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2. 发明授权

US08232276B2 Anhydrous topical skin preparations 有权
标题翻译：无水局部皮肤制剂
公开(公告)号：US08232276B2
公开(公告)日：2012-07-31
申请号：US10722134
申请日：2003-11-26
申请人： Katherine M. Burnett , Ellen S. Kurtz
发明人： Katherine M. Burnett , Ellen S. Kurtz
IPC分类号： A01N43/58 , A01N43/60 , A01N43/52 , A01N43/26 , A01N25/34 , A61K31/50 , A61K31/495 , A61K31/415 , A61K31/335
CPC分类号： A61K9/0014 , A61K47/10 , A61K47/32 , A61K47/38 , Y10S514/944
摘要： The present invention provides anhydrous compositions for topical delivery of a medicament comprising (A) a penetration enhancer/solvent selected from the group consisting of alcohol, propylene glycol, or a combination thereof; (B) a humectant/solvent selected from the group consisting of polyethylene glycol, glycerin, sorbitol, xylitol, or any combination of any of the foregoing; and (C) an anhydrous vehicle. In an alternate embodiment, the present invention provides anhydrous compositions for topical delivery of a medicament which comprise (A) a penetration enhancer/solvent selected from the group consisting of alcohol, propylene glycol, or a combination thereof; (B) a humectant/solvent selected from the group consisting of polyethylene glycol, glycerin, sorbitol, xylitol or any combination of any of the foregoing; (C) an anhydrous vehicle; and (D) a medicament. Also provided are methods for topically delivering a medicament to an animal, such as a mammal or a human patient, in need of the medicament by topically administering to the animal the compositions of the present invention.
摘要翻译：本发明提供了用于局部递送药物的无水组合物，其包含（A）渗透促进剂/选自醇，丙二醇或其组合的溶剂; （B）选自聚乙二醇，甘油，山梨糖醇，木糖醇或任何上述任何组合的保湿剂/溶剂; 和（C）无水载体。在一个替代实施方案中，本发明提供用于局部递送药物的无水组合物，其包含（A）渗透促进剂/选自醇，丙二醇或其组合的溶剂; （B）选自聚乙二醇，甘油，山梨糖醇，木糖醇或任何上述任何组合的湿润剂/溶剂; （C）无水车辆; 和（D）药物。还提供了通过向动物局部施用本发明的组合物来将药物局部递送给需要该药物的动物例如哺乳动物或人类患者的方法。

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