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1. 发明授权

US12018239B2 Laser processing machine 有权
公开(公告)号：US12018239B2
公开(公告)日：2024-06-25
申请号：US17103539
申请日：2020-11-24
申请人： KATAOKA CORPORATION , NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
发明人： Masami Suzuki , Norio Nishi , Junichi Matsumoto , Kimio Sumaru , Toshiyuki Kanamori
IPC分类号： C12M1/34 , C12M1/00 , C12M1/12 , C12M1/26 , C12M1/32 , C12M1/42 , C12N1/00 , C12N1/02 , C12N5/00 , C12N13/00
CPC分类号： C12M1/42 , C12M1/005 , C12M1/3446 , C12M23/20 , C12M25/06 , C12M31/02 , C12M33/06 , C12M33/10 , C12M47/04 , C12N1/00 , C12N1/02 , C12N5/0081 , C12N13/00
摘要： A laser processing machine for killing specific cells from a group of cells on a surface of a layer containing an ingredient capable of absorbing laser light, the laser processing machine being configured to: control a laser light source to output laser light at 5W or less and at a wavelength of 380 nm or greater such that the laser light source is applied to a second area on a second surface of the layer opposed to the first surface; and control an actuator to provide a relative movement between the second area where the laser light is applied and the layer at a rate of 2000 mm/sec or less such that the irradiated second area absorbs energy to generate heat that kills unwanted cells on a first area of the first surface and the laser light does not instantly kill the specific cells on the first area upon irradiation.

2. 发明公开

US20240157470A1 LASER PROCESSING DEVICE 审中-公开
公开(公告)号：US20240157470A1
公开(公告)日：2024-05-16
申请号：US18421370
申请日：2024-01-24
申请人： KATAOKA CORPORATION
发明人： Etsushi KATO , Takeshi YAMAMURA , Keisuke HAYASHI
IPC分类号： B23K26/046 , B23K26/06 , B23K26/073 , B23K26/082 , B23K26/21
CPC分类号： B23K26/046 , B23K26/0604 , B23K26/0648 , B23K26/073 , B23K26/082 , B23K26/21
摘要： A laser processing device 0 includes a combiner unit 3 configured to superimpose a plurality of laser beams L1 and L2 having different wavelengths on the same optical axis; a focus shifter unit 4 configured to adjust a focal length of the laser beams L1 and L2 superimposed by the combiner unit 3; and a Galvano scanner unit 5 located downstream of the focus shifter unit 4 and configured to change a direction of the optical axis of the laser beams L1 and L2 traveling toward a processing object, and the adjustment in the focal length performed by the focus shifter unit 4 is synchronized with the change in the direction of the optical axis performed by the Galvano scanner unit 5.

3. 发明公开

US20230347456A1 WELDING JIG AND LASER PROCESSING MACHINE 审中-公开
公开(公告)号：US20230347456A1
公开(公告)日：2023-11-02
申请号：US17800633
申请日：2021-02-19
申请人： KATAOKA CORPORATION
发明人： Katsutoshi NAGASAKI , Keisuke HAYASHI
IPC分类号： B23K37/04 , B23K26/21 , H01M10/04 , H01M50/566
CPC分类号： B23K37/0443 , B23K26/21 , H01M10/0409 , H01M10/049 , H01M50/566 , B23K2101/36
摘要： A welding jig including a first support member; a second support member; and a pressure adjusting mechanism. Wherein the first support member has a through hole through which a laser beam can pass, the second support member being configured to be insertable into and detachable from a hollow shaft core portion of a jelly roll type electrode assembly, and one end of the second support member supporting an electrode and a bottom of a battery can disposed on a side of one end of the jelly roll type electrode assembly. The pressure adjusting mechanism being configured to adjust a pressure applied between the first support member and the second support member, and the through hole being configured to allow the laser beam to weld the battery can and the electrode.

4. 发明授权

US11603514B2 Cell treatment apparatus 有权
公开(公告)号：US11603514B2
公开(公告)日：2023-03-14
申请号：US16627108
申请日：2019-05-30
申请人： KATAOKA CORPORATION
发明人： Junichi Matsumoto , Norihiro Yamagishi
IPC分类号： C12M1/00 , C12M1/42 , C12M1/34
摘要： The present invention provides a cell treatment apparatus that can improve the operating rates of an observation unit and a laser irradiation unit in the case of treating a plurality of cell culture vessels. The cell treatment apparatus of the present invention includes: a cell treatment chamber in which cells in a cell culture vessel are treated; an observation unit that can observe the cells in the cell culture vessel; a laser irradiation unit that can irradiate the cells with lasers; a first moving unit that can move the observation unit; and a second moving unit that can move the laser irradiation unit, wherein the cell treatment chamber includes a plurality of regions in which the cells can be treated, each region includes a first cell culture vessel placement unit and a second cell culture vessel placement unit, in the first cell culture vessel placement unit, the cells in the cell culture vessel are observed by the observation unit, in the second cell culture vessel placement unit, the cells in the cell culture vessel are irradiated with lasers by the laser irradiation unit, the observation unit is moved by the first moving unit in a state of being able to observe the cells in the cell culture vessel in the first cell culture vessel placement unit of each region, and the laser irradiation unit is moved by the second moving unit in a state of being able to irradiate the cells in the cell culture vessel in the second cell culture vessel placement unit of each region with lasers.

5. 发明授权

US11499129B2 Cell treatment apparatus 有权
公开(公告)号：US11499129B2
公开(公告)日：2022-11-15
申请号：US16485356
申请日：2017-09-20
申请人： KATAOKA CORPORATION
发明人： Junichi Matsumoto , Norihiro Yamagishi
IPC分类号： C12M1/00 , B01L3/00 , C12M3/00
摘要： A cell treatment apparatus capable of treating cells in a cell culture vessel. The cell treatment apparatus (100) according to the present invention includes a first region (1), a second region (3), and a third region (5). The first region (1) and the second region (3) are placed in succession. The first region (1) is a cell treatment chamber for treating cells. The cell treatment chamber can be closed from the outside of the cell treatment chamber and includes a culture vessel placement portion for placing a cell culture vessel. The second region (3) includes a laser irradiation device capable of irradiating the cell culture vessel placed in the culture vessel placement portion with a laser. The third region (5) includes a control device that controls at least one device in the cell treatment apparatus (100) and a power supply device (52) that supplies electric power to at least one device in the cell treatment apparatus (100). The culture vessel placement portion is placed to be adjacent to the second region (3) in the cell treatment chamber. An adjacent portion to the second region (3) in the culture vessel placement portion is translucent.

6. 发明授权

US11459546B2 Method for producing somatic cell, somatic cell, and composition 有权
公开(公告)号：US11459546B2
公开(公告)日：2022-10-04
申请号：US16336985
申请日：2017-09-27
申请人： Kyoto Prefectural Public University Corporation , KATAOKA CORPORATION
发明人： Yuta Murakami , Yasuhiro Yoshioka , Ping Dai , Toshikazu Yoshikawa , Yoshinori Harada
IPC分类号： C12N5/077 , C12N5/0793
摘要： The present invention addresses the problem of providing: a method for producing brown adipocytes, osteoblasts, cartilage cells, neural cells, or cardiac cells from somatic cells without performing artificial gene transfer; brown adipocytes, osteoblasts, cartilage cells, neural cells, or cardiac cells; or a composition including a combination of chemical substances that can be used for the aforementioned production method. An example of the present invention is a method for producing brown adipocytes, osteoblasts, cartilage cells, neural cells, or cardiac cells including a step for culturing somatic cells in the presence or absence of an inhibitor or activator selected from the group consisting of an ALK5 inhibitor, an ALK6 inhibitor, an AMPK inhibitor, a cAMP activator, an ALK2 inhibitor, an ALK3 inhibitor, a GSK3 inhibitor, and an Erk inhibitor.

7. 发明申请

US20210363475A1 CELL TREATMENT APPARATUS 有权
公开(公告)号：US20210363475A1
公开(公告)日：2021-11-25
申请号：US16627108
申请日：2019-05-30
申请人： KATAOKA CORPORATION
发明人： Junichi MATSUMOTO , Norihiro YAMAGISHI
IPC分类号： C12M1/00 , C12M1/42 , C12M1/34
摘要： The present invention provides a cell treatment apparatus that can improve the operating rates of an observation unit and a laser irradiation unit in the case of treating a plurality of cell culture vessels. The cell treatment apparatus of the present invention includes: a cell treatment chamber in which cells in a cell culture vessel are treated; an observation unit that can observe the cells in the cell culture vessel; a laser irradiation unit that can irradiate the cells with lasers; a first moving unit that can move the observation unit; and a second moving unit that can move the laser irradiation unit, wherein the cell treatment chamber includes a plurality of regions in which the cells can be treated, each region includes a first cell culture vessel placement unit and a second cell culture vessel placement unit, in the first cell culture vessel placement unit, the cells in the cell culture vessel are observed by the observation unit, in the second cell culture vessel placement unit, the cells in the cell culture vessel are irradiated with lasers by the laser irradiation unit, the observation unit is moved by the first moving unit in a state of being able to observe the cells in the cell culture vessel in the first cell culture vessel placement unit of each region, and the laser irradiation unit is moved by the second moving unit in a state of being able to irradiate the cells in the cell culture vessel in the second cell culture vessel placement unit of each region with lasers.

8. 发明授权

US10876086B2 Cell treatment method, laser processing machine, and cell culture vessel 有权
公开(公告)号：US10876086B2
公开(公告)日：2020-12-29
申请号：US15576228
申请日：2016-03-25
申请人： KATAOKA CORPORATION , NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
发明人： Masami Suzuki , Norio Nishi , Junichi Matsumoto , Kimio Sumaru , Toshiyuki Kanamori
IPC分类号： C12M1/42 , C12N1/00 , C12M1/00 , C12M1/34 , C12M1/32 , C12M1/26 , C12N1/02 , C12N5/00 , C12N13/00 , C12M1/12
CPC分类号： C12M1/42 , C12M1/005 , C12M1/3446 , C12M23/20 , C12M25/06 , C12M31/02 , C12M33/06 , C12M33/10 , C12M47/04 , C12N1/00 , C12N1/02 , C12N5/0081 , C12N13/00
摘要： A method of killing specific cells from among a group of cells cultured in a culture vessel by quick and brief laser treatment, the cell culture vessel comprising a main body and a to-be-irradiated layer attached to the main body, the to-be-irradiated layer containing an ingredient capable of absorbing laser light upon laser irradiation, the group of cells being cultured on the surface of the to-be-irradiated layer, the method comprising:

applying laser light to a partial area of the to-be-irradiated layer directly below the specific cells.

9. 发明申请

US20230140027A1 CELL-CULTURING INSTRUMENT-MACHINING DEVICE 有权
公开(公告)号：US20230140027A1
公开(公告)日：2023-05-04
申请号：US17911527
申请日：2021-03-12
申请人： KATAOKA CORPORATION
发明人： Tadao MORISHITA , Junichi MATSUMOTO
IPC分类号： C12M1/42 , C12M1/22 , C12N13/00
摘要： The processing apparatus 200 of the present disclosure includes: a laser irradiation unit 21 capable of applying a laser to the photothermal conversion layer 13 of the cell culture tool 100 including the cell culture base layer 11 and the photothermal conversion layer 13; and a control unit 22 for controlling the laser irradiation unit 21. The control unit 22 includes a setting section 221 and an irradiation control section 222. The setting section 221 sets an irradiation region to be irradiated with the laser in the cell culture tool 100. The irradiation control section 222 controls the laser irradiation unit 21 based on the irradiation region such that the laser irradiation unit 21 applies the laser to a corresponding region of the photothermal conversion layer 13.

10. 发明申请

US20230082555A1 Composition for Medium 有权
公开(公告)号：US20230082555A1
公开(公告)日：2023-03-16
申请号：US17779639
申请日：2020-11-18
申请人： Kataoka Corporation , Kyoto Prefectural Public University Corporation
发明人： Ping Dai , Yukimasa Takeda , Yoshinori Harada , Junichi Matsumoto
IPC分类号： C12N5/077
摘要： The present invention is primarily directed to provide a new composition for a medium which can be used for differentiation induction from somatic cells to brown adipocytes.
The present invention can include, for example, a composition for a medium used in differentiation induction from somatic cells to brown adipocytes, wherein the composition comprises the following seven components: a thyroid hormone receptor agonist, a glucocorticoid receptor agonist, a phosphodiesterase inhibitor, insulin, an ascorbic acid derivative, albumin, and an antibiotic.
According to the present invention, direct differentiation induction from somatic cells to brown adipocytes can be effectively performed. In addition, according to the present invention, it is possible to effectively maintain brown adipocytes.

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