm extends partially within the tubular body of the stent graft and partially outside the tubular body of the stent graft. The loose fold of graft material can be formed by the graft material defining a recess in the wall of the stent graft. To enable movement or angulation proximally and distally and from side to side the loose fold of graft material is provided both proximally and distally of the tubular side arm and circumferentially to each side of the tubular side arm.
摘要翻译：支架移植物具有管状侧臂，其能够在近端和远端并且从一侧到另一侧成角度。在侧臂附近的支架移植物的壁具有移植材料的松散折叠，并且侧臂被紧固到移植物材料的松散褶皱上。管状侧臂具有内端和外端，并且通过在内端和外端之间围绕管状侧臂的周向紧固而紧固到移植材料的松动折叠中，使得管状侧臂部分地在管状侧壁内延伸支架植入物的主体和部分位于支架移植物的管状体外部。接枝材料的松散折叠可以通过在支架移植物的壁中限定凹部的移植材料形成。为了使近端和远端以及从一侧到另一侧的移动或角度，移植材料的松散折叠被提供在管状侧臂的近端和远端，并且周向地设置在管状侧臂的每一侧。

3. 发明申请

US20110160844A1 INTRAVASCULAR DEVICE ATTACHMENT SYSTEM HAVING BIOLOGICAL MATERIAL 审中-公开
标题翻译：具有生物材料的血管内装置附件系统
公开(公告)号：US20110160844A1
公开(公告)日：2011-06-30
申请号：US12863038
申请日：2009-01-16
申请人： Kenneth Haselby , Brian D. Choules , Blayne A. Roeder , Richard B. Sisken , David Eric Orr , James D. Purdy , Steven J. Charlebois , David D. Grewe , Neal E. Fearnot , Alan R. Leewood
发明人： Kenneth Haselby , Brian D. Choules , Blayne A. Roeder , Richard B. Sisken , David Eric Orr , James D. Purdy , Steven J. Charlebois , David D. Grewe , Neal E. Fearnot , Alan R. Leewood
IPC分类号： A61F2/84
CPC分类号： A61M1/125 , A61B5/076 , A61B5/14535 , A61B5/14539 , A61B5/6862 , A61B5/6876 , A61B5/6882 , A61F2/0077 , A61F2/2418 , A61F2/2475 , A61F2/86 , A61F2002/068 , A61F2002/8486 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2230/005 , A61F2230/0071 , A61F2230/008 , A61M1/1006 , A61M1/1008 , A61M1/101 , A61M1/1098 , A61M1/122 , A61M1/3653 , A61M1/3659
摘要： An attachment system for attaching an intravascular device to a vessel wall of a body vessel is disclosed. The attachment system includes an intravascular device and biological attachment material connected to the intravascular device. The biological attachment material is configured to attach the intravascular device to the vessel wall.
摘要翻译：公开了一种用于将血管内装置附接到身体血管的血管壁的附接系统。附着系统包括连接到血管内装置的血管内装置和生物附着材料。生物附着材料构造成将血管内装置附接到血管壁。

4. 发明授权

US07867275B2 Coated implantable medical device method 有权
标题翻译：涂层可植入医疗器械方法
公开(公告)号：US07867275B2
公开(公告)日：2011-01-11
申请号：US11515395
申请日：2006-09-01
申请人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees, III , Thomas G. Kozma
发明人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees, III , Thomas G. Kozma
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/24 , A61F2/82 , A61F2/885 , A61F2250/0068 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L33/022 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61N5/1002 , C08L65/04
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。此外，至少一个多孔层20可以放置在生物活性材料层18上方，其中多孔层包括聚合物并提供生物活性材料通过其控制释放。优选地，结构12是冠状动脉支架。多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

5. 发明授权

US07862605B2 Coated implantable medical device 有权
标题翻译：涂层可植入医疗器械
公开(公告)号：US07862605B2
公开(公告)日：2011-01-04
申请号：US11604539
申请日：2006-11-27
申请人： Anthony O. Ragheb , Brian L. Bates , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
发明人： Anthony O. Ragheb , Brian L. Bates , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
IPC分类号： A61F2/06
CPC分类号： A61K51/1282 , A61F2/24 , A61F2/82 , A61F2250/0068 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L33/022 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , A61N5/1002 , C08L65/04
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of a bioactive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of bioactive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of bioactive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a stent graft. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative which is deposited without solvents, heat or catalysts, but rather by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12，以及至少一个位于结构的至少一个表面上的生物活性剂层18 任选地，装置10可以包括位于生物活性剂层18上方的至少一个多孔的，优选的聚合物层20，并且还可以包括至少一个被涂覆在结构12的一个表面上的涂层16，至少一层生物活性剂层依次放置在涂层16的至少一部分上。多孔层20和涂层16各自提供生物活性材料从装置10的受控释放。结构12是优选构造为支架移植物。多孔层20的聚合物优选通过蒸气或等离子体沉积来施加。特别优选的是聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不用溶剂，加热或催化剂沉积，而是通过单体蒸气的冷凝而沉积。

6. 发明申请

US20100323052A1 NEEDLE-TO-NEEDLE ELECTROSPINNING 有权
标题翻译：针对针电极
公开(公告)号：US20100323052A1
公开(公告)日：2010-12-23
申请号：US12870581
申请日：2010-08-27
申请人： DAVID E. ORR , William F. Moore
发明人： DAVID E. ORR , William F. Moore
IPC分类号： B29C35/10
CPC分类号： B05D1/04 , B05B5/0255 , B05B5/08 , B05B5/087 , B05B5/12 , B05D2252/10 , B05D2254/02 , B05D2254/04 , D01D5/0061 , D01D5/0084
摘要： The disclosure relates to a method and apparatus for coating a medical device. The method includes providing an electrospinning apparatus and simultaneously electrospinning at least one solution onto a first surface and an opposing second surface. The apparatus comprises a first spinneret and a second spinneret. An energy source is electrically coupled to the first spinneret and the second spinneret. The first spinneret and second spinneret comprise a reservoir and an orifice fluidly coupled to the reservoir. The first spinneret orifice is located substantially opposite the second spinneret orifice.
摘要翻译：本公开涉及一种用于涂覆医疗装置的方法和装置。该方法包括提供静电纺丝装置，同时将至少一种溶液静电纺丝到第一表面和相对的第二表面上。该装置包括第一喷丝头和第二喷丝头。能量源电耦合到第一喷丝头和第二喷丝头。第一喷丝头和第二喷丝头包括流体耦合到储存器的储存器和孔口。第一喷丝孔与第二喷丝孔大致相对。

7. 发明申请

US20100292778A1 EXPANDABLE STENT COMPRISING END MEMBERS HAVING AN INTERLOCKING CONFIGURATION 审中-公开
标题翻译：包含具有互锁配置的终端成员的可扩展性
公开(公告)号：US20100292778A1
公开(公告)日：2010-11-18
申请号：US12467047
申请日：2009-05-15
申请人： Blayne A. Roeder , Seoggwan Kim , Richard A. Swift
发明人： Blayne A. Roeder , Seoggwan Kim , Richard A. Swift
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2002/9522 , A61F2230/0054 , A61F2250/0098
摘要： An expandable stent for use in a body vessel comprises a thin-walled tubular framework including two or more circumferentially adjacent end members extending in a longitudinal direction from an end of the framework. In a delivery configuration of the tubular framework, the end members have an interlocking configuration. Each end member has a first interlocking side and a second interlocking side, where the first interlocking side has a circumferentially directed protrusion and the second interlocking side has a circumferentially directed recess. The protrusion of a first end member mates with the recess of a second end member. In an expanded configuration of the tubular framework, the end members are disengaged from the interlocking configuration. Each end member may be an eyelet including an opening for a radiopaque rivet. A method of preparing the expandable stent for delivery into a body vessel is also described.
摘要翻译：用于体内容器的可扩张支架包括薄壁管状框架，其包括从框架的端部沿纵向方向延伸的两个或更多个周向相邻的端部构件。在管状框架的输送构造中，端部构件具有互锁构造。每个端构件具有第一互锁侧和第二互锁侧，其中第一互锁侧具有周向定向的突出部，并且第二互锁侧具有周向定向的凹部。第一端构件的突出部与第二端构件的凹部配合。在管状框架的扩展构造中，端部构件与联锁构型脱离。每个端部构件可以是包括用于不透射线的铆钉的开口的孔眼。还描述了制备用于输送到体内容器中的可扩张支架的方法。

8. 发明申请

US20100104658A2 GRAFT PROSTHESIS, MATERIALS AND METHODS 有权
标题翻译： GRAFT PROSTHESIS，材料和方法
公开(公告)号：US20100104658A2
公开(公告)日：2010-04-29
申请号：US11931811
申请日：2007-10-31
申请人： William Cook , Michael Hiles , Thomas Kozma , Umesh Patel
发明人： William Cook , Michael Hiles , Thomas Kozma , Umesh Patel
IPC分类号： A61F2/02 , A61K35/24
CPC分类号： A61L27/24 , A61F2/06 , A61F2/07 , A61L2/0088 , A61L27/3604 , A61L27/3662 , A61L27/3683 , A61L27/3695 , A61L27/3839 , A61L27/3843 , A61L27/386 , A61L29/005 , A61L31/005 , Y10S623/925
摘要： A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.
摘要翻译：移植假体（11），用于植入，移植，替换或修复患者的一部分的材料和方法。移植假体包括从粘膜下层组织源移除的纯化的基于胶原的基质结构。通过消毒和去除步骤来净化粘膜下组织来源，以去活化和去除污染物，从而使纯化的结构生物相容并适于在患者和/或患者中接枝。

9. 发明申请

US20100016953A1 Anchoring Barb for Attachment to a Medical Prosthesis 有权
标题翻译：锚固肢体附属于医疗假体
公开(公告)号：US20100016953A1
公开(公告)日：2010-01-21
申请号：US12506012
申请日：2009-07-20
申请人： Richard B. Sisken , Brian D. Choules , Benjamin Nickless , Charles W. Agnew
发明人： Richard B. Sisken , Brian D. Choules , Benjamin Nickless , Charles W. Agnew
IPC分类号： A61F2/06
CPC分类号： A61F2/86 , A61F2/02 , A61F2/07 , A61F2/82 , A61F2/848 , A61F2002/8483 , A61F2220/0016
摘要： Disclosed is an anchoring element for an implantable prosthesis that includes a barb, wherein the anchoring element, which includes a basal portion, comprises a thin layer of material, such as a cannula or sheet of metal, that extends or wraps at least partially around the strut of the prosthesis to which it is attached. The barb is configured to extend outward from the basal portion to penetrate adjacent tissue. The anchoring element is either permanently affixed to the strut, such as by laser or spot welding, crimping, or some other method of bonding, or allowed to slide longitudinally over the strut between two points or stops in order to relieve any excessive loads placed upon the barb that could cause fracture. The anchoring element and strut may be configured to limit axial rotation of the barb, while still allowing longitudinal movement. In another embodiment, the slidable anchoring element may be manipulated following initial deployment to reorient the barb toward the implantation site.
摘要翻译：公开了一种用于可植入假体的锚定元件，其包括倒钩，其中包括基部的锚固元件包括薄层材料，例如套管或金属片，其至少部分地围绕与其相连的假肢的支柱。倒钩构造成从基部向外延伸以穿透相邻的组织。锚定元件永久地固定在支柱上，例如通过激光或点焊，压接或某种其它粘合方法，或者允许在两个点或止挡之间在支柱上纵向滑动，以便减轻放置在可能导致骨折的倒钩。锚定元件和支柱可以被配置为限制倒钩的轴向旋转，同时仍允许纵向运动。在另一个实施例中，可以在初始部署之后操纵可滑动锚定元件，以将倒钩朝向植入部位重新定向。

10. 发明申请

US20090248144A1 ENDOLUMINAL DEVICE WITH EXTRACELLULAR MATRIX MATERIAL AND METHODS 有权
标题翻译：具有细胞基质材料和方法的内膜装置
公开(公告)号：US20090248144A1
公开(公告)日：2009-10-01
申请号：US12468383
申请日：2009-05-19
申请人： Clinton D. Bahler , Michael P. DeBruyne , Neal E. Fearnot , Alan R. Leewood , Jason A. Mead , Thomas A. Osborne , Jichao Sun , Lal Ninan
发明人： Clinton D. Bahler , Michael P. DeBruyne , Neal E. Fearnot , Alan R. Leewood , Jason A. Mead , Thomas A. Osborne , Jichao Sun , Lal Ninan
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/0077 , A61F2/848 , A61F2/89 , A61F2/915 , A61F2002/061 , A61F2002/065 , A61F2002/075 , A61F2002/8483 , A61F2002/8486 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0065
摘要： An endoluminal device comprises a stent and a tubular graft supported by the stent. The graft has a proximal and a distal opening and comprises a synthetic material and a bioremodelable material. The bioremodelable material is disposed on an exterior surface in at least one band adjacent at least one of the proximal and distal openings.
摘要翻译：腔内装置包括支架和由支架支撑的管状移植物。移植物具有近端和远端开口，并且包括合成材料和生物可重构材料。生物可重塑材料设置在邻近近端和远端开口中的至少一个的至少一个带中的外表面上。

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